Details of the Target

General Information of Target

Target ID LDTP04201
Target Name T-complex protein 1 subunit epsilon (CCT5)
Gene Name CCT5
Gene ID 22948
Synonyms
CCTE; KIAA0098; T-complex protein 1 subunit epsilon; TCP-1-epsilon; CCT-epsilon
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKM
MVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEA
EQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNS
CHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMP
KKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLA
ICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQ
EISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVY
GGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRAR
QVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESE
E
Target Bioclass
Other
Family
TCP-1 chaperonin family
Subcellular location
Cytoplasm
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Uniprot ID
P48643
Ensemble ID
ENST00000280326.9
HGNC ID
HGNC:1618
ChEMBL ID
CHEMBL4295766

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.E119G DBIA    Probe Info 
NCIH1155 SNV: p.Q238Ter DBIA    Probe Info 
OVCAR4 SNV: p.A40S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 58 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.33  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
A-EBA
 Probe Info  		4.21  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
W1
 Probe Info  		11.37  LDD0235  [5]
TH211
 Probe Info  		Y274(20.00); Y420(13.45); Y137(10.95); Y446(10.46)  LDD0257  [6]
TH214
 Probe Info  		Y280(11.90); Y274(6.36)  LDD0258  [6]
TH216
 Probe Info  		Y280(19.47); Y420(17.07); Y446(11.45); Y274(10.71)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
BTD
 Probe Info  		C181(3.77)  LDD1699  [8]
AZ-9
 Probe Info  		E207(0.83)  LDD2208  [9]
ONAyne
 Probe Info  		N.A.  LDD0273  [10]
OPA-S-S-alkyne
 Probe Info  		K214(1.21); K514(2.42); K399(2.73); K392(2.73)  LDD3494  [11]
Probe 1
 Probe Info  		Y137(23.11); Y274(73.92)  LDD3495  [12]
JZ128-DTB
 Probe Info  		C253(0.00); C302(0.00)  LDD0462  [13]
THZ1-DTB
 Probe Info  		C253(1.11); C429(1.10); C302(1.09); C440(1.06)  LDD0460  [13]
AHL-Pu-1
 Probe Info  		C302(3.89); C440(2.93); C429(2.80); C253(2.40)  LDD0168  [14]
EA-probe
 Probe Info  		C253(0.81)  LDD2210  [15]
HHS-482
 Probe Info  		Y274(0.97)  LDD0285  [16]
HHS-475
 Probe Info  		Y446(1.06)  LDD0264  [17]
HHS-465
 Probe Info  		Y274(10.00); Y280(10.00)  LDD2237  [18]
DBIA
 Probe Info  		C440(1.21); C253(1.04); C407(1.04)  LDD0078  [19]
5E-2FA
 Probe Info  		H495(0.00); H236(0.00); H505(0.00); H264(0.00)  LDD2235  [20]
AMP probe
 Probe Info  		K259(0.00); K261(0.00); K263(0.00); K265(0.00)  LDD0200  [21]
ATP probe
 Probe Info  		K265(0.00); K176(0.00); K275(0.00); K223(0.00)  LDD0199  [21]
N1
 Probe Info  		C493(0.00); C253(0.00); D492(0.00); E256(0.00)  LDD0245  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C440(0.00); C493(0.00); C302(0.00); C253(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C253(0.00); C302(0.00); C493(0.00); C377(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C302(0.00); C253(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C493(0.00); C377(0.00); C302(0.00); C181(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C440(0.00); C493(0.00); C302(0.00); C253(0.00)  LDD0037  [22]
ATP probe
 Probe Info  		K370(0.00); K392(0.00); K514(0.00); K352(0.00)  LDD0035  [25]
JW-RF-010
 Probe Info  		C253(0.00); C377(0.00)  LDD0026  [26]
NAIA_4
 Probe Info  		C253(0.00); C302(0.00); C377(0.00); C493(0.00)  LDD2226  [27]
TFBX
 Probe Info  		N.A.  LDD0027  [26]
WYneN
 Probe Info  		C181(0.00); C493(0.00)  LDD0021  [28]
WYneO
 Probe Info  		C493(0.00); C181(0.00); C440(0.00)  LDD0022  [28]
KY-26
 Probe Info  		N.A.  LDD0301  [29]
Compound 10
 Probe Info  		C253(0.00); C302(0.00); C493(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C253(0.00); C302(0.00)  LDD2213  [30]
ENE
 Probe Info  		C181(0.00); C493(0.00); C253(0.00)  LDD0006  [28]
IPM
 Probe Info  		C253(0.00); C493(0.00); C377(0.00); C181(0.00)  LDD0005  [28]
NHS
 Probe Info  		K160(0.00); K170(0.00); K275(0.00); K392(0.00)  LDD0010  [28]
PF-06672131
 Probe Info  		C253(0.00); C493(0.00)  LDD0017  [31]
PPMS
 Probe Info  		N.A.  LDD0008  [28]
SF
 Probe Info  		K223(0.00); Y274(0.00); K275(0.00)  LDD0028  [32]
STPyne
 Probe Info  		K170(0.00); K275(0.00); K261(0.00); K265(0.00)  LDD0009  [28]
VSF
 Probe Info  		N.A.  LDD0007  [28]
Phosphinate-6
 Probe Info  		C253(0.00); C181(0.00); C493(0.00); C377(0.00)  LDD0018  [33]
1c-yne
 Probe Info  		K263(0.00); K232(0.00); K496(0.00); K529(0.00)  LDD0228  [34]
1d-yne
 Probe Info  		K176(0.00); K160(0.00)  LDD0357  [34]
Acrolein
 Probe Info  		C493(0.00); C253(0.00); H505(0.00); C302(0.00)  LDD0217  [35]
Cinnamaldehyde
 Probe Info  		C493(0.00); C181(0.00)  LDD0220  [35]
Crotonaldehyde
 Probe Info  		C377(0.00); C493(0.00); C181(0.00)  LDD0219  [35]
Methacrolein
 Probe Info  		C493(0.00); C377(0.00); C181(0.00); C253(0.00)  LDD0218  [35]
AOyne
 Probe Info  		15.00  LDD0443  [36]
NAIA_5
 Probe Info  		C377(0.00); C493(0.00); C302(0.00); C253(0.00)  LDD2223  [27]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.92  LDD0471  [37]
FFF probe12
 Probe Info  		5.61  LDD0473  [37]
FFF probe13
 Probe Info  		10.89  LDD0475  [37]
FFF probe14
 Probe Info  		13.44  LDD0477  [37]
FFF probe2
 Probe Info  		11.66  LDD0463  [37]
FFF probe3
 Probe Info  		6.89  LDD0464  [37]
FFF probe6
 Probe Info  		6.35  LDD0467  [37]
JN0003
 Probe Info  		12.30  LDD0469  [37]
STS-2
 Probe Info  		N.A.  LDD0138  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
BD-F
 Probe Info  		G103(0.00); V111(0.00); D104(0.00); L112(0.00)  LDD0024  [40]
LD-F
 Probe Info  		I102(0.00); T107(0.00); G103(0.00); D104(0.00)  LDD0015  [40]
DA-2
 Probe Info  		N.A.  LDD0070  [41]
STS-1
