Details of the Target

General Information of Target

Target ID LDTP01245
Target Name Enoyl-CoA delta isomerase 2 (ECI2)
Gene Name ECI2
Gene ID 10455
Synonyms
DRS1; HCA88; PECI; Enoyl-CoA delta isomerase 2; EC 5.3.3.8; DRS-1; Delta(3),delta(2)-enoyl-CoA isomerase; D3,D2-enoyl-CoA isomerase; Diazepam-binding inhibitor-related protein 1; DBI-related protein 1; Dodecenoyl-CoA isomerase; Hepatocellular carcinoma-associated antigen 88; Peroxisomal 3,2-trans-enoyl-CoA isomerase; pECI; Renal carcinoma antigen NY-REN-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMAYLAWRLARRSCPSSLQVTSFPVVQLHMNRTAMRASQKDFENSMNQVKLLKKDPGNE
VKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSP
SLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAAS
KDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIA
VVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEML
IFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKL
HAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Mitochondrion; Peroxisome matrix
Function Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates.
Uniprot ID
O75521
Ensemble ID
ENST00000380118.8
HGNC ID
HGNC:14601

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.D323H DBIA    Probe Info 
HCT15 SNV: p.R174H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y195(20.00); Y169(13.60)  LDD0257  [3]
TH214
 Probe Info  		Y169(20.00)  LDD0258  [3]
TH216
 Probe Info  		Y169(20.00)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K161(5.06); K177(4.17); K304(9.44); K349(3.99)  LDD0277  [5]
THZ1-DTB
 Probe Info  		C282(1.09)  LDD0460  [6]
BTD
 Probe Info  		C368(0.82)  LDD2091  [7]
AHL-Pu-1
 Probe Info  		C380(2.21)  LDD0170  [8]
HHS-475
 Probe Info  		Y285(1.96)  LDD0264  [9]
DBIA
 Probe Info  		C380(1.02)  LDD0078  [10]
5E-2FA
 Probe Info  		H274(0.00); H361(0.00); H170(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K161(0.00); K92(0.00); K359(0.00); K90(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C282(0.00); C368(0.00); C312(0.00); C77(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C368(0.00); C312(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		C282(0.00); C380(0.00); C312(0.00); C368(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C312(0.00); C368(0.00); C77(0.00); C380(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [16]
NAIA_4
 Probe Info  		C312(0.00); C368(0.00); C380(0.00)  LDD2226  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
IPM
 Probe Info  		C368(0.00); C380(0.00)  LDD0005  [18]
NHS
 Probe Info  		N.A.  LDD0010  [18]
SF
 Probe Info  		Y69(0.00); Y195(0.00)  LDD0028  [20]
TFBX
 Probe Info  		C282(0.00); C368(0.00); C312(0.00); C380(0.00)  LDD0148  [16]
VSF
 Probe Info  		N.A.  LDD0007  [18]
Phosphinate-6
 Probe Info  		C380(0.00); C312(0.00); C282(0.00); C368(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		C368(0.00); C312(0.00)  LDD0217  [23]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [23]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C368(0.00); C380(0.00)  LDD2223  [17]
HHS-465
 Probe Info  		K289(0.00); Y285(0.00); K92(0.00)  LDD2240  [26]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.06  LDD1838  [27]
C165
 Probe Info  		23.92  LDD1845  [27]
C346
 Probe Info  		11.47  LDD2007  [27]
C361
 Probe Info  		18.00  LDD2022  [27]
FFF probe11
 Probe Info  		6.80  LDD0472  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe2
 Probe Info  		14.09  LDD0463  [28]
FFF probe3
 Probe Info  		20.00  LDD0464  [28]
FFF probe6
 Probe Info  		7.24  LDD0467  [28]
OEA-DA
 Probe Info  		7.23  LDD0046  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C368(0.79)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C368(0.76)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C368(0.92)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C77(0.82)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C368(1.40)  LDD2152  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C368(0.64)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C380(2.21)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C380(7.17)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C380(1.04)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C368(1.20)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C368(0.89)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C368(0.92)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C368(0.81)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C368(0.74)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C368(0.94)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C368(0.92)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C368(0.88)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C368(0.98)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C368(0.84)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C368(1.25)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C368(1.15)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C368(0.76)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C368(0.88)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C368(0.94)  LDD0546  [10]
