Details of the Target

General Information of Target

Target ID LDTP07317
Target Name Tensin-3 (TNS3)
Gene Name TNS3
Gene ID 64759
Synonyms
TEM6; TENS1; TPP; Tensin-3; EC 3.1.3.-; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNLSEKRYD
LTKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISS
YMHFTNVSASADQALDRFAMKKFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASPLFL
HFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGPENPSRICIVIEPAQLLKGDV
MVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDRFPDYGKVELVFSA
TPEKIQGSEHLYNDHGVIVDYNTTDPLIRWDSYENLSADGEVLHTQGPVDGSLYAKVRKK
SSSDPGIPGGPQAIPATNSPDHSDHTLSVSSDSGHSTASARTDKTEERLAPGTRRGLSAQ
EKAELDQLLSGFGLEDPGSSLKEMTDARSKYSGTRHVVPAQVHVNGDAALKDRETDILDD
EMPHHDLHSVDSLGTLSSSEGPQSAHLGPFTCHKSSQNSLLSDGFGSNVGEDPQGTLVPD
LGLGMDGPYERERTFGSREPKQPQPLLRKPSVSAQMQAYGQSSYSTQTWVRQQQMVVAHQ
YSFAPDGEARLVSRCPADNPGLVQAQPRVPLTPTRGTSSRVAVQRGVGSGPHPPDTQQPS
PSKAFKPRFPGDQVVNGAGPELSTGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHM
NALGSQANGSVSPDSVGGGLRASSRLPDTGEGPSRATGRQGSSAEQPLGGRLRKLSLGQY
DNDAGGQLPFSKCAWGKAGVDYAPNLPPFPSPADVKETMTPGYPQDLDIIDGRILSSKES
MCSTPAFPVSPETPYVKTALRHPPFSPPEPPLSSPASQHKGGREPRSCPETLTHAVGMSE
SPIGPKSTMLRADASSTPSFQQAFASSCTISSNGPGQRRESSSSAERQWVESSPKPMVSL
LGSGRPTGSPLSAEFSGTRKDSPVLSCFPPSELQAPFHSHELSLAEPPDSLAPPSSQAFL
GFGTAPVGSGLPPEEDLGALLANSHGASPTPSIPLTATGAADNGFLSHNFLTVAPGHSSH
HSPGLQGQGVTLPGQPPLPEKKRASEGDRSLGSVSPSSSGFSSPHSGSTISIPFPNVLPD
FSKASEAASPLPDSPGDKLVIVKFVQDTSKFWYKADISREQAIAMLKDKEPGSFIVRDSH
SFRGAYGLAMKVATPPPSVLQLNKKAGDLANELVRHFLIECTPKGVRLKGCSNEPYFGSL
TALVCQHSITPLALPCKLLIPERDPLEEIAESSPQTAANSAAELLKQGAACNVWYLNSVE
MESLTGHQAIQKALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFFRRHYPVNSVIF
CALDPQDRKWIKDGPSSKVFGFVARKQGSATDNVCHLFAEHDPEQPASAIVNFVSKVMIG
SPKKV
Target Bioclass
Enzyme
Family
PTEN phosphatase protein family
Subcellular location
Cell junction, focal adhesion
Function
May act as a protein phosphatase and/or a lipid phosphatase (Probable). Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Increases DOCK5 guanine nucleotide exchange activity towards Rac and plays a role in osteoclast podosome organization. Enhances RHOA activation in the presence of DLC1. Required for growth factor-induced epithelial cell migration; growth factor stimulation induces TNS3 phosphorylation which changes its binding preference from DLC1 to the p85 regulatory subunit of the PI3K kinase complex, displacing PI3K inhibitor PTEN and resulting in translocation of the TNS3-p85 complex to the leading edge of migrating cells to promote RAC1 activation. Meanwhile, PTEN switches binding preference from p85 to DLC1 and the PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA. Acts as an adapter protein by bridging the association of scaffolding protein PEAK1 with integrins ITGB1, ITGB3 and ITGB5 which contributes to the promotion of cell migration. Controls tonsil-derived mesenchymal stem cell proliferation and differentiation by regulating the activity of integrin ITGB1.
Uniprot ID
Q68CZ2
Ensemble ID
ENST00000311160.14
HGNC ID
HGNC:21616
ChEMBL ID
CHEMBL4295861

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.C1251F .
AU565 SNV: p.S944C DBIA    Probe Info 
CCLP1 SNV: p.L1031H DBIA    Probe Info 
CORL23 SNV: p.R668S DBIA    Probe Info 
HCT15 SNV: p.P918S .
HT1376 SNV: p.H1068P DBIA    Probe Info 
IGR1 Substitution: p.P767F DBIA    Probe Info 
JURKAT SNV: p.S29Y .
