Details of the Target

General Information of Target

Target ID LDTP05930
Target Name SNW domain-containing protein 1 (SNW1)
Gene Name SNW1
Gene ID 22938
Synonyms
SKIIP; SKIP; SNW domain-containing protein 1; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; Ski-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGD
GGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLV
PKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYT
PSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVK
EQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKARE
AVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRR
KERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDS
GFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSG
SDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
Target Bioclass
Other
Family
SNW family
Subcellular location
Nucleus
Function
Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD.; (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter.; (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters.
Uniprot ID
Q13573
Ensemble ID
ENST00000261531.12
HGNC ID
HGNC:16696

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y260(20.00); Y292(11.22)  LDD0260  [2]
STPyne
 Probe Info  		K110(0.75); K153(10.00); K170(6.91); K193(6.79)  LDD0277  [3]
Probe 1
 Probe Info  		Y176(34.21); Y407(31.92); Y430(12.55); Y433(9.68)  LDD3495  [4]
BTD
 Probe Info  		C250(1.38)  LDD2090  [5]
AHL-Pu-1
 Probe Info  		C250(2.08)  LDD0171  [6]
HHS-475
 Probe Info  		Y407(0.43); Y179(0.58); Y459(0.74); Y116(0.88)  LDD0264  [7]
HHS-465
 Probe Info  		Y116(4.06); Y179(10.00); Y260(10.00); Y292(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C250(8.32)  LDD0080  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K255(0.00); K258(0.00)  LDD0199  [11]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
NAIA_5
 Probe Info  		N.A.  LDD2224  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
PF-06672131
 Probe Info  		N.A.  LDD0017  [17]
SF
 Probe Info  		Y176(0.00); Y407(0.00); Y292(0.00); Y46(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
AOyne
 Probe Info  		15.00  LDD0443  [22]
HHS-482
 Probe Info  		Y116(1.39); Y260(0.84); Y448(0.94)  LDD2239  [8]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.05  LDD0471  [23]
FFF probe13
 Probe Info  		13.25  LDD0475  [23]
FFF probe2
 Probe Info  		7.67  LDD0463  [23]
FFF probe3
 Probe Info  		12.04  LDD0465  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C250(1.13)  LDD2112  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C250(2.08)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C250(0.98)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C250(1.17)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C250(0.94)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C250(1.02)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C250(0.94)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C250(1.22)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C250(1.10)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C250(1.20)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C250(1.19)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C250(1.18)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C250(0.88)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C250(0.96)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C250(1.27)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C250(1.13)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C250(1.12)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C250(1.17)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C250(0.92)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C250(1.15)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C250(1.12)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C250(1.14)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C250(0.99)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C250(0.99)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C250(1.06)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C250(1.02)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C250(1.22)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C250(0.94)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C250(1.09)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C250(1.03)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C250(0.95)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C250(1.02)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C250(1.31)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C250(1.21)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C250(0.86)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C250(0.70)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C250(0.82)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C250(0.69)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C250(0.66)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C250(0.70)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C250(0.78)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C250(0.75)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C250(0.76)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C250(0.75)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C250(0.81)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C250(0.78)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C250(1.03)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C250(0.83)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C250(0.77)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C250(0.68)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C250(1.21)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C250(1.30)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C250(1.11)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C250(1.23)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C250(1.17)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C250(1.41)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C250(1.30)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C250(1.22)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C250(1.08)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C250(1.03)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C250(1.30)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C250(1.74)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C250(1.29)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C250(1.37)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C250(1.16)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C250(1.09)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C250(1.06)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C250(1.19)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C250(1.15)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C250(1.03)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C250(1.16)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C250(1.22)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C250(1.11)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C250(1.13)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