 LDCM0230  AC113 HEK-293T C230(1.07); C368(1.07); C380(1.10)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C230(0.96); C368(0.96); C380(1.18)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C230(1.09); C368(1.09); C380(1.30)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C230(1.17); C368(1.17); C380(1.24)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C230(1.20); C368(1.20); C380(1.21)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C230(1.21); C368(1.21); C380(1.43)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C230(1.06); C368(1.06); C380(1.41)  LDD0834  [10]
 LDCM0237  AC12 HCT 116 C368(1.18)  LDD0554  [10]
 LDCM0238  AC120 HEK-293T C230(1.09); C368(1.09); C380(1.32)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C230(1.25); C368(1.25); C380(1.74)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C230(1.29); C368(1.29); C380(1.97)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C230(1.25); C368(1.25); C380(1.92)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C230(1.18); C368(1.18); C380(1.38)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C230(1.44); C368(1.44); C380(1.72)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C230(1.38); C368(1.38); C380(2.68)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C230(1.46); C368(1.46); C380(2.87)  LDD0843  [10]
 LDCM0246  AC128 HCT 116 C368(0.84)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C368(0.78)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C368(0.70)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C368(0.74)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C368(0.78)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C368(0.74)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C368(0.75)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C368(0.82)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C368(0.70)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C368(0.64)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C368(0.63)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C368(0.71)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C368(1.17)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C368(0.69)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C368(0.66)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C368(0.66)  LDD0579  [10]
 LDCM0263  AC143 HEK-293T C230(1.11); C368(1.11)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C230(0.98); C368(0.98)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C230(1.07); C368(1.07)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C230(1.05); C368(1.05)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C230(1.03); C368(1.03)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C230(0.98); C368(0.98)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C230(0.83); C368(0.83)  LDD0867  [10]
 LDCM0270  AC15 HCT 116 C368(1.10)  LDD0587  [10]
 LDCM0271  AC150 HEK-293T C230(1.02); C368(1.02)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C230(1.11); C368(1.11)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C230(0.89); C368(0.89)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C230(1.06); C368(1.06)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C230(0.90); C368(0.90)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C230(1.08); C368(1.08)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C230(1.21); C368(1.21)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C230(1.04); C368(1.04)  LDD2165  [10]
 LDCM0276  AC17 HCT 116 C380(1.24)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C380(2.16)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C380(1.35)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C380(0.86)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C380(1.41)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C380(1.55)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C380(1.27)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C380(1.44)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C380(1.37)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C380(0.84); C368(1.35)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C380(0.96); C368(1.51)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C380(0.91); C368(1.36)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C380(0.99); C368(1.06)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C380(0.82); C368(1.17)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C380(0.88)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C380(1.05); C368(1.51)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C380(1.18); C368(1.21)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C380(0.96); C368(1.30)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C368(1.15); C380(1.20)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C368(1.07); C380(1.40)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C380(0.76)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C380(0.86)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C380(0.81)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C380(0.99)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C380(0.94)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C380(0.89)