Details of the Target

General Information of Target

Target ID LDTP10843
Target Name MMS19 nucleotide excision repair protein homolog (MMS19)
Gene Name MMS19
Gene ID 64210
Synonyms
MMS19L; MMS19 nucleotide excision repair protein homolog; hMMS19; MET18 homolog; MMS19-like protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEAT
IINSSTSIKGASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKE
ILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKT
NSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEV
VSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCI
DITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRV
VQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDEN
TMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNI
SRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDS
SSNHVDEFEDNLLIESDVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGR
STACQRQQVFCDEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLV
QNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL
Target Bioclass
Other
Family
MET18/MMS19 family
Subcellular location
Nucleus
Function
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur (Fe-S) cluster assembly into ERCC2/XPD. Together with CIAO2, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Uniprot ID
Q96T76
Ensemble ID
ENST00000327238.14
HGNC ID
HGNC:13824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.D686N DBIA    Probe Info 
DU145 SNV: p.A330V DBIA    Probe Info 
HCT116 SNV: p.Q443K .
HCT15 SNV: p.E342D DBIA    Probe Info 
HSC3 SNV: p.E545K .
HUH28 SNV: p.Q600E DBIA    Probe Info 
JURKAT SNV: p.C79Y Compound 10    Probe Info 
MFE319 SNV: p.M450V DBIA    Probe Info 
PF382 SNV: p.D953N DBIA    Probe Info 
SKMEL2 Deletion: p.P229_Q237del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.08  LDD0402  [1]
TH211
 Probe Info  		Y289(7.67); Y992(6.03)  LDD0257  [2]
TH216
 Probe Info  		Y992(20.00)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K373(7.93)  LDD0277  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
Sulforaphane-probe2
 Probe Info  		1.85  LDD0160  [6]
DA-P3
 Probe Info  		4.39  LDD0182  [7]
AHL-Pu-1
 Probe Info  		C977(2.89); C549(3.22); C819(2.88)  LDD0168  [8]
HPAP
 Probe Info  		3.17  LDD0063  [9]
Alkyne-RA190
 Probe Info  		67.30  LDD0300  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
DBIA
 Probe Info  		C549(117.82); C819(8.55); C502(955.58); C361(6.95)  LDD0209  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C386(0.00); C760(0.00); C794(0.00); C331(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_L
 Probe Info  		C386(0.00); C331(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C386(0.00); C760(0.00); C794(0.00); C331(0.00)  LDD0037  [13]
BTD
 Probe Info  		N.A.  LDD0004  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		C331(0.00); C386(0.00); C549(0.00); C848(0.00)  LDD2226  [18]
TFBX
 Probe Info  		C819(0.00); C549(0.00); C599(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C331(0.00); C386(0.00); C819(0.00); C549(0.00)  LDD0021  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
Compound 10
 Probe Info  		C386(0.00); C549(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
ENE
 Probe Info  		C502(0.00); C549(0.00); C794(0.00); C819(0.00)  LDD0006  [16]
IPM
 Probe Info  		C331(0.00); C750(0.00); C386(0.00); C760(0.00)  LDD0005  [16]
VSF
 Probe Info  		C794(0.00); C386(0.00); C549(0.00); C331(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
W1
 Probe Info  		C386(0.00); C819(0.00); C794(0.00); C502(0.00)  LDD0236  [22]
AOyne
 Probe Info  		11.70  LDD0443  [23]
NAIA_5
 Probe Info  		C386(0.00); C331(0.00); C977(0.00); C848(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.93  LDD0475  [24]
FFF probe3
 Probe Info  		5.66  LDD0465  [24]
JN0003
 Probe Info  		5.32  LDD0469  [24]
STS-1
 Probe Info  		N.A.  LDD0137  [25]
STS-2
 Probe Info  		N.A.  LDD0138  [25]
VE-P
 Probe Info  		N.A.  LDD0396  [26]
OEA-DA
 Probe Info  		3.53  LDD0046  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C819(1.03); C502(1.01)  LDD2117  [28]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C819(1.01)  LDD2152  [28]
