Details of the Target

General Information of Target

Target ID LDTP09580
Target Name Programmed cell death 6-interacting protein (PDCD6IP)
Gene Name PDCD6IP
Gene ID 10015
Synonyms
AIP1; ALIX; KIAA1375; Programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDK
HEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEK
SCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDIS
PDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKE
VFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDF
SDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVP
VSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTK
SRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTP
SNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPA
KTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALS
VTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAY
DNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAP
SIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAG
TAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQS
PGQAPYPGPQQPSYPFPQPPQQSYYPQQ
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP. By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier.; (Microbial infection) Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function requires the interaction with CHMP4B. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as enveloped virus budding (HIV-1 and other lentiviruses).
Uniprot ID
Q8WUM4
Ensemble ID
ENST00000307296.8
HGNC ID
HGNC:8766

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK SNV: p.Q154Ter DBIA    Probe Info 
DU145 SNV: p.D572N DBIA    Probe Info 
HT115 SNV: p.N822T DBIA    Probe Info 
HT1197 SNV: p.S554T DBIA    Probe Info 
HUH1 SNV: p.T12P DBIA    Probe Info 
NCIH1703 SNV: p.G185W DBIA    Probe Info 
NCIH2172 SNV: p.D328Y DBIA    Probe Info 
UACC257 SNV: p.T12P DBIA    Probe Info 
VMRCRCW SNV: p.A732V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [2]
A-EBA
 Probe Info  		3.45  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y29(20.00); Y39(20.00); Y223(9.01)  LDD0260  [5]
TH216
 Probe Info  		Y223(20.00); Y233(12.28); Y258(5.23)  LDD0259  [5]
ONAyne
 Probe Info  		K374(0.00); K48(0.00)  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K486(0.78); K640(0.89); K313(2.29); K303(2.47)  LDD3494  [7]
Probe 1
 Probe Info  		Y29(9.02); Y39(11.35); Y223(27.22); Y291(26.22)  LDD3495  [8]
AHL-Pu-1
 Probe Info  		C524(2.00)  LDD0170  [9]
DBIA
 Probe Info  		C90(5.86)  LDD0209  [10]
HHS-475
 Probe Info  		Y291(0.31); Y233(0.89); Y727(1.23)  LDD0264  [11]
HHS-465
 Probe Info  		Y233(9.83)  LDD2237  [12]
5E-2FA
 Probe Info  		H735(0.00); H320(0.00); H633(0.00); H61(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K11(0.00); K334(0.00); K339(0.00); K285(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C691(0.00); C524(0.00); C512(0.00); C40(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C40(0.00); C76(0.00); C250(0.00); C524(0.00)  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C691(0.00); C524(0.00); C40(0.00); C250(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		K671(0.00); K339(0.00)  LDD0035  [18]
BTD
 Probe Info  		N.A.  LDD0004  [19]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		C40(0.00); C512(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C40(0.00); C76(0.00); C691(0.00)  LDD0027  [20]
WYneN
 Probe Info  		C76(0.00); C512(0.00); C40(0.00)  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
1d-yne
 Probe Info  		K357(0.00); K23(0.00)  LDD0356  [22]
Compound 10
 Probe Info  		C40(0.00); C691(0.00)  LDD2216  [23]
IPM
 Probe Info  		C512(0.00); C250(0.00)  LDD0005  [19]
NHS
 Probe Info  		K313(0.00); K101(0.00); K285(0.00); K501(0.00)  LDD0010  [19]
NPM
 Probe Info  		N.A.  LDD0016  [19]
PF-06672131
 Probe Info  		C40(0.00); C76(0.00)  LDD0017  [24]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
Phosphinate-6
 Probe Info  		C40(0.00); C250(0.00)  LDD0018  [25]
1c-yne
 Probe Info  		K229(0.00); K707(0.00); K23(0.00); K19(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C524(0.00); H735(0.00); C76(0.00); H633(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		C76(0.00); C512(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C76(0.00); C512(0.00)  LDD0218  [26]
W1
 Probe Info  		C40(0.00); C76(0.00)  LDD0236  [27]
AOyne
 Probe Info  		8.60  LDD0443  [28]
NAIA_5
 Probe Info  		C512(0.00); C691(0.00); C524(0.00); C40(0.00)  LDD2223  [21]
HHS-482
 Probe Info  		Y727(1.44)  LDD2239  [12]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.00  LDD0471  [29]
FFF probe13
 Probe Info  		14.66  LDD0475  [29]
FFF probe14
 Probe Info  		13.18  LDD0477  [29]
FFF probe2
 Probe Info  		7.35  LDD0463  [29]
FFF probe3
 Probe Info  		12.27  LDD0464  [29]
