Details of the Target

General Information of Target

Target ID LDTP03967
Target Name Lamina-associated polypeptide 2, isoform alpha (TMPO)
Gene Name TMPO
Gene ID 7112
Synonyms
LAP2; Lamina-associated polypeptide 2, isoform alpha; Thymopoietin isoform alpha; TP alpha; Thymopoietin-related peptide isoform alpha; TPRP isoform alpha) [Cleaved into: Thymopoietin; TP; Splenin; Thymopentin; TP5)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLPAGTNSK
GPPDFSSDEEREPTPVLGSGAAAAGRSRAAVGRKATKKTDKPRQEDKDDLDVTELTNEDL
LDQLVKYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTISSSAENTRQNGSNDS
DRYSDNEEGKKKEHKKVKSTRDIVPFSELGTTPSGGGFFQGISFPEISTRPPLGSTELQA
AKKVHTSKGDLPREPLVATNLPGRGQLQKLASERNLFISCKSSHDRCLEKSSSSSSQPEH
SAMLVSTAASPSLIKETTTGYYKDIVENICGREKSGIQPLCPERSHISDQSPLSSKRKAL
EESESSQLISPPLAQAIRDYVNSLLVQGGVGSLPGTSNSMPPLDVENIQKRIDQSKFQET
EFLSPPRKVPRLSEKSVEERDSGSFVAFQNIPGSELMSSFAKTVVSHSLTTLGLEVAKQS
QHDKIDASELSFPFHESILKVIEEEWQQVDRQLPSLACKYPVSSREATQILSVPKVDDEI
LGFISEATPLGGIQAASTESCNQQLDLALCRAYEAAASALQIATHTAFVAKAMQADISQA
AQILSSDPSRTHQALGILSKTYDAASYICEAAFDEVKMAAHTMGNATVGRRYLWLKDCKI
NLASKNKLASTPFKGGTLFGGEVCKVIKKRGNKH
Target Bioclass
Other
Family
LEM family
Subcellular location
Nucleus
Function
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.; TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Uniprot ID
P42166
Ensemble ID
ENST00000266732.8
HGNC ID
HGNC:11875

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.68  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		9.00  LDD0387  [2]
A-EBA
 Probe Info  		5.07  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		19.08  LDD0235  [5]
TH211
 Probe Info  		Y573(20.00); Y520(5.61)  LDD0257  [6]
STPyne
 Probe Info  		K243(5.57); K248(7.14); K269(8.98); K281(10.00)  LDD0277  [7]
AZ-9
 Probe Info  		E6(10.00)  LDD2208  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
Probe 1
 Probe Info  		Y127(10.48); Y183(236.94)  LDD3495  [9]
THZ1-DTB
 Probe Info  		C570(0.86)  LDD0460  [10]
BTD
 Probe Info  		C518(1.14)  LDD1700  [11]
Sulforaphane-probe2
 Probe Info  		2.80  LDD0042  [12]
DA-P3
 Probe Info  		4.94  LDD0181  [13]
AHL-Pu-1
 Probe Info  		C561(3.21)  LDD0169  [14]
HPAP
 Probe Info  		5.05  LDD0062  [15]
Alkyne-RA190
 Probe Info  		2.02  LDD0300  [16]
EA-probe
 Probe Info  		N.A.  LDD0440  [17]
HHS-475
 Probe Info  		Y127(0.82); Y321(0.88); Y322(1.80)  LDD0264  [18]
DBIA
 Probe Info  		C341(1.12); C684(1.02); C518(1.01); C330(1.00)  LDD0078  [19]
5E-2FA
 Probe Info  		H585(0.00); H44(0.00); H641(0.00); H346(0.00)  LDD2235  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C330(0.00); C280(0.00); C518(0.00); C341(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [22]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [23]
IPIAA_L
 Probe Info  		C629(0.00); C330(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C684(0.00); C280(0.00); C518(0.00); C341(0.00)  LDD0037  [21]
JW-RF-010
 Probe Info  		C518(0.00); C629(0.00); C684(0.00); C280(0.00)  LDD0026  [24]
NAIA_4
 Probe Info  		C330(0.00); C341(0.00); C518(0.00); C561(0.00)  LDD2226  [25]
TFBX
 Probe Info  		C684(0.00); C280(0.00); C341(0.00); C629(0.00)  LDD0027  [24]
WYneN
 Probe Info  		C341(0.00); C518(0.00); C280(0.00)  LDD0021  [26]
WYneO
 Probe Info  		C280(0.00); C684(0.00)  LDD0022  [26]
Compound 10
 Probe Info  		C280(0.00); C330(0.00); C341(0.00); C518(0.00)  LDD2216  [27]
Compound 11
 Probe Info  		C280(0.00); C330(0.00); C341(0.00); C518(0.00)  LDD2213  [27]
ENE
 Probe Info  		C330(0.00); C341(0.00); C684(0.00); C518(0.00)  LDD0006  [26]
IPM
 Probe Info  		C341(0.00); C518(0.00); C280(0.00)  LDD0005  [26]
NHS
 Probe Info  		K13(0.00); K269(0.00); K356(0.00); K17(0.00)  LDD0010  [26]
PF-06672131
 Probe Info  		C280(0.00); C330(0.00); C341(0.00); C684(0.00)  LDD0017  [28]
PPMS
 Probe Info  		N.A.  LDD0008  [26]
SF
 Probe Info  		N.A.  LDD0028  [29]
VSF
 Probe Info  		C684(0.00); C330(0.00)  LDD0007  [26]
Phosphinate-6
 Probe Info  		C518(0.00); C684(0.00); C287(0.00); C341(0.00)  LDD0018  [30]
Acrolein
 Probe Info  		C629(0.00); H346(0.00); H612(0.00); C280(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		C330(0.00); H346(0.00); C684(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C518(0.00); C330(0.00); C684(0.00)  LDD0218  [31]
AOyne
 Probe Info  		12.00  LDD0443  [32]
NAIA_5
 Probe Info  		C330(0.00); C684(0.00); C518(0.00); C629(0.00)  LDD2223  [25]
HHS-465
 Probe Info  		Y127(0.00); K323(0.00); Y321(0.00)  LDD2240  [33]
HHS-482
 Probe Info  		Y321(0.81); Y322(0.85); Y573(0.81)  LDD2239  [34]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		5.06  LDD1945  [35]
C349
 Probe Info  		12.82  LDD2010  [35]
C350
 Probe Info  		22.16  LDD2011  [35]
C362
 Probe Info  		28.44  LDD2023  [35]
C364
 Probe Info  		25.99  LDD2025  [35]
C407
 Probe Info  		11.39  LDD2064  [35]
C409
 Probe Info  		5.28  LDD2066  [35]
FFF probe11
 Probe Info  		20.00  LDD0471  [36]
FFF probe13
 Probe Info  		16.63  LDD0475  [36]
FFF probe14
 Probe Info  		20.00  LDD0477  [36]
FFF probe2
 Probe Info  		18.21  LDD0463  [36]
FFF probe3
 Probe Info  		20.00  LDD0464  [36]
FFF probe4
 Probe Info  		20.00  LDD0466  [36]
JN0003
 Probe Info  		12.11  LDD0469  [36]
STS-1
 Probe Info  		N.A.  LDD0136  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
OEA-DA
 Probe Info  		10.99  LDD0046  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C330(1.90)  LDD2142  [11]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C330(2.09)  LDD2112  [11]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C518(1.01); C341(0.92)  LDD2130  [11]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C287(1.24); C518(0.82); C280(0.88)  LDD2117  [11]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C518(1.15)  LDD2152  [11]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C518(1.11); C684(1.09)  LDD2103  [11]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C518(0.69)  LDD2131  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C561(3.21)  LDD0169  [14]
