Details of the Target

General Information of Target

Target ID LDTP04117
Target Name Ras GTPase-activating-like protein IQGAP1 (IQGAP1)
Gene Name IQGAP1
Gene ID 8826
Synonyms
KIAA0051; Ras GTPase-activating-like protein IQGAP1; p195
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRWMEACLGE
DLPPTTELEEGLRNGVYLAKLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQWL
NAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSLYLFKLGLAPQIQDLYGKVDFTEE
EINNMKTELEKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPADTFAAL
KNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAKNRTENSERERDVYEELLTQAEIQGNI
NKVNTFSALANIDLALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLSDKQQKRQS
GQTDPLQKEELQSGVDAANSAAQQYQRRLAAVALINAAIQKGVAEKTVLELMNPEAQLPQ
VYPFAADLYQKELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALESGDVNTVWKQLS
SSVTGLTNIEEENCQRYLDELMKLKAQAHAENNEFITWNDIQACVDHVNLVVQEEHERIL
AIGLINEALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRAKREKAQEIQDESAV
LWLDEIQGGIWQSNKDTQEAQKFALGIFAINEAVESGDVGKTLSALRSPDVGLYGVIPEC
GETYHSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQEGGWDEPPNFVQNSMQL
SREEIQSSISGVTAAYNREQLWLANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAIT
CIQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQARKRYRDRLQYFRDHINDII
KIQAFIRANKARDDYKTLINAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVITLI
RSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKLTKKNKEQLSDMMMINKQKGGLKA
LSKEKREKLEAYQHLFYLLQTNPTYLAKLIFQMPQNKSTKFMDSVIFTLYNYASNQREEY
LLLRLFKTALQEEIKSKVDQIQEIVTGNPTVIKMVVSFNRGARGQNALRQILAPVVKEIM
DDKSLNIKTDPVDIYKSWVNQMESQTGEASKLPYDVTPEQALAHEEVKTRLDSSIRNMRA
VTDKFLSAIVSSVDKIPYGMRFIAKVLKDSLHEKFPDAGEDELLKIIGNLLYYRYMNPAI
VAPDAFDIIDLSAGGQLTTDQRRNLGSIAKMLQHAASNKMFLGDNAHLSIINEYLSQSYQ
KFRRFFQTACDVPELQDKFNVDEYSDLVTLTKPVIYISIGEIINTHTLLLDHQDAIAPEH
NDPIHELLDDLGEVPTIESLIGESSGNLNDPNKEALAKTEVSLTLTNKFDVPGDENAEMD
ARTILLNTKRLIVDVIRFQPGETLTEILETPATSEQEAEHQRAMQRRAIRDAKTPDKMKK
SKSVKEDSNLTLQEKKEKIQTGLKKLTELGTVDPKNKYQELINDIARDIRNQRRYRQRRK
AELVKLQQTYAALNSKATFYGEQVDYYKSYIKTCLDNLASKGKVSKKPREMKGKKSKKIS
LKYTAARLHEKGVLLEIEDLQVNQFKNVIFEISPTEEVGDFEVKAKFMGVQMETFMLHYQ
DLLQLQYEGVAVMKLFDRAKVNVNLLIFLLNKKFYGK
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest.
Uniprot ID
P46940
Ensemble ID
ENST00000268182.10
HGNC ID
HGNC:6110
ChEMBL ID
CHEMBL4295763

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.01  LDD0402  [1]
P1
 Probe Info  		10.00  LDD0452  [2]
P8
 Probe Info  		10.00  LDD0455  [2]
A-EBA
 Probe Info  		2.95  LDD0215  [3]
CY-1
 Probe Info  		17.24  LDD0243  [4]
CY4
 Probe Info  		19.25  LDD0244  [4]
N1
 Probe Info  		35.61  LDD0242  [4]
TH211
 Probe Info  		Y654(10.39); Y287(10.35)  LDD0257  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		K1128(4.91); K1168(0.86); K1389(8.48); K1465(1.02)  LDD0274  [7]
STPyne
 Probe Info  		K1037(5.26); K104(6.32); K1077(10.00); K1088(6.41)  LDD0277  [7]
AZ-9
 Probe Info  		E739(1.17)  LDD2208  [8]
OPA-S-S-alkyne
 Probe Info  		K856(1.47); K1128(2.32); K104(2.32); K368(3.38)  LDD3494  [9]
Probe 1
 Probe Info  		Y41(12.37); Y172(7.03); Y287(9.52); Y385(41.66)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C660(0.00); C45(0.00)  LDD0462  [11]
AHL-Pu-1
 Probe Info  		C45(2.66)  LDD0171  [12]
HHS-482
 Probe Info  		Y1193(1.00); Y172(1.47); Y654(1.18); Y977(1.04)  LDD0285  [13]
HHS-475
 Probe Info  		Y695(0.49); Y1526(0.54); Y697(0.69); Y1478(0.73)  LDD0264  [14]
HHS-465
 Probe Info  		Y385(10.00); Y654(6.89); Y977(4.12)  LDD2237  [15]
DBIA
 Probe Info  		C781(1.01); C494(0.89)  LDD0078  [16]
5E-2FA
 Probe Info  		H1247(0.00); H16(0.00); H46(0.00); H443(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K1571(0.00); K922(0.00); K1541(0.00); K1543(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C524(0.00); C1270(0.00); C781(0.00); C494(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [20]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [21]
IPIAA_L
 Probe Info  		C45(0.00); C660(0.00); C1534(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C524(0.00); C781(0.00); C494(0.00); C45(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K1571(0.00); K1653(0.00)  LDD0035  [22]
BTD
 Probe Info  		N.A.  LDD0004  [23]
NAIA_4
 Probe Info  		C781(0.00); C1534(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C1534(0.00); C494(0.00)  LDD0027  [25]
WYneN
 Probe Info  		N.A.  LDD0021  [23]
WYneO
 Probe Info  		C1270(0.00); C1534(0.00)  LDD0022  [23]
Compound 10
 Probe Info  		N.A.  LDD2216  [26]
ENE
 Probe Info  		N.A.  LDD0006  [23]
IPM
 Probe Info  		N.A.  LDD0005  [23]
NHS
 Probe Info  		K1445(0.00); K88(0.00); K1027(0.00); K935(0.00)  LDD0010  [23]
OSF
 Probe Info  		N.A.  LDD0029  [27]
PF-06672131
 Probe Info  		N.A.  LDD0152  [28]
PPMS
 Probe Info  		N.A.  LDD0008  [23]
SF
 Probe Info  		Y172(0.00); Y17(0.00); Y287(0.00); Y1193(0.00)  LDD0028  [27]
VSF
 Probe Info  		N.A.  LDD0007  [23]
Ox-W18
 Probe Info  		N.A.  LDD2175  [29]
1c-yne
 Probe Info  		K1445(0.00); K348(0.00); K1516(0.00); K856(0.00)  LDD0228  [30]
1d-yne
 Probe Info  		N.A.  LDD0357  [30]
Acrolein
 Probe Info  		C494(0.00); C660(0.00); C1270(0.00); C45(0.00)  LDD0217  [31]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [31]
Methacrolein
 Probe Info  		C1270(0.00); C494(0.00); C1534(0.00)  LDD0218  [31]
NAIA_5
 Probe Info  		C756(0.00); C781(0.00); C45(0.00); C1534(0.00)  LDD2223  [24]
TPP-AC
 Probe Info  		N.A.  LDD0427  [32]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.55  LDD0472  [33]
FFF probe13
 Probe Info  		12.64  LDD0475  [33]
FFF probe14
 Probe Info  		12.27  LDD0477  [33]
FFF probe3