FFF probe4
 Probe Info  		6.41  LDD0466  [29]
JN0003
 Probe Info  		12.43  LDD0469  [29]
STS-1
 Probe Info  		N.A.  LDD0136  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]
OEA-DA
 Probe Info  		4.47  LDD0046  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C40(0.76); C512(0.90)  LDD2142  [34]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C512(0.95)  LDD2112  [34]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C40(0.94)  LDD2130  [34]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C40(1.12); C512(1.36); C524(1.28); C691(1.04)  LDD2117  [34]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C512(1.48)  LDD2152  [34]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C512(0.98)  LDD2103  [34]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C40(0.56); C512(0.54); C231(0.66)  LDD2132  [34]
 LDCM0025  4SU-RNA DM93 C524(2.00)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA DM93 C90(3.13)  LDD0171  [9]
 LDCM0214  AC1 HEK-293T C250(1.07); C691(1.05); C40(1.25); C76(1.04)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C250(0.98); C691(1.08); C40(0.96); C76(1.02)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C250(0.95); C691(1.05); C40(0.99); C76(0.96)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C250(0.94); C40(1.01); C76(0.93); C524(0.89)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C250(1.06); C40(0.98); C76(0.88); C524(0.84)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C250(0.96); C691(1.13); C40(1.16); C76(0.97)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C250(1.02); C691(1.07); C40(1.06); C76(1.07)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C250(0.92); C691(1.00); C40(1.17); C76(1.06)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C250(0.81); C691(0.86); C40(0.87); C76(0.92)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C250(0.99); C691(1.04); C40(1.08); C76(1.07)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C250(1.00); C40(1.20); C76(1.00); C524(0.94)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C250(1.01); C691(1.02); C40(0.86); C76(1.03)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C250(1.06); C40(1.15); C76(1.02); C524(0.91)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C250(0.96); C691(1.08); C40(1.03); C76(1.04)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C250(0.99); C40(0.90); C76(1.16); C524(0.85)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C250(1.02); C691(1.05); C40(1.24); C76(1.07)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C250(0.98); C691(1.02); C40(1.13); C76(1.06)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C250(0.98); C691(0.99); C40(0.88); C76(0.98)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C250(0.96); C40(1.08); C76(1.00); C524(0.91)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C250(0.95); C691(1.09); C40(1.09); C76(1.04)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C250(1.01); C691(0.87); C40(0.83); C76(1.05)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C250(1.02); C40(1.20); C76(1.08); C524(0.89)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C250(0.99); C691(1.02); C40(1.01); C76(0.99)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C250(1.04); C40(1.03); C76(0.96); C524(0.86)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C250(1.03); C691(1.10); C40(0.96); C76(1.08)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C250(0.95); C691(1.03); C40(1.13); C76(1.05)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C250(1.02); C691(0.99); C40(0.87); C76(0.97)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C250(0.92); C40(1.08); C76(0.99); C524(0.96)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C250(1.01); C691(1.13); C40(1.19); C76(1.03)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C250(1.07); C40(1.12); C76(0.95); C524(0.81)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C250(0.98); C691(1.16); C40(1.10); C76(0.99)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C250(0.98); C40(1.02); C76(1.01); C524(0.95)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C250(1.04); C40(0.98); C76(0.87); C524(0.91)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C250(1.02); C691(1.21); C40(1.03); C76(1.10)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C250(0.94); C691(1.10); C40(1.08); C76(0.99)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C250(0.99); C691(1.04); C40(0.90); C76(0.97)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C250(0.86); C40(1.03); C76(1.02); C524(0.93)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C250(0.99); C691(1.02); C40(0.95); C76(1.01)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C250(1.11); C40(1.04); C76(0.99); C