 LDCM0561  Abegg_cp(-)-10 HeLa C658(2.17)  LDD0312  [24]
 LDCM0214  AC1 HCT 116 C280(0.77); C330(1.05); C341(0.95); C518(0.95)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C280(1.06); C330(0.93); C341(1.27); C518(0.93)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C280(1.15); C330(0.92); C341(0.95); C518(1.08)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C280(1.02); C330(1.07); C341(0.99); C518(0.99)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C280(1.09); C330(1.04); C341(0.98); C518(1.01)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C280(1.46); C330(1.13); C341(1.14); C518(1.11)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C280(1.06); C330(1.04); C341(0.96); C518(1.06)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C280(1.40); C330(1.13); C341(1.13); C518(1.10)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C280(1.44); C330(1.12); C341(1.31); C518(1.08)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C280(1.44); C330(0.92); C341(1.33); C518(1.21)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C280(1.18); C330(1.17); C341(0.93); C518(0.99)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C280(0.96); C330(0.87); C341(0.85); C518(0.92)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C280(1.38); C330(0.97); C341(1.19); C518(0.99)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C280(1.18); C330(1.09); C341(1.05); C518(0.94)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C280(1.21); C330(1.26); C341(1.00); C518(1.04)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C280(1.37); C330(1.36); C341(1.15); C518(1.14)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C280(1.21); C330(1.03); C341(0.85); C518(0.94)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C280(1.02); C330(1.10); C341(0.98); C518(1.00)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C280(1.05); C330(1.27); C341(1.10); C518(1.10)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C280(0.98); C330(1.24); C341(1.12); C518(0.89)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C280(0.96); C330(1.11); C341(1.00); C518(0.90)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C280(1.18); C330(1.15); C341(1.04); C518(0.88)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C280(1.16); C330(1.15); C341(0.92); C518(0.92)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C280(1.26); C330(0.92); C341(1.11); C518(1.00)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C280(1.11); C330(1.06); C341(1.03); C518(0.96)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C280(0.99); C330(0.94); C341(1.18); C518(0.89)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C280(1.11); C330(1.03); C341(1.28); C518(0.91)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C280(0.94); C330(0.99); C341(0.74); C518(0.95)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C280(0.98); C330(1.11); C341(0.85); C518(0.86)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C280(1.07); C330(1.09); C341(0.98); C518(0.84)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C280(0.96); C330(1.20); C341(1.35); C518(1.15)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C280(1.20); C330(1.33); C341(1.41); C518(1.10)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C280(0.88); C330(0.95); C341(1.03); C518(1.10)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C280(0.85); C330(0.78); C341(1.06); C518(1.07)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C280(1.03); C330(1.01); C341(0.89); C518(1.02)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C280(0.93); C330(0.80); C341(0.86); C518(1.23)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C280(0.73); C330(0.94); C341(0.80); C518(0.92)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C280(0.83); C330(0.95); C341(0.79); C518(0.91)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C280(0.92); C330(0.99); C341(0.86); C518(1.09)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C280(0.90); C330(0.96); C341(0.95); C518(0.94)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C280(0.75); C330(1.01); C341(0.87); C518(0.95)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C280(0.65); C330(0.85); C341(0.69); C518(0.94)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C280(0.78); C330(1.02); C341(0.86); C518(1.06)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C280(0.81); C330(0.88); C341(0.77); C518(0.94)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C280(1.02); C330(1.03); C341(0.97); C518(0.89)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C280(0.91); C330(1.05); C341(0.96); C518(1.02)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C280(0.84); C330(0.92); C341(1.02); C518(1.05)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C280(0.66); C330(0.78); C341(0.68); C518(0.90)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C518(1.01); C341(1.10); C330(1.11); C629(1.11)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C330(1.07); C629(1.20); C518(1.21); C341(1.30)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C629(0.90); C518(1.06); C280(1.15); C341(1.20)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C330(0.75); C629(1.03); C518(1.07); C280(1.20)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C330(1.06); C629(1.16); C518(1.17); C280(1.28)