Details of the Target

General Information of Target

Target ID LDTP04103
Target Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Gene Name MAP2K3
Gene ID 5606
Synonyms
MEK3; MKK3; PRKMK3; SKK2; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAPKK 3; EC 2.7.12.2; MAPK/ERK kinase 3; MEK 3; Stress-activated protein kinase kinase 2; SAPK kinase 2; SAPKK-2; SAPKK2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Function
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
Uniprot ID
P46734
Ensemble ID
ENST00000316920.10
HGNC ID
HGNC:6843
ChEMBL ID
CHEMBL2109

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A97V .
HEC1 SNV: p.K18T DBIA    Probe Info 
HEC1B SNV: p.K18T IA-alkyne    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.P36L DBIA    Probe Info 
JHH1 SNV: p.G128E DBIA    Probe Info 
REH Substitution: p.V81G DBIA    Probe Info 
RL952 SNV: p.V118I DBIA    Probe Info 
TOV21G SNV: p.S6Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y214(11.49); Y75(9.09); Y316(6.50)  LDD0257  [3]
TH216
 Probe Info  		Y214(13.87)  LDD0259  [3]
ONAyne
 Probe Info  		K80(1.82)  LDD0274  [4]
STPyne
 Probe Info  		K105(7.93); K243(9.09); K332(3.50); K80(6.45)  LDD0277  [4]
DBIA
 Probe Info  		C310(3.87)  LDD3311  [5]
BTD
 Probe Info  		C29(1.03)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C29(2.86)  LDD0168  [7]
HPAP
 Probe Info  		3.48  LDD0062  [8]
EA-probe
 Probe Info  		C207(0.97); C207(0.92)  LDD2210  [9]
AMP probe
 Probe Info  		N.A.  LDD0200  [10]
ATP probe
 Probe Info  		K93(0.00); K192(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C305(0.00); C29(0.00); C207(0.00); C227(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C305(0.00); C29(0.00); C207(0.00); C227(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C207(0.00); C227(0.00); C305(0.00)  LDD2226  [13]
TFBX
 Probe Info  		C207(0.00); C29(0.00)  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
aHNE
 Probe Info  		N.A.  LDD0001  [15]
IPM
 Probe Info  		C207(0.00); C29(0.00); C227(0.00)  LDD0005  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C305(0.00); H83(0.00)  LDD0217  [17]
W1
 Probe Info  		C305(0.00); C227(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C207(0.00); C227(0.00)  LDD2223  [13]
HHS-482
 Probe Info  		Y214(1.07); Y75(1.03)  LDD2239  [20]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.98)  LDD2142  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C29(0.74)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C29(1.03)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C29(0.83)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C29(1.15)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C29(1.14)  LDD2103  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C29(0.72)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C29(2.86)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C29(9.95)  LDD0169  [7]
 LDCM0561  Abegg_cp(-)-10 HeLa C305(2.36)  LDD0312  [14]
 LDCM0562  Abegg_cp(-)-11 HeLa C305(2.53)  LDD0313  [14]
 LDCM0214  AC1 HEK-293T C227(0.95); C29(1.05); C207(1.04); C305(1.08)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C227(0.90); C29(1.02); C207(1.10); C305(0.96)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C29(0.92); C207(1.01); C305(0.94); C139(1.04)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C227(0.86); C29(0.93); C207(1.07); C305(0.95)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C227(0.83); C29(0.98); C207(1.06); C305(1.09)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C227(0.88); C29(0.94); C207(1.01); C305(1.01)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C227(0.86); C29(1.05); C207(1.11); C305(1.09)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C227(0.92); C29(1.02); C207(1.54); C305(0.93)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C29(1.20); C207(1.02); C305(1.11); C139(0.92)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C227(0.91); C29(1.00); C207(1.07); C305(0.96)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C227(0.83); C29(0.93); C207(0.92); C305(1.01)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C227(0.96); C29(0.99); C207(1.00); C305(0.98)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C227(0.87); C29(0.94); C207(0.99); C305(1.10)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C227(0.87); C29(0.94); C207(1.00); C305(1.01)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C227(0.92); C29(0.99); C207(0.97); C305(1.05)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C227(0.85); C29(0.96); C207(1.07); C305(1.17)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C227(0.87); C29(0.99); C207(0.98); C305(1.11)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C29(1.00); C207(1.12); C305(1.00); C139(1.33)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C227(0.72); C29(0.91); C207(2.59); C305(1.52)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C227(0.92); C29(0.96); C207(1.02); C305(0.99)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C29(0.98); C207(1.09); C305(1.00); C139(0.87)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C227(0.88); C29(0.93); C207(0.99); C305(1.01)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C227(0.93); C29(1.00); C207(1.02); C305(0.98)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C227(0.92); C29(1.05); C207(0.93); C305(1.02)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C227(0.88); C29(1.02); C207(1.01); C305(1.07)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C227(0.93); C29(1.02); C207(0.96); C305(1.07)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C29(0.98); C207(1.03); C305(1.01); C139(1.18)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C227(0.86); C29(0.98); C207