 Probe Info  		N.A.  LDD0068  [42]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C377(0.69); C253(0.65); C493(0.56); C181(0.45)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C377(0.66); C253(0.47); C493(0.65); C181(0.57)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C377(0.67); C253(0.66); C493(0.60); C181(0.54)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C377(1.00); C253(0.84); C493(0.88); C181(0.96)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C377(1.24); C253(1.15); C493(1.27); C181(0.88)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C377(1.28); C253(1.22); C493(1.35); C181(1.31)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C377(1.54); C253(0.89); C493(1.35); C181(1.04)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C377(0.54); C253(0.78); C493(0.55); C181(0.49)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C377(0.81); C253(0.98); C493(0.65); C181(0.69)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C302(3.89); C440(2.93); C429(2.80); C253(2.40)  LDD0168  [14]
 LDCM0026  4SU-RNA+native RNA HEK-293T C302(7.76); C440(2.66); C429(4.50); C407(2.46)  LDD0169  [14]
 LDCM0214  AC1 HCT 116 C181(1.00); C253(1.13); C302(0.48); C377(0.86)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C181(0.83); C253(1.18); C377(0.94); C407(0.71)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C181(1.01); C253(0.99); C302(0.54); C377(0.63)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C181(1.09); C253(0.98); C302(0.53); C377(0.65)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C181(1.06); C253(1.06); C302(0.57); C377(0.76)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C181(1.09); C253(1.15); C302(0.40); C377(0.61)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C181(1.18); C253(0.99); C302(0.46); C377(0.67)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C181(0.95); C253(1.19); C302(0.39); C377(0.66)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C181(0.95); C253(1.10); C302(0.46); C377(0.64)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C181(0.99); C253(1.18); C302(0.44); C377(0.61)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C181(1.05); C253(1.07); C302(0.45); C377(0.72)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C181(0.99); C253(0.95); C302(0.63); C377(0.74)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C181(0.63); C253(1.23); C377(0.90); C407(0.76)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C181(0.98); C253(1.03); C302(0.66); C377(0.65)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C181(1.05); C253(0.97); C302(0.70); C377(0.63)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C181(1.22); C253(1.14); C302(0.36); C377(0.65)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C181(0.95); C253(0.97); C377(1.11); C407(1.03)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C181(0.87); C253(1.08); C377(1.03); C407(0.97)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C181(1.02); C253(1.17); C377(0.93); C407(1.03)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C181(0.95); C253(1.11); C377(0.91); C407(1.02)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C181(0.86); C253(1.08); C377(1.08); C407(0.93)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C181(0.84); C253(1.04); C377(1.10); C407(0.93)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C181(0.89); C253(1.09); C377(1.01); C407(0.93)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C181(0.94); C253(1.08); C377(1.05); C407(0.94)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C181(0.96); C253(1.11); C377(1.08); C407(1.24)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C181(0.89); C253(1.08); C377(1.05); C407(0.85)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C181(0.86); C253(1.14); C377(1.07); C407(0.89)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C181(1.03); C253(1.14); C377(1.17); C407(0.94)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C181(0.82); C253(1.04); C377(1.01); C407(0.90)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C181(0.98); C253(1.10); C377(1.01); C407(0.86)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C181(0.88); C253(1.15); C377(1.12); C407(0.96)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C181(0.78); C253(1.12); C377(1.03); C407(0.93)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C181(0.55); C253(1.33); C377(1.57); C407(0.98)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C181(0.43); C253(0.97); C377(1.71); C407(0.89)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C181(0.45); C253(1.15); C377(1.36); C407(0.91)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C181(0.43); C253(0.93); C377(1.33); C407(0.88)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C181(0.61); C253(1.09); C377(1.39); C407(0.94)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C181(0.53); C253(1.15); C377(1.41); C407(0.93)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C181(0.55); C253(1.30); C377(1.24); C407(1.04)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C181(0.50); C253(1.20); C377(1.56); C407(0.95)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C181(0.84); C253(1.18); C377(1.45); C407(1.12)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C181(0.69); C253(1.19); C377(1.37); C407(1.09)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C181(0.51); C253(1.35); C377(1.01); C407(1.12)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C181(0.49); C253(1.23); C377(1.20); C407(0.94)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C181(0.99); C253(1.13); C377(0.82); C407(1.21)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C181(0.54); C253(1.31); C377(1.05); C407(1.08)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C181(0.50); C253(1.27); C377(1.13); C407(1.00)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C181(0.46); C253(1.09); C377(1.32); C407(1.01)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C181(0.91); C253(1.24); C377(0.92); C407(0.83)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C429(0.54); C493(0.66); C407(0.90); C440(0.93)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C429(0.53); C440(0.73); C493(0.75); C181(0.96)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