 Probe Info  		8.34  LDD0464  [33]
STS-2
 Probe Info  		N.A.  LDD0138  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
DA-2
 Probe Info  		N.A.  LDD0071  [36]
STS-1
 Probe Info  		N.A.  LDD0068  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C494(0.47); C45(0.93)  LDD2142  [38]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C494(0.86); C45(0.87)  LDD2112  [38]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1534(0.94)  LDD2095  [38]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1534(0.64)  LDD2130  [38]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1534(1.34); C494(1.10); C781(1.08); C45(1.80)  LDD2117  [38]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1534(1.48)  LDD2152  [38]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1534(0.46); C781(1.12)  LDD2132  [38]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1534(0.44); C494(0.77)  LDD2131  [38]
 LDCM0026  4SU-RNA+native RNA DM93 C45(2.66)  LDD0171  [12]
 LDCM0214  AC1 HCT 116 C1270(1.32); C1534(1.02); C494(1.28); C660(1.29)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C1270(1.00); C1534(0.99); C45(0.63); C494(1.18)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C1270(0.69); C1534(0.79); C45(0.73); C494(1.09)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C1270(0.61); C1534(0.75); C45(0.77); C494(1.14)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C1270(0.63); C1534(0.80); C45(0.67); C494(1.06)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C1270(0.57); C1534(0.70); C45(0.52); C494(1.18)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C1270(0.72); C1534(0.76); C45(0.50); C494(1.00)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C1270(0.58); C1534(0.72); C45(0.58); C494(1.18)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C1270(0.59); C1534(0.77); C45(0.56); C494(1.26)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C1270(0.66); C1534(0.79); C45(0.81); C494(1.24)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C1270(0.69); C1534(0.82); C45(0.44); C494(1.13)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C1270(0.69); C1534(0.79); C45(0.51); C494(0.87)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C1270(0.98); C1534(1.00); C45(0.86); C494(1.11)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C1270(0.67); C1534(0.78); C45(0.47); C494(1.02)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C1270(0.64); C1534(0.74); C45(0.51); C494(1.30)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C1270(0.56); C1534(0.75); C45(0.68); C494(1.10)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C1270(0.88); C1534(1.11); C494(0.92); C660(0.80)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C1270(0.88); C1534(1.21); C494(0.93); C660(0.48)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C1270(0.85); C1534(1.08); C494(1.07); C660(0.37)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C1270(0.88); C1534(1.13); C494(1.27); C660(0.42)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C1270(0.88); C1534(1.11); C494(0.94); C660(0.51)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C1270(1.08); C1534(1.15); C494(1.17); C660(0.44)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C1270(1.01); C1534(1.11); C494(1.22); C660(0.54)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C1270(1.02); C1534(1.08); C45(0.81); C494(0.97)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C1270(0.80); C1534(1.09); C494(1.10); C660(0.45)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C1270(1.06); C1534(1.15); C494(1.08); C660(0.63)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C1270(1.06); C1534(1.18); C494(0.96); C660(0.78)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C1270(0.95); C1534(1.15); C494(0.89); C660(0.82)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C1270(1.06); C1534(1.26); C494(0.99); C660(0.66)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C1270(1.12); C1534(1.23); C494(1.07); C660(0.77)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C1270(1.02); C1534(1.16); C494(1.02); C660(0.43)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C1270(0.96); C1534(1.19); C494(0.98); C660(0.50)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C1270(1.38); C1534(1.06); C45(0.78); C494(0.89)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C1270(1.37); C1534(1.11); C45(1.19); C494(0.76)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C1270(1.28); C1534(1.15); C45(0.87); C494(1.08)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C1270(1.17); C1534(1.02); C45(1.01); C494(0.86)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C1270(1.29); C1534(1.17); C45(1.28); C494(0.87)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C1270(1.28); C1534(1.17); C45(1.06); C494(0.82)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C1270(1.11); C1534(1.01); C45(1.06); C494(0.93)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C1270(1.27); C1534(1.07); C45(0.87); C494(1.04)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C1270(1.29); C1534(1.08); C45(1.12); C494(0.88)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C1270(1.21); C1534(1.09); C45(1.27); C494(0.89)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C1270(1.30); C1534(1.11); C45(1.04); C494(1.01)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C1270(1.23); C1534(1.09); C45(1.15); C494(1.00)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C1270(0.94); C1534(0.89); C45(0.72); C494(1.55)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C1270(1.20); C1534(1.07); C45(1.01); C494(1.