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C380(1.11)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C380(0.83)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C380(0.98)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C380(1.00)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C380(0.96)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C380(1.14)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C380(0.91)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C380(0.91)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C380(1.11)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C380(1.28)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C380(0.95)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C380(1.47)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C380(0.79)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C380(1.36)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C380(1.36)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C380(1.20)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C380(1.33)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C380(1.51)  LDD0636  [10]
 LDCM0320  AC57 HEK-293T C230(0.99); C368(0.99); C380(1.04); C77(0.74)  LDD0918  [10]
 LDCM0321  AC58 HEK-293T C230(0.90); C368(0.90); C380(0.85); C77(1.01)  LDD0919  [10]
 LDCM0322  AC59 HEK-293T C230(0.90); C368(0.90); C380(0.95); C77(0.95)  LDD0920  [10]
 LDCM0323  AC6 HCT 116 C368(0.95)  LDD0640  [10]
 LDCM0324  AC60 HEK-293T C230(1.80); C368(1.80); C380(1.05); C77(0.80)  LDD0922  [10]
 LDCM0325  AC61 HEK-293T C230(1.23); C368(1.23); C380(1.40); C77(1.51)  LDD0923  [10]
 LDCM0326  AC62 HEK-293T C230(1.02); C368(1.02); C380(1.09); C77(1.75)  LDD0924  [10]
 LDCM0327  AC63 HEK-293T C230(1.14); C368(1.14); C380(1.30); C77(1.36)  LDD0925  [10]
 LDCM0328  AC64 HEK-293T C230(0.84); C368(0.84); C380(1.08); C77(1.42)  LDD0926  [10]
 LDCM0329  AC65 HEK-293T C230(1.19); C368(1.19); C380(1.17); C77(1.59)  LDD0927  [10]
 LDCM0330  AC66 HEK-293T C230(1.00); C368(1.00); C380(0.95); C77(1.38)  LDD0928  [10]
 LDCM0331  AC67 HEK-293T C230(0.96); C368(0.96); C380(1.29); C77(1.29)  LDD0929  [10]
 LDCM0332  AC68 HCT 116 C380(1.91)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C380(2.28)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C368(1.04)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C380(1.39)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C380(1.68)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C380(2.46)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C380(2.06)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C380(1.98)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C380(1.73)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C380(1.87)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C380(1.95)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C380(1.88)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C380(1.26)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C368(1.12)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C380(2.09)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C380(0.32)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C380(1.29)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C380(1.49); C368(2.47)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C380(1.19); C368(2.24)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C380(1.26); C368(2.69)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C380(1.07); C368(2.17)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C380(0.92); C368(2.23)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C380(1.65); C368(2.88)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C380(1.47); C368(2.67)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C380(1.07); C368(2.25)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C380(1.34); C368(2.70)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C380(1.43); C368(2.38)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C380(1.20); C368(1.94)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C380(1.09); C368(2.98)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C380(1.17); C368(2.62)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C380(1.31); C368(2.49)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C380(1.40); C368(2.35)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C368(0.85)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C368(0.98)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C368(0.50)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C368(0.71)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C368(1.64)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C368(1.32)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C368(0.97)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 12.35  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C380(1.02)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C368(0.82)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C312(0.00); C368(0.00)  LDD0222  [23]
 LDCM0367  CL1 HEK-293T C230(1.05); C312(1.00); C368(0.75); C380(0.98)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C230(1.34); C312(0.77); C368(1.33); C380(2.77)  LDD0966  [10]
