Details of the Target

General Information of Target

Target ID LDTP11191
Target Name WW domain-containing adapter protein with coiled-coil (WAC)
Gene Name WAC
Gene ID 51322
Synonyms
KIAA1844; WW domain-containing adapter protein with coiled-coil
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPTLPSYWCSQQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSY
QRSMHAYQREKMKEEKRRSLEARREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQH
GKLKSAKEEQRKLIAEQLLYEHWKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEATA
EQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKE
QENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRIL
QALLEKEDESQRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEK
REAEWARERSARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELAR
REKEESEKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETM
AEQGYRPKPYGHPKIAWN
Target Bioclass
Other
Subcellular location
Nucleus speckle
Function
Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
Uniprot ID
Q9BTA9
Ensemble ID
ENST00000347934.8
HGNC ID
HGNC:17327

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T244K; p.L611S DBIA    Probe Info 
CAL51 SNV: p.I386K DBIA    Probe Info 
COLO678 SNV: p.Q371K DBIA    Probe Info 
G361 SNV: p.Q275Ter DBIA    Probe Info 
MEWO SNV: p.S12I DBIA    Probe Info 
MFE319 SNV: p.Y25C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K79(9.02)  LDD0277  [2]
Probe 1
 Probe Info  		Y129(33.81)  LDD3495  [3]
BTD
 Probe Info  		C615(1.58)  LDD2092  [4]
AHL-Pu-1
 Probe Info  		C553(2.88)  LDD0169  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
DBIA
 Probe Info  		C615(0.70)  LDD0531  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C553(0.00); C15(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C553(0.00); C615(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C553(0.00); C150(0.00); C15(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [12]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C15(0.00); C615(0.00); C553(0.00)  LDD0018  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
AOyne
 Probe Info  		14.90  LDD0443  [15]
NAIA_5
 Probe Info  		C602(0.00); C553(0.00); C615(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C046
 Probe Info  		42.81  LDD1745  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C553(0.78)  LDD2103  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C553(2.88)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C615(0.70)  LDD0531  [7]
 LDCM0215  AC10 HEK-293T C553(1.11)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C553(0.91); C15(0.94)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C553(1.11)  LDD1510  [17]
 LDCM0246  AC128 HCT 116 C615(0.82)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C615(0.93)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C615(0.75)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C615(0.94)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C615(0.96)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C615(0.93)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C615(1.29)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C615(0.96)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C615(0.80)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C615(0.78)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C615(0.96)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C615(1.19)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C553(1.08)  LDD1512  [17]
 LDCM0260  AC140 HCT 116 C615(1.23)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C615(0.98)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C615(1.02)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C615(1.05)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C615(1.08)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C615(0.92)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C615(0.99)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C615(1.36)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C615(1.69)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C615(1.00)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C553(1.03); C15(0.92)  LDD1513  [17]
 LDCM0271  AC150 HCT 116 C615(0.84)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C615(1.24)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C615(1.21)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C615(1.30)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C615(1.45)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C615(1.29)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C615(0.80)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C615(1.07)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C615(1.23)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C615(1.03)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C615(1.01)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C615(0.83)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C615(1.46)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C615(1.37)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C615(0.98)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C615(0.99)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C615(1.12)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C553(1.01); C15(1.02)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C553(1.01)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C553(1.03); C15(1.01)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C553(1.06)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C553(0.94)  LDD1528  [17]
 LDCM0290  AC3 HCT 116 C615(1.35)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C553(1.07)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C553(1.00); C15(0.91)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C553(1.00)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C553(1.11); C15(0.99)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C553(1.11)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C553(1.04); C15(0.97)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C553(1.05)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C553(1.03)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C553(1.13)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C553(1.08); C15(0.94)  LDD1539  [17]
 LDCM0301  AC4 HCT 116 C615(1.16)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C553(1.07)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C553(1.15); C15(0.96)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C553(1.08)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C553(0.95); C15(0.97)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C553(1.02)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C553(1.03)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C553(1.01)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C553(1.04); C15(0.91)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C553(1.08)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C553(1.03); C15(0.97)  LDD1550  [17]