11)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C1270(1.17); C1534(1.05); C45(1.17); C494(1.00)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C1270(1.24); C1534(1.24); C45(1.59); C494(1.15)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C1534(0.97); C660(1.01); C494(1.06); C1270(1.08)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C660(0.51); C1534(1.02); C1270(1.26); C494(1.37)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C660(0.61); C1534(1.00); C494(1.11); C781(1.21)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C660(0.45); C1270(1.07); C1534(1.12); C494(1.22)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C660(0.39); C1534(1.14); C1270(1.15); C494(1.43)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C660(0.43); C1534(0.93); C1270(1.15); C494(1.33)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C660(0.44); C1270(1.00); C1534(1.01); C781(1.28)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C660(0.70); C1534(0.85); C45(0.86); C494(0.97)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C660(0.96); C1534(1.05); C781(1.11); C1270(1.13)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C660(0.61); C1270(1.08); C1534(1.12); C781(1.18)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C660(0.48); C1534(1.07); C494(1.11); C1270(1.15)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C660(0.42); C1534(1.04); C1270(1.06); C494(1.59)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C1270(1.24); C1534(1.10); C494(1.26); C660(0.57)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C1270(1.14); C1534(1.12); C494(1.11); C660(0.48)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C1270(1.20); C1534(1.16); C494(0.92); C660(0.85)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C1270(1.06); C1534(1.13); C494(0.87); C660(1.38)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C660(0.69); C1270(0.85); C494(0.96); C781(1.13)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C660(0.48); C1270(0.76); C494(0.96); C781(1.15)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C660(0.61); C1270(0.81); C494(0.91); C1534(1.10)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C660(0.76); C1534(1.04); C781(1.15); C1270(1.16)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C660(0.77); C1270(0.82); C494(0.95); C781(1.06)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C660(0.66); C1270(0.84); C494(0.91); C781(1.12)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C1270(0.91); C494(0.97); C660(1.06); C781(1.08)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C660(0.69); C1270(0.83); C494(0.86); C781(0.99)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C1270(0.82); C660(0.82); C1534(0.98); C494(1.00)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C660(0.52); C1270(0.87); C1534(0.92); C781(0.99)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C660(0.40); C1270(0.74); C1534(0.90); C781(1.02)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C660(0.40); C1270(0.74); C1534(0.90); C781(1.02)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C660(0.38); C1270(0.78); C1534(0.90); C781(1.08)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C660(0.44); C1270(0.69); C1534(0.89); C781(1.10)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C660(1.04); C1534(1.06); C494(1.09); C781(1.24)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C660(0.33); C1270(0.70); C1534(0.97); C781(1.00)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C660(0.42); C1270(0.73); C781(0.97); C1534(1.05)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C660(0.31); C1270(0.69); C1534(1.02); C781(1.09)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C660(0.31); C1270(0.69); C1534(0.96); C781(1.14)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C660(0.32); C1270(0.68); C1534(0.87); C781(1.16)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C494(0.81); C781(1.03); C1534(1.07); C1270(1.17)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C1270(0.92); C494(0.93); C1534(1.02); C660(1.02)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C660(0.94); C494(0.96); C1534(1.00); C1270(1.11)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C494(0.98); C1270(1.04); C781(1.04); C660(1.10)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C660(0.91); C781(1.02); C1270(1.03); C1534(1.09)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C660(0.79); C1534(1.02); C781(1.11); C494(1.27)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C660(0.86); C1270(1.02); C494(1.09); C1534(1.18)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C660(0.86); C1270(0.93); C494(0.95); C1534(1.11)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C660(0.84); C494(0.94); C1270(0.99); C1534(1.08)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C1270(0.93); C660(0.95); C494(1.07); C1534(1.09)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C660(0.84); C494(1.00); C1270(1.06); C781(1.10)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C660(0.78); C494(1.02); C1270(1.09); C1534(1.14)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C1270(0.79); C660(1.00); C781(1.05); C1534(1.11)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C1270(0.89); C781(1.00); C1534(1.02); C660(1.04)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C781(1.04); C1270(1.11); C1534(1.12); C494(1.22)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C1270(0.75); C660(0.82); C1534(0.98); C781(1.15)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C660(0.83); C1534(1.04); C781(1.09); C494(1.35)