(0.92); C305(0.93)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C227(0.88); C29(0.93); C207(0.99); C305(1.07)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C227(0.82); C29(0.88); C207(0.94); C305(0.95)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C227(0.87); C29(0.89); C207(1.00); C305(1.06)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C227(0.94); C29(1.02); C207(0.98); C305(0.95)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C227(0.81); C29(0.91); C207(2.59); C305(1.22)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C227(0.88); C29(1.04); C207(1.03); C305(1.06)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C227(0.92); C29(1.02); C207(0.95); C305(0.99)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C29(0.95); C207(1.05); C305(1.03); C139(1.13)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C227(0.91); C29(0.96); C207(1.00); C305(0.93)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C227(0.94); C29(1.09); C207(0.99); C305(0.97)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C227(0.87); C29(0.94); C207(0.98); C305(1.06)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C227(0.93); C29(0.92); C207(1.03); C305(0.99)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C227(0.99); C29(0.98); C207(1.00); C305(0.96)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C227(0.91); C29(1.06); C207(1.00); C305(1.09)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C227(0.86); C29(0.94); C207(1.09); C305(1.11)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C227(0.90); C29(1.01); C207(1.04); C305(0.94)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C29(1.01); C207(1.05); C305(0.94); C139(1.02)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C227(0.87); C29(0.92); C207(1.21); C305(1.07)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C227(0.92); C29(1.02); C207(0.94); C305(0.97)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C227(0.87); C29(0.95); C207(1.04); C305(1.01)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C227(0.90); C29(0.95); C207(0.97); C305(0.94)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C227(0.99); C29(1.03); C207(0.97); C305(1.06)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C227(0.97); C29(1.08); C207(1.09); C305(1.11)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C227(0.90); C29(1.01); C207(1.04); C305(0.95)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C29(0.94); C207(1.04); C305(0.97); C139(1.11)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C227(0.98); C29(1.01); C207(1.03); C305(1.00)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C227(0.90); C29(1.04); C207(1.03); C305(0.94)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C227(0.89); C29(1.04); C207(0.97); C305(0.97)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C227(0.90); C29(0.92); C207(1.03); C305(1.00)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C227(0.80); C29(0.93); C207(1.43); C305(1.10)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C227(1.04); C29(1.09); C207(1.02); C305(1.02)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C227(0.91); C29(0.94); C207(1.02); C305(1.04)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C227(1.00); C29(1.05); C207(0.98); C305(0.92)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C29(0.41); C227(0.49)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C29(0.68)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C227(0.96); C29(0.97); C207(0.99); C305(0.99)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C227(0.92); C29(1.11); C207(0.99); C305(1.05)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C227(0.90); C29(1.04); C207(1.17); C305(0.99)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C29(0.47); C227(0.72)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C207(1.56)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C305(20.00); C207(2.60); C305(1.25); C227(0.93)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C227(0.71); C29(0.97); C207(1.67); C305(1.19)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C227(0.96); C29(0.84); C207(2.43); C305(0.98)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C227(0.90); C29(1.01); C207(0.91); C305(1.03)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C227(0.92); C29(1.00); C207(1.03); C305(0.98)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C227(0.92); C29(0.97); C207(1.26); C305(1.15)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C227(0.88); C29(0.93); C207(1.01); C305(0.97)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C227(0.93); C29(0.92); C207(0.96); C305(1.02)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C227(0.88); C29(1.03); C207(0.89); C305(1.02)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C227(0.91); C29(0.97); C207(0.94); C305(0.97)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C227(0.87); C29(0.89); C207(1.03); C305(1.03)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C227(0.88); C29(1.01); C207(0.90); C305(0.98)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C227(0.86); C29(1.01); C207(0.97); C305(0.98)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C227(1.01); C29(0.84); C207(1.27); C305(1.05)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C227(0.92); C29(1.05); C207(1.03); C305(0.99)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C227(0.94); C29(0.98); C207(1.25); C305(0.99)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C227(0.93); C29(1.01); C207(0.97); C305(0.98)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C227(0.87); C29(1.01); C207(0.92); C305(0.98)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C227(0.93); C29(1.03); C207(1.08); C305(1.11)