C429(0.50); C493(0.65); C440(0.75); C407(0.94)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C429(0.71); C493(0.75); C377(0.97); C440(0.97)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C429(0.53); C493(0.61); C440(0.77); C181(0.95)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C429(0.48); C493(0.55); C440(0.76); C407(0.91)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C181(0.85); C429(0.91); C493(0.94); C377(1.02)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C493(0.76); C440(0.89); C429(0.91); C407(0.97)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C493(0.64); C429(0.70); C440(0.82); C407(0.85)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C493(0.63); C429(0.75); C440(0.80); C407(1.05)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C429(0.39); C493(0.55); C440(0.72); C377(0.82)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C181(1.07); C253(1.16); C377(0.95); C407(1.03)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C181(1.11); C253(1.18); C377(0.97); C407(0.90)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C181(0.98); C253(1.03); C377(0.89); C407(0.92)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C181(0.92); C253(0.91); C377(1.00); C407(0.83)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C429(0.86); C493(0.89); C440(0.90); C181(0.90)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C493(0.93); C429(0.94); C377(0.98); C407(1.03)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C429(0.91); C181(0.94); C302(0.95); C493(0.96)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C302(0.77); C407(0.97); C377(1.01); C493(1.07)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C429(0.76); C407(0.83); C440(0.87); C493(0.97)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C429(0.70); C440(0.82); C302(0.90); C493(0.93)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C429(0.72); C302(0.82); C377(0.92); C181(0.95)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C493(0.98); C429(1.00); C181(1.03); C440(1.04)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C181(0.82); C253(1.01); C407(1.02); C493(1.03)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C181(0.61); C302(0.70); C407(0.73); C429(0.86)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C181(0.59); C302(0.84); C407(0.85); C429(0.88)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C302(0.57); C407(0.72); C181(0.78); C493(0.88)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C181(0.67); C302(0.76); C407(0.85); C493(0.94)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C302(0.76); C181(0.85); C377(0.94); C493(0.97)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C302(1.00); C253(1.09); C407(1.10); C377(1.13)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C302(0.70); C429(0.79); C181(0.82); C493(0.90)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C302(0.56); C181(0.63); C407(0.80); C429(0.89)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C302(0.57); C181(0.79); C493(0.90); C407(0.92)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C302(0.63); C181(0.77); C429(0.79); C407(0.87)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C302(0.55); C429(0.70); C377(0.81); C181(0.86)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C429(0.58); C253(0.91); C181(0.94); C440(0.96)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C429(0.90); C407(0.96); C253(0.97); C440(1.01)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C429(0.54); C407(0.86); C377(0.89); C181(0.96)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C429(0.78); C440(0.90); C181(0.92); C253(0.95)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C429(0.64); C440(0.86); C493(0.92); C407(0.94)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C302(0.72); C407(1.04); C377(1.06); C493(1.08)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C429(0.59); C407(0.83); C493(0.87); C440(0.89)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C429(0.62); C407(0.96); C377(1.05); C253(1.06)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C429(0.85); C407(0.99); C181(1.00); C493(1.08)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C429(0.56); C407(0.76); C377(0.89); C440(0.90)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C429(0.74); C407(0.94); C493(1.05); C377(1.06)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C429(0.60); C407(0.83); C377(0.89); C493(0.96)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C440(0.73); C181(0.78); C407(0.82); C377(0.99)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C181(0.71); C302(0.80); C440(0.82); C407(0.85)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C302(0.60); C429(0.79); C377(0.88); C440(0.91)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C302(0.71); C407(0.84); C429(0.85); C493(0.89)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C302(0.72); C440(1.01); C493(1.04); C429(1.09)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C181(0.74); C302(0.77); C407(0.84); C377(0.91)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C181(0.67); C407(0.87); C377(1.05); C253(1.11)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C429(0.81); C302(0.82); C181(0.90); C377(0.95)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C181(0.58); C429(0.86); C302(0.90); C493(0.98)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C302(0.60); C377(0.84); C429(0.85); C407(0.92)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C181(0.51); C302(0.51); C429(0.63); C493(0.80)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C302(0.45); C429(0.67); C181(0.70); C377(0.72)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C302(0.45); C440(0.64); C181(0.78); C493(0.80)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C302(0.37); C440(0.74); C377(0.76); C493(0.79)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C302(0.51); C440(0.70); C493(0.80); C377(0.83)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C429(0.74); C181(0.80); C407(0.83); C377(0.88)