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C1270(0.80); C660(0.82); C1534(1.03); C781(1.09)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C1270(0.89); C781(0.91); C494(0.98); C1534(1.00)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C660(0.91); C1270(0.93); C1534(1.05); C781(1.10)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C1270(0.96); C1534(0.98); C660(1.03); C494(1.07)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C660(0.98); C1270(1.01); C1534(1.07); C781(1.08)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C660(0.83); C1270(0.95); C1534(1.00); C781(1.17)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C660(0.77); C1270(0.85); C1534(1.05); C494(1.22)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C1270(0.83); C781(1.10); C1534(1.15); C494(1.33)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C1270(0.77); C1534(1.03); C781(1.14); C494(1.24)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C1270(0.79); C1534(1.03); C781(1.06); C494(1.35)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C660(0.72); C45(0.77); C1270(0.82); C1534(0.90)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C1270(0.71); C781(1.04); C1534(1.06); C45(1.13)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C1270(0.86); C781(1.00); C45(1.20); C1534(1.23)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C1270(0.87); C781(1.07); C1534(1.08); C45(1.50)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C1270(0.73); C1534(1.08); C781(1.09); C45(1.21)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C1270(0.84); C1534(0.96); C781(1.03); C45(1.23)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C1270(0.80); C1534(1.02); C781(1.17); C45(1.30)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C1270(0.86); C781(1.03); C1534(1.15); C45(1.27)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C1270(0.72); C1534(1.13); C781(1.29); C45(1.39)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C1534(0.91); C781(1.00); C1270(1.00); C494(1.29)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C1534(0.87); C494(1.05); C781(1.11); C1270(1.33)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C45(0.62); C660(0.69); C1270(0.91); C781(0.94)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C1534(0.96); C494(1.09); C1270(1.15); C781(1.21)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C1534(0.93); C494(1.04); C781(1.05); C1270(1.49)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C1534(0.97); C494(1.11); C1270(1.15); C781(1.19)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C1534(0.93); C1270(1.00); C494(1.26); C781(1.60)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C1534(0.95); C494(1.18); C1270(1.36); C781(1.48)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C1534(0.87); C1270(0.99); C494(1.08); C781(1.58)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C1534(0.94); C494(1.09); C1270(1.28); C781(1.33)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C1534(0.90); C1270(0.91); C494(1.12); C781(1.30)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C1534(0.98); C1270(1.00); C494(1.02); C781(1.23)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C1534(0.96); C1270(1.06); C494(1.18); C781(1.20)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C660(0.68); C45(0.75); C1270(0.84); C781(0.98)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C1534(0.98); C494(1.05); C781(1.21); C1270(1.31)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C781(0.97); C1534(1.00); C494(1.05); C1270(1.26)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C1534(0.98); C494(1.08); C1270(1.25); C781(1.56)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C660(0.45); C45(0.47); C1270(0.90); C1534(0.96)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C660(0.52); C45(0.58); C1270(0.93); C1534(0.97)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C660(0.66); C1270(0.85); C45(0.94); C1534(0.96)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C660(0.63); C45(0.72); C1270(0.94); C1534(1.03)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C1270(0.95); C45(0.97); C1534(1.09); C494(1.17)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C660(0.56); C45(0.74); C1270(0.86); C1534(0.97)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C660(0.53); C45(0.57); C1270(0.88); C1534(1.05)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C45(0.93); C781(0.96); C1534(1.04); C1270(1.08)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C45(0.46); C660(0.47); C1270(0.97); C1534(1.00)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C660(0.44); C45(0.49); C1270(0.92); C1534(0.99)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C660(0.48); C45(0.66); C1270(0.87); C1534(1.02)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C660(0.73); C45(0.73); C494(1.05); C1534(1.15)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C1270(0.77); C45(0.85); C1534(1.03); C781(1.25)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C660(0.57); C45(0.62); C1534(1.07); C1270(1.09)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C660(0.52); C45(0.62); C1270(0.79); C1534(1.06)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C660(0.16); C45(0.34); C1270(0.57); C1534(0.73)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C660(0.36); C1270(0.65); C45(0.72); C1534(0.80)  LDD0683  [16]
 LDCM0520  AKOS000195272 MDA-MB-231 C1534(1.12); C494(0.66)  LDD2113  [38]