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C227(0.89); C29(0.98); C207(1.02); C305(1.04)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C227(0.87); C29(0.97); C207(0.94); C305(1.02)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C227(0.88); C29(1.03); C207(0.98); C305(0.77)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C227(0.97); C29(1.01); C207(1.00); C305(1.00)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C227(0.91); C29(0.95); C207(1.00); C305(1.02)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C227(1.14); C29(0.93); C207(1.04); C305(1.08)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C227(0.96); C29(0.96); C207(0.92); C305(1.01)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C227(0.89); C29(1.01); C207(0.93); C305(1.00)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C227(0.80); C29(0.99); C207(2.00); C305(1.17)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C227(0.89); C29(1.01); C207(1.28); C305(1.03)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C227(0.95); C29(0.94); C207(0.99); C305(1.08)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C227(0.93); C29(1.02); C207(1.12); C305(0.93)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C227(1.00); C29(1.02); C207(1.15); C305(1.11)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C227(0.94); C29(1.04); C207(1.02); C305(1.03)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C227(0.90); C29(0.97); C207(0.89); C305(1.04)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C227(0.87); C29(1.08); C207(1.10); C305(0.95)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C227(0.82); C29(0.99); C207(0.97); C305(1.03)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C227(0.68); C29(0.90); C207(2.32); C305(1.24)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C227(0.88); C29(0.93); C207(0.94); C305(1.07)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C227(0.86); C29(0.94); C207(1.62); C305(1.07)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C227(0.88); C29(0.97); C207(1.00); C305(0.97)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C29(0.92); C207(1.12); C305(1.03); C139(1.16)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C227(0.86); C29(1.03); C207(1.04); C305(1.04)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C227(0.99); C29(0.87); C207(1.07); C305(0.92)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C227(1.01); C29(0.92); C207(1.26); C305(1.05)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C227(0.98); C29(0.85); C207(0.99); C305(1.00)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C227(1.07); C29(0.89); C207(1.06); C305(1.07)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C227(1.25); C29(0.91); C207(0.99); C305(1.09)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C227(0.90); C29(1.02); C207(1.02); C305(0.80)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C227(0.87); C29(0.96); C207(1.00); C305(0.91)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C227(0.86); C29(0.92); C207(0.93); C305(0.93)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C227(0.89); C29(0.89); C207(0.98); C305(1.02)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C227(0.88); C29(0.98); C207(0.98); C305(1.00)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C227(0.79); C29(0.94); C207(1.17); C305(1.06)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C227(1.19); C29(0.93); C207(0.97); C305(1.15)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C29(0.91); C207(1.09); C305(0.93); C139(0.98)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C227(0.95); C29(0.88); C207(1.02); C305(0.97)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C227(1.10); C29(0.88); C207(1.26); C305(1.16)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C227(1.04); C29(0.84); C207(1.03); C305(1.02)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C227(1.20); C29(0.87); C207(1.12); C305(0.96)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C227(1.25); C29(0.88); C207(1.08); C305(1.12)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C227(0.86); C29(1.00); C207(0.98); C305(0.92)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C227(0.82); C29(0.93); C207(1.76); C305(0.98)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C227(0.82); C29(0.92); C207(1.06); C305(1.12)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C227(0.91); C29(0.96); C207(0.90); C305(1.04)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C227(0.95); C29(1.05); C207(1.46); C305(1.06)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C227(1.00); C29(0.98); C207(0.96); C305(0.89)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C29(0.91); C207(0.94); C305(0.89); C139(1.03)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C227(0.96); C29(0.85); C207(1.07); C305(1.00)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C227(1.04); C29(0.86); C207(1.01); C305(1.05)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C227(1.06); C29(0.84); C207(1.08); C305(1.04)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C227(1.16); C29(0.83); C207(1.06); C305(0.97)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C227(1.32); C29(0.87); C207(1.06); C305(1.00)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C227(0.85); C29(1.05); C207(1.04); C305(1.05)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C227(0.95); C29(0.98); C207(1.03); C305(1.15)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C227(0.93); C29(0.89); C207(1.02); C305(0.71)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C227(0.88); C29(0.96); C207(0.92); C305(1.05)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C227(0.98); C29(1.09); C207(1.19); C305(1.06)