General Information of Target

Target ID LDTP03777
Target Name Nuclear pore complex protein Nup214 (NUP214)
Gene Name NUP214
Gene ID 8021
Synonyms
CAIN; CAN; KIAA0023; Nuclear pore complex protein Nup214; 214 kDa nucleoporin; Nucleoporin Nup214; Protein CAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGDEMDAMIPEREMKDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFAGGASGLQ
IFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSII
AFFDVRTFSNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVT
ETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPPFYESDHP
VRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTE
RQHHYYLSYIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDS
LPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSLIKTPERL
SLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPT
VFSFGSSSLKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVA
PSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTAAATSTPV
SSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVP
SMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEEL
KARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVE
EAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHL
EQKKKQRHLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAV
PSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVR
STAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVR
TPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAP
SPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMG
SSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAV
TSTPSASGQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGG
SKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGEL
LFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVL
GKHTEPPVTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFS
FGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSA
LPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSL
VALSAEATPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASST
TSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAAS
TAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAA
SVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQ
SNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGI
VFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSN
LFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPP
TFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLAS
QNAPTFGSLSQQTSGFGTQSSGFSGFGSGTGGFSFGSNNSSVQGFGGWRS
Target Bioclass
Transporter and channel
Subcellular location
Nucleus, nuclear pore complex
Function
Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.; (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro).
Uniprot ID
P35658
Ensemble ID
ENST00000359428.10
HGNC ID
HGNC:8064

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.V228SfsTer9 .
786O SNV: p.V1510L DBIA    Probe Info 
COLO320 SNV: p.A1678P DBIA    Probe Info 
EFO27 Deletion: p.V228SfsTer29 DBIA    Probe Info 
HCT116 Deletion: p.V228SfsTer29 .
JURKAT Deletion: p.P1378RfsTer3 Compound 10    Probe Info 
KMS27 SNV: p.V373E DBIA    Probe Info 
KYSE30 SNV: p.E735K DBIA    Probe Info 
LNCaP clone FGC SNV: p.S2020R DBIA    Probe Info 
MELJUSO Deletion: p.S297_T299delinsR
SNV: p.A1088V
DBIA    Probe Info 
MFE319 Deletion: p.V228SfsTer29 DBIA    Probe Info 
MINO SNV: p.Q1525H .
MOLT4 SNV: p.E292D; p.R815W IA-alkyne    Probe Info 
NALM6 Deletion: p.P1378RfsTer3 DBIA    Probe Info 
NCIH1048 Deletion: p.V228SfsTer29 DBIA    Probe Info 
NCIH1155 SNV: p.S1978R; p.R2089Ter DBIA    Probe Info 
SNGM Insertion: p.E280RfsTer32
SNV: p.A1159T
DBIA    Probe Info 
SNU1 Deletion: p.P1378RfsTer3 DBIA    Probe Info 
SW403 SNV: p.Q1100K DBIA    Probe Info 
TOV21G SNV: p.A1254T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
11.39  LDD0402  [1]
A-EBA
 Probe Info 
4.16  LDD0215  [2]
CY-1
 Probe Info 
100.00  LDD0243  [3]
TH211
 Probe Info 
Y141(16.04)  LDD0260  [4]
STPyne
 Probe Info 
K143(5.43); K205(4.65); K226(5.00); K691(10.00)  LDD0277  [5]
ONAyne
 Probe Info 
K721(9.09)  LDD0275  [5]
Probe 1
 Probe Info 
Y502(61.40)  LDD3495  [6]
BTD
 Probe Info 
C1003(0.98)  LDD1700  [7]
AHL-Pu-1
 Probe Info 
C1003(2.54)  LDD0169  [8]
DBIA
 Probe Info 
C728(10.40)  LDD0209  [9]
HHS-475
 Probe Info 
Y1145(0.25); Y799(0.43); Y141(0.94)  LDD0264  [10]
HHS-465
 Probe Info 
Y141(10.00)  LDD2237  [11]
5E-2FA
 Probe Info 
H748(0.00); H1152(0.00); H1031(0.00)  LDD2235  [12]
ATP probe
 Probe Info 
N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info 
C728(0.00); C399(0.00); C1003(0.00); C917(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info 
C728(0.00); C917(0.00); C399(0.00); C1003(0.00)  LDD0036  [14]
Lodoacetamide azide
 Probe Info 
C728(0.00); C399(0.00); C917(0.00); C1003(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info 
N.A.  LDD0026  [15]
NAIA_4
 Probe Info 
C917(0.00); C1003(0.00)  LDD2226  [16]
TFBX
 Probe Info 
N.A.  LDD0027  [15]
WYneN
 Probe Info 
C728(0.00); C1003(0.00)  LDD0021  [17]
WYneO
 Probe Info 
C1003(0.00); C728(0.00)  LDD0022  [17]
Compound 10
 Probe Info 
N.A.  LDD2216  [18]
Compound 11
 Probe Info 
N.A.  LDD2213  [18]
ENE
 Probe Info 
C1003(0.00); C728(0.00)  LDD0006  [17]
IPM
 Probe Info 
C728(0.00); C1003(0.00)  LDD0005  [17]
SF
 Probe Info 
N.A.  LDD0028  [19]
VSF
 Probe Info 
C186(0.00); C728(0.00); C1003(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info 
C1003(0.00); C728(0.00)  LDD0018  [20]
1c-yne
 Probe Info 
K843(0.00); K769(0.00); K1316(0.00)  LDD0228  [21]
Acrolein
 Probe Info 
C1003(0.00); H848(0.00); C199(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info 
C1003(0.00); H928(0.00); H1039(0.00)  LDD0219  [22]
Methacrolein
 Probe Info 
N.A.  LDD0218  [22]
NAIA_5
 Probe Info 
C399(0.00); C1003(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C417
 Probe Info 
14.42  LDD2072  [23]
FFF probe11
 Probe Info 
20.00  LDD0471  [24]
FFF probe13
 Probe Info 
7.53  LDD0476  [24]