KMCH1 SNV: p.S1122C DBIA    Probe Info 
MELJUSO SNV: p.P365L DBIA    Probe Info 
NCIH2286 SNV: p.A1427S DBIA    Probe Info 
SISO SNV: p.Q921Ter; p.Q1166E DBIA    Probe Info 
SKN Deletion: p.P747HfsTer17 DBIA    Probe Info 
TF1 SNV: p.N1043D DBIA    Probe Info 
TOV21G SNV: p.S452N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1158(1.15); K1170(5.88); K147(5.88); K792(10.00)  LDD0277  [1]
m-APA
 Probe Info  		13.04  LDD0403  [2]
BTD
 Probe Info  		C615(0.65)  LDD2116  [3]
Sulforaphane-probe2
 Probe Info  		2.35  LDD0160  [4]
AHL-Pu-1
 Probe Info  		C842(4.52)  LDD0170  [5]
DBIA
 Probe Info  		C928(1.10); C842(1.04); C1241(1.02); C615(0.95)  LDD0078  [6]
JW-RF-010
 Probe Info  		C615(0.00); C25(0.00)  LDD0026  [7]
NAIA_4
 Probe Info  		C25(0.00); C615(0.00); C842(0.00); C888(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		C615(0.00); C888(0.00); C1241(0.00)  LDD0021  [9]
WYneO
 Probe Info  		C888(0.00); C615(0.00)  LDD0022  [9]
IA-alkyne
 Probe Info  		C615(0.00); C1241(0.00)  LDD0151  [10]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Phosphinate-6
 Probe Info  		C1241(0.00); C615(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C842(0.00); C25(0.00); C1241(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		C842(0.00); C1241(0.00)  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		C888(0.00); C1241(0.00); C197(0.00); C1311(0.00)  LDD2223  [8]
HHS-482
 Probe Info  		Y855(4.42)  LDD2239  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1241(1.10)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C842(4.52)  LDD0170  [5]
 LDCM0215  AC10 HEK-293T C615(1.08)  LDD1508  [15]
 LDCM0216  AC100 HCT 116 C615(0.84)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C615(0.97)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C615(0.76)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C615(0.86)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C615(0.91)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C615(0.96)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C615(0.94)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C615(0.97)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C615(0.70)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C615(0.56)  LDD0542  [6]
 LDCM0227  AC110 HCT 116 C615(0.70)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C615(0.76)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C615(0.95)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C615(0.84)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C615(0.79)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C615(1.03)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C615(1.43)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C615(1.08)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C615(1.01)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C615(0.90)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C615(0.99)  LDD1510  [15]
 LDCM0238  AC120 HCT 116 C615(0.90)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C615(1.59)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C615(0.80)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C615(0.94)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C615(1.16)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C615(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C615(1.38)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C615(1.57)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C615(1.05)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C615(0.82)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C615(1.25)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C615(1.12)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C615(0.68)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C615(1.08)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C615(1.01)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C615(1.27)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C615(0.93)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C615(0.78)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C615(0.87)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C615(1.14)  LDD0575  [6]
 LDCM0259  AC14 HEK-293T C615(1.25)  LDD1512  [15]
 LDCM0260  AC140 HCT 116 C615(0.90)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C615(0.79)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C615(0.79)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C615(1.19)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C615(1.18)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C615(1.23)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C615(1.33)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C615(1.30)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C615(1.67)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C615(1.32)  LDD0586  [6]
 LDCM0271  AC150 HCT 116 C615(1.30)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C615(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C615(1.19)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C615(1.70)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C615(1.17)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C615(1.39)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C615(1.14)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C615(1.25)  LDD2161  [6]
 LDCM0277  AC18 HEK-293T C615(1.13)  LDD1516  [15]
 LDCM0279  AC2 HEK-293T C615(1.26)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C615(1.01)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C1241(1.10)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C615(0.94)  LDD1521  [15]
 LDCM0286  AC26 HEK-293T C615(1.10)  LDD1525  [15]
 LDCM0288  AC28 HEK-293T C615(0.67)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C1241(1.00)  LDD1528  [15]