C250(1.06)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C250(1.57)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C250(1.62)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C250(1.84)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C250(2.10)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C250(2.65)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C250(0.95)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C250(2.80)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C250(1.31)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C250(1.68)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C250(2.17)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C250(2.83)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C250(1.27)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C250(1.63)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C250(1.75)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C250(1.60)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C250(1.82)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C250(1.12)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C250(2.42)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C250(1.96)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C250(1.74)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C250(2.16)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C250(2.27)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C250(2.48)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C250(1.12)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C250(1.24)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C250(1.14)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C250(1.66)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C250(1.01)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C250(1.62)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C250(0.85)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C250(1.10)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C250(1.72)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C250(1.44)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C250(2.14)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C250(2.99)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C250(1.48)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C250(1.58)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C250(1.52)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C250(1.32)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C250(1.62)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C250(1.32)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C250(1.61)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C250(1.62)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C250(1.56)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C250(1.05)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C250(1.01)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C250(1.11)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C250(1.17)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C250(1.23)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C250(0.99)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C250(1.45)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C250(1.06)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C250(1.47)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C250(1.74)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C250(1.36)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C250(1.78)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C250(1.17)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C250(1.38)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C250(1.20)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C250(1.31)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C250(1.15)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C250(1.17)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C250(1.32)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C250(1.52)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C250(1.56)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C250(1.46)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C250(1.28)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C250(1.23)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C250(1.05)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C250(1.22)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C250(1.38)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C250(0.91)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C250(1.66)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C250(1.57)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C250(1.23)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C250(1.32)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C250(1.33)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C250(1.47)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C250(1.58)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C250(1.64)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C250(0.92)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C250(0.94)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C250(1.09)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C250(1.92)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C250(1.03)  LDD2171  [9]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C250(20.00)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C250(0.98)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C250(1.67)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C250(1.13)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C250(1.20)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C250(1.03)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C250(0.96)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C250(1.05)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C250(1.23)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C250(1.49)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C250(1.28)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C250(1.39)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C250(1.38)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C250(1.71)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C250(1.47)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C250(1.22)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C250(1.34)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C250(1.64)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C250(2.39)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C250(2.53)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C250(2.24)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C250(2.28)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C250(1.13)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C250(1.29)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C250(1.49)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C250(1.53)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C250(1.07)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