 LDCM0248  AKOS034007472 HCT 116 C1270(1.01); C1534(0.94); C45(0.62); C494(1.01)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C45(0.73); C660(0.81); C1270(0.88); C1534(0.90)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C660(0.42); C45(0.71); C1270(0.84); C1534(0.89)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C781(1.01); C494(0.89)  LDD0078  [16]
 LDCM0108  Chloroacetamide HeLa H578(0.00); C494(0.00); C660(0.00); C57(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C45(20.00); C781(1.83); C1534(1.15)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C494(0.92); C781(0.96); C1534(1.02); C1270(1.05)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C1270(0.86); C494(1.10); C781(1.25); C1534(1.29)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C660(0.73); C1534(0.94); C781(1.10); C494(1.10)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C660(0.50); C45(0.62); C1534(0.74); C1270(0.83)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C660(0.73); C1534(0.74); C45(0.75); C781(0.83)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C45(0.59); C660(0.63); C1534(0.84); C1270(0.95)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C1534(0.76); C45(0.79); C660(0.90); C494(0.95)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C660(0.50); C1270(0.80); C494(0.96); C781(1.04)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C660(0.44); C1270(0.86); C494(0.94); C781(1.22)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C660(0.42); C1270(0.85); C494(1.08); C781(1.13)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C660(0.45); C1270(0.85); C781(1.17); C494(1.17)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C660(0.51); C1270(0.82); C494(0.91); C781(1.08)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C1534(0.92); C1270(0.95); C781(1.17); C494(1.24)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C660(0.39); C1270(0.79); C494(0.92); C781(0.98)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C660(0.52); C1270(0.76); C494(0.94); C781(1.06)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C660(0.66); C1270(0.78); C1534(0.86); C781(0.91)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C660(0.34); C1270(0.69); C1534(0.91); C781(1.08)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C660(0.44); C1270(0.68); C1534(0.87); C781(1.01)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C660(0.44); C1270(0.71); C1534(0.88); C781(1.04)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C660(0.42); C1270(0.78); C1534(0.93); C781(0.95)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C660(0.81); C1270(1.04); C1534(1.13); C494(1.25)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C660(0.84); C1270(0.95); C781(0.99); C494(1.01)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C660(0.88); C1270(1.02); C494(1.06); C1534(1.06)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C1270(0.90); C1534(1.06); C494(1.06); C781(1.39)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C660(0.90); C494(0.96); C1270(1.00); C781(1.09)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C660(0.69); C781(0.76); C1270(0.87); C1534(1.08)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C1270(0.89); C660(1.00); C1534(1.00); C781(1.04)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C660(0.91); C1270(0.94); C1534(0.97); C781(1.01)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C1270(0.95); C660(0.97); C1534(1.03); C494(1.23)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C1270(0.77); C781(0.97); C1534(1.10); C494(1.16)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C1270(0.97); C781(1.00); C1534(1.10); C494(1.20)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C1270(0.79); C781(1.05); C494(1.14); C1534(1.15)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C1270(0.87); C781(0.99); C1534(1.21); C494(1.43)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C1270(0.89); C494(1.06); C1534(1.08); C781(1.18)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C1270(0.93); C494(0.94); C1534(1.03); C781(1.13)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C1534(0.80); C1270(0.89); C781(1.21); C494(1.22)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C1270(0.90); C1534(0.96); C781(1.10); C494(1.12)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C1270(0.80); C494(0.82); C781(0.94); C1534(1.05)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C1270(0.82); C781(0.94); C494(0.99); C1534(1.03)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C1534(0.92); C781(0.93); C1270(0.96); C494(1.01)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C494(1.05); C1270(1.05); C1534(1.06); C781(1.13)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C660(0.58); C1270(0.91); C1534(1.04); C781(1.08)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C660(0.43); C1534(0.87); C494(0.89); C1270(0.90)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C660(0.52); C1270(0.98); C1534(0.99); C494(1.15)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C1270(0.87); C494(0.95); C1534(0.99); C660(1.02)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C660(0.60); C1270(0.97); C781(1.01); C1534(1.09)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C1270(0.98); C1534(0.92); C494(1.14); C660(0.63)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C1270(0.85); C1534(1.06); C494(0.94); C660(0.70)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C1270(0.96); C1534(1.05); C494(1.01); C660(0.86)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C1270(0.86); C1534(0.91); C494(1.07); C660(0.71)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C1270(0.92); C1534(0.96); C494(0.99); C660(0.62)