 LDCM0369  CL100 HCT 116 C380(0.96)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C368(1.17)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C368(1.19)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C368(1.18)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C368(1.06)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C380(1.58)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C380(2.20)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C380(2.12)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C380(2.18)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C380(1.65)  LDD0695  [10]
 LDCM0379  CL11 HEK-293T C230(1.59); C312(0.71); C368(1.35); C380(2.38)  LDD0977  [10]
 LDCM0380  CL110 HCT 116 C380(2.04)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C380(1.69)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C380(0.65); C368(1.08)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C368(0.92); C380(1.14)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C368(0.86); C380(0.90)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C380(0.87); C368(0.88)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C380(0.93); C368(1.20)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C380(1.45)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C380(0.95)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C380(1.01)  LDD0706  [10]
 LDCM0390  CL12 HEK-293T C230(1.13); C312(0.92); C368(0.99); C380(1.16)  LDD0988  [10]
 LDCM0391  CL120 HCT 116 C380(0.90)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C380(1.21)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C380(1.15)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C380(1.15)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C380(1.20)  LDD0712  [10]
 LDCM0396  CL125 HEK-293T C230(0.88); C368(0.88); C380(1.02); C77(0.96)  LDD0994  [10]
 LDCM0397  CL126 HEK-293T C230(1.01); C368(1.01); C380(1.02); C77(0.79)  LDD0995  [10]
 LDCM0398  CL127 HEK-293T C230(0.85); C368(0.85); C380(0.85); C77(0.75)  LDD0996  [10]
 LDCM0399  CL128 HEK-293T C230(0.92); C368(0.92); C380(0.85); C77(0.96)  LDD0997  [10]
 LDCM0400  CL13 HEK-293T C230(0.99); C312(0.82); C368(0.97); C380(1.11)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C230(1.05); C312(0.98); C368(0.81); C380(1.24)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C230(1.49); C312(0.82); C368(1.14); C380(1.54)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C312(0.78); C380(0.71); C77(0.85)  LDD1001  [10]
 LDCM0404  CL17 HEK-293T C312(0.87); C380(0.85); C77(0.86)  LDD1002  [10]
 LDCM0405  CL18 HEK-293T C312(0.88); C380(1.05); C77(1.05)  LDD1003  [10]
 LDCM0406  CL19 HEK-293T C312(1.29); C380(0.99); C77(0.97)  LDD1004  [10]
 LDCM0407  CL2 HEK-293T C230(0.97); C312(0.95); C368(0.90); C380(1.24)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C312(0.91); C380(0.97); C77(1.03)  LDD1006  [10]
 LDCM0409  CL21 HEK-293T C312(1.21); C380(1.10); C77(1.08)  LDD1007  [10]
 LDCM0410  CL22 HEK-293T C312(0.95); C380(1.12); C77(0.88)  LDD1008  [10]
 LDCM0411  CL23 HEK-293T C312(0.83); C380(0.94); C77(1.33)  LDD1009  [10]
 LDCM0412  CL24 HEK-293T C312(0.82); C380(0.91); C77(1.04)  LDD1010  [10]
 LDCM0413  CL25 HEK-293T C312(0.82); C380(1.05); C77(0.89)  LDD1011  [10]
 LDCM0414  CL26 HEK-293T C312(0.82); C380(1.02); C77(1.03)  LDD1012  [10]
 LDCM0415  CL27 HEK-293T C312(0.98); C380(0.96); C77(1.02)  LDD1013  [10]
 LDCM0416  CL28 HEK-293T C312(0.86); C380(0.95); C77(0.87)  LDD1014  [10]
 LDCM0417  CL29 HEK-293T C312(0.98); C380(0.97); C77(1.20)  LDD1015  [10]
 LDCM0418  CL3 HEK-293T C230(1.01); C312(0.86); C368(0.93); C380(1.17)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C312(0.95); C380(1.33); C77(1.21)  LDD1017  [10]
 LDCM0420  CL31 HCT 116 C368(1.04)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C368(0.82)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C368(0.77)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C368(0.93)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C368(0.81)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C368(0.82)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C368(1.03)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C368(0.89)  LDD0745  [10]
 LDCM0429  CL4 HEK-293T C230(0.97); C312(0.91); C368(0.92); C380(1.18)  LDD1027  [10]
 LDCM0430  CL40 HCT 116 C368(0.79)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C368(0.97)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C368(0.83)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C368(0.99)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C368(0.92)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C368(1.00)  LDD0752  [10]
 LDCM0436  CL46 HEK-293T C230(1.01); C312(0.82); C368(1.01); C380(1.07)  LDD1034  [10]
 LDCM0437  CL47 HEK-293T C230(0.94); C312(0.97); C368(0.94); C380(0.98)  LDD1035  [10]
 LDCM0438  CL48 HEK-293T C230(0.84); C312(1.01); C368(0.84); C380(0.89)  LDD1036  [10]
 LDCM0439  CL49 HEK-293T C230(0.98); C312(0.95); C368(0.98); C380(0.95)  LDD1037  [10]
 LDCM0440  CL5 HEK-293T C230(0.99); C312(0.89); C368(0.92); C380(1.24)  LDD1038  [10]