524(0.84)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C250(1.01); C691(1.11); C40(1.15); C76(1.05)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C250(1.03); C40(0.92); C76(0.94); C524(0.89)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C250(0.99); C691(1.19); C40(1.09); C76(1.09)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C250(0.97); C691(1.02); C40(0.89); C76(1.03)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C250(0.92); C691(1.06); C40(1.09); C76(1.05)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C250(0.98); C691(1.08); C40(0.87); C76(1.02)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C250(0.92); C40(1.00); C76(1.03); C524(0.95)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C250(0.96); C691(1.08); C40(0.94); C76(1.02)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C250(1.01); C40(1.15); C76(0.98); C524(0.89)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C250(0.99); C691(1.18); C40(1.12); C76(0.99)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C250(1.03); C40(1.02); C76(0.92); C524(0.90)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C250(0.94); C691(1.03); C40(1.40); C76(1.16)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C250(0.87); C691(1.05); C40(1.38); C76(1.04)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C250(0.93); C691(0.93); C40(0.88); C76(1.02)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C250(1.00); C40(0.97); C76(0.86); C524(0.91)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C250(0.90); C40(1.18); C76(0.95); C524(0.90)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C250(0.90); C691(1.05); C40(0.97); C76(1.03)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C250(0.96); C40(1.02); C76(0.95); C524(1.03)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C250(0.91); C691(1.03); C40(1.04); C76(1.03)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C250(1.04); C40(1.03); C76(0.91); C524(1.03)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C250(1.00); C691(1.14); C40(1.11); C76(1.04)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C250(1.01); C40(0.94); C76(1.00); C524(0.91)  LDD1569  [35]
 LDCM0545  Acetamide MDA-MB-231 C512(0.41); C231(0.99)  LDD2138  [34]
 LDCM0520  AKOS000195272 MDA-MB-231 C512(0.88)  LDD2113  [34]
 LDCM0248  AKOS034007472 HEK-293T C250(1.03); C691(1.14); C40(1.02); C76(1.03)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C250(1.01); C691(1.05); C40(1.01); C76(1.33)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C250(1.06); C40(0.92); C76(1.00); C524(0.83)  LDD1514  [35]
 LDCM0156  Aniline NCI-H1299 11.59  LDD0403  [2]
 LDCM0498  BS-3668 MDA-MB-231 C512(0.62); C231(0.87)  LDD2091  [34]
 LDCM0108  Chloroacetamide HeLa C524(0.00); C76(0.00); C512(0.00); H633(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C524(20.00); C231(2.73); C512(2.38); C512(1.59)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C250(0.95); C691(1.20); C40(1.36); C76(0.89)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C250(1.68); C40(1.05); C76(0.88); C524(0.69)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C250(1.01); C691(1.02); C40(1.04); C76(1.01)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C250(0.99); C691(1.01); C40(1.53); C76(0.91)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C250(1.01); C691(1.04); C40(1.06); C76(0.94)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C250(0.99); C691(1.03); C40(0.89); C76(0.99)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C250(0.97); C691(1.11); C40(1.10); C76(1.06)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C250(0.99); C691(1.02); C40(1.18); C76(0.96)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C250(0.96); C691(1.05); C40(1.09); C76(1.04)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C250(1.02); C691(0.86); C40(0.97); C76(1.06)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C250(1.10); C691(1.25); C40(0.99); C76(1.02)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C250(0.94); C691(1.14); C40(1.04); C76(0.92)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C250(1.48); C691(1.09); C40(1.17); C76(1.04)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C250(0.99); C691(1.09); C40(0.99); C76(0.93)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C250(0.93); C691(0.92); C40(0.84); C76(0.93)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C250(0.97); C691(1.18); C40(1.00); C76(1.02)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C250(0.98); C691(1.07); C40(0.95); C76(0.89)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C250(0.96); C691(1.05); C40(1.10); C76(0.96)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C250(1.40); C691(1.05); C40(0.86); C