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C227(0.86); C29(0.91); C207(1.31); C305(0.94)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C29(0.91); C207(1.05); C305(1.01); C139(1.18)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C227(0.94); C29(0.88); C207(1.02); C305(0.92)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C227(0.97); C29(0.92); C207(1.04); C305(0.94)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C227(1.02); C29(0.82); C207(1.01); C305(1.03)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C227(1.16); C29(0.84); C207(1.09); C305(0.88)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C227(0.88); C29(0.99); C207(1.09); C305(1.00)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C227(1.34); C29(0.84); C207(1.16); C305(1.02)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C227(0.87); C29(0.98); C207(1.04); C305(0.96)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C227(0.84); C29(0.95); C207(0.99); C305(0.93)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C227(0.88); C29(0.97); C207(1.01); C305(1.00)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C227(0.88); C29(0.93); C207(1.04); C305(1.10)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C227(0.87); C29(0.98); C207(1.02); C305(1.09)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C227(0.93); C29(0.93); C207(1.07); C305(0.97)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C29(0.90); C207(1.10); C305(1.01); C139(1.07)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C227(0.95); C29(0.82); C207(0.98); C305(0.95)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C227(1.08); C29(0.92); C207(1.04); C305(0.96)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C29(0.95); C207(1.56); C305(1.02); C139(1.04)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C227(0.99); C29(0.86); C207(1.02); C305(0.95)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C227(1.08); C29(0.84); C207(1.13); C305(0.97)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C227(1.16); C29(0.94); C207(1.00); C305(0.95)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C227(0.88); C29(1.05); C207(1.16); C305(0.98)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C227(0.86); C29(0.98); C207(0.91); C305(1.03)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C227(0.89); C29(0.93); C207(0.94); C305(0.96)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C227(0.98); C29(1.01); C207(1.17); C305(1.12)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C227(0.90); C29(0.99); C207(1.01); C305(0.98)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C29(0.93); C207(1.04); C305(0.95); C139(0.93)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C227(0.92); C29(0.79); C207(3.14); C305(1.02)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C227(0.96); C29(0.87); C207(1.01); C305(0.95)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C227(1.02); C29(0.90); C207(0.98); C305(0.97)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C227(0.97); C29(0.86); C207(1.00); C305(0.95)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C227(1.01); C29(0.88); C207(1.04); C305(1.01)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C227(1.11); C29(0.92); C207(1.26); C305(1.12)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C227(0.89); C29(1.14); C207(1.06); C305(0.88)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C227(0.96); C29(1.00); C207(1.01); C305(1.04)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C227(0.85); C29(1.03); C207(1.15); C305(0.96)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C227(0.89); C29(1.01); C207(0.94); C305(1.04)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C227(0.91); C29(1.01); C207(1.08); C305(1.13)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C227(1.01); C29(0.87); C207(1.09); C305(0.92)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C227(0.89); C29(0.90); C207(2.77); C305(1.25)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C29(0.91); C207(1.04); C305(0.87); C139(1.28)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C227(0.91); C29(0.90); C207(1.04); C305(0.94)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C227(1.00); C29(0.97); C207(1.11); C305(0.97)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C227(0.94); C29(0.91); C207(1.03); C305(0.97)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C227(1.10); C29(0.93); C207(1.11); C305(1.10)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C227(1.07); C29(0.96); C207(1.08); C305(1.03)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C227(0.92); C29(0.98); C207(1.02); C305(0.98)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C227(0.94); C29(0.96); C207(1.06); C305(1.05)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C227(0.99); C29(1.05); C207(1.00); C305(0.95)  LDD1697  [23]
 LDCM0634  CY-0357 Hep-G2 C207(1.60)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C227(0.84); C29(0.54); C207(0.96); C305(0.98)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C29(2.39)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa C207(0.97); C207(0.92)  LDD2210  [9]
 LDCM0625  F8 Ramos C227(1.55); C305(0.68); C29(1.17)  LDD2187  [25]
 LDCM0572  Fragment10 MDA-MB-231 C207(1.61)  LDD1389  [26]
 LDCM0573  Fragment11 MDA-MB-231 C207(0.99)  LDD1391  [26]
 LDCM0574  Fragment12 Ramos C207(0.62)  LDD1394  [26]
 LDCM0575  Fragment13 MDA-MB-231 C207(2.26)  LDD1395  [26]
 LDCM0576  Fragment14 MDA-MB-231 C207(20.00)  LDD1397  [26]
 LDCM0579  Fragment20 MDA-MB-231 C207(1.62)  LDD1402  [26]
 LDCM0580  Fragment21 MDA-MB-231 C207(0.78)  LDD1404  [26]
 LDCM0581  Fragment22 MDA-MB-231 C207(0.96)  LDD1406  [26]
 LDCM0582  Fragment23 MDA-MB-231 C207(4.95)  LDD1408  [26]