 LDCM0291  AC30 HEK-293T C615(1.23)  LDD1530  [15]
 LDCM0295  AC34 HEK-293T C615(1.03)  LDD1534  [15]
 LDCM0297  AC36 HEK-293T C615(0.81)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C1241(1.10)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C615(1.23)  LDD1538  [15]
 LDCM0301  AC4 HEK-293T C615(0.91)  LDD1540  [15]
 LDCM0304  AC42 HEK-293T C615(1.20)  LDD1543  [15]
 LDCM0306  AC44 HEK-293T C615(0.85)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C1241(0.93)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C615(1.17)  LDD1547  [15]
 LDCM0312  AC5 HEK-293T C1241(0.98)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C615(1.60)  LDD1552  [15]
 LDCM0315  AC52 HEK-293T C615(1.09)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C1241(1.07)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C615(1.08)  LDD1556  [15]
 LDCM0321  AC58 HEK-293T C615(1.00)  LDD1560  [15]
 LDCM0323  AC6 HEK-293T C615(0.86)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C615(1.09)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C1241(1.01)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C615(1.26)  LDD1565  [15]
 LDCM0365  AC98 HCT 116 C615(1.04)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C615(0.78)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C1241(1.03)  LDD1511  [15]
 LDCM0156  Aniline NCI-H1299 13.04  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C928(1.10); C842(1.04); C1241(1.02); C615(0.95)  LDD0078  [6]
 LDCM0630  CCW28-3 231MFP C928(1.36); C1241(1.35); C888(0.99)  LDD2214  [16]
 LDCM0108  Chloroacetamide HeLa C842(0.00); C1241(0.00)  LDD0222  [12]
 LDCM0368  CL10 HEK-293T C615(0.89)  LDD1572  [15]
 LDCM0405  CL18 HEK-293T C615(0.98)  LDD1609  [15]
 LDCM0408  CL20 HEK-293T C615(1.35)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C1241(0.96)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C615(0.83)  LDD1614  [15]
 LDCM0419  CL30 HEK-293T C615(1.16)  LDD1623  [15]
 LDCM0421  CL32 HEK-293T C615(1.01)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C1241(1.31)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C615(0.71)  LDD1627  [15]
 LDCM0432  CL42 HEK-293T C615(1.33)  LDD1636  [15]
 LDCM0434  CL44 HEK-293T C615(1.04)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C1241(0.98)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C615(1.03)  LDD1640  [15]
 LDCM0445  CL54 HEK-293T C615(1.02)  LDD1648  [15]
 LDCM0447  CL56 HEK-293T C615(0.94)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C1241(0.95)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C615(0.89)  LDD1652  [15]
 LDCM0451  CL6 HEK-293T C615(1.04)  LDD1654  [15]
 LDCM0453  CL61 HCT 116 C615(0.47)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C615(0.59)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C615(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C615(1.48)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C615(1.15)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C615(1.52)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C615(1.18)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C615(0.94)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C615(0.95)  LDD0778  [6]
 LDCM0463  CL70 HCT 116 C615(1.01)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C615(1.13)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C615(0.99)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C615(1.23)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C615(1.00)  LDD0784  [6]
 LDCM0471  CL78 HEK-293T C615(1.29)  LDD1674  [15]
 LDCM0473  CL8 HEK-293T C615(0.79)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C615(1.12)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C1241(0.98)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C615(0.91)  LDD1679  [15]
 LDCM0484  CL9 HEK-293T C1241(1.02)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C615(0.97)  LDD1688  [15]
 LDCM0487  CL92 HEK-293T C615(1.04)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C1241(0.98)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C615(1.08)  LDD1692  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1241(1.26); C888(1.07)  LDD1702  [3]
 LDCM0575  Fragment13 MDA-MB-231 C888(1.42)  LDD1395  [17]
 LDCM0576  Fragment14 MDA-MB-231 C888(1.89)  LDD1397  [17]
 LDCM0579  Fragment20 MDA-MB-231 C888(2.82)  LDD1402  [17]
 LDCM0580  Fragment21 MDA-MB-231 C888(0.89)  LDD1404  [17]
 LDCM0578  Fragment27 MDA-MB-231 C888(0.40)  LDD1401  [17]
 LDCM0588  Fragment30 MDA-MB-231 C888(20.00)  LDD1419  [17]
 LDCM0590  Fragment32 MDA-MB-231 C888(4.01)  LDD1423  [17]
 LDCM0468  Fragment33 HCT 116 C615(1.25)  LDD0785  [6]
 LDCM0596  Fragment38 MDA-MB-231 C888(1.14)  LDD1433  [17]
 LDCM0599  Fragment41 MDA-MB-231 C888(1.32)  LDD1438  [17]
 LDCM0601  Fragment43 MDA-MB-231 C888(2.16)  LDD1441  [17]
 LDCM0604  Fragment46 MDA-MB-231 C888(1.01)  LDD1445  [17]
 LDCM0605  Fragment47 MDA-MB-231 C888(1.01)  LDD1446  [17]
 LDCM0607  Fragment49 MDA-MB-231 C888(2.76)  LDD1448  [17]
 LDCM0614  Fragment56 MDA-MB-231 C888(0.96)  LDD1458  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 MDA-MB-231 C888(2.07)  LDD1374  [17]
 LDCM0023  KB03 MDA-MB-231 C888(2.53)  LDD1701  [3]
 LDCM0024  KB05 G361 C615(2.62); C842(1.58); C227(1.50)  LDD3311  [18]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C615(0.65)  LDD2116  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C615(0.73)  LDD2120  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C615(0.96)  LDD2143  [3]
 LDCM0131  RA190 MM1.R C928(3.89); C842(3.42); C1251(3.31); C888(3.07)  LDD0304  [19]
 LDCM0003  Sulforaphane MDA-MB-231 2.35  LDD0160  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cadherin-1 (CDH1) . P12830
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD006279
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.