Details of the Target

General Information of Target

Target ID LDTP11340
Target Name Cyclin-dependent kinase 19 (CDK19)
Gene Name CDK19
Gene ID 23097
Synonyms
CDC2L6; CDK11; KIAA1028; Cyclin-dependent kinase 19; EC 2.7.11.22; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGRAEAGEAEEEAGAGSGSEAEEDALWERIEGVRHRLARALNPAKLTPYLRQCRVIDEQ
DEEEVLSTYRFPCRVNRTGRLMDILRCRGKRGYEAFLEALEFYYPEHFTLLTGQEPAQRC
SMILDEEGPEGLTQFLMTEVRRLREARKSQLQREQQLQARGRVLEEERAGLEQRLRDQQQ
AQERCQRLREDWEAGSLELLRLKDENYMIAMRLAQLSEEKNSAVLRSRDLQLAVDQLKLK
VSRLEEECALLRRARGPPPGAEEKEKEKEKEKEPDNVDLVSELRAENQRLTASLRELQEG
LQQEASRPGAPGSERILLDILEHDWREAQDSRQELCQKLHAVQGELQWAEELRDQYLQEM
EDLRLKHRTLQKDCDLYKHRMATVLAQLEEIEKERDQAIQSRDRIQLQYSQSLIEKDQYR
KQVRGLEAERDELLTTLTSLEGTKALLEVQLQRAQGGTCLKACASSHSLCSNLSSTWSLS
EFPSPLGGPEATGEAAVMGGPEPHNSEEATDSEKEINRLSILPFPPSAGSILRRQREEDP
APPKRSFSSMSDITGSVTLKPWSPGLSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAI
RVSGRSPPGGPEPQDKGPDGLSFYGDRWSGAVVRRVLSGPGSARMEPREQRVEAAGLEGA
CLEAEAQQRTLLWNQGSTLPSLMDSKACQSFHEALEAWAKGPGAEPFYIRANLTLPERAD
PHALCVKAQEILRLVDSAYKRRQEWFCTRVDPLTLRDLDRGTVPNYQRAQQLLEVQEKCL
PSSRHRGPRSNLKKRALDQLRLVRPKPVGAPAGDSPDQLLLEPCAEPERSLRPYSLVRPL
LVSALRPVVLLPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEELCPSSAPGAPKAQPA
TPGLGSRIRAIQESVGKKHCLLELGARGVRELVQNEIYPIVIHVEVTEKNVREVRGLLGR
PGWRDSELLRQCRGSEQVLWGLPCSWVQVPAHEWGHAEELAKVVRGRILQEQARLVWVEC
GSSRGCPSSSEA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm
TTD ID
T98034
Uniprot ID
Q9BWU1
DrugMap ID
TTNABU9
Ensemble ID
ENST00000323817.7
HGNC ID
HGNC:19338
ChEMBL ID
CHEMBL6002

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.T287M .
HEC1B SNV: p.T287M .
HT115 SNV: p.L204R .
LNCaP clone FGC SNV: p.T31N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C349(2.56)  LDD1374  [1]
DBIA
 Probe Info  		C64(0.76)  LDD0533  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C349(0.91); C64(1.17)  LDD1507  [6]
 LDCM0215  AC10 PaTu 8988t C64(0.92)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C64(0.76)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C64(0.85)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C64(1.10)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C64(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C64(1.00)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C64(0.94)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C64(0.81)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C64(0.85)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C64(1.04)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C64(1.03)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C64(0.88)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C64(0.80)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C64(0.96)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C64(0.78)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C64(1.24)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C64(1.13)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C64(1.18)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C64(1.19)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C64(0.93)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C64(1.09)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C64(1.13)  LDD0553  [2]
 LDCM0237  AC12 PaTu 8988t C64(0.65)  LDD1116  [2]
 LDCM0238  AC120 HCT 116 C64(1.42)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C64(0.80)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C64(1.37)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C64(0.76)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C64(1.00)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C64(1.39)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C64(1.53)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C64(1.27)  LDD0562  [2]
 LDCM0259  AC14 PaTu 8988t C64(0.98)  LDD1138  [2]
 LDCM0263  AC143 PaTu 8988t C64(0.68)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C64(0.88)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C64(1.46)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C64(1.21)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C64(1.38)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C64(0.95)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C64(0.81)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C64(0.72)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C64(0.70)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C64(1.00)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C64(0.84)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C64(0.89)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C64(1.16)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C64(1.07)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C64(0.99)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C64(1.06)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C64(0.90)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C64(1.24)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C64(1.06)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C349(1.13); C64(1.03); C25(1.02)  LDD1518  [6]
 LDCM0280  AC20 HCT 116 C64(0.95)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C64(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C64(0.93)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C64(1.10)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C64(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C64(1.15)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C64(1.01)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C64(1.05)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C64(1.00)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C64(0.86)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C349(1.03); C64(0.90)  LDD1529  [6]
 LDCM0291  AC30 HCT 116 C64(0.95)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C64(1.02)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C64(0.95)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C64(1.09)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C64(0.90)  LDD0612  [2]