76(1.03)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C250(1.05); C691(1.07); C40(0.98); C76(1.05)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C250(0.92); C691(1.14); C40(1.07); C76(0.88)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C250(0.97); C691(1.11); C40(1.25); C76(0.98)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C250(1.00); C691(0.97); C40(1.03); C76(1.03)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C250(0.90); C40(0.90); C76(1.16); C524(0.69)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C250(0.91); C691(1.11); C40(1.01); C76(1.05)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C250(0.98); C691(1.09); C40(1.21); C76(0.92)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C250(0.93); C691(1.13); C40(1.03); C76(1.03)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C250(1.12); C691(1.10); C40(0.91); C76(1.00)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C250(0.84); C691(1.31); C40(1.01); C76(1.03)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C250(0.80); C691(0.97); C40(0.98); C76(1.00)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C250(0.85); C691(0.94); C40(1.08); C76(1.08)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C250(0.94); C691(0.97); C40(0.96); C76(1.01)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C250(0.85); C691(1.06); C40(1.15); C76(1.06)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C250(1.49); C691(1.11); C40(0.99); C76(0.91)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C250(1.09); C691(1.12); C40(1.07); C76(1.09)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C250(0.87); C691(1.10); C40(0.80); C76(1.04)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C250(1.22); C691(1.11); C40(1.17); C76(1.10)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C250(0.91); C691(1.16); C40(1.00); C76(1.88)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C250(0.93); C691(1.09); C40(1.01); C76(1.05)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C250(1.07); C691(1.15); C40(0.86); C76(1.03)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C250(1.06); C691(1.19); C40(1.02); C76(1.04)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C250(0.87); C40(0.90); C76(1.05); C524(0.69)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C250(0.96); C691(1.30); C40(1.10); C76(1.43)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C250(1.19); C40(0.95); C76(1.05); C524(0.65)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C250(0.85); C691(1.12); C40(1.24); C76(1.11)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C250(0.92); C40(0.94); C76(1.31); C524(0.70)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C250(2.61); C691(1.23); C40(1.03); C76(0.88)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C250(0.99); C691(1.05); C40(1.00); C76(0.98)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C250(1.04); C691(0.91); C40(0.90); C76(1.03)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C250(1.18); C691(1.05); C40(0.99); C76(0.97)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C250(1.09); C691(1.14); C40(1.08); C76(1.13)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C250(1.18); C691(0.97); C40(0.86); C76(1.11)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C250(0.95); C691(1.10); C40(1.07); C76(1.05)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C250(1.04); C691(1.04); C40(0.82); C76(0.96)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C250(0.93); C40(1.00); C76(1.05); C524(0.68)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C250(0.84); C691(1.35); C40(0.90); C76(1.17)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C250(1.12); C40(1.00); C76(1.01); C524(0.60)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C250(0.82); C691(1.09); C40(1.12); C76(1.01)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C250(0.90); C40(1.00); C76(1.07); C524(0.65)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C250(0.89); C691(0.97); C40(1.12); C76(1.05)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C250(1.17); C691(1.03); C40(0.98); C76(1.02)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C250(0.96); C691(1.01); C40(1.11); C76(1.12)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C250(1.02); C691(1.08); C40(1.12); C76(1.07)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C250(1.00); C691(1.04); C40(1.36); C76(1.80)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C250(0.92); C691(1.11); C40(1.39); C76(1.14)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C250(0.97); C691(1.00); C40(0.91); C76(1.04)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C250(0.96); C40(1.16); C76(0.98); C524(0.68)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