 LDCM0584  Fragment25 MDA-MB-231 C207(0.93)  LDD1411  [26]
 LDCM0578  Fragment27 MDA-MB-231 C207(0.93)  LDD1401  [26]
 LDCM0586  Fragment28 MDA-MB-231 C207(0.96)  LDD1415  [26]
 LDCM0587  Fragment29 MDA-MB-231 C207(1.19)  LDD1417  [26]
 LDCM0588  Fragment30 MDA-MB-231 C207(1.05)  LDD1419  [26]
 LDCM0589  Fragment31 MDA-MB-231 C207(6.10)  LDD1421  [26]
 LDCM0590  Fragment32 MDA-MB-231 C207(4.42)  LDD1423  [26]
 LDCM0468  Fragment33 MDA-MB-231 C207(1.25)  LDD1425  [26]
 LDCM0593  Fragment35 MDA-MB-231 C207(0.75)  LDD1429  [26]
 LDCM0596  Fragment38 MDA-MB-231 C207(1.54)  LDD1433  [26]
 LDCM0566  Fragment4 MDA-MB-231 C207(1.49)  LDD1378  [26]
 LDCM0599  Fragment41 MDA-MB-231 C207(2.29)  LDD1438  [26]
 LDCM0603  Fragment45 MDA-MB-231 C207(1.47)  LDD1482  [26]
 LDCM0604  Fragment46 MDA-MB-231 C207(1.08)  LDD1445  [26]
 LDCM0605  Fragment47 MDA-MB-231 C207(1.16)  LDD1446  [26]
 LDCM0607  Fragment49 MDA-MB-231 C207(12.06)  LDD1448  [26]
 LDCM0608  Fragment50 MDA-MB-231 C207(2.00)  LDD1449  [26]
 LDCM0427  Fragment51 Ramos C207(0.68)  LDD1451  [26]
 LDCM0610  Fragment52 Ramos C227(1.28); C305(0.67); C29(0.84)  LDD2204  [25]
 LDCM0611  Fragment53 MDA-MB-231 C207(0.88)  LDD1454  [26]
 LDCM0614  Fragment56 MDA-MB-231 C207(1.03)  LDD1458  [26]
 LDCM0568  Fragment6 MDA-MB-231 C207(1.06)  LDD1382  [26]
 LDCM0569  Fragment7 MDA-MB-231 C207(1.79)  LDD1383  [26]
 LDCM0570  Fragment8 MDA-MB-231 C207(1.30)  LDD1385  [26]
 LDCM0571  Fragment9 MDA-MB-231 C207(1.30)  LDD1387  [26]
 LDCM0015  HNE MDA-MB-231 C305(0.86)  LDD0346  [25]
 LDCM0022  KB02 MDA-MB-231 C207(2.44)  LDD1374  [26]
 LDCM0023  KB03 MDA-MB-231 C207(3.52)  LDD1376  [26]
 LDCM0024  KB05 G361 C310(3.87)  LDD3311  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C29(1.16)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C29(0.56); C227(0.84)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0225  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C29(0.69)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C29(0.99)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C29(1.03)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C29(1.15)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C29(0.85); C227(1.67)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C29(0.83)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C29(1.11)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C29(0.70)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C29(0.79)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C29(1.23)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C29(1.52)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C29(0.80); C227(1.26)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C29(0.68)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C29(0.74)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C29(0.87)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C29(0.66)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C29(0.99)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C29(1.09)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C29(1.98)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C29(1.02)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C29(0.99)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C29(0.72); C227(0.65)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C29(0.99)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C29(0.72)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C29(0.95)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C29(0.90)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C29(1.03)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C29(0.83)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C29(0.79)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C29(0.69)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C29(0.86)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C29(1.08)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C29(0.80)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C29(1.03)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C29(0.60); C227(0.68)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C29(0.87)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C29(1.00)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C29(2.73)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C29(0.69)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C29(1.38)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C29(0.85)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C29(0.95)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C29(0.29); C227(0.51)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C29(2.38)  LDD2151  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C227(0.89); C29(0.65)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C29(1.40); C305(0.43); C227(0.38)  LDD2207  [27]
 LDCM0014  Panhematin HEK-293T 3.48  LDD0062  [8]
 LDCM0131  RA190 MM1.R C227(1.00)  LDD0304  [28]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitogen-activated protein kinase 14 (MAPK14) CMGC Ser/Thr protein kinase family Q16539
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) CMGC Ser/Thr protein kinase family Q9Y463
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) STE Ser/Thr protein kinase family Q99683
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
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Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
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Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
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27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
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