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C302(0.45); C440(0.65); C493(0.74); C377(0.76)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C302(0.24); C440(0.57); C181(0.71); C377(0.74)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C302(0.33); C181(0.63); C440(0.74); C493(0.80)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C302(0.35); C181(0.68); C440(0.69); C493(0.76)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C302(0.60); C440(0.66); C181(0.67); C493(0.76)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C302(0.46); C440(0.58); C181(0.74); C493(0.82)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C302(0.31); C181(0.59); C440(0.59); C493(0.77)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C302(0.22); C493(0.65); C429(0.66); C440(0.67)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C377(0.92); C181(0.96); C407(1.00); C429(1.03)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C377(0.81); C493(0.88); C407(0.92); C181(0.99)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C429(0.73); C181(0.80); C493(0.81); C407(0.83)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C377(0.85); C181(0.88); C429(0.88); C493(0.90)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C181(0.95); C253(0.98); C440(1.04); C377(1.07)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C440(0.90); C377(0.92); C407(0.96); C493(0.97)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C377(0.74); C429(0.78); C493(0.84); C181(0.88)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C493(0.62); C377(0.63); C429(0.68); C181(0.87)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C377(0.63); C429(0.70); C493(0.75); C407(0.92)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C377(0.88); C181(0.93); C407(0.95); C429(1.01)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C377(0.74); C181(0.79); C407(0.81); C429(0.83)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C377(0.67); C407(0.77); C429(0.80); C493(0.85)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C407(0.93); C377(0.96); C493(0.96); C181(0.99)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C429(0.71); C377(0.86); C493(0.91); C407(0.97)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C429(0.83); C377(0.89); C493(0.93); C440(0.97)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C181(0.84); C429(0.93); C253(0.94); C377(0.99)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C429(0.54); C377(0.56); C493(0.57); C181(0.84)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C377(0.76); C429(0.82); C302(0.87); C440(0.91)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C377(0.85); C302(0.87); C429(0.93); C440(0.98)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C429(0.83); C377(0.90); C440(1.03); C493(1.04)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C181(1.05); C253(1.12); C407(1.13); C377(1.21)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C253(0.97); C377(1.11); C181(1.15); C407(1.19)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C253(1.01); C407(1.27); C377(1.28); C493(1.35)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C377(0.98); C407(1.13); C253(1.14); C493(1.16)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C181(0.80); C407(0.92); C253(0.98); C493(1.35)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C377(0.92); C302(0.93); C429(0.99); C181(1.10)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C377(1.11); C181(1.15); C493(1.23); C302(1.24)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C253(1.07); C440(1.15); C429(1.17); C377(1.20)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C253(1.09); C377(1.13); C181(1.16); C302(1.19)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C377(0.81); C302(0.83); C181(0.94); C407(1.02)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C181(0.85); C377(0.90); C407(1.04); C493(1.09)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C377(1.01); C429(1.02); C493(1.09); C440(1.14)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C302(0.09); C429(0.32); C493(0.37); C440(0.40)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C302(0.61); C440(0.66); C377(0.71); C493(0.76)  LDD0683  [19]
 LDCM0545  Acetamide MDA-MB-231 C377(0.68); C253(0.59); C493(0.67); C181(0.53)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C377(0.72); C253(0.79); C493(0.75); C181(0.71)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C181(0.75); C253(1.09); C377(0.92); C407(0.70)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C429(0.65); C493(0.73); C377(0.80); C440(0.92)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C429(0.64); C493(0.73); C377(0.79); C407(0.98)  LDD0592  [19]
 LDCM0020  ARS-1620 HCC44 C440(1.21); C253(1.04); C407(1.04)  LDD0078  [19]
 LDCM0498  BS-3668 MDA-MB-231 C377(0.94); C253(0.64); C493(0.85)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C253(1.55)  LDD2214  [43]
 LDCM0108  Chloroacetamide HeLa C302(0.00); C253(0.00); C493(0.00); C377(0.00)  LDD0222  [35]
 LDCM0632  CL-Sc Hep-G2 C377(1.87); C253(1.77); C181(1.25); C493(1.18)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C181(0.67); C407(0.84); C253(0.87); C377(0.92)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C302(0.50); C181(0.71); C429(0.78); C493(0.88)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C302(0.74); C440(0.86); C181(0.91); C407(1.02)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C429(0.74); C377(0.76); C493(0.76); C181(0.84)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C429(0.74); C181(0.84); C493(0.90); C377(0.93)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C181(0.73); C407(0.80); C429(0.82); C493(0.83)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C429(0.74); C493(0.78); C407(0.81); C181(0.82)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C429(0.66); C440(0.72); C181(0.83); C377(0.90)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C429(0.58); C440(0.65); C302(0.79); C493(0.92)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C429(0.66); C