C250(1.41)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C250(2.07)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C250(2.09)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C250(0.94)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C250(1.41)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C250(1.10)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C250(1.46)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C250(1.28)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C250(1.07)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C250(1.23)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C250(1.10)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C250(1.17)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C250(0.92)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C250(0.84)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C250(0.93)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C250(0.89)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C250(1.16)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C250(0.94)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C250(1.09)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C250(0.99)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C250(1.29)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C250(1.17)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C250(0.94)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C250(1.09)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C250(0.90)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C250(0.94)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C250(0.92)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C250(0.99)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C250(1.07)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C250(1.40)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C250(1.08)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C250(1.04)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C250(1.28)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C250(1.08)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C250(1.10)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C250(1.21)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C250(1.76)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C250(1.12)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C250(1.18)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C250(1.07)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C250(0.99)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C250(1.12)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C250(1.08)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C250(0.89)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C250(1.00)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C250(0.78)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C250(0.91)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C250(0.86)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C250(0.96)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C250(0.99)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C250(1.13)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C250(1.14)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C250(1.02)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C250(0.94)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C250(0.81)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C250(1.17)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C250(0.88)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C250(1.33)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C250(0.87)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C250(1.17)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C250(1.25)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C250(1.45)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C250(2.05)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C250(1.17)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C250(1.98)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C250(1.77)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C250(1.64)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C250(1.49)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C250(1.18)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C250(1.53)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C250(1.76)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C250(1.30)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C250(1.77)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C250(1.69)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C250(1.17)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C250(1.22)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C250(1.24)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C250(1.61)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C250(2.28)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C250(1.09)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C250(1.38)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C250(1.98)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C250(1.76)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C250(1.99)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C250(1.35)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C250(1.11)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C250(1.32)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C250(1.61)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C250(2.12)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C250(1.17)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C250(1.21)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C250(1.27)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C250(1.27)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C250(1.09)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C250(1.63)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C250(1.91)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C250(1.17)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C250(1.22)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C250(1.22)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C250(1.08)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C250(1.11)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C250(4.67)  LDD1702  [5]
 LDCM0625  F8 Ramos C250(0.64)  LDD2187  [25]
 LDCM0572  Fragment10 MDA-MB-231 C250(2.65)  LDD1389  [26]
 LDCM0573  Fragment11 MDA-MB-231 C250(2.25)  LDD1391  [26]
 LDCM0574  Fragment12 MDA-MB-231 C250(4.38)  LDD1393  [26]
 LDCM0575  Fragment13 Ramos C250(0.75)  LDD1396  [26]
 LDCM0576  Fragment14 MDA-MB-231 C250(1.71)  LDD1397  [26]
 LDCM0577  Fragment15 Ramos C250(2.09)  LDD1400  [26]
 LDCM0579  Fragment20 MDA-MB-231 C250(6.62)  LDD1402  [26]
 LDCM0580  Fragment21 MDA-MB-231 C250(1.37)  LDD1404  [26]
 LDCM0581  Fragment22 Ramos C250(0.99)  LDD1407  [26]
 LDCM0582  Fragment23 MDA-MB-231 C250(0.99)  LDD1408  [26]
 LDCM0583  Fragment24 Ramos C250(1.40)  LDD1410  [26]
 LDCM0584  Fragment25 MDA-MB-231 C250(0.93)  LDD1411  [26]