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C330(0.80); C629(0.98); C518(1.37); C280(1.45)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C629(0.89); C330(0.97); C518(1.21); C280(1.33)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C518(0.92); C629(0.95); C341(1.02); C330(1.14)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C330(0.77); C518(0.97); C341(1.00); C280(1.01)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C518(1.01); C280(1.09); C341(1.16); C629(1.17)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C330(0.99); C629(1.04); C518(1.25); C341(1.27)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C330(0.82); C629(0.94); C518(1.69); C280(1.97)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C280(1.26); C330(0.89); C341(1.49); C518(1.09)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C280(1.31); C330(0.89); C341(1.42); C518(1.19)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C280(1.06); C330(0.91); C341(1.08); C518(1.04)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C280(1.18); C330(0.93); C341(1.27); C518(1.36)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C280(0.66); C330(0.77); C629(0.91); C341(1.02)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C280(0.65); C330(0.73); C341(0.82); C629(1.06)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C280(0.53); C330(0.77); C341(1.07); C629(1.17)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C561(0.63); C570(0.63); C280(0.72); C518(0.81)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C280(0.77); C330(0.93); C629(1.05); C341(1.06)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C280(0.68); C330(0.92); C629(1.06); C518(1.28)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C330(0.77); C280(0.83); C629(1.17); C518(1.27)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C280(0.73); C330(0.90); C629(0.95); C341(1.00)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C280(0.71); C330(0.83); C341(1.08); C629(1.08)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C629(0.91); C684(0.94); C518(1.07); C341(1.67)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C629(0.89); C684(0.91); C518(1.09); C341(1.62)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C629(0.92); C684(1.00); C518(1.08); C330(1.65)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C629(0.93); C684(0.97); C518(1.13); C341(2.02)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C629(0.99); C518(1.11); C684(1.22); C341(1.69)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C561(0.62); C570(0.62); C629(0.72); C280(0.74)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C629(0.83); C518(1.14); C684(1.35); C341(1.77)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C684(0.86); C629(0.88); C518(1.02); C341(1.42)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C684(0.87); C629(0.88); C518(1.12); C341(1.59)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C629(0.98); C518(1.12); C684(1.14); C330(1.67)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C629(1.13); C518(1.24); C684(1.25); C330(1.89)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C518(0.95); C280(1.01); C684(1.04); C341(1.05)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C684(0.82); C518(0.95); C341(1.00); C280(1.18)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C341(1.00); C518(1.03); C684(1.03); C280(1.14)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C518(0.99); C684(1.01); C341(1.08); C330(1.18)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C518(0.96); C341(1.10); C330(1.14); C684(1.18)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C561(0.51); C570(0.51); C280(0.78); C341(0.79)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C518(1.08); C341(1.10); C684(1.21); C330(1.26)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C684(1.02); C341(1.03); C518(1.04); C330(1.31)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C518(0.97); C330(1.09); C341(1.13); C684(1.15)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C518(1.07); C341(1.08); C684(1.26); C330(1.34)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C518(1.06); C684(1.16); C330(1.19); C280(1.25)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C518(1.08); C330(1.14); C341(1.18); C684(1.40)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C341(1.04); C280(1.06); C629(1.07); C518(1.10)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C629(0.90); C330(1.07); C341(1.08); C518(1.10)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C629(0.94); C518(1.13); C341(1.17); C330(1.26)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C330(1.13); C629(1.14); C518(1.22); C280(1.33)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C561(0.45); C570(0.45); C341(0.66); C280(0.68)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C629(1.08); C330(1.16); C341(1.27); C518(1.34)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C629(1.01); C341(1.03); C518(1.04); C280(1.26)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C629(0.93); C330(1.10); C518(1.16); C341(1.23)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C629(0.94); C518(1.16); C330(1.16); C341(1.20)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C629(0.96); C330(1.02); C518(1.14); C341(1.24)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C629(0.97); C330(1.20); C518(1.29); C341(1.40)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C629(1.08); C330(1.29); C341(1.56); C518(1.63)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C330(0.78); C561(0.82); C570(0.82); C629(0.85)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C561(0.48); C570(0.48); C330(0.90); C629