440(0.93); C493(0.98); C377(1.06)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C493(0.87); C429(0.89); C440(0.90); C302(1.10)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C429(0.75); C493(0.85); C377(0.93); C440(0.99)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C302(0.44); C181(0.79); C429(0.83); C493(0.84)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C493(0.90); C181(0.94); C440(1.02); C429(1.04)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C429(0.80); C493(0.88); C377(0.97); C181(1.08)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C181(0.58); C302(0.91); C253(0.96); C493(1.01)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C181(0.59); C302(0.66); C429(0.82); C493(0.84)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C302(0.68); C429(0.72); C181(0.75); C493(0.81)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C302(0.68); C429(0.69); C493(0.78); C181(0.80)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C302(0.69); C429(0.70); C377(0.92); C493(0.94)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C429(0.56); C493(0.76); C377(0.77); C440(0.84)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C429(0.92); C407(0.93); C440(1.03); C377(1.04)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C429(0.60); C407(0.75); C493(0.89); C377(0.91)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C302(0.57); C181(0.75); C429(0.85); C377(1.01)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C429(0.59); C407(0.69); C377(0.93); C493(0.93)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C429(0.80); C377(0.82); C493(0.93); C440(0.94)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C302(0.57); C429(0.68); C377(0.79); C493(0.79)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C302(0.73); C429(0.85); C377(0.88); C181(0.89)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C429(0.65); C302(0.66); C440(0.80); C181(0.84)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C440(0.64); C181(0.69); C407(0.82); C302(0.82)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C440(0.63); C181(0.81); C377(0.86); C302(0.90)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C302(0.53); C440(0.60); C429(0.83); C377(0.88)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C302(0.57); C440(0.62); C493(0.79); C181(0.81)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C302(0.40); C181(0.76); C429(0.84); C493(0.84)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C302(0.76); C181(0.80); C407(0.88); C253(0.94)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C302(0.40); C181(0.67); C493(0.85); C407(0.88)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C429(0.64); C377(0.72); C493(0.76); C302(0.78)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C302(0.40); C377(0.74); C429(0.80); C407(0.82)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C302(0.24); C377(0.56); C429(0.64); C440(0.93)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C302(0.43); C377(0.67); C429(0.75); C440(0.93)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C181(0.67); C407(0.86); C377(0.90); C253(0.93)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C302(0.45); C407(0.76); C429(0.78); C377(0.80)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C302(0.29); C377(0.73); C429(0.84); C493(0.90)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C302(0.37); C377(0.76); C429(0.78); C493(0.87)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C377(0.81); C493(0.85); C429(0.99); C440(1.04)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C302(0.48); C429(0.80); C377(0.82); C493(0.87)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C253(1.37); C302(0.48); C377(0.74); C407(0.96)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C253(1.18); C302(1.09); C377(0.74); C407(0.93)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C253(1.19); C302(0.53); C377(0.79); C407(1.07)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C253(1.20); C302(0.46); C377(0.68); C407(0.81)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C253(1.29); C302(0.39); C377(0.73); C407(0.94)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C181(0.67); C253(0.91); C302(1.06); C377(1.04)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C253(1.07); C302(0.33); C377(0.74); C407(1.17)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C181(0.88); C253(1.10); C302(0.84); C377(1.13)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C181(0.93); C253(1.29); C302(0.50); C377(0.82)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C181(0.94); C253(1.16); C302(0.58); C377(0.83)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C181(1.01); C253(1.33); C302(0.57); C377(0.94)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C181(1.12); C253(1.18); C302(0.96); C377(1.01)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C181(1.07); C253(1.18); C302(0.95); C377(0.99)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C181(1.06); C253(1.36); C302(0.76); C377(1.00)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C181(1.07); C253(1.38); C302(0.76); C377(1.06)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C181(0.88); C253(0.89); C302(1.08); C377(0.93)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C181(0.94); C253(1.26); C302(0.77); C377(0.85)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C181(1.06); C253(1.23); C302(0.97); C377(1.04)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C181(1.26); C253(2.12); C302(0.55); C377(0.97)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C181(1.10); C253(1.64); C302(0.63); C377(0.99)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C181(0.89); C253(1.42); C302(0.58); C377(0.94)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C181(0.98); C253(1.48); C302(0.52); C377(0.96)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C181(0.81); C253(0.87); C302(1.42); C377(1.11)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C181(0.92); C253(0.86); C302(1.30); C377(1.15)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