 LDCM0025  4SU-RNA HEK-293T C977(2.89); C549(3.22); C819(2.88)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C361(2.39); C819(4.08); C549(2.61)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C361(1.03); C549(1.01); C819(1.00); C599(0.99)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C361(1.05); C549(0.99); C819(0.94); C599(1.05)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C361(0.97); C549(0.88); C819(0.93); C599(1.00)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C549(0.96); C819(0.90); C599(1.09); C760(0.97)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C361(1.03); C549(0.93); C819(1.01); C599(0.92)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C549(1.01); C819(0.95); C599(1.07); C760(1.00)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C361(1.04); C549(0.92); C819(0.94); C599(1.02)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C361(1.07); C549(0.97); C819(0.97); C599(1.02)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C361(1.47); C549(1.21); C819(1.02); C599(1.15)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C361(1.02); C549(0.84); C819(0.96); C599(1.23)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C549(0.94); C819(0.98); C599(0.76); C760(1.12)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C361(1.01); C549(1.01); C819(0.98); C599(0.95)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C361(0.96); C549(1.02); C819(1.05); C599(1.01)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C549(0.97); C819(0.94); C599(1.07); C760(0.99)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C549(1.07); C819(1.05); C599(0.95); C760(1.00)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C361(1.03); C549(1.03); C819(1.01); C599(0.92)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C361(1.03); C549(1.03); C819(0.93); C599(1.05)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C361(1.03); C549(0.83); C819(0.99); C599(0.99)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C549(0.88); C819(0.97); C599(0.72); C760(1.02)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C361(1.06); C549(1.05); C819(0.95); C599(0.97)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C361(0.98); C549(0.85); C819(1.04); C599(1.00)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C361(1.00); C549(0.96); C819(1.01); C599(0.99)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C549(1.18); C819(0.92); C599(1.10); C760(1.00)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C549(0.86); C819(1.06); C599(1.13); C760(0.99)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C361(1.01); C549(1.07); C819(1.01); C599(0.97)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C361(1.01); C549(0.92); C819(0.91); C599(1.08)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C361(0.91); C549(0.87); C819(1.02); C599(1.04)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C549(1.12); C819(0.96); C599(0.79); C760(0.96)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C361(1.06); C549(0.96); C819(1.00); C599(0.96)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C361(1.00); C549(0.93); C819(0.98); C599(1.02)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C549(1.04); C819(0.98); C599(1.10); C760(0.99)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C549(1.00); C819(1.02); C599(1.00); C760(0.95)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C549(0.99); C819(1.03); C599(0.99); C760(1.00)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C361(1.06); C549(1.01); C819(0.95); C599(1.02)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C361(1.08); C549(1.07); C819(1.00); C599(1.04)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C361(0.88); C549(0.92); C819(0.95); C599(1.10)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C549(1.18); C819(0.89); C599(0.89); C760(0.97)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C361(1.04); C549(1.04); C819(0.91); C599(0.95)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C361(0.96); C549(0.87); C819(0.99); C599(1.05)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C549(1.01); C819(0.92); C599(1.07); C760(0.98)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C549(0.91); C819(0.96); C599(0.95); C760(1.03)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C361(1.03); C549(1.08); C819(0.97); C599(0.96)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C361(1.07); C549(1.01); C819(0.87); C599(1.03)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C361(1.05); C549(1.00); C819(0.88); C599(1.13)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C361(0.97); C549(0.82); C819(1.02); C599(1.09)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C549(1.00); C819(0.91); C599(0.96); C760(0.97)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C361(0.97); C549(1.00); C819(0.91); C599(0.94)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C361(1.03); C549(0.92); C819(0.97); C599(1.03)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C549(1.14); C819(0.93); C599(1.10); C760(1.00)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C549(0.91); C819(1.04); C599(1.02); C760(1.01)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C361(1.00); C549(1.15); C819(0.97); C599(0.95)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C361(1.05); C549(1.04); C819(0.93); C599(1.12)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C361(0.93); C549(0.96); C819(0.90); C599(1.04)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