(0.99)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C561(0.62); C570(0.62); C629(0.79); C341(0.89)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C629(0.95); C518(1.01); C330(1.04); C280(1.15)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C561(0.47); C570(0.47); C629(0.77); C330(0.91)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C561(0.47); C570(0.47); C330(0.71); C629(0.82)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C561(0.74); C570(0.74); C330(0.76); C280(1.01)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C561(0.55); C570(0.55); C330(0.88); C629(0.99)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C561(0.47); C570(0.47); C330(0.81); C629(0.84)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C561(0.45); C570(0.45); C341(0.64); C629(0.72)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C561(0.57); C570(0.57); C341(0.58); C330(0.81)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C561(0.40); C570(0.40); C629(0.73); C341(0.73)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C629(1.05); C518(1.09); C280(1.52); C330(1.76)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C629(1.16); C518(1.28); C280(1.71); C330(1.81)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C629(0.75); C518(0.92); C341(0.95); C330(1.03)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C629(0.93); C518(1.24); C280(1.90); C330(2.01)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C629(0.86); C518(1.06); C280(1.37); C330(1.77)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C629(1.17); C518(1.31); C280(1.79); C330(2.25)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C629(1.37); C518(1.51); C330(1.72); C280(2.16)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C629(1.36); C518(1.41); C280(1.58); C330(1.71)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C629(1.48); C518(1.59); C330(1.92); C280(2.16)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C629(1.14); C518(1.19); C280(1.53); C330(1.82)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C629(1.30); C518(1.35); C280(1.78); C330(2.04)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C629(0.99); C518(1.29); C280(1.64); C330(1.77)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C629(0.97); C518(1.20); C280(1.62); C341(2.07)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C629(0.91); C330(0.95); C518(0.96); C341(1.06)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C629(1.07); C518(1.25); C280(1.36); C330(1.70)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C629(0.85); C518(1.21); C280(1.50); C330(1.87)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C629(1.28); C518(1.64); C330(1.71); C280(1.85)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C629(1.11); C561(1.20); C570(1.20); C330(1.35)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C629(0.97); C330(1.28); C561(1.34); C570(1.34)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C629(0.87); C330(1.11); C561(1.12); C570(1.12)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C629(0.99); C330(1.10); C518(1.12); C341(1.22)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C629(0.93); C341(1.10); C561(1.11); C570(1.11)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C629(1.05); C341(1.20); C518(1.24); C280(1.31)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C330(1.16); C629(1.16); C280(1.43); C341(1.44)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C629(0.99); C518(1.03); C330(1.04); C280(1.07)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C629(1.24); C561(1.45); C570(1.45); C341(1.59)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C629(1.16); C561(1.32); C570(1.32); C330(1.40)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C629(1.04); C561(1.14); C570(1.14); C330(1.24)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C629(1.07); C561(1.08); C570(1.08); C341(1.23)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C629(1.07); C330(1.20); C280(1.30); C518(1.37)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C629(1.09); C330(1.27); C561(1.33); C570(1.33)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C629(1.09); C561(1.26); C570(1.26); C330(1.39)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C629(0.85); C330(1.10); C684(1.11); C518(1.23)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C629(0.78); C684(0.93); C341(0.96); C518(1.01)  LDD0683  [19]
 LDCM0545  Acetamide MDA-MB-231 C518(0.43)  LDD2138  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C518(0.85); C684(0.97)  LDD2113  [11]
 LDCM0248  AKOS034007472 HCT 116 C280(1.05); C330(1.23); C341(1.07); C518(0.88)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C629(0.73); C518(0.94); C341(1.23); C280(1.29)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C629(0.97); C518(1.16); C330(1.18); C280(1.51)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 C280(0.00); C330(0.00); C561(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C341(1.12); C684(1.02); C518(1.01); C330(1.00)  LDD0078  [19]
 LDCM0498  BS-3668 MDA-MB-231 C341(0.66)  LDD2091  [11]
 LDCM0087  Capsaicin HEK-293T 9.00  LDD0185  [13]
 LDCM0630  CCW28-3 231MFP C561(1.51); C684(0.19)  LDD2214  [40]
