Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name KB05  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 87 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 20.0
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 20.0
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) C522 20.0
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 20.0
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 20.0
 LDTP03400  Deoxycytidine kinase (DCK) C45 20.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 20.0
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 20.0
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) C914 20.0
 LDTP10002  Ribonuclease P/MRP protein subunit POP5 (POP5) C146 20.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 20.0
 LDTP03496  Protein PML (PML) C389 13.5
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 10.6
 LDTP02672  Elongation factor 2 (EEF2) C41 10.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 8.0
 LDTP04689  Adenosine kinase (ADK) C353 6.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 6.4
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 6.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 6.1
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 5.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 4.6
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) C482 4.5
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 4.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 4.0
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 3.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 3.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 3.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 3.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 3.1
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 2.8
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 2.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 2.6
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 2.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 2.5
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 2.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.3
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.2
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 2.2
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 2.1
 LDTP02223  Cathepsin B (CTSB) C319 2.0
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.8
 LDTP04374  Dynamin-2 (DNM2) C27 1.8
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.7
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.7
 LDTP07317  Tensin-3 (TNS3) C888 1.7
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.5
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.5
 LDTP02502  Thioredoxin (TXN) C32 1.5
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.4
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.4
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.3
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.2
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.2
 LDTP13147  Cathepsin Z (CTSZ) C92 1.1
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.1
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.0
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.0
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP06211  Caspase-8 (CASP8) C360 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 0.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 0.9
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 0.8
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.8
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.8
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 0.7
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.7
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.4
Transporter and channel
Click to Show/Hide to Show 14 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00501  Exportin-1 (XPO1) C528 20.0
 LDTP04801  Gasdermin-D (GSDMD) C268 20.0
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 20.0
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 2.3
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.5
 LDTP01574  Importin-7 (IPO7) C757 1.4
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.2
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.9
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.9
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03393  Aryl hydrocarbon receptor nuclear translocator (ARNT) C119 20.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.6
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 0.9
Other
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 20.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 20.0
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 20.0
 LDTP13580  Coronin-1C (CORO1C) C456 20.0
 LDTP04487  Cyclin-H (CCNH) C244 20.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 20.0
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 20.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 20.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 20.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 20.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 20.0
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 20.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 20.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP00768  Protein CBFA2T2 (CBFA2T2) C111 20.0
 LDTP11235  Protein PAXX (PAXX) C180 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP04363  Serpin H1 (SERPINH1) C156 20.0
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 20.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 20.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 13.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 9.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 6.8
 LDTP05867  Treacle protein (TCOF1) C38 6.7
 LDTP06330  Plectin (PLEC) C3110 5.4
 LDTP02205  Tubulin beta chain (TUBB) C354 4.3
 LDTP12443  Anillin (ANLN) C712 4.3
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 4.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 3.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 3.0
 LDTP06330  Plectin (PLEC) C992 2.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 2.7
 LDTP10864  Calponin-2 (CNN2) C164 2.6
 LDTP02205  Tubulin beta chain (TUBB) C239 2.5
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 2.5
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 2.5
 LDTP12571  LanC-like protein 2 (LANCL2) C187 2.3
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.3
 LDTP13580  Coronin-1C (CORO1C) C420 2.3
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 2.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 2.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.9
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.8
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.7
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.6
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.4
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.4
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.4
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.3
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.3
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.3
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.2
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.2
 LDTP02692  Plastin-3 (PLS3) C33 1.1
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 1.0
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 1.0
 LDTP03244  Cofilin-1 (CFL1) C80 0.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.9
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.