C361(0.99); C549(0.97); C819(1.01); C599(1.00)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C549(1.13); C819(0.92); C599(0.83); C760(0.99)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C361(1.08); C549(1.06); C819(0.87); C599(1.06)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C361(0.98); C549(0.93); C819(0.85); C599(1.01)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C549(1.04); C819(0.94); C599(1.05); C760(0.94)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C549(1.08); C819(0.96); C599(1.02); C760(1.04)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C549(1.14); C819(0.88); C599(1.12); C760(0.96)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C549(0.88); C819(1.04); C599(0.97); C760(0.96)  LDD1569  [29]
 LDCM0248  AKOS034007472 HEK-293T C361(1.09); C549(1.09); C819(0.91); C599(0.97)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C361(1.06); C549(1.11); C819(0.98); C599(1.13)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C549(1.03); C819(1.04); C599(0.92); C760(1.06)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0630  CCW28-3 231MFP C819(1.36); C848(0.88); C747(0.63)  LDD2214  [30]
 LDCM0108  Chloroacetamide HeLa C331(0.00); C361(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C386(20.00); C819(2.20); C331(1.31); C554(0.47)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C361(0.97); C549(1.14); C819(1.29); C599(0.97)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C361(0.97); C549(1.20); C819(1.46); C599(1.10)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C361(1.02); C549(1.04); C819(1.09); C599(0.97)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C361(0.97); C549(1.02); C819(1.00); C599(1.03)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C361(1.04); C549(1.00); C819(1.58); C599(0.99)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C361(1.03); C549(1.03); C819(0.92); C599(0.98)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C361(0.99); C549(1.05); C819(1.00); C599(0.89)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C361(0.91); C549(0.95); C819(1.06); C599(1.03)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C361(0.98); C549(1.01); C819(1.18); C599(0.95)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C361(1.04); C549(1.04); C819(0.89); C599(0.94)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C361(0.97); C549(0.93); C819(0.96); C599(0.98)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C361(0.92); C549(0.98); C819(1.19); C599(0.99)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C549(1.07); C819(1.34); C599(1.28); C760(0.94)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C361(1.02); C549(1.03); C819(1.78); C599(0.87)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C361(1.10); C549(1.04); C819(1.20); C599(0.94)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C361(0.94); C549(1.03); C819(1.09); C599(0.90)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C361(0.99); C549(1.00); C819(0.99); C599(1.03)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C361(1.11); C549(1.07); C819(2.02); C599(0.99)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C361(1.07); C549(1.03); C819(0.98); C599(1.03)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C361(0.92); C549(1.09); C819(1.02); C599(1.07)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C361(0.98); C549(1.05); C819(0.92); C599(0.99)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C361(1.05); C549(0.94); C819(0.88); C599(0.93)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C361(1.11); C549(1.18); C819(0.97); C599(0.88)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C549(1.07); C819(1.38); C599(0.91); C760(1.00)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C361(0.95); C549(0.93); C819(0.97); C599(1.11)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C361(0.95); C549(1.16); C819(0.95); C599(1.00)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C361(1.00); C549(1.03); C819(1.11); C599(0.93)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C361(1.08); C549(1.29); C819(1.32); C599(1.04)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C361(1.05); C549(1.20); C819(1.24); C599(1.15)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C361(0.91); C549(1.12); C819(0.85); C599(1.04)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C361(0.96); C549(0.93); C819(1.02); C599(1.01)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C361(1.03); C549(1.06); C819(0.83); C599(0.96)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C361(0.93); C549(1.15); C819(0.93); C599(0.99)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C361(0.95); C549(0.95); C819(1.05); C599(0.97)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C361(0.97); C549(1