 LDCM0108  Chloroacetamide HeLa C629(0.00); C280(0.00); H612(0.00); C330(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C629(2.34); C684(0.90); C330(0.83); C658(0.75)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C330(0.91); C280(0.99); C518(1.00); C629(1.10)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C341(0.83); C629(0.91); C330(1.11); C518(1.15)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C561(0.64); C570(0.64); C629(0.78); C280(0.81)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C330(0.79); C629(0.85); C518(0.99); C341(1.14)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C629(0.70); C518(0.94); C341(1.00); C280(1.04)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C629(0.76); C330(0.93); C518(0.96); C341(1.13)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C330(0.84); C629(0.91); C518(1.02); C341(1.02)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C280(0.64); C330(0.80); C341(0.91); C629(0.92)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C280(0.60); C330(0.71); C629(0.91); C341(1.13)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C280(0.66); C330(0.80); C341(0.96); C629(0.99)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C280(0.54); C330(0.70); C629(0.95); C341(1.03)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C330(0.80); C280(0.86); C341(1.00); C629(1.14)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C629(1.01); C330(1.01); C518(1.21); C341(1.25)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C280(0.47); C330(0.78); C341(0.89); C629(1.12)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C280(0.47); C330(0.61); C341(0.98); C629(1.08)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C629(0.85); C684(0.85); C518(0.98); C330(1.31)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C684(0.86); C629(0.88); C518(1.14); C341(1.62)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C629(0.76); C684(0.97); C518(1.02); C341(1.72)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C629(0.88); C518(1.02); C684(1.14); C341(2.35)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C629(0.80); C518(1.01); C684(1.19); C341(1.84)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C330(1.11); C518(1.15); C341(1.43); C280(1.55)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C518(0.94); C341(0.95); C280(1.03); C330(1.11)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C518(1.05); C684(1.08); C341(1.16); C330(1.22)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C330(0.97); C341(1.04); C518(1.13); C629(1.30)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C684(1.01); C518(1.02); C341(1.12); C280(1.24)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C518(0.92); C341(0.97); C629(1.00); C330(1.02)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C629(0.91); C518(1.05); C341(1.14); C330(1.15)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C330(0.89); C629(0.94); C341(1.15); C518(1.18)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C629(1.08); C518(1.24); C330(1.31); C280(1.39)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C561(0.63); C570(0.63); C629(0.73); C684(0.79)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C561(0.45); C570(0.45); C629(0.64); C330(0.71)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C561(0.44); C570(0.44); C629(0.83); C341(0.86)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C561(0.54); C570(0.54); C330(0.66); C280(0.85)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C330(0.82); C341(1.01); C629(1.05); C518(1.12)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C341(0.88); C330(0.99); C629(1.03); C518(1.04)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C330(0.78); C341(0.79); C629(1.02); C518(1.06)  LDD0719  [19]
 LDCM0403  CL16 HCT 116 C629(1.02); C518(1.03); C280(1.15); C330(1.41)  LDD0720  [19]
 LDCM0404  CL17 HCT 116 C629(0.99); C518(1.07); C330(1.15); C280(1.16)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C629(1.00); C330(1.19); C518(1.29); C341(1.35)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C330(0.98); C629(1.02); C518(1.02); C280(1.23)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C341(0.89); C330(0.90); C280(1.02); C518(1.03)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C330(1.10); C518(1.20); C629(1.26); C280(1.44)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C330(0.93); C629(1.12); C518(1.15); C341(1.27)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C330(0.98); C518(1.36); C341(1.38); C629(1.49)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C341(0.98); C629(1.19); C330(1.23); C518(1.26)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C280(1.68); C330(1.15); C341(1.40); C518(1.35)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C280(1.56); C330(0.98); C341(1.47); C518(1.29)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C280(1.47); C330(1.19); C341(2.34); C518(1.26)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C280(1.31); C330(1.15); C341(1.73); C518(0.99)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C280(1.41); C330(1.24); C341(1.57); C518(1.13)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C280(1.42); C330(1.27); C341(1.72); C518(1.19)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C280(1.11); C330(1.13); C341(1.24); C518(1.01)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C280(1.34); C330(1.22); C341(2.00); C518(1.13)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C280(1.25); C330(0.84); C341(1.00); C518(1.14)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C280(1.26); C330(0.98); C341(0.87); C518(1.26)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C280(1.38); C330(0.82); C341(1.13); C518(1.29)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C280(1.70); C330(1.08); C341(1.05); C518(1.29)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C280(1.78); C330(1.08); C341(1.10); C518(1.40)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C280(1.42); C330(1.14); C341(0.92); C518(1.29)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C280(1.68); C330(1.33); C341(1.10