C181(1.10); C253(0.80); C302(1.50); C377(1.21)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C181(1.03); C253(0.87); C302(1.67); C377(1.13)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C181(0.77); C253(0.92); C302(0.96); C377(1.01)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C181(0.99); C253(0.78); C302(1.75); C377(1.22)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C181(0.92); C253(0.87); C302(1.56); C377(1.19)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C181(0.89); C253(0.84); C302(1.24); C377(1.01)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C181(1.08); C253(0.76); C302(1.19); C377(1.00)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C181(0.77); C253(0.76); C302(2.55); C377(1.24)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C181(0.77); C253(0.82); C302(1.83); C377(1.10)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C181(0.88); C253(0.95); C302(1.18); C377(1.04)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C181(1.04); C253(0.79); C302(1.57); C377(1.16)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C181(0.73); C253(0.83); C302(1.37); C377(1.08)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C181(0.70); C253(0.87); C302(1.74); C377(1.23)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C181(0.61); C253(1.07); C302(0.54); C377(0.84)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C181(0.96); C253(0.88); C302(1.25); C377(1.11)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C181(1.00); C253(1.03); C302(0.83); C377(1.03)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C181(1.01); C253(0.98); C302(0.84); C377(1.20)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C181(1.03); C253(1.25); C302(0.90); C377(0.95)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C181(1.06); C253(1.25); C302(0.77); C377(1.02)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C181(1.14); C253(1.05); C302(0.82); C377(1.05)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C181(1.26); C253(1.52); C302(0.49); C377(0.95)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C181(1.36); C253(1.30); C302(0.72); C377(0.95)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C181(1.38); C253(1.40); C302(0.54); C377(0.88)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C181(0.93); C253(0.94); C302(0.45); C377(0.69)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C181(0.78); C253(1.16); C302(0.60); C377(0.98)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C181(0.97); C253(1.20); C302(0.52); C377(0.95)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C181(1.16); C253(1.15); C302(0.94); C377(1.02)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C181(1.11); C253(1.00); C302(0.97); C377(1.04)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C181(1.15); C253(1.18); C302(0.48); C377(0.96)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C181(1.19); C253(1.18); C302(0.55); C377(1.01)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C181(0.75); C253(1.17); C377(0.69); C407(1.54)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C181(0.87); C253(1.02); C377(0.82); C407(1.41)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C181(0.96); C253(1.16); C377(0.82); C407(1.09)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C181(1.12); C253(1.25); C377(0.85); C407(1.22)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C181(0.88); C253(1.33); C302(0.52); C377(0.79)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C181(0.79); C253(1.06); C377(0.67); C407(1.20)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C181(0.94); C253(1.14); C377(0.89); C407(0.92)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C181(1.17); C253(1.47); C377(0.78); C407(1.18)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C181(1.15); C253(1.43); C377(0.73); C407(1.13)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C181(1.11); C253(1.62); C377(0.63); C407(1.13)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C181(0.86); C253(1.27); C377(0.83); C407(1.54)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C181(0.82); C253(1.16); C377(0.90); C407(1.44)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C181(0.93); C253(1.25); C377(0.83); C407(1.33)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C181(1.07); C253(1.38); C377(0.82); C407(1.68)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C181(0.95); C253(1.78); C377(0.63); C407(1.33)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C181(0.79); C253(1.07); C302(0.89); C377(0.89)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C181(0.92); C253(0.90); C377(0.97); C407(1.12)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C181(1.13); C253(1.12); C302(0.91); C377(0.93)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C181(1.03); C253(0.99); C302(0.67); C377(0.89)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C181(0.99); C253(1.03); C302(0.63); C377(0.87)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C181(1.07); C253(0.99); C302(0.75); C377(0.93)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C181(1.23); C253(1.04); C302(0.62); C377(0.93)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C181(1.43); C253(1.04); C302(0.58); C377(0.82)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C181(1.36); C253(1.04); C302(0.69); C377(0.87)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C181(1.31); C253(1.15); C302(0.85); C377(1.05)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C181(1.17); C253(1.17); C302(0.82); C377(0.98)  LDD0811  [19]
 LDCM0185  Compound 17 HEK-293T 3.11  LDD0512  [37]
 LDCM0191  Compound 21 HEK-293T 3.77  LDD0508  [37]
 LDCM0190  Compound 34 HEK-293T 3.41  LDD0510  [37]
 LDCM0193  Compound 36 HEK-293T 3.06  LDD0511  [37]
 LDCM0634  CY-0357 Hep-G2 C181(1.68); C407(1.37); C377(0.77); C493(0.74)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C181(0.91); C440(1.05); C407(1.03); C377(0.94)  LDD1698  [44]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C377(1.16); C440(1.04); C181(0.91); C253(0.82)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa C253(0.81)  LDD2210  [15]