 LDCM0312  AC5 HCT 116 C615(1.06)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C553(0.96)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C553(0.94); C15(0.95)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C553(0.98)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C553(0.99)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C553(0.93)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C553(0.97); C15(0.89)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C553(1.01)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C553(1.02); C15(1.03)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C553(0.95)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C553(0.87); C15(0.91)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C553(1.05)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C553(1.02)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C553(1.00)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C553(0.94)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C553(1.03); C15(0.95)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C553(1.00)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C553(1.00); C15(0.88)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C553(0.98)  LDD1569  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C615(0.65)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C553(1.01)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C553(1.05); C15(1.00)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C553(1.04)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 14.15  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C615(1.08)  LDD2171  [7]
 LDCM0630  CCW28-3 231MFP C553(1.32)  LDD2214  [18]
 LDCM0632  CL-Sc Hep-G2 C602(20.00); C553(1.25)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C615(0.74)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C615(1.06)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C615(1.02)  LDD0686  [7]
 LDCM0370  CL101 HEK-293T C553(1.01)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C553(1.34); C15(1.08)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C553(1.01); C15(1.02)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C553(0.98)  LDD1577  [17]
 LDCM0374  CL105 HCT 116 C615(1.02)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C615(1.19)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C615(0.94)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C615(1.10)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C615(1.04)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C615(0.79)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C615(0.86)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C615(0.79)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C553(1.30)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C553(1.03)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C553(1.71); C15(1.01)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C553(1.06); C15(0.93)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C553(1.10)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C553(0.95)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C553(0.96); C15(1.07)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C553(0.94); C15(0.95)  LDD1593  [17]
 LDCM0390  CL12 HCT 116 C615(0.84)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C553(1.11)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C553(1.03)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C553(1.03); C15(0.97)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C553(1.54); C15(0.87)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C553(1.17)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C553(0.69)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C553(0.94); C15(0.90)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C553(0.82); C15(0.88)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C553(0.89)  LDD1603  [17]
 LDCM0400  CL13 HCT 116 C615(0.88)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C615(0.87)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C615(0.78)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C553(1.18)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C553(1.62); C15(0.92)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C553(0.88)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C553(0.79); C15(0.99)  LDD1610  [17]
 LDCM0407  CL2 HCT 116 C615(0.75)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C553(1.01)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C553(1.46)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C553(0.94)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C553(1.02); C15(0.97)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C553(1.04)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C553(1.25)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C553(1.02); C15(1.00)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C553(0.95); C15(0.97)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C553(1.05)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C553(1.02); C15(0.98)  LDD1621  [17]
 LDCM0418  CL3 HCT 116 C615(0.73)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C553(0.86)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C553(0.88); C15(1.08)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C553(0.92)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C553(1.57)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C553(1.04)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C553(1.02); C15(0.96)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C553(1.19)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C553(0.96)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C553(1.13); C15(0.68)  LDD1632  [17]
 LDCM0429  CL4 HCT 116 C615(0.84)  LDD0746  [7]
 LDCM0430  CL40 HEK-293T C553(1.00)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C553(1.41); C15(1.02)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C553(0.84)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C553(0.93); C15(1.09)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C553(0.97)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C553(1.11)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C553(0.95)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C553(1.05); C15(0.97)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C553(0.92)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C553(0.93)  LDD1643  [17]
 LDCM0440  CL5 HCT 116 C615(0.88)  LDD0757  [7]
 LDCM0441  CL50 HEK-293T C553(1.60); C15(1.00)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C553(1.13)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C553(1.75); C15(0.97)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C553(1.52)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C553(1.00); C15(0.98)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C553(0.98)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C553(1.10)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C553(0.91)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C553(0.97); C15(1.00)  LDD1653  [17]