.16); C819(0.94); C599(1.00)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C361(1.30); C549(1.30); C819(1.54); C599(1.05)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C361(0.98); C549(1.04); C819(1.02); C599(1.10)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C361(1.15); C549(1.45); C819(2.02); C599(1.10)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C361(1.09); C549(1.05); C819(0.90); C599(1.18)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C361(1.00); C549(0.83); C819(0.98); C599(1.07)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C361(0.98); C549(0.99); C819(0.98); C599(0.98)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C549(1.00); C819(1.05); C599(0.88); C760(0.95)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C361(1.19); C549(1.41); C819(1.61); C599(0.85)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C361(0.89); C549(1.06); C819(1.19); C599(1.07)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C549(1.06); C819(1.00); C599(1.33); C760(1.00)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C549(0.95); C819(1.11); C599(0.96); C760(0.99)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C361(1.08); C549(1.15); C819(1.39); C599(1.03)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C361(0.97); C549(0.82); C819(0.95); C599(1.04)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C361(1.04); C549(1.08); C819(0.90); C599(0.95)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C361(1.01); C549(1.00); C819(1.05); C599(1.00)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C361(1.10); C549(1.00); C819(0.92); C599(1.02)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C361(1.07); C549(1.13); C819(1.01); C599(1.06)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C361(0.97); C549(0.88); C819(0.91); C599(1.06)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C361(1.05); C549(0.99); C819(1.10); C599(1.13)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C549(1.00); C819(1.10); C599(0.84); C760(1.02)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C361(1.31); C549(2.16); C819(1.67); C599(1.06)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C361(0.80); C549(1.05); C819(1.22); C599(1.03)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C549(1.02); C819(1.03); C599(1.19); C760(1.04)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C549(1.19); C819(1.31); C599(1.03); C760(1.04)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C361(0.90); C549(1.06); C819(1.16); C599(1.11)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C361(1.07); C549(1.18); C819(1.05); C599(0.91)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C361(1.08); C549(1.07); C819(1.29); C599(0.99)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C361(0.97); C549(0.88); C819(0.95); C599(1.05)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C361(1.10); C549(1.09); C819(1.32); C599(1.07)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C361(0.99); C549(1.01); C819(0.91); C599(1.01)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C361(0.92); C549(0.82); C819(1.12); C599(1.06)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C549(0.85); C819(1.10); C599(0.81); C760(1.01)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C361(1.04); C549(1.35); C819(1.39); C599(0.91)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C361(0.88); C549(0.95); C819(1.11); C599(1.06)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C549(1.03); C819(1.08); C599(1.14); C760(0.98)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C549(1.26); C819(1.35); C599(0.89); C760(1.01)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C361(1.00); C549(1.06); C819(1.01); C599(1.10)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C361(1.11); C549(1.07); C819(1.02); C599(1.07)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C361(1.02); C549(1.10); C819(1.26); C599(1.01)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C361(1.04); C549(1.00); C819(1.00); C599(1.16)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C361(1.13); C549(1.16); C819(1.84); C599(1.03)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C361(1.36); C549(1.36); C819(1.62); C599(1.14)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C361(1.01); C549(0.83); C819(1.09); C599(1.06)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C549(0.96); C819(1.13); C599(0.80); C760(0.96)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C361(1.07); C549(1.59); C819(1.23); C599(0.93)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C361(0.89); C549(1.06); C819(1.18); C599(1.06)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C549(0.92); C819(1.07); C599(1.29); C760(1.05)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C361(1.25); C549(1.38); C819(1.71); C599(1.20)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C549(1.06); C819(1.33); C599(0.99); C760(1.03)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C361(0.90); C549(0.93); C819(0.85); C599(1.07)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C361(0.91); C549(1.00); C819(0.88); C599(0.96)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C361(0.96); C549(1.06); C819(0.86); C599(0.96)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C361(0.99); C549(1.32); C819(1.39); C599(1.09)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C361(1.02); C549(1.11); C819(0.98); C599(1.01)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C361(1.04); C549(1.11); C819(1.05); C599(1.16)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C361(0.97); C549(0.86); C819(1.07); C599(1.08)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C549(1.07); C819(1.10); C599(0.96); C760(0.99)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C361(1.13); C549(1.16); C819(1.08); C599(1.06)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C361(1.01); C549(0.87); C819(1.07); C599(1.11)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C361(0.87); C549(1.02); C819(1.17); C599(1.05)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C549(1.15); C819(0.93); C599(1.22); C760(1.05)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C549(1.10); C819(1.14); C599(1.01); C760(1.06)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C361(0.88); C549(1.08); C819(1.24); C599(1.02)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C361(0.99); C549(0.88); C819(0.96); C599(0.96)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C361(0.96); C549(0.95); C819(0.94); C599(1.05)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C361(1.01); C549(1.21); C819(1.83); C599(0.98)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C361(1.03); C549(0.93); C819(0.90); C599(1.16)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C361(1.02); C549(0.85); C819(0.91); C599(1.04)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C549(1.68); C819(2.85); C599(1.31); C760(2.19)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C549(1.04); C819(0.98); C599(0.94); C760(0.95)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C361(1.09); C549(1.06); C819(1.04); C599(0.97)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C361(0.98); C549(0.92); C819(1.05); C599(1.02)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C549(1.04); C819(1.25); C599(1.17); C760(1.01)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C549(1.16); C819(1.36); C599(0.96); C760(1.09)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C361(0.90); C549(1.13); C819(0.90); C599(1.04)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C361(1.01); C549(0.97); C819(0.93); C599(1.08)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C361(0.97); C549(1.10); C819(0.83); C599(1.04)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C361(0.98); C549(0.95); C819(0.95); C599(1.14)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C361(1.05); C549(1.07); C819(0.85); C599(1.03)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C361(1.26); C549(1.38); C819(1.16); C599(0.92)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C361(1.50); C549(2.04); C819(2.42); C599(1.18)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C361(0.91); C549(1.07); C819(1.02); C599(0.97)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C549(1.08); C819(1.30); C599(1.17); C760(0.99)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C361(1.13); C549(1.36); C819(1.36); C599(0.96)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C361(1.02); C549(0.98); C819(0.96); C599(1.05)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C549(1.53); C819(2.08); C599(1.34); C760(1.47)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C549(1.32); C819(1.35); C599(0.96); C760(1.07)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C361(1.06); C549(1.13); C819(1.37); C599(0.98)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C361(0.95); C549(0.95); C819(1.14); C599(1.02)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C361(1.05); C549(0.65); C819(1.00); C599(0.99)  LDD1697  [29]
 LDCM0634  CY-0357 Hep-G2 C549(1.84); C819(0.72)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C361(1.07); C549(0.99); C819(0.95); C599(1.02)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C386(23.53); C760(21.67); C554(1.08)  LDD1702  [28]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.31  LDD0183  [7]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0204  EV-97 T cell C819(10.71)  LDD0525  [31]
 LDCM0625  F8 Ramos C977(0.76); C502(1.17); C760(0.99); C819(1.28)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C848(1.00)  LDD1390  [33]