C250(1.08); C691(1.10); C40(0.87); C76(1.23)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C250(1.20); C40(1.16); C76(0.94); C524(0.65)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C250(0.95); C691(1.14); C40(1.08); C76(1.00)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C250(1.45); C40(0.95); C76(1.07); C524(0.65)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C250(0.99); C691(1.27); C40(1.07); C76(0.98)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C250(1.00); C691(1.07); C40(0.98); C76(1.17)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C250(0.97); C691(1.13); C40(0.96); C76(1.02)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C250(1.09); C691(1.11); C40(1.17); C76(1.04)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C250(0.95); C691(1.15); C40(1.10); C76(2.06)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C250(0.98); C691(1.15); C40(1.01); C76(1.08)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C250(0.93); C691(1.07); C40(0.89); C76(1.04)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C250(0.96); C40(1.22); C76(1.01); C524(0.71)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C250(0.91); C691(1.23); C40(0.97); C76(1.21)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C250(0.92); C40(1.01); C76(1.08); C524(0.59)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C250(0.85); C691(1.24); C40(1.20); C76(1.02)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C250(0.89); C691(0.99); C40(1.13); C76(1.44)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C250(0.91); C40(0.98); C76(1.20); C524(0.67)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C250(0.84); C691(1.01); C40(1.06); C76(1.01)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C250(1.14); C691(1.04); C40(0.95); C76(1.05)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C250(0.97); C691(0.89); C40(1.17); C76(1.00)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C250(0.94); C691(1.07); C40(1.22); C76(0.95)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C250(1.03); C691(1.12); C40(1.51); C76(1.10)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C250(1.12); C691(1.17); C40(1.19); C76(1.15)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C250(1.01); C691(1.13); C40(0.89); C76(1.00)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C250(1.02); C40(1.23); C76(1.06); C524(0.74)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C250(1.09); C691(1.11); C40(0.98); C76(1.20)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C250(0.96); C691(1.10); C40(0.93); C76(1.03)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C250(1.09); C40(0.99); C76(1.05); C524(0.62)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C250(0.83); C691(1.19); C40(1.11); C76(1.01)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C250(0.91); C40(1.02); C76(1.12); C524(0.64)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C250(0.92); C691(1.09); C40(0.92); C76(0.97)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C250(0.95); C691(1.00); C40(1.07); C76(1.02)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C250(1.01); C691(1.13); C40(1.06); C76(1.06)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C250(0.96); C691(1.14); C40(1.35); C76(1.66)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C250(0.97); C691(1.10); C40(1.14); C76(1.02)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C250(1.10); C691(1.17); C40(0.95); C76(1.07)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C250(0.58); C40(1.03); C76(0.91); C524(0.68)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C250(0.93); C40(1.08); C76(1.01); C524(0.77)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C250(1.01); C691(1.07); C40(0.95); C76(1.18)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C250(1.14); C40(1.00); C76(1.06); C524(0.68)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C250(0.93); C691(1.10); C40(1.06); C76(1.02)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C250(0.88); C40(0.91); C76(0.98); C524(0.68)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C250(0.82); C691(1.13); C40(1.23); C76(0.94)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C250(0.74); C691(0.94); C40(1.16); C76(1.04)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C250(1.31); C691(0.93); C40(1.02); C76(0.98)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C250(0.80); C691(1.04); C40(1.09); C76(1.11)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C250(0.89); C691(1.03); C40(1.72); C76(1.12)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C250(1.25); C691(1.28); C40(1.11); C76(1.23)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C250(0.76); C691(1.23); C40(1.05