 LDCM0585  Fragment26 Ramos C250(0.89)  LDD1412  [26]
 LDCM0578  Fragment27 MDA-MB-231 C250(0.92)  LDD1401  [26]
 LDCM0586  Fragment28 MDA-MB-231 C250(0.96)  LDD1415  [26]
 LDCM0587  Fragment29 MDA-MB-231 C250(1.18)  LDD1417  [26]
 LDCM0588  Fragment30 Ramos C250(1.33)  LDD1420  [26]
 LDCM0589  Fragment31 MDA-MB-231 C250(1.79)  LDD1421  [26]
 LDCM0590  Fragment32 Ramos C250(7.08)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C250(1.59)  LDD0785  [9]
 LDCM0594  Fragment36 MDA-MB-231 C250(1.42)  LDD1431  [26]
 LDCM0596  Fragment38 MDA-MB-231 C250(1.08)  LDD1433  [26]
 LDCM0566  Fragment4 MDA-MB-231 C250(3.96)  LDD1378  [26]
 LDCM0599  Fragment41 Ramos C250(1.10)  LDD1439  [26]
 LDCM0600  Fragment42 Ramos C250(0.96)  LDD1440  [26]
 LDCM0602  Fragment44 MDA-MB-231 C250(0.73)  LDD1443  [26]
 LDCM0603  Fragment45 MDA-MB-231 C250(20.00)  LDD1444  [26]
 LDCM0604  Fragment46 MDA-MB-231 C250(1.05)  LDD1445  [26]
 LDCM0605  Fragment47 MDA-MB-231 C250(1.02)  LDD1446  [26]
 LDCM0606  Fragment48 MDA-MB-231 C250(1.41)  LDD1447  [26]
 LDCM0608  Fragment50 MDA-MB-231 C250(4.44)  LDD1449  [26]
 LDCM0427  Fragment51 HCT 116 C250(2.68)  LDD0744  [9]
 LDCM0610  Fragment52 MDA-MB-231 C250(1.78)  LDD1452  [26]
 LDCM0611  Fragment53 MDA-MB-231 C250(0.49)  LDD1454  [26]
 LDCM0614  Fragment56 MDA-MB-231 C250(0.64)  LDD1458  [26]
 LDCM0569  Fragment7 MDA-MB-231 C250(2.08)  LDD1383  [26]
 LDCM0570  Fragment8 MDA-MB-231 C250(2.66)  LDD1385  [26]
 LDCM0571  Fragment9 MDA-MB-231 C250(1.34)  LDD1387  [26]
 LDCM0116  HHS-0101 DM93 Y407(0.43); Y179(0.58); Y459(0.74); Y116(0.88)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y407(0.26); Y459(0.44); Y448(0.69); Y260(0.75)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y407(0.53); Y260(0.61); Y459(0.69); Y176(0.92)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y179(0.57); Y260(0.64); Y459(0.68); Y116(0.69)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y46(0.45); Y260(0.63); Y459(0.66); Y116(0.69)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C250(8.32)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C250(1.95)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C250(2.70)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C250(1.38)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C250(1.14)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C250(1.04)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C250(0.88)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C250(1.49)  LDD2098  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C250(0.89)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C250(1.21)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C250(0.77)  LDD2106  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C250(0.85)  LDD2108  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C250(0.97)  LDD2114  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C250(1.07)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C250(1.03)  LDD2122  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C250(0.95)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C250(1.01)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C250(1.49)  LDD2126  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C250(1.12)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C250(0.85)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C250(0.87)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C250(1.77)  LDD2145  [5]
 LDCM0021  THZ1 HCT 116 C250(1.03)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine synthase isoform type-2 (MAT2A) AdoMet synthase family P31153
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) Cyclophilin-type PPIase family Q9Y3C6
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) Helicase family P19447
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Caspase-6 (CASP6) Peptidase C14A family P55212
Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) Peptidase M16 family P22695
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
ADP-ribosylation factor-like protein 8A (ARL8A) Arf family Q96BM9
ADP-ribosylation factor-like protein 8B (ARL8B) Arf family Q9NVJ2
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTP-binding nuclear protein Ran (RAN) Ran family P62826
GTPase HRas (HRAS) Ras family P01112
Transporter and channel
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Cytochrome c (CYCS) Cytochrome c family P99999
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7) Ligand-gated ion channel family P36544
Neurogenic locus notch homolog protein 1 (NOTCH1) NOTCH family P46531
Vitamin D3 receptor (VDR) Nuclear hormone receptor family P11473
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Pinin (PNN) Pinin family Q9H307
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 2 (SMAD2) Dwarfin/SMAD family Q15796
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Nuclear receptor corepressor 2 (NCOR2) N-CoR nuclear receptor corepressors family Q9Y618
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
Forkhead box protein N3 (FOXN3) . O00409
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Upstream stimulatory factor 1 (USF1) . P22415
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2 adrenergic receptor (ADRB2) G-protein coupled receptor 1 family P07550
Other
Click To Hide/Show 48 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thyroid hormone receptor-associated protein 3 (THRAP3) BCLAF1/THRAP3 family Q9Y2W1
Bystin (BYSL) Bystin family Q13895
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Pre-mRNA-splicing factor SYF1 (XAB2) Crooked-neck family Q9HCS7
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cytospin-A (SPECC1L) Cytospin-A family Q69YQ0
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Peripherin (PRPH) Intermediate filament family P41219
Prelamin-A/C (LMNA) Intermediate filament family P02545
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
U4/U6.U5 tri-snRNP-associated protein 1 (SART1) SNU66/SART1 family O43290
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Testis-expressed protein 11 (TEX11) SPO22 family Q8IYF3
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Torsin-1A-interacting protein 1 (TOR1AIP1) TOR1AIP family Q5JTV8
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Beta-catenin-like protein 1 (CTNNBL1) . Q8WYA6
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 125 (CCDC125) . Q86Z20
Cytoplasmic protein NCK2 (NCK2) . O43639
GA-binding protein subunit beta-1 (GABPB1) . Q06547
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Heat shock factor 2-binding protein (HSF2BP) . O75031
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen 1 (MAGEA1) . P43355
Merlin (NF2) . P35240
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Polyadenylate-binding protein 2 (PABPN1) . Q86U42
PRKCA-binding protein (PICK1) . Q9NRD5
RING finger protein 11 (RNF11) . Q9Y3C5
Smad nuclear-interacting protein 1 (SNIP1) . Q8TAD8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquilin-1 (UBQLN1) . Q9UMX0
Zinc finger protein 830 (ZNF830) . Q96NB3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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