 LDCM0625  F8 Ramos C377(1.09); C493(1.59); C253(1.25); C181(1.55)  LDD2187  [45]
 LDCM0572  Fragment10 MDA-MB-231 C253(1.71)  LDD1389  [46]
 LDCM0573  Fragment11 MDA-MB-231 C253(1.16)  LDD1391  [46]
 LDCM0574  Fragment12 MDA-MB-231 C253(20.00)  LDD1393  [46]
 LDCM0575  Fragment13 Ramos C253(0.78)  LDD1396  [46]
 LDCM0576  Fragment14 MDA-MB-231 C253(0.85)  LDD1397  [46]
 LDCM0577  Fragment15 Ramos C253(1.23)  LDD1400  [46]
 LDCM0579  Fragment20 MDA-MB-231 C253(2.29)  LDD1402  [46]
 LDCM0580  Fragment21 MDA-MB-231 C253(2.48)  LDD1404  [46]
 LDCM0581  Fragment22 Ramos C253(0.37)  LDD1407  [46]
 LDCM0582  Fragment23 MDA-MB-231 C253(1.95)  LDD1408  [46]
 LDCM0583  Fragment24 Ramos C253(1.31)  LDD1410  [46]
 LDCM0584  Fragment25 MDA-MB-231 C253(0.94)  LDD1411  [46]
 LDCM0578  Fragment27 MDA-MB-231 C253(0.81)  LDD1401  [46]
 LDCM0586  Fragment28 Ramos C253(0.94)  LDD1416  [46]
 LDCM0587  Fragment29 MDA-MB-231 C253(1.03)  LDD1417  [46]
 LDCM0588  Fragment30 Ramos C377(1.12); C493(1.38); C253(0.97); C181(1.33)  LDD2199  [45]
 LDCM0589  Fragment31 MDA-MB-231 C253(1.15)  LDD1421  [46]
 LDCM0590  Fragment32 MDA-MB-231 C253(5.65)  LDD1423  [46]
 LDCM0468  Fragment33 HCT 116 C181(1.15); C253(1.12); C302(0.74); C377(0.95)  LDD0785  [19]
 LDCM0593  Fragment35 MDA-MB-231 C253(0.85)  LDD1429  [46]
 LDCM0594  Fragment36 MDA-MB-231 C253(2.36)  LDD1431  [46]
 LDCM0596  Fragment38 MDA-MB-231 C253(1.13)  LDD1433  [46]
 LDCM0597  Fragment39 MDA-MB-231 C253(1.27)  LDD1435  [46]
 LDCM0566  Fragment4 MDA-MB-231 C253(1.08)  LDD1378  [46]
 LDCM0598  Fragment40 Ramos C253(0.93)  LDD1437  [46]
 LDCM0599  Fragment41 MDA-MB-231 C253(0.86)  LDD1438  [46]
 LDCM0600  Fragment42 Ramos C253(0.88)  LDD1440  [46]
 LDCM0601  Fragment43 MDA-MB-231 C253(1.79)  LDD1441  [46]
 LDCM0603  Fragment45 MDA-MB-231 C253(1.16)  LDD1482  [46]
 LDCM0604  Fragment46 MDA-MB-231 C253(0.96)  LDD1445  [46]
 LDCM0605  Fragment47 MDA-MB-231 C253(1.03)  LDD1446  [46]
 LDCM0606  Fragment48 MDA-MB-231 C253(1.00)  LDD1447  [46]
 LDCM0608  Fragment50 MDA-MB-231 C253(4.46)  LDD1449  [46]
 LDCM0427  Fragment51 HCT 116 C181(1.26); C253(1.76); C302(0.55); C377(0.89)  LDD0744  [19]
 LDCM0610  Fragment52 MDA-MB-231 C253(1.27)  LDD1452  [46]
 LDCM0611  Fragment53 Ramos C253(0.82)  LDD1455  [46]
 LDCM0614  Fragment56 MDA-MB-231 C253(0.91)  LDD1458  [46]
 LDCM0568  Fragment6 MDA-MB-231 C253(1.12)  LDD1382  [46]
 LDCM0569  Fragment7 MDA-MB-231 C253(1.23)  LDD1383  [46]
 LDCM0570  Fragment8 MDA-MB-231 C253(1.29)  LDD1385  [46]
 LDCM0571  Fragment9 MDA-MB-231 C253(1.25)  LDD1387  [46]
 LDCM0116  HHS-0101 DM93 Y446(1.06)  LDD0264  [17]
 LDCM0117  HHS-0201 DM93 Y274(0.23); Y446(0.60)  LDD0265  [17]
 LDCM0118  HHS-0301 DM93 Y446(0.76); Y274(1.50)  LDD0266  [17]
 LDCM0119  HHS-0401 DM93 Y446(0.80)  LDD0267  [17]
 LDCM0120  HHS-0701 DM93 Y446(0.76)  LDD0268  [17]
 LDCM0015  HNE MDA-MB-231 C253(1.05)  LDD0346  [45]
 LDCM0107  IAA HeLa C493(0.00); H505(0.00); C302(0.00); C377(0.00)  LDD0221  [35]
 LDCM0123  JWB131 DM93 Y274(0.97)  LDD0285  [16]
 LDCM0124  JWB142 DM93 Y274(0.72); Y446(0.82)  LDD0286  [16]
 LDCM0125  JWB146 DM93 Y274(1.13); Y446(0.81)  LDD0287  [16]
 LDCM0126  JWB150 DM93 Y274(2.84); Y446(0.11)  LDD0288  [16]
 LDCM0127  JWB152 DM93 Y274(1.51); Y446(1.95)  LDD0289  [16]
 LDCM0128  JWB198 DM93 Y274(1.02)  LDD0290  [16]
 LDCM0129  JWB202 DM93 Y274(0.78)  LDD0291  [16]
 LDCM0130  JWB211 DM93 Y274(0.88); Y446(0.81)  LDD0292  [16]
 LDCM0179  JZ128 PC-3 C253(0.00); C302(0.00)  LDD0462  [13]
 LDCM0022  KB02 HCT 116 C429(2.02); C181(1.03); C302(1.58); C440(1.04)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C429(3.04); C181(1.22); C302(1.51); C440(1.36)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C429(2.72); C181(1.83); C302(1.51); C440(1.41)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C377(1.76); C253(0.98); C493(1.77)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C377(0.91); C253(0.65); C493(1.05); C181(0.51)  LDD2121  [8]
 LDCM0109  NEM HeLa H264(0.00); H505(0.00); H236(0.00); H37(0.00)  LDD0223  [35]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C377(1.03); C253(0.73); C493(1.11); C181(0.76)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C377(1.15); C253(1.09); C493(1.70); C181(1.45)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C377(1.17); C253(0.96)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C377(1.31); C253(1.37); C493(1.35); C181(1.10)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C377(2.11); C253(1.17)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C253(0.32); C493(0.25); C181(0.12)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C377(0.65); C253(0.78); C493(0.84); C181(0.76)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C377(0.61); C253(0.79); C493(0.81); C181(0.45)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C377(1.49); C253(1.01); C493(1.44); C181(0.96)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C377(0.31); C253(0.45); C493(0.42)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C377(0.75); C253(0.83); C493(0.98); C181(0.50)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C377(0.81); C181(0.51)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C377(1.91); C253(1.07); C493(1.69)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C377(0.89); C253(0.46); C493(0.34)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C377(1.02); C253(0.90); C493(0.94); C181(0.83)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C377(0.49); C253(0.67); C493(0.66)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C377(0.90); C253(0.85); C493(0.87); C181(0.58)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C253(0.95); C181(1.44)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C377(1.32); C253(1.19); C493(1.33); C181(0.95)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C253(0.66); C493(0.59); C181(1.11)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C377