); C76(1.12)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C250(0.86); C691(1.17); C40(0.93); C76(1.06)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C250(1.01); C40(1.30); C76(0.93); C524(0.77)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C250(1.30); C691(1.19); C40(0.80); C76(1.09)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C250(1.22); C40(1.18); C76(1.02); C524(0.74)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C250(0.74); C691(1.28); C40(1.06); C76(0.86)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C250(0.79); C40(0.91); C76(1.00); C524(0.86)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C250(0.99); C691(1.06); C40(1.16); C76(0.90)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C250(1.11); C691(1.02); C40(0.98); C76(1.03)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C250(1.02); C691(0.99); C40(0.90); C76(0.97)  LDD1697  [35]
 LDCM0634  CY-0357 Hep-G2 C40(0.97); C76(0.89)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C250(0.99); C691(1.11); C40(0.88); C76(1.00)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C40(2.86); C512(1.31); C691(0.65)  LDD1702  [34]
 LDCM0204  EV-97 T cell C90(11.08)  LDD0525  [36]
 LDCM0625  F8 Ramos C76(0.91); C512(2.10); C231(1.35); C250(3.19)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C76(0.67); C512(1.59); C231(0.84); C40(0.15)  LDD2189  [37]
 LDCM0573  Fragment11 MDA-MB-231 C250(1.37)  LDD1391  [38]
 LDCM0574  Fragment12 Ramos C250(1.64)  LDD1394  [38]
 LDCM0575  Fragment13 Ramos C250(1.55)  LDD1396  [38]
 LDCM0576  Fragment14 MDA-MB-231 C250(1.25)  LDD1397  [38]
 LDCM0577  Fragment15 MDA-MB-231 C250(1.29)  LDD1399  [38]
 LDCM0579  Fragment20 MDA-MB-231 C250(1.42)  LDD1402  [38]
 LDCM0580  Fragment21 Ramos C76(0.72); C512(1.07); C231(0.85); C40(0.76)  LDD2195  [37]
 LDCM0581  Fragment22 Ramos C250(0.97)  LDD1407  [38]
 LDCM0582  Fragment23 MDA-MB-231 C250(0.42)  LDD1408  [38]
 LDCM0583  Fragment24 Ramos C250(6.03)  LDD1410  [38]
 LDCM0584  Fragment25 MDA-MB-231 C250(0.82)  LDD1411  [38]
 LDCM0585  Fragment26 Ramos C250(0.90)  LDD1412  [38]
 LDCM0578  Fragment27 MDA-MB-231 C250(1.03)  LDD1401  [38]
 LDCM0586  Fragment28 Ramos C250(1.26)  LDD1416  [38]
 LDCM0587  Fragment29 MDA-MB-231 C250(0.94)  LDD1417  [38]
 LDCM0588  Fragment30 MDA-MB-231 C250(1.37)  LDD1419  [38]
 LDCM0589  Fragment31 MDA-MB-231 C250(1.11)  LDD1421  [38]
 LDCM0590  Fragment32 MDA-MB-231 C250(20.00)  LDD1423  [38]
 LDCM0468  Fragment33 HEK-293T C250(1.05); C691(0.92); C40(0.94); C76(0.99)  LDD1671  [35]
 LDCM0592  Fragment34 MDA-MB-231 C250(1.19)  LDD1427  [38]
 LDCM0596  Fragment38 MDA-MB-231 C250(1.03)  LDD1433  [38]
 LDCM0566  Fragment4 MDA-MB-231 C250(0.88)  LDD1378  [38]
 LDCM0599  Fragment41 MDA-MB-231 C250(1.29)  LDD1438  [38]
 LDCM0600  Fragment42 Ramos C250(1.01)  LDD1440  [38]
 LDCM0601  Fragment43 MDA-MB-231 C250(20.00)  LDD1441  [38]
 LDCM0604  Fragment46 MDA-MB-231 C250(0.80)  LDD1445  [38]
 LDCM0605  Fragment47 MDA-MB-231 C250(1.08)  LDD1446  [38]
 LDCM0608  Fragment50 MDA-MB-231 C250(0.96)  LDD1449  [38]
 LDCM0427  Fragment51 HEK-293T C250(1.08); C691(1.00); C40(1.20); C76(1.00)  LDD1631  [35]
 LDCM0610  Fragment52 MDA-MB-231 C250(0.93)  LDD1452  [38]
 LDCM0611  Fragment53 Ramos C250(1.17)  LDD1455  [38]
 LDCM0614  Fragment56 MDA-MB-231 C250(0.80)  LDD1458  [38]
 LDCM0568  Fragment6 MDA-MB-231 C250(0.96)  LDD1382  [38]
 LDCM0569  Fragment7 MDA-MB-231 C250(0.94)  LDD1383  [38]
 LDCM0570  Fragment8 MDA-MB-231 C250(1.58)  LDD1385  [38]
 LDCM0571  Fragment9 MDA-MB-231 C250(1.07)  LDD1387  [38]
 LDCM0116  HHS-0101 DM93 Y291(0.31); Y233(0.89); Y727(1.23)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y291(0.50); Y233(0.86); Y727(2.05)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y233(0.81); Y291(1.13); Y727(3.31)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y291(0.52); Y233(0.98); Y727(1.04)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y291(0.77); Y233(0.89); Y727(1.68)  LDD0268  [11]
 LDCM0107  IAA HeLa H249(0.00); H279(0.00); H633(0.00); C76(0.00)  LDD0221  [26]
 LDCM0022  KB02 MDA-MB-231 C250(1.38)  LDD1374  [38]
 LDCM0023  KB03 Jurkat C90(5.86)  LDD0209  [10]
 LDCM0024  KB05 COLO792 C517(2.10); C40(3.50); C76(2.33)  LDD3310  [39]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C512(1.14)  LDD2102  [34]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C512(0.74)  LDD2121  [34]