 LDCM0573  Fragment11 MDA-MB-231 C848(4.16)  LDD1391  [33]
 LDCM0574  Fragment12 MDA-MB-231 C848(20.00)  LDD1468  [33]
 LDCM0575  Fragment13 Ramos C848(1.18)  LDD1396  [33]
 LDCM0576  Fragment14 MDA-MB-231 C848(3.25)  LDD1397  [33]
 LDCM0577  Fragment15 Ramos C848(20.00)  LDD1400  [33]
 LDCM0579  Fragment20 Ramos C848(3.79)  LDD1403  [33]
 LDCM0580  Fragment21 Ramos C848(1.95)  LDD1405  [33]
 LDCM0581  Fragment22 MDA-MB-231 C848(0.94)  LDD1406  [33]
 LDCM0582  Fragment23 MDA-MB-231 C848(20.00)  LDD1408  [33]
 LDCM0583  Fragment24 Ramos C848(1.96)  LDD1410  [33]
 LDCM0585  Fragment26 Ramos C848(0.92)  LDD1412  [33]
 LDCM0578  Fragment27 MDA-MB-231 C848(0.83)  LDD1401  [33]
 LDCM0586  Fragment28 MDA-MB-231 C848(1.04)  LDD1415  [33]
 LDCM0587  Fragment29 MDA-MB-231 C848(0.94)  LDD1417  [33]
 LDCM0588  Fragment30 MDA-MB-231 C848(1.10)  LDD1419  [33]
 LDCM0589  Fragment31 MDA-MB-231 C848(20.00)  LDD1421  [33]
 LDCM0590  Fragment32 MDA-MB-231 C848(6.96)  LDD1423  [33]
 LDCM0468  Fragment33 MDA-MB-231 C848(1.10)  LDD1425  [33]
 LDCM0592  Fragment34 Ramos C848(1.33)  LDD1428  [33]
 LDCM0593  Fragment35 MDA-MB-231 C848(1.08)  LDD1429  [33]
 LDCM0595  Fragment37 Ramos C848(1.03)  LDD1432  [33]
 LDCM0596  Fragment38 MDA-MB-231 C848(1.25)  LDD1433  [33]
 LDCM0566  Fragment4 MDA-MB-231 C848(2.11)  LDD1378  [33]
 LDCM0598  Fragment40 MDA-MB-231 C848(0.89)  LDD1436  [33]
 LDCM0599  Fragment41 MDA-MB-231 C848(1.44)  LDD1438  [33]
 LDCM0600  Fragment42 Ramos C848(0.68)  LDD1440  [33]
 LDCM0601  Fragment43 MDA-MB-231 C848(2.51)  LDD1441  [33]
 LDCM0602  Fragment44 MDA-MB-231 C848(0.83)  LDD1443  [33]
 LDCM0603  Fragment45 MDA-MB-231 C848(20.00); C819(20.00)  LDD1482  [33]
 LDCM0604  Fragment46 MDA-MB-231 C848(1.16)  LDD1445  [33]
 LDCM0607  Fragment49 MDA-MB-231 C848(20.00)  LDD1448  [33]
 LDCM0427  Fragment51 Ramos C848(1.15)  LDD1451  [33]
 LDCM0610  Fragment52 Ramos C977(1.98); C502(1.25); C819(2.57); C549(2.70)  LDD2204  [32]
 LDCM0611  Fragment53 MDA-MB-231 C848(1.21)  LDD1454  [33]
 LDCM0612  Fragment54 MDA-MB-231 C848(1.09)  LDD1456  [33]
 LDCM0614  Fragment56 MDA-MB-231 C848(0.99)  LDD1458  [33]
 LDCM0568  Fragment6 MDA-MB-231 C848(0.91)  LDD1382  [33]
 LDCM0569  Fragment7 Ramos C977(0.84); C502(0.99); C760(2.63); C819(11.61)  LDD2186  [32]
 LDCM0570  Fragment8 MDA-MB-231 C848(1.96)  LDD1385  [33]
 LDCM0571  Fragment9 MDA-MB-231 C848(2.15)  LDD1387  [33]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 MDA-MB-231 C848(9.21)  LDD1374  [33]
 LDCM0023  KB03 Jurkat C549(117.82); C819(8.55); C502(955.58); C361(6.95)  LDD0209  [12]
 LDCM0024  KB05 G361 C781(4.22); C998(1.71); C840(2.75)  LDD3311  [34]
 LDCM0030  Luteolin HEK-293T 4.39  LDD0182  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C819(1.04)  LDD2092  [28]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C819(1.48)  LDD2094  [28]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C819(1.17)  LDD2099  [28]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C502(1.21)  LDD2107  [28]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C331(0.87)  LDD2111  [28]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C819(1.21)  LDD2119  [28]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C819(1.02); C977(0.77)  LDD2123  [28]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C819(1.17); C502(1.09)  LDD2125  [28]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C819(1.09)  LDD2129  [28]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C819(1.28)  LDD2135  [28]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C819(1.57)  LDD2136  [28]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C502(0.94); C977(0.71)  LDD2140  [28]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C819(0.98); C977(1.02)  LDD2144  [28]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C819(0.95)  LDD2146  [28]
 LDCM0627  NUDT7-COV-1 HEK-293T C599(0.76); C549(0.51); C819(0.12)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C599(1.94); C549(0.59); C819(0.47)  LDD2207  [35]
 LDCM0014  Panhematin K562 3.17  LDD0063  [9]
 LDCM0131  RA190 MM1.R 67.30  LDD0300  [10]
 LDCM0003  Sulforaphane MDA-MB-231 1.85  LDD0160  [6]
 LDCM0112  W16 Hep-G2 C819(0.59)  LDD0239  [22]
 LDCM0113  W17 Hep-G2 C794(3.27)  LDD0240  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fanconi anemia group J protein (BRIP1) DEAD box helicase family Q9BX63
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) Helicase family P18074
Regulator of telomere elongation helicase 1 (RTEL1) Helicase family Q9NZ71
Cytosolic iron-sulfur assembly component 3 (CIAO3) NARF family Q9H6Q4
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) WD repeat CIA1 family O76071

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD039908 , PXD029761
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