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C1270(1.02); C1534(0.95); C494(0.98); C781(1.11)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C1270(0.99); C1534(1.03); C494(0.95); C660(0.90)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C1270(1.00); C1534(1.00); C494(1.05); C781(0.86)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C1270(0.88); C1534(1.30); C494(1.29); C781(0.95)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C1270(0.77); C1534(0.95); C494(1.02); C781(0.95)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C1270(0.83); C1534(0.99); C494(1.19); C781(1.03)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C1270(0.90); C1534(1.10); C494(1.42); C781(0.95)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C1270(0.85); C1534(1.00); C494(1.16); C781(0.98)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C1270(0.93); C1534(0.87); C494(1.22); C781(1.01)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C1270(0.94); C1534(1.12); C494(1.32); C781(0.91)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C1270(0.85); C1534(0.88); C494(1.09); C781(1.04)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C1270(0.82); C1534(0.80); C494(0.99); C781(1.00)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C1270(0.89); C1534(0.88); C494(1.24); C781(1.04)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C1270(0.87); C1534(0.90); C494(1.32); C781(1.24)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C1270(0.84); C1534(0.99); C494(1.30); C781(1.03)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C1270(0.91); C1534(1.04); C494(1.34); C781(1.06)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C1270(0.86); C1534(1.03); C494(1.31); C781(1.10)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C1270(1.01); C1534(1.13); C45(1.01); C494(0.84)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C1270(0.93); C1534(1.02); C45(0.91); C494(0.88)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C1270(0.95); C1534(1.06); C45(0.97); C494(0.79)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C1270(1.07); C1534(0.98); C45(0.91); C494(0.84)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C1270(0.98); C1534(0.90); C494(1.01); C781(1.02)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C1270(0.96); C1534(1.08); C45(0.96); C494(0.78)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C1270(1.04); C1534(1.00); C45(0.84); C494(0.74)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C1270(0.97); C1534(0.92); C45(0.92); C494(0.72)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C1270(0.91); C1534(0.96); C45(1.10); C494(0.78)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C1270(0.97); C1534(0.98); C45(1.02); C494(0.90)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C1270(1.02); C1534(1.15); C45(1.02); C494(0.74)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C1270(0.89); C1534(1.07); C45(0.99); C494(0.88)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C1270(0.89); C1534(0.91); C45(1.03); C494(0.81)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C1270(0.92); C1534(1.07); C45(0.97); C494(0.80)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C1270(0.94); C1534(0.98); C45(0.97); C494(0.82)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C1270(0.82); C1534(0.93); C494(0.98); C781(1.28)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C1270(0.90); C1534(0.97); C45(1.01); C494(1.07)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C1270(0.91); C1534(1.22); C494(1.04); C660(0.95)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C1270(1.00); C1534(1.12); C494(1.02); C660(0.73)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C1270(1.03); C1534(1.15); C494(1.16); C660(0.75)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C1270(0.87); C1534(1.44); C494(1.27); C660(0.61)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C1270(1.02); C1534(1.15); C494(1.14); C660(0.89)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C1270(1.02); C1534(1.08); C494(1.36); C660(0.61)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C1270(0.91); C1534(1.03); C494(1.27); C660(0.68)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C1270(0.78); C1534(1.09); C494(1.15); C660(0.71)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C1270(0.81); C1534(1.36); C494(1.12); C660(1.53)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C1270(0.96); C1534(1.11); C494(1.31); C781(1.22)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C1270(0.87); C1534(1.37); C494(1.09); C660(0.80)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C1270(0.87); C1534(1.10); C494(1.11); C660(0.63)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C1270(0.89); C1534(1.26); C494(1.00); C660(1.04)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C1270(0.87); C1534(1.13); C494(1.17); C660(0.99)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C1270(0.91); C1534(1.00); C494(1.07); C660(0.80)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C1270(0.86); C1534(1.04); C494(0.93); C660(1.25)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C1270(0.92); C1534(0.89); C494(0.90); C660(1.06)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C1270(0.93); C1534(1.02); C494(1.08); C660(0.66)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C1270(0.93); C1534(0.82); C494(1.00); C660(0.76)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C1270(0.84); C1534(0.85); C494(1.09); C781(1.24)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C1270(0.86); C1534(0.92); C494(1.00); C660(1.53)