 LDCM0296  AC35 HEK-293T C349(1.00); C64(1.09)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C349(1.05); C64(1.12)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C349(0.95); C64(1.04)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C349(0.97); C64(1.10); C25(1.03)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C349(1.15); C64(0.95); C236(1.18)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C349(1.04); C64(1.03)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C349(1.14); C64(1.08)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C349(0.99); C64(0.96)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C349(1.21); C64(1.05); C25(0.99)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C349(1.11); C64(1.00)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C349(1.02); C64(0.92)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C349(1.05); C64(0.96)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C349(0.91); C64(0.98); C25(1.07)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C349(1.08); C64(1.17); C236(0.99)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C349(1.17); C64(0.98)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C349(0.98); C64(1.03)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C349(1.01); C64(1.34)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C349(1.13); C64(0.96); C25(1.04)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C349(0.93); C64(0.92)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C349(1.10); C64(0.99)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C349(1.01); C64(1.11)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C349(1.04); C64(0.93); C25(0.96)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C349(1.08); C64(1.05); C236(1.00)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C349(1.02); C64(0.93)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C349(0.96); C64(1.04)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C349(1.08); C64(1.15); C25(1.10)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C349(0.97); C64(0.90)  LDD1561  [6]
 LDCM0323  AC6 PaTu 8988t C64(0.80)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C349(1.05); C64(1.03)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C349(1.05); C64(1.16)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C349(1.05); C64(1.11); C25(1.10)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C349(1.13); C64(1.03); C236(1.06)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C349(1.01); C64(1.09)  LDD1567  [6]
 LDCM0334  AC7 PaTu 8988t C64(1.28)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C64(0.94)  LDD1224  [2]
 LDCM0349  AC83 PaTu 8988t C64(1.27)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C64(1.35)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C64(1.21)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C64(1.37)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C64(1.59)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C64(1.44)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C64(1.14)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C64(1.33)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C64(1.03)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C64(1.07)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C64(1.67)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C64(1.14)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C64(1.43)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C64(1.65)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C64(0.87)  LDD1243  [2]
 LDCM0365  AC98 HCT 116 C64(0.89)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C64(0.76)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C64(0.89)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C64(0.86)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C64(0.98)  LDD1154  [2]
 LDCM0367  CL1 HEK-293T C349(0.97); C64(0.95)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C349(1.00); C64(1.06); C25(0.91)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C349(1.02); C64(1.25); C25(1.14)  LDD1573  [6]
 LDCM0370  CL101 PaTu 8988t C64(1.07)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C64(0.86)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C64(0.98)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C64(0.89)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C64(1.11)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C64(1.21)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C64(1.13)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C64(1.06)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C64(0.98)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C349(1.34); C64(0.88); C236(1.48)  LDD1583  [6]
 LDCM0380  CL110 HCT 116 C64(1.19)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C64(0.99)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C64(1.04)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C64(0.85)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C64(0.84)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C64(0.85)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C64(0.98)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C349(0.94); C64(0.96)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C349(0.99); C64(0.99); C25(0.98)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C64(0.90); C25(1.06)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C349(1.15); C64(1.06)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C349(1.00); C64(1.07); C25(1.06)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C349(0.95); C64(1.10)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C349(1.04); C64(1.04); C25(1.23)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C64(0.78); C25(1.15)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C349(0.97); C64(1.12); C25(1.16)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C349(1.07); C64(1.23)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C349(0.92); C64(1.15); C25(1.12)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C64(0.93); C25(1.09)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C349(0.96); C64(1.28); C25(1.14)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C349(0.92); C64(0.98)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C349(1.12); C64(1.06); C25(1.07)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C64(0.97); C25(1.25)  LDD1606  [6]
 LDCM0403  CL16 PaTu 8988t C64(1.04)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C64(0.77)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C64(1.06)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C64(0.89)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C349(1.14); C64(0.95); C25(0.98)  LDD1611  [6]
 LDCM0408  CL20 PaTu 8988t C64(0.93)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C64(1.07)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C64(1.04)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C64(0.87)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C64(1.05)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C64(0.86)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C64(0.93)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C64(0.93)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C64(0.99)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C64(1.17)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C64(0.89); C25(1.14)  LDD1622  [6]