 LDCM0109  NEM HeLa H735(0.00); H279(0.00); H633(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C512(0.62)  LDD2089  [34]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C512(0.93)  LDD2092  [34]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C512(1.43)  LDD2093  [34]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C512(0.91)  LDD2094  [34]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C512(2.00); C691(0.16)  LDD2096  [34]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C512(1.93)  LDD2097  [34]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C512(0.90)  LDD2098  [34]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C40(1.07); C512(1.23); C691(0.90)  LDD2099  [34]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C512(0.79)  LDD2100  [34]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C512(1.20)  LDD2101  [34]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C512(0.95); C691(0.42)  LDD2104  [34]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C512(1.04)  LDD2105  [34]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C40(0.63)  LDD2106  [34]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C40(1.01); C512(1.00)  LDD2107  [34]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C512(1.03)  LDD2108  [34]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C40(0.94); C512(0.83)  LDD2109  [34]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C512(0.98)  LDD2111  [34]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C512(0.75)  LDD2114  [34]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C512(0.77)  LDD2115  [34]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C691(0.13)  LDD2116  [34]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C512(2.30); C231(0.39); C524(0.53); C691(0.10)  LDD2118  [34]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C512(2.02)  LDD2119  [34]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C512(0.57); C691(0.80)  LDD2120  [34]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C524(0.42); C691(0.06)  LDD2122  [34]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C40(1.02); C512(0.92); C691(1.09)  LDD2123  [34]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C512(2.40); C524(0.42); C691(0.13)  LDD2124  [34]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C40(0.96); C512(1.04)  LDD2125  [34]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C524(0.34); C691(0.07)  LDD2126  [34]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C512(1.17)  LDD2127  [34]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C512(0.55)  LDD2128  [34]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C40(1.08); C512(1.02)  LDD2129  [34]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C512(0.80)  LDD2133  [34]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C512(0.96)  LDD2134  [34]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C40(0.96); C512(1.12)  LDD2135  [34]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C40(1.25); C512(1.39)  LDD2136  [34]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C40(1.03); C512(0.98); C524(0.94)  LDD2137  [34]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C512(2.38)  LDD1700  [34]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C40(0.78); C512(1.20)  LDD2140  [34]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C512(0.88)  LDD2141  [34]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C512(0.75)  LDD2143  [34]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C512(2.48)  LDD2144  [34]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C512(8.80)  LDD2145  [34]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C40(0.85); C512(1.21)  LDD2146  [34]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C512(1.14)  LDD2147  [34]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C512(0.75)  LDD2148  [34]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C691(0.05)  LDD2149  [34]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C512(0.84)  LDD2150  [34]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C231(1.63); C691(0.06)  LDD2151  [34]
 LDCM0627  NUDT7-COV-1 HEK-293T C250(0.64); C90(0.43)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C90(0.42); C250(0.32)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C40(1.35); C122(0.71); C127(0.71)  LDD0304  [41]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CD2-associated protein (CD2AP) . Q9Y5K6
Galectin-3 (LGALS3) . P17931
Programmed cell death protein 6 (PDCD6) . O75340
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Charged multivesicular body protein 4a (CHMP4A) SNF7 family Q9BY43
Charged multivesicular body protein 4b (CHMP4B) SNF7 family Q9H444
Charged multivesicular body protein 4c (CHMP4C) SNF7 family Q96CF2
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4

References

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Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
34 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
39 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.