 LDCM0441  CL50 HEK-293T C230(1.17); C312(0.76); C368(1.17); C380(1.29)  LDD1039  [10]
 LDCM0442  CL51 HEK-293T C230(1.26); C312(0.95); C368(1.26); C380(1.07)  LDD1040  [10]
 LDCM0443  CL52 HEK-293T C230(0.91); C312(1.12); C368(0.91); C380(0.87)  LDD1041  [10]
 LDCM0444  CL53 HEK-293T C230(1.15); C312(1.47); C368(1.15); C380(0.85)  LDD1042  [10]
 LDCM0445  CL54 HEK-293T C230(1.16); C312(0.98); C368(1.16); C380(1.12)  LDD1043  [10]
 LDCM0446  CL55 HEK-293T C230(1.18); C312(0.78); C368(1.18); C380(1.25)  LDD1044  [10]
 LDCM0447  CL56 HEK-293T C230(0.91); C312(0.98); C368(0.91); C380(1.12)  LDD1045  [10]
 LDCM0448  CL57 HEK-293T C230(1.07); C312(1.34); C368(1.07); C380(1.11)  LDD1046  [10]
 LDCM0449  CL58 HEK-293T C230(1.38); C312(0.99); C368(1.38); C380(1.12)  LDD1047  [10]
 LDCM0450  CL59 HEK-293T C230(1.14); C312(0.74); C368(1.14); C380(1.16)  LDD1048  [10]
 LDCM0451  CL6 HEK-293T C230(1.03); C312(0.88); C368(0.91); C380(1.30)  LDD1049  [10]
 LDCM0452  CL60 HEK-293T C230(1.32); C312(0.67); C368(1.32); C380(1.22)  LDD1050  [10]
 LDCM0453  CL61 HEK-293T C230(1.01); C368(0.99); C380(1.13)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C230(1.06); C368(1.21); C380(1.28)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C230(0.90); C368(1.08); C380(1.34)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C230(0.89); C368(0.98); C380(1.08)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C230(1.02); C368(1.17); C380(1.53)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C230(0.94); C368(1.09); C380(1.20)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C230(1.11); C368(1.38); C380(1.19)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C230(1.48); C368(1.42); C380(1.30)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C230(1.00); C368(0.97); C380(1.06)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C230(1.12); C312(0.71); C368(1.03); C380(1.62)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C230(1.33); C368(1.27); C380(1.06)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C230(1.07); C368(1.19); C380(1.44)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C230(0.97); C368(1.09); C380(1.01)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C230(1.28); C368(1.35); C380(1.20)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C230(1.32); C368(1.62); C380(1.62)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C230(1.29); C368(1.29); C380(1.13)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C230(1.20); C368(1.20); C380(1.07)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C230(1.66); C368(1.66); C380(0.85)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C230(1.53); C368(1.53); C380(0.89)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C312(0.95); C368(1.36)  LDD1071  [10]
 LDCM0474  CL80 HEK-293T C230(1.37); C368(1.37); C380(0.95)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C230(1.40); C368(1.40); C380(1.13)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C230(1.09); C368(1.09); C380(1.04)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C230(1.04); C368(1.04); C380(1.19)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C230(1.60); C368(1.60); C380(0.86)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C230(1.54); C368(1.54); C380(0.93)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C230(2.04); C368(2.04); C380(0.88)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C230(1.47); C368(1.47); C380(1.02)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C230(1.30); C368(1.30); C380(1.04)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C230(1.34); C368(1.34); C380(1.03)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C312(0.99); C368(1.26)  LDD1082  [10]
 LDCM0485  CL90 HEK-293T C230(1.18); C368(1.18); C380(1.20)  LDD1083  [10]
 LDCM0486  CL91 HCT 116 C380(0.95)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C380(0.76)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C380(0.94)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C380(0.94)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C380(0.92)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C380(0.84)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C380(0.98)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C380(1.10)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C380(0.82)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C77(1.05); C368(1.16); C230(0.93); C312(1.08)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C312(1.18); C368(1.11); C282(1.08)  LDD1702  [7]
 LDCM0625  F8 Ramos C368(1.31); C380(0.50); C282(1.86); C312(0.69)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C380(20.00)  LDD1389  [32]
 LDCM0573  Fragment11 MDA-MB-231 C380(2.16)  LDD1391  [32]
 LDCM0574  Fragment12 MDA-MB-231 C380(1.59)  LDD1393  [32]
 LDCM0575  Fragment13 MDA-MB-231 C380(0.97)  LDD1395  [32]
 LDCM0576  Fragment14 MDA-MB-231 C380(1.90)  LDD1397  [32]
 LDCM0579  Fragment20 MDA-MB-231 C380(2.27)  LDD1402  [32]
 LDCM0580  Fragment21 MDA-MB-231 C380(0.82)  LDD1404  [32]
 LDCM0581  Fragment22 MDA-MB-231 C380(1.04)  LDD1406  [32]
 LDCM0582  Fragment23 MDA-MB-231 C380(6.08)  LDD1408  [32]
 LDCM0578  Fragment27 MDA-MB-231 C380(0.94)  LDD1401  [32]