 LDCM0419  CL30 PaTu 8988t C64(0.75)  LDD1298  [2]
 LDCM0420  CL31 PaTu 8988t C64(0.86)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C64(0.75)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C64(0.86)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C64(1.02)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C64(0.71)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C64(0.41)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C64(0.89)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C64(0.81)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C349(1.00); C64(1.25); C25(1.20)  LDD1633  [6]
 LDCM0430  CL40 PaTu 8988t C64(0.73)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C64(0.77)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C64(0.90)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C64(0.92)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C64(0.89)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C64(0.85)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C64(0.99)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C64(1.02)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C64(0.93)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C64(0.94)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C349(1.11); C64(1.13)  LDD1644  [6]
 LDCM0441  CL50 PaTu 8988t C64(0.88)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C64(1.14)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C64(0.88)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C64(0.80)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C64(0.97)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C64(0.99)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C64(0.51)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C64(0.93)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C64(0.90)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C64(0.97)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C349(1.09); C64(1.13); C25(0.90)  LDD1654  [6]
 LDCM0452  CL60 PaTu 8988t C64(1.02)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C64(0.98)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C64(1.08)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C64(1.00)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C64(0.91)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C64(0.94)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C64(0.96)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C64(1.01)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C64(1.03)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C64(1.00)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C349(1.12); C64(1.17)  LDD1665  [6]
 LDCM0463  CL70 PaTu 8988t C64(0.94)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C64(0.96)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C64(1.16)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C64(1.03)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C64(1.03)  LDD1346  [2]
 LDCM0469  CL76 PaTu 8988t C64(0.91)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C64(0.88)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C64(0.86)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C64(0.90)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C349(0.74); C64(1.20)  LDD1676  [6]
 LDCM0474  CL80 PaTu 8988t C64(0.83)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C64(0.84)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C64(0.89)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C64(0.77)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C64(0.88)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C64(0.90)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C64(0.89)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C64(0.84)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C64(0.94)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C64(0.92)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C349(1.10); C64(1.03)  LDD1687  [6]
 LDCM0485  CL90 PaTu 8988t C64(0.87)  LDD1364  [2]
 LDCM0486  CL91 HEK-293T C349(0.94); C64(1.16)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C349(1.05); C64(1.05)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C349(1.10); C64(0.96)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C349(1.03); C64(1.01); C25(0.96)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C349(1.08); C64(1.55); C236(0.85)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C349(1.10); C64(1.30)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C349(0.95); C64(1.20)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C349(1.13); C64(1.20); C25(1.12)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C64(1.06); C25(1.16)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C64(0.95); C25(0.99)  LDD1698  [6]
 LDCM0572  Fragment10 Ramos C349(0.70)  LDD1390  [1]
 LDCM0573  Fragment11 Ramos C349(1.02)  LDD1392  [1]
 LDCM0574  Fragment12 Ramos C349(0.71)  LDD1394  [1]
 LDCM0575  Fragment13 Ramos C349(0.77)  LDD1396  [1]
 LDCM0576  Fragment14 Ramos C349(1.63)  LDD1398  [1]
 LDCM0577  Fragment15 Ramos C349(1.43)  LDD1400  [1]
 LDCM0579  Fragment20 MDA-MB-231 C349(1.21)  LDD1402  [1]
 LDCM0580  Fragment21 MDA-MB-231 C349(0.92)  LDD1404  [1]
 LDCM0582  Fragment23 MDA-MB-231 C349(1.08)  LDD1408  [1]
 LDCM0583  Fragment24 Ramos C349(1.06)  LDD1410  [1]
 LDCM0578  Fragment27 MDA-MB-231 C349(1.12)  LDD1401  [1]
 LDCM0587  Fragment29 MDA-MB-231 C349(1.04)  LDD1417  [1]
 LDCM0589  Fragment31 MDA-MB-231 C349(4.29)  LDD1421  [1]
 LDCM0590  Fragment32 Ramos C349(1.02)  LDD1424  [1]
 LDCM0468  Fragment33 PaTu 8988t C64(0.86)  LDD1347  [2]
 LDCM0593  Fragment35 Ramos C349(1.00)  LDD1430  [1]
 LDCM0595  Fragment37 Ramos C349(0.71)  LDD1432  [1]
 LDCM0596  Fragment38 MDA-MB-231 C349(0.73)  LDD1433  [1]
 LDCM0566  Fragment4 MDA-MB-231 C349(0.99)  LDD1378  [1]
 LDCM0600  Fragment42 Ramos C349(0.97)  LDD1440  [1]
 LDCM0601  Fragment43 MDA-MB-231 C349(0.94)  LDD1441  [1]
 LDCM0427  Fragment51 PaTu 8988t C64(0.77)  LDD1306  [2]
 LDCM0610  Fragment52 MDA-MB-231 C349(0.80)  LDD1452  [1]
 LDCM0614  Fragment56 MDA-MB-231 C349(0.66)  LDD1458  [1]
 LDCM0568  Fragment6 MDA-MB-231 C349(0.80)  LDD1382  [1]
 LDCM0569  Fragment7 MDA-MB-231 C349(1.04)  LDD1383  [1]
 LDCM0570  Fragment8 MDA-MB-231 C349(1.04)  LDD1385  [1]
 LDCM0571  Fragment9 MDA-MB-231 C349(1.08)  LDD1387  [1]
 LDCM0022  KB02 MDA-MB-231 C349(2.56)  LDD1374  [1]
 LDCM0023  KB03 MDA-MB-231 C349(1.21)  LDD1376  [1]
 LDCM0024  KB05 MDA-MB-231 C349(20.00)  LDD1380  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sel120 Small molecular drug DOJG79

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402