(0.60); C253(0.53); C493(0.52); C181(0.53)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C253(0.49); C181(0.13)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C377(0.48); C253(0.45); C181(0.19)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C377(1.64); C253(2.23); C493(1.89); C181(2.32)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C377(1.00); C253(0.89); C493(0.71); C181(0.72)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C253(0.50); C181(0.19)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C377(1.21); C253(1.04); C493(1.08); C181(0.80)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C377(0.38); C253(0.56); C493(0.50); C181(0.13)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C377(1.21); C253(0.98); C493(1.08); C181(0.76)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C377(0.50); C253(0.65); C493(1.07); C181(0.13)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C377(1.39); C253(0.99); C493(1.29); C181(0.94)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C377(0.81); C253(0.93); C493(0.59); C181(0.74)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C253(1.38); C493(1.21); C181(1.04)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C377(1.29); C253(0.70); C493(0.66); C181(0.92)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C377(0.45); C253(0.63); C493(0.45); C181(0.43)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C377(1.66); C253(1.49); C493(1.55); C181(1.35)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C253(1.09); C493(1.40); C181(0.94)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C377(1.19); C253(1.00); C493(1.14); C181(0.96)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C377(2.38); C493(2.37); C253(2.27); C181(2.03)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C377(1.29); C253(0.96); C493(0.93); C181(0.68)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C253(0.39); C493(0.71); C181(0.16)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C377(0.98); C253(0.92); C493(0.79); C181(0.83)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C377(1.93); C253(2.22); C493(2.36); C181(2.51)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C493(5.24); C181(2.61); C429(0.23)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C377(0.99); C253(0.89); C493(1.12); C181(0.85)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C377(1.35); C253(1.61); C493(1.19); C181(2.68)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C377(0.56); C253(0.60); C493(0.55); C181(0.46)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C253(0.56); C493(0.68); C181(0.16)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C377(0.82); C253(0.51); C493(0.64)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C377(0.13); C253(0.60); C493(0.76); C181(0.16)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C377(1.52); C253(1.81); C493(2.21); C181(1.69)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C253(0.92); C181(0.91); C407(0.75)  LDD2206  [47]
 LDCM0628  OTUB2-COV-1 HEK-293T C253(0.71); C181(0.49)  LDD2207  [47]
 LDCM0131  RA190 MM1.R C429(1.05); C440(1.05); C253(1.02); C377(0.99)  LDD0304  [48]
 LDCM0021  THZ1 HeLa S3 C253(1.11); C429(1.10); C302(1.09); C440(1.06)  LDD0460  [13]
 LDCM0110  W12 Hep-G2 C253(8.90)  LDD0237  [5]
 LDCM0111  W14 Hep-G2 C493(1.44); C253(1.83)  LDD0238  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1) Gfo/Idh/MocA family Q9NXC2
Hexokinase-3 (HK3) Hexokinase family P52790
Peptidoglycan recognition protein 3 (PGLYRP3) N-acetylmuramoyl-L-alanine amidase 2 family Q96LB9
STAM-binding protein (STAMBP) Peptidase M67C family O95630
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Ubiquitin-conjugating enzyme E2 W (UBE2W) Ubiquitin-conjugating enzyme family Q96B02
F-box/LRR-repeat protein 2 (FBXL2) . Q9UKC9
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) . Q1L5Z9
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Voltage-dependent anion-selective channel protein 2 (VDAC2) Eukaryotic mitochondrial porin family P45880
Huntingtin (HTT) Huntingtin family P42858
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
COP9 signalosome complex subunit 7b (COPS7B) CSN7/EIF3M family Q9H9Q2
Epithelial splicing regulatory protein 1 (ESRP1) ESRP family Q6NXG1
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Huntingtin-interacting protein M (H2AP) . O75409
Pleckstrin homology domain-containing family G member 7 (PLEKHG7) . Q6ZR37
Protein ZNRD2 (ZNRD2) . O60232

References

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2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
16 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
17 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
22 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
23 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
24 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
25 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
26 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
29 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
32 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
33 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
34 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
35 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
36 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
37 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
38 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
39 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
40 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
41 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
42 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
43 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
44 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
45 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
46 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
47 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
48 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.