); C518(1.34)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C280(1.51); C330(1.03); C341(1.12); C518(1.36)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C280(0.99); C330(0.87); C341(0.92); C518(0.96)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C280(1.52); C330(1.06); C341(1.06); C518(1.43)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C280(1.44); C330(1.44); C341(1.12); C518(1.23)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C280(2.26); C330(0.92); C341(1.14); C518(1.71)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C280(1.82); C330(1.16); C341(1.24); C518(1.53)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C280(1.72); C330(1.12); C341(1.32); C518(1.29)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C280(1.94); C330(1.08); C341(1.43); C518(1.40)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C280(0.96); C330(0.96); C341(1.21); C518(1.05)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C280(0.99); C330(1.00); C341(1.07); C518(1.07)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C280(1.06); C330(1.17); C341(1.13); C518(1.12)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C280(1.03); C330(1.20); C341(0.98); C518(1.11)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C280(1.20); C330(0.89); C341(0.83); C518(1.06)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C280(1.09); C330(1.40); C341(1.19); C518(1.02)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C280(1.13); C330(1.21); C341(1.06); C518(1.02)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C280(1.13); C330(1.23); C341(1.24); C518(1.05)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C280(1.13); C330(1.13); C341(1.06); C518(1.19)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C280(1.04); C330(1.05); C341(1.05); C518(1.06)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C280(1.09); C330(1.19); C341(1.07); C518(1.17)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C280(1.09); C330(1.22); C341(1.00); C518(1.19)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C280(0.99); C330(1.16); C341(0.87); C518(0.98)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C280(1.04); C330(0.98); C341(1.09); C518(1.07)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C280(1.18); C330(1.09); C341(1.08); C518(1.05)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C280(1.34); C330(1.01); C341(1.05); C518(1.05)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C280(1.21); C330(1.07); C341(1.12); C518(1.12)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C280(1.13); C330(1.13); C341(0.93); C518(1.09)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C280(1.21); C330(1.23); C341(0.92); C518(1.12)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C280(1.58); C330(1.03); C341(0.98); C518(1.09)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C280(1.43); C330(0.87); C341(0.78); C518(1.00)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C280(1.10); C330(0.96); C341(0.85); C518(1.00)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C280(1.36); C330(0.85); C341(1.03); C518(1.10)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C280(1.59); C330(1.03); C341(0.98); C518(1.17)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C280(1.33); C330(0.97); C341(0.80); C518(1.02)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C280(1.22); C330(1.10); C341(1.05); C518(1.22)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C280(1.35); C330(0.84); C341(0.89); C518(0.99)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C280(1.29); C330(1.08); C341(0.93); C518(1.22)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C280(1.34); C330(0.94); C341(0.85); C518(1.27)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C280(1.30); C330(1.06); C341(0.89); C518(1.05)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C280(1.34); C330(1.13); C341(0.86); C518(1.02)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C280(1.61); C330(1.05); C341(0.98); C518(1.08)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C280(1.22); C330(0.90); C341(0.98); C518(0.99)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C280(1.28); C330(1.04); C341(0.83); C518(1.01)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C280(1.24); C330(0.93); C341(1.02); C518(0.97)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C280(1.63); C330(0.90); C341(1.02); C518(1.10)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C280(1.90); C330(1.01); C341(2.28); C518(1.30)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C280(1.38); C330(0.88); C341(0.98); C518(1.06)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C280(1.41); C330(0.95); C341(0.94); C518(1.03)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C280(2.24); C330(0.67); C341(1.28); C518(1.11)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C280(1.42); C330(0.95); C341(1.01); C518(1.15)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C280(1.89); C330(1.04); C341(1.17); C518(1.17)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C280(0.86); C330(1.17); C341(0.92); C518(1.06)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C280(0.62); C330(0.92); C341(0.73); C518(0.99)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C280(0.82); C330(0.93); C341(0.80); C518(0.97)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C280(1.49); C330(1.00); C341(1.05); C518(1.02)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C280(2.07); C330(0.99); C341(1.23); C518(1.30)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C280(1.33); C330(1.06); C341(1.26); C518(1.13)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C280(0.69); C330(0.78); C341(0.96); C518(0.98)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C280(1.02); C330(0.98); C341(0.86); C518(1.01)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C280(1.02); C330(1.04); C341(0.77); C518(0.99)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C280(0.97); C330(0.96); C341(0.89); C518(0.96)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C280(1.19); C330(0.82); C341(0.95); C518(0.94)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C280(1.15); C330(0.97); C341(1.03); C518(0.95)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C280(1.12); C330(1.05); C341(0.76); C518(0.87)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C280(0.76); C330(0.96); C341(0.88); C518(0.91)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C280(0.85); C330(1.06); C341(1.17); C518(0.85)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C280(0.78); C330(0.91); C341(0.94); C518(0.87)  LDD0811  [19]
 LDCM0634  CY-0357 Hep-G2 C518(1.90); C341(0.95); C684(0.83); C629(0.73)  LDD2228  [25]
 LDCM0495  E2913 HEK-293T C341(1.04); C518(0.85); C280(0.89); C330(1.08)  LDD1698  [41]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C518(2.61); C330(1.85); C280(1.83); C341(1.65)  LDD1702  [11]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [17]
 LDCM0625  F8 Ramos C280(0.90); C684(1.39); C658(1.85); C330(1.05)  LDD2187  [42]
 LDCM0572  Fragment10 MDA-MB-231 C561(2.92); C341(3.29); C684(1.54); C280(3.62)  LDD1389  [43]
 LDCM0573  Fragment11 MDA-MB-231 C561(9.93); C341(2.92); C280(2.98)  LDD1391  [43]
 LDCM0574  Fragment12 MDA-MB-231 C561(1.27); C341(1.57); C684(2.00); C280(1.46)  LDD1393  [43]
 LDCM0575  Fragment13 MDA-MB-231 C561(0.93); C341(0.84); C684(1.01); C280(1.04)  LDD1395  [43]
 LDCM0576  Fragment14 MDA-MB-231 C561(3.86); C341(1.92); C684(1.54); C280(1.01)  LDD1397  [43]
 LDCM0577  Fragment15 MDA-MB-231 C561(2.34)  LDD1399  [43]
 LDCM0579  Fragment20 MDA-MB-231 C561(1.85); C341(3.14); C684(2.06)  LDD1402  [43]
 LDCM0580  Fragment21 MDA-MB-231 C561(1.23); C341(1.30); C684(1.58); C280(1.11)  LDD1404  [43]
 LDCM0581  Fragment22 Ramos C561(0.89)  LDD1407  [43]
 LDCM0582  Fragment23 MDA-MB-231 C561(1.85); C341(2.38); C280(3.18)  LDD1408  [43]
 LDCM0583  Fragment24 Ramos C561(1.25); C341(1.34)  LDD1410  [43]
 LDCM0584  Fragment25 MDA-MB-231 C561(0.97); C341(0.79); C684(0.77); C280(0.86)  LDD1411  [43]
 LDCM0578  Fragment27 MDA-MB-231 C561(0.90); C341(0.90); C684(0.98); C280(1.02)  LDD1401  [43]
 LDCM0586  Fragment28 MDA-MB-231 C561(0.93); C341(0.94); C684(0.89); C280(0.90)  LDD1415  [43]
 LDCM0587  Fragment29 MDA-MB-231 C561(1.21); C341(1.66); C684(1.27); C280(1.65)  LDD1417  [43]
 LDCM0588  Fragment30 MDA-MB-231 C561(1.12)  LDD1419  [43]
 LDCM0589  Fragment31 MDA-MB-231 C561(1.45); C341(1.95); C684(2.59)  LDD1421  [43]
 LDCM0590  Fragment32 MDA-MB-231 C561(2.12); C341(4.82); C684(3.06)  LDD1423  [43]
 LDCM0468  Fragment33 HCT 116 C280(1.36); C330(1.10); C341(0.84); C518(1.02)  LDD0785  [19]
 LDCM0593  Fragment35 MDA-MB-231 C561(0.94); C341(0.71)  LDD1429  [43]
 LDCM0594  Fragment36 MDA-MB-231 C561(1.21); C341(1.59)  LDD1431  [43]
 LDCM0595  Fragment37 Ramos C561(1.01); C341(0.95); C684(0.90); C280(0.87)  LDD1432  [43]
 LDCM0596  Fragment38 MDA-MB-231 C561(1.48); C341(0.99); C684(0.89); C280(1.22)  LDD1433  [43]
 LDCM0566  Fragment4 MDA-MB-231 C561(1.65); C341(1.96); C280(2.12)  LDD1378  [43]
 LDCM0598  Fragment40 MDA-MB-231 C341(0.59)  LDD1436  [43]
 LDCM0599  Fragment41 MDA-MB-231 C341(1.23)  LDD1438  [43]
 LDCM0600  Fragment42 Ramos C561(1.43)  LDD1440  [43]
 LDCM0601  Fragment43 MDA-MB-231 C561(1.73); C341(2.96); C684(1.15)  LDD1441  [43]
 LDCM0602  Fragment44 MDA-MB-231 C561(0.90)  LDD1443  [43]
 LDCM0603  Fragment45 MDA-MB-231 C561(20.00); C684(5.47)  LDD1444  [43]
 LDCM0604  Fragment46 MDA-MB-231 C561(1.17); C341(1.20); C684(1.04)  LDD1445  [43]
 LDCM0605  Fragment47 MDA-MB-231 C561(2.36); C341(1.50); C684(1.36)  LDD1446  [43]
 LDCM0606  Fragment48 MDA-MB-231 C561(1.10); C341(1.27); C684(1.57)  LDD1447  [43]
 LDCM0607  Fragment49 MDA-MB-231 C684(7.78); C280(20.00)  LDD1448  [43]
 LDCM0608  Fragment50 MDA-MB-231 C561(1.84); C341(2.52); C684(2.28); C280(3.36)  LDD1449  [43]
 LDCM0427  Fragment51 HCT 116 C280(2.29); C330(1.09); C341(1.37); C518(1.53)  LDD0744  [19]
 LDCM0610  Fragment52 MDA-MB-231 C561(1.46); C341(1.30); C684(1.45); C280(1.24)  LDD1452  [43]
 LDCM0611  Fragment53 MDA-MB-231 C561(1.06); C341(1.07)  LDD1454  [43]
 LDCM0614  Fragment56 MDA-MB-231 C561(1.29); C341(1.02); C684(1.04)  LDD1458  [43]
 LDCM0568  Fragment6 MDA-MB-231 C561(1.22)  LDD1382  [43]
 LDCM0569  Fragment7 MDA-MB-231 C561(1.73); C684(1.46)  LDD1383  [43]
 LDCM0570  Fragment8 MDA-MB-231 C561(2.38); C341(3.91); C684(2.00); C280(3.45)  LDD1385  [43]
 LDCM0571  Fragment9 MDA-MB-231 C561(1.75); C341(1.53); C684(1.26); C280(2.63)  LDD1387  [43]
 LDCM0116  HHS-0101 DM93 Y127(0.82); Y321(0.88); Y322(1.80)  LDD0264  [18]
 LDCM0117  HHS-0201 DM93 Y127(0.62); Y321(0.84); Y322(2.02)  LDD0265  [18]
 LDCM0118  HHS-0301 DM93 Y127(0.81); Y321(0.85)  LDD0266  [18]
 LDCM0119  HHS-0401 DM93 Y127(0.64); Y321(0.81)  LDD0267  [18]
 LDCM0120  HHS-0701 DM93 Y127(0.80); Y321(0.98); Y322(2.55)  LDD0268  [18]
 LDCM0015  HNE MDA-MB-231 C684(1.12); C518(0.81)  LDD0346  [42]
 LDCM0107  IAA HeLa C629(0.00); H612(0.00); H346(0.00)  LDD0221  [31]
 LDCM0022  KB02 HCT 116 C629(1.41); C280(2.87); C330(2.30); C341(2.50)  LDD0080  [19]
 LDCM0023  KB03 HCT 116 C629(2.86); C280(1.92); C330(2.31); C341(2.93)  LDD0081  [19]
 LDCM0024  KB05 HCT 116 C629(9.22); C280(4.33); C330(4.03); C341(3.20)  LDD0082  [19]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C684(1.23)  LDD2102  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C518(0.57)  LDD2121  [11]