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C1270(0.96); C1534(1.01); C494(1.03); C660(1.00)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C1270(1.06); C1534(0.96); C494(1.08); C660(0.71)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C1270(0.99); C1534(0.90); C494(1.11); C660(0.65)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C1270(0.86); C1534(0.94); C494(1.25); C660(0.52)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C1270(0.98); C1534(1.01); C494(1.09); C660(0.69)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C1270(1.06); C1534(0.99); C494(1.07); C660(1.87)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C1270(1.02); C1534(0.96); C494(1.01); C660(0.63)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C1270(1.02); C1534(1.05); C494(1.05); C660(0.48)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C1270(0.99); C1534(1.01); C494(1.27); C660(0.52)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C1270(0.89); C1534(1.09); C494(1.06); C781(1.25)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C1270(0.87); C1534(0.83); C494(0.88); C660(0.98)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C1270(1.04); C1534(0.99); C494(1.17); C660(0.68)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C1270(0.98); C1534(0.88); C494(1.12); C660(0.81)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C1270(1.25); C1534(0.86); C494(1.01); C660(0.82)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C1270(1.13); C1534(0.87); C494(0.96); C660(0.84)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C1270(1.09); C1534(0.89); C494(1.15); C660(0.87)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C1270(1.02); C1534(0.90); C494(1.07); C660(0.87)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C1270(0.91); C1534(0.98); C494(1.27); C660(0.82)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C1270(1.11); C1534(1.05); C494(1.17); C660(0.72)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C1270(1.26); C1534(1.01); C494(1.33); C660(0.73)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C1534(0.99); C45(1.10); C781(0.98); C1270(0.96)  LDD1698  [39]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C781(1.40); C494(1.03); C1534(0.74)  LDD1702  [38]
 LDCM0625  F8 Ramos C1534(1.01)  LDD2187  [40]
 LDCM0572  Fragment10 MDA-MB-231 C781(3.56)  LDD1389  [41]
 LDCM0573  Fragment11 MDA-MB-231 C781(20.00)  LDD1391  [41]
 LDCM0574  Fragment12 Ramos C1534(0.52); C781(0.41); C494(0.42)  LDD2191  [40]
 LDCM0575  Fragment13 MDA-MB-231 C781(1.45)  LDD1395  [41]
 LDCM0576  Fragment14 MDA-MB-231 C781(2.44)  LDD1397  [41]
 LDCM0577  Fragment15 MDA-MB-231 C781(1.08)  LDD1399  [41]
 LDCM0579  Fragment20 Ramos C781(2.28)  LDD1403  [41]
 LDCM0580  Fragment21 MDA-MB-231 C781(1.36)  LDD1404  [41]
 LDCM0581  Fragment22 MDA-MB-231 C781(1.48)  LDD1406  [41]
 LDCM0582  Fragment23 MDA-MB-231 C781(2.04)  LDD1408  [41]
 LDCM0583  Fragment24 Ramos C781(0.32)  LDD1410  [41]
 LDCM0584  Fragment25 MDA-MB-231 C781(1.12)  LDD1411  [41]
 LDCM0578  Fragment27 MDA-MB-231 C781(1.09)  LDD1401  [41]
 LDCM0586  Fragment28 MDA-MB-231 C781(0.90)  LDD1415  [41]
 LDCM0587  Fragment29 MDA-MB-231 C781(1.53)  LDD1417  [41]
 LDCM0588  Fragment30 MDA-MB-231 C781(1.05)  LDD1419  [41]
 LDCM0589  Fragment31 MDA-MB-231 C781(1.94)  LDD1421  [41]
 LDCM0590  Fragment32 MDA-MB-231 C781(4.19)  LDD1423  [41]
 LDCM0468  Fragment33 HCT 116 C1270(0.84); C1534(1.22); C494(1.12); C660(0.71)  LDD0785  [16]
 LDCM0596  Fragment38 MDA-MB-231 C781(1.03)  LDD1433  [41]
 LDCM0566  Fragment4 MDA-MB-231 C781(3.12)  LDD1378  [41]
 LDCM0598  Fragment40 Ramos C781(1.02)  LDD1437  [41]
 LDCM0599  Fragment41 MDA-MB-231 C781(1.53)  LDD1438  [41]
 LDCM0601  Fragment43 MDA-MB-231 C781(5.02)  LDD1441  [41]
 LDCM0604  Fragment46 MDA-MB-231 C781(1.24)  LDD1445  [41]
 LDCM0605  Fragment47 MDA-MB-231 C781(1.37)  LDD1446  [41]
 LDCM0606  Fragment48 MDA-MB-231 C781(1.16)  LDD1447  [41]
 LDCM0607  Fragment49 MDA-MB-231 C781(20.00)  LDD1448  [41]
 LDCM0608  Fragment50 MDA-MB-231 C781(2.66)  LDD1449  [41]
 LDCM0427  Fragment51 HCT 116 C1270(0.78); C1534(0.68); C494(1.38); C781(1.35)  LDD0744  [16]
 LDCM0610  Fragment52 MDA-MB-231 C781(1.17)  LDD1452  [41]
 LDCM0611  Fragment53 MDA-MB-231 C781(0.98)  LDD1454  [41]
 LDCM0612  Fragment54 MDA-MB-231 C781(1.05)  LDD1456  [41]
 LDCM0614  Fragment56 MDA-MB-231 C781(1.08)  LDD1458  [41]
 LDCM0569  Fragment7 MDA-MB-231 C781(2.95)  LDD1383  [41]
 LDCM0570  Fragment8 MDA-MB-231 C781(13.23)  LDD1385  [41]
 LDCM0571  Fragment9 MDA-MB-231 C781(2.21)  LDD1387  [41]
 LDCM0116  HHS-0101 DM93 Y695(0.49); Y1526(0.54); Y697(0.69); Y1478(0.73)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y1192(0.70); Y695(0.70); Y172(0.72); Y1193(0.74)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y695(0.71); Y1478(0.78); Y1193(0.79); Y172(0.80)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y1192(0.67); Y1193(0.70); Y654(0.75); Y695(0.77)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y695(0.48); Y697(0.73); Y1478(0.81); Y1193(0.82)  LDD0268  [14]
 LDCM0107  IAA HeLa H1124(0.00); H874(0.00); H933(0.00); H16(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y1193(1.00); Y172(1.47); Y654(1.18); Y977(1.04)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y1193(0.81); Y172(0.41); Y385(0.07); Y654(0.78)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y1193(0.85); Y172(1.02); Y385(0.05); Y654(0.65)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y1193(4.52); Y172(4.11); Y654(11.57); Y977(3.25)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y1193(3.91); Y172(2.06); Y654(3.27); Y977(1.52)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y1193(1.54); Y172(1.48); Y977(1.06)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y1193(0.61); Y172(0.39); Y385(0.05); Y654(0.51)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y1193(1.03); Y172(1.10); Y385(0.05); Y977(1.09)  LDD0292  [13]