 LDCM0451  CL6 HCT 116 C615(0.76)  LDD0768  [7]
 LDCM0452  CL60 HEK-293T C553(0.98)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C553(0.91)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C553(1.12); C15(1.02)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C553(1.03); C15(0.92)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C553(1.33)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C553(1.14); C15(1.00)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C553(1.01)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C553(0.99); C15(1.01)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C553(1.05)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C553(1.12)  LDD1664  [17]
 LDCM0462  CL7 HCT 116 C615(0.82)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C553(0.98)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C553(1.13); C15(0.91)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C553(1.03)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C553(1.03)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C553(0.93); C15(0.95)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C553(1.02)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C553(1.33); C15(0.90)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C553(0.90)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C553(0.87); C15(0.99)  LDD1675  [17]
 LDCM0473  CL8 HCT 116 C615(0.80)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C553(0.86)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C553(0.87)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C553(0.94)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C553(1.01); C15(0.86)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C553(1.23)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C553(0.80)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C553(0.73); C15(0.80)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C553(0.78); C15(0.94)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C553(0.89)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C553(0.79); C15(0.81)  LDD1686  [17]
 LDCM0484  CL9 HCT 116 C615(0.82)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C553(1.39)  LDD1688  [17]
 LDCM0486  CL91 HCT 116 C615(0.96)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C615(0.79)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C615(1.22)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C615(0.98)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C615(0.80)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C615(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C615(0.93)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C615(0.85)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C615(1.02)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C15(0.90)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C553(1.15); C15(0.95)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C15(2.82); C150(1.18)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C15(1.42); C615(0.59); C553(1.43)  LDD2187  [19]
 LDCM0572  Fragment10 MDA-MB-231 C553(20.00)  LDD1465  [20]
 LDCM0573  Fragment11 MDA-MB-231 C553(2.87)  LDD1391  [20]
 LDCM0574  Fragment12 MDA-MB-231 C553(20.00)  LDD1393  [20]
 LDCM0575  Fragment13 MDA-MB-231 C553(0.91)  LDD1395  [20]
 LDCM0576  Fragment14 MDA-MB-231 C553(2.41)  LDD1397  [20]
 LDCM0577  Fragment15 Ramos C553(1.53)  LDD1400  [20]
 LDCM0579  Fragment20 MDA-MB-231 C553(2.62)  LDD1402  [20]
 LDCM0580  Fragment21 MDA-MB-231 C553(15.52)  LDD1404  [20]
 LDCM0581  Fragment22 Ramos C553(1.24)  LDD1407  [20]
 LDCM0582  Fragment23 MDA-MB-231 C553(1.01)  LDD1408  [20]
 LDCM0584  Fragment25 MDA-MB-231 C553(1.15)  LDD1411  [20]
 LDCM0578  Fragment27 MDA-MB-231 C553(0.90)  LDD1401  [20]
 LDCM0586  Fragment28 MDA-MB-231 C553(0.96)  LDD1415  [20]
 LDCM0587  Fragment29 MDA-MB-231 C553(1.03)  LDD1417  [20]
 LDCM0588  Fragment30 MDA-MB-231 C553(1.30)  LDD1419  [20]
 LDCM0589  Fragment31 MDA-MB-231 C553(2.30)  LDD1421  [20]
 LDCM0590  Fragment32 Ramos C553(20.00)  LDD1424  [20]
 LDCM0468  Fragment33 HEK-293T C553(0.92); C15(0.90)  LDD1671  [17]
 LDCM0594  Fragment36 MDA-MB-231 C553(1.27)  LDD1431  [20]
 LDCM0596  Fragment38 MDA-MB-231 C553(1.10)  LDD1433  [20]
 LDCM0566  Fragment4 MDA-MB-231 C553(2.42)  LDD1378  [20]
 LDCM0598  Fragment40 MDA-MB-231 C553(0.87)  LDD1436  [20]
 LDCM0599  Fragment41 MDA-MB-231 C553(0.93)  LDD1438  [20]
 LDCM0600  Fragment42 Ramos C553(0.88)  LDD1440  [20]
 LDCM0601  Fragment43 MDA-MB-231 C553(5.83)  LDD1441  [20]
 LDCM0603  Fragment45 MDA-MB-231 C553(20.00)  LDD1444  [20]
 LDCM0604  Fragment46 MDA-MB-231 C553(0.84)  LDD1445  [20]
 LDCM0605  Fragment47 MDA-MB-231 C553(1.37)  LDD1446  [20]
 LDCM0606  Fragment48 MDA-MB-231 C553(1.16)  LDD1447  [20]
 LDCM0607  Fragment49 MDA-MB-231 C553(5.37)  LDD1448  [20]
 LDCM0427  Fragment51 MDA-MB-231 C553(1.02)  LDD1450  [20]
 LDCM0610  Fragment52 MDA-MB-231 C553(1.07)  LDD1452  [20]
 LDCM0611  Fragment53 MDA-MB-231 C553(0.93)  LDD1454  [20]
 LDCM0614  Fragment56 MDA-MB-231 C553(1.12)  LDD1458  [20]
 LDCM0569  Fragment7 MDA-MB-231 C553(1.79)  LDD1383  [20]
 LDCM0570  Fragment8 MDA-MB-231 C553(2.19)  LDD1385  [20]
 LDCM0571  Fragment9 MDA-MB-231 C553(1.34)  LDD1387  [20]
 LDCM0022  KB02 MDA-MB-231 C553(13.67)  LDD1374  [20]
 LDCM0023  KB03 Ramos C553(12.84)  LDD1377  [20]
 LDCM0024  KB05 COLO792 C615(1.96)  LDD3310  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C615(1.58)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C615(0.80)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C553(1.31)  LDD2094  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C615(0.82)  LDD2097  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C615(0.70)  LDD2101  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C615(1.93)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C615(1.18)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C615(0.43)  LDD2108  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C615(1.09)  LDD2111  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C615(0.35)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C615(0.48)  LDD2134  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C615(1.05)  LDD2137  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C615(0.61)  LDD2151  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C553(1.38)  LDD2206  [22]
 LDCM0628  OTUB2-COV-1 HEK-293T C553(0.87)  LDD2207  [22]
 LDCM0131  RA190 MM1.R C615(2.54); C553(1.60)  LDD0304  [23]
 LDCM0021  THZ1 HCT 116 C615(1.08)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Synaptotagmin-like protein 5 (SYTL5) . Q8TDW5
TNF receptor-associated factor 1 (TRAF1) . Q13077
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.