 LDCM0109  NEM HeLa H346(0.00); H612(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C518(0.57)  LDD2089  [11]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C684(1.53)  LDD2090  [11]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C518(1.72)  LDD2092  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C287(0.87); C518(0.93)  LDD2093  [11]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C287(1.20); C518(1.67)  LDD2094  [11]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C684(0.75)  LDD2096  [11]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C518(0.82)  LDD2097  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C287(0.39); C684(0.95)  LDD2098  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C287(0.86); C518(0.89); C684(1.44); C330(1.03)  LDD2099  [11]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C518(0.79); C684(1.21)  LDD2101  [11]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C330(1.39)  LDD2104  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C518(1.44)  LDD2105  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C287(1.55); C518(0.98); C280(0.77)  LDD2107  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C287(0.86); C518(0.82); C684(1.31); C280(0.67)  LDD2109  [11]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C518(0.99)  LDD2111  [11]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C330(4.00)  LDD2114  [11]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C684(0.85)  LDD2115  [11]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C287(0.74); C518(0.62); C341(0.67); C684(1.04)  LDD2118  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C287(2.01); C518(2.59)  LDD2119  [11]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C518(1.02); C684(1.05); C280(0.75)  LDD2120  [11]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C341(0.54); C684(0.91)  LDD2122  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C287(0.73); C518(0.86)  LDD2123  [11]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C341(1.07)  LDD2124  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C287(0.79); C518(0.67)  LDD2125  [11]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C684(1.32)  LDD2126  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C287(1.52); C518(0.91); C684(1.27)  LDD2127  [11]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C518(1.11)  LDD2128  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C287(0.99); C518(0.97)  LDD2129  [11]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C518(0.58); C280(0.50)  LDD2134  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C287(0.97); C518(1.33); C280(1.51); C330(0.91)  LDD2135  [11]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C518(1.08); C341(1.80)  LDD2136  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C287(1.01); C518(0.98); C280(0.94)  LDD2137  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C518(1.14)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C287(0.81); C518(0.76); C684(1.07); C280(0.82)  LDD2140  [11]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C518(1.03); C341(0.71); C280(0.67)  LDD2143  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C518(2.88)  LDD2144  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C287(0.90); C518(0.90); C341(0.87); C280(1.16)  LDD2146  [11]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C518(2.93); C684(2.15); C280(0.64)  LDD2147  [11]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C684(0.61)  LDD2148  [11]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C341(1.16); C684(1.28)  LDD2149  [11]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C518(0.54)  LDD2150  [11]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C518(1.68)  LDD2153  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C341(0.70)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C518(0.83); C341(0.61)  LDD2207  [44]
 LDCM0014  Panhematin HEK-293T 5.05  LDD0062  [15]
 LDCM0029  Quercetin HEK-293T 4.94  LDD0181  [13]
 LDCM0131  RA190 MM1.R 2.02  LDD0300  [16]
 LDCM0170  Structure8 Ramos 5.43  LDD0433  [45]
 LDCM0003  Sulforaphane MCF-7 2.80  LDD0042  [12]
 LDCM0021  THZ1 HeLa S3 C570(0.86)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 C341(18.87)  LDD0237  [5]
 LDCM0111  W14 Hep-G2 Q488(0.89); C341(4.03)  LDD0238  [5]
 LDCM0112  W16 Hep-G2 C684(0.52); C341(0.60); C280(0.70); C330(0.70)  LDD0239  [5]
 LDCM0113  W17 Hep-G2 C330(6.83)  LDD0240  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prelamin-A/C (LMNA) Intermediate filament family P02545

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
13 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
17 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
18 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
27 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
28 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
29 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
30 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
33 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
34 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
35 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
40 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
41 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
42 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
43 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
44 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
45 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.