 LDCM0179  JZ128 PC-3 C660(0.00); C45(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C781(5.27); C1534(1.17); C494(1.41)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C781(2.43); C1534(1.23); C494(1.38)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C781(2.97); C1534(1.33); C494(1.30)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C45(0.78)  LDD2102  [38]
 LDCM0109  NEM HeLa H1124(0.00); H578(0.00); H933(0.00); H16(0.00)  LDD0223  [31]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C494(1.01); C45(1.35)  LDD2090  [38]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C494(1.02); C45(1.17)  LDD2092  [38]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C494(1.09)  LDD2093  [38]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C494(0.94); C45(1.45)  LDD2094  [38]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C45(0.91)  LDD2096  [38]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1534(1.30); C494(0.99)  LDD2097  [38]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1534(0.71); C494(0.77); C45(0.86)  LDD2098  [38]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1534(1.18); C1270(1.32)  LDD2099  [38]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C494(0.49); C45(1.34)  LDD2100  [38]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1534(0.94)  LDD2101  [38]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C494(0.57); C45(0.83)  LDD2104  [38]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C494(1.27); C45(0.61)  LDD2105  [38]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C45(1.03); C1270(0.82)  LDD2106  [38]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1534(0.74); C494(1.15); C1270(1.33)  LDD2107  [38]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1534(0.74); C494(0.50); C45(0.96)  LDD2108  [38]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1534(0.96); C781(0.74); C1270(0.93)  LDD2109  [38]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C494(0.60); C45(1.75)  LDD2110  [38]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1534(1.41); C494(1.02)  LDD2111  [38]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C494(0.48); C45(0.93); C1270(0.75)  LDD2114  [38]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C494(0.51)  LDD2115  [38]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1534(1.57)  LDD2119  [38]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C781(1.06)  LDD2120  [38]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1534(2.55)  LDD2123  [38]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1534(1.10); C781(0.87); C45(1.50); C1270(1.09)  LDD2125  [38]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1534(1.22); C494(1.17)  LDD2127  [38]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C494(1.37)  LDD2129  [38]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C494(0.54)  LDD2134  [38]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C494(1.00); C781(0.69)  LDD2135  [38]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1534(1.73); C494(1.04); C45(1.48); C1270(1.58)  LDD2136  [38]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C494(0.92); C781(1.05); C1270(1.03)  LDD2137  [38]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C494(0.97); C1270(0.83)  LDD2140  [38]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C494(0.76); C45(1.07)  LDD2141  [38]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C781(1.08)  LDD2143  [38]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C494(2.19)  LDD2144  [38]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1534(0.35)  LDD2148  [38]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C781(0.67)  LDD2150  [38]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C494(1.57); C45(1.05)  LDD2153  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C781(1.04)  LDD2207  [42]
 LDCM0131  RA190 MM1.R C494(1.22); C781(1.12)  LDD0304  [43]
 LDCM0021  THZ1 HCT 116 C781(0.97)  LDD2173  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2-5A-dependent ribonuclease (RNASEL) Protein kinase superfamily Q05823
Serine/threonine-protein kinase B-raf (BRAF) TKL Ser/Thr protein kinase family P15056
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Cell division control protein 42 homolog (CDC42) Rho family P60953
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Podocin (NPHS2) Band 7/mec-2 family Q9NP85
Podocalyxin (PODXL) Podocalyxin family O00592
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
CD2-associated protein (CD2AP) . Q9Y5K6
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Transcription factor LBX1 (LBX1) . P52954
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C chemokine receptor type 2 (CXCR2) G-protein coupled receptor 1 family P25025
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nephrin (NPHS1) Immunoglobulin superfamily O60500
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-4 (ACTN4) Alpha-actinin family O43707
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Interleukin enhancer-binding factor 2 (ILF2) . Q12905
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) . Q96QZ7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039908 , PXD029761
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