 LDCM0586  Fragment28 MDA-MB-231 C380(1.08)  LDD1415  [32]
 LDCM0587  Fragment29 MDA-MB-231 C380(1.17)  LDD1417  [32]
 LDCM0588  Fragment30 MDA-MB-231 C380(0.82)  LDD1419  [32]
 LDCM0589  Fragment31 MDA-MB-231 C380(1.43)  LDD1421  [32]
 LDCM0590  Fragment32 MDA-MB-231 C380(1.72)  LDD1423  [32]
 LDCM0468  Fragment33 HEK-293T C230(1.49); C368(1.53); C380(1.84)  LDD1066  [10]
 LDCM0593  Fragment35 MDA-MB-231 C380(0.69)  LDD1429  [32]
 LDCM0594  Fragment36 MDA-MB-231 C380(2.26)  LDD1431  [32]
 LDCM0595  Fragment37 Ramos C380(0.92)  LDD1432  [32]
 LDCM0596  Fragment38 MDA-MB-231 C380(0.97)  LDD1433  [32]
 LDCM0566  Fragment4 MDA-MB-231 C380(7.02)  LDD1378  [32]
 LDCM0599  Fragment41 MDA-MB-231 C380(2.86)  LDD1438  [32]
 LDCM0601  Fragment43 MDA-MB-231 C380(2.04)  LDD1441  [32]
 LDCM0602  Fragment44 MDA-MB-231 C380(0.81)  LDD1443  [32]
 LDCM0603  Fragment45 MDA-MB-231 C380(2.35)  LDD1444  [32]
 LDCM0604  Fragment46 MDA-MB-231 C380(1.00)  LDD1445  [32]
 LDCM0605  Fragment47 MDA-MB-231 C380(1.34)  LDD1446  [32]
 LDCM0606  Fragment48 MDA-MB-231 C380(1.09)  LDD1447  [32]
 LDCM0607  Fragment49 MDA-MB-231 C380(2.00)  LDD1448  [32]
 LDCM0608  Fragment50 MDA-MB-231 C380(1.36)  LDD1449  [32]
 LDCM0427  Fragment51 HCT 116 C368(0.64)  LDD0744  [10]
 LDCM0610  Fragment52 MDA-MB-231 C380(1.32)  LDD1452  [32]
 LDCM0611  Fragment53 MDA-MB-231 C380(0.90)  LDD1454  [32]
 LDCM0613  Fragment55 MDA-MB-231 C380(1.01)  LDD1457  [32]
 LDCM0614  Fragment56 MDA-MB-231 C380(0.94)  LDD1458  [32]
 LDCM0568  Fragment6 MDA-MB-231 C380(1.66)  LDD1382  [32]
 LDCM0569  Fragment7 MDA-MB-231 C380(1.62)  LDD1383  [32]
 LDCM0570  Fragment8 MDA-MB-231 C380(1.71)  LDD1385  [32]
 LDCM0571  Fragment9 MDA-MB-231 C380(1.65)  LDD1387  [32]
 LDCM0116  HHS-0101 DM93 Y285(1.96)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y285(8.31)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y285(7.19)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y285(10.45)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y285(1.49)  LDD0268  [9]
 LDCM0107  IAA HeLa C368(0.00); H361(0.00)  LDD0221  [23]
 LDCM0022  KB02 MDA-MB-231 C380(2.44)  LDD1374  [32]
 LDCM0023  KB03 MDA-MB-231 C380(3.60)  LDD1376  [32]
 LDCM0024  KB05 COLO792 C368(2.03); C380(4.01)  LDD3310  [33]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C368(0.72)  LDD2121  [7]
 LDCM0109  NEM HeLa H361(0.00); H170(0.00)  LDD0223  [23]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C77(0.34)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C368(1.12)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C368(1.25)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C368(1.32)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C368(0.68)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C368(0.86)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C77(0.50)  LDD2104  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C368(1.08)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C368(0.85); C77(0.40)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C368(1.12)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C368(0.74)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C368(0.45)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C368(1.57)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C77(0.98)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C368(1.03)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C368(0.96); C77(0.85)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C368(1.03); C77(0.99)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C368(0.71); C77(1.01)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C368(1.19)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C368(0.53)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C368(1.09)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C368(0.99)  LDD2136  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C368(1.04); C77(0.92)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C368(0.77)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C77(1.05)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C368(1.84)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C368(0.15)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C368(0.91)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C368(0.53)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C368(1.00)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C282(2.11); C380(1.69); C368(1.21); C368(1.07)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C380(0.81); C368(0.78); C380(0.73); C282(0.63)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C380(1.25)  LDD0304  [35]
 LDCM0021  THZ1 HeLa S3 C282(1.09)  LDD0460  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) Enoyl-CoA hydratase/isomerase family Q13011
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transportin-3 (TNPO3) . Q9Y5L0

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Myristic Acid Small molecular drug DB08231

References

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3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
33 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.