FFF probe14
 Probe Info 
20.00  LDD0477  [24]
FFF probe3
 Probe Info 
6.55  LDD0465  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1003(0.79)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1003(0.82)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1003(0.62)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1003(0.91)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1003(0.96); C728(1.33)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1003(0.97)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1003(0.62)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1003(0.72)  LDD2131  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1003(2.54)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C728(1.06); C1003(1.18); C186(0.95); C298(0.99)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C728(0.96); C917(0.97); C1003(1.39); C186(0.95)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C728(1.16); C1003(1.39); C231(1.03); C186(0.95)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C728(1.03); C917(0.96); C1003(1.26); C186(0.92)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C728(0.92); C917(1.03); C1003(1.42); C231(0.95)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C728(1.00); C917(0.91); C1003(1.19); C186(1.02)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C728(1.06); C1003(1.26); C186(0.93); C298(1.02)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C728(1.07); C917(0.85); C1003(1.16); C186(0.92)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C728(1.06); C1003(1.22); C231(1.02); C186(0.85)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C728(1.06); C917(0.90); C1003(1.31); C186(0.95)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C728(1.03); C917(0.94); C1003(1.28); C186(1.01)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C728(1.05); C917(0.98); C1003(1.10); C186(1.02)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C728(1.05); C917(1.15); C1003(1.36); C231(0.96)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C728(0.89); C917(0.91); C1003(1.17); C186(1.12)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C728(0.92); C917(1.13); C1003(1.08); C186(1.02)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C728(1.08); C1003(1.20); C186(0.93); C298(0.95)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C728(1.01); C917(0.91); C1003(1.23); C186(1.00)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C728(1.00); C1003(1.46); C231(1.03); C186(0.94)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C728(1.04); C917(1.01); C1003(1.18); C186(0.98)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C728(1.05); C917(1.06); C1003(1.19); C186(1.01)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C728(1.09); C1003(1.50); C231(1.07); C186(0.95)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C728(0.99); C917(1.03); C1003(1.27); C231(0.87)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C728(0.95); C917(0.92); C1003(1.17); C186(1.03)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C728(0.98); C917(1.04); C1003(1.06); C186(1.01)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C728(1.19); C1003(1.32); C186(0.92); C298(0.92)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C728(1.02); C917(0.99); C1003(1.31); C186(1.04)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C728(1.04); C1003(1.56); C231(1.12); C186(0.79)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C728(0.97); C917(1.11); C1003(1.47); C186(0.92)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C728(0.93); C917(1.16); C1003(1.29); C186(1.09)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C728(1.02); C917(1.06); C1003(1.31); C231(0.99)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C728(0.93); C917(0.96); C1003(1.20); C186(1.01)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C728(1.00); C917(0.97); C1003(1.29); C186(0.96)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C728(1.02); C917(1.15); C1003(1.07); C186(1.11)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C728(1.10); C1003(1.17); C186(0.87); C298(1.02)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C728(1.12); C917(0.99); C1003(1.32); C186(0.97)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C728(0.98); C1003(1.36); C231(1.12); C186(0.96)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C728(0.98); C917(0.93); C1003(1.21); C186(0.96)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C728(0.99); C917(1.00); C1003(1.29); C186(1.06)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C728(0.96); C917(1.05); C1003(1.23); C231(0.92)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C728(1.02); C917(0.94); C1003(1.18); C186(1.08)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C728(0.94); C917(1.15); C1003(0.95); C186(0.96)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C728(1.11); C1003(1.27); C186(0.90); C298(0.90)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C728(0.97); C917(1.09); C1003(1.39); C186(1.05)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C728(1.02); C917(0.93); C1003(1.35); C186(0.89)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C728(0.96); C1003(1.40); C231(0.99); C186(0.87)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C728(0.97); C917(0.90); C1003(1.19); C186(1.00)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C728(1.05); C917(1.03); C1003(1.31); C186(0.98)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C728(0.98); C917(0.91); C1003(1.27); C231(1.03)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C728(0.93); C917(0.86); C1003(1.16); C186(0.93)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C728(1.04); C917(0.94); C1003(0.97); C186(0.93)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C728(1.08); C1003(1.24); C186(0.94); C298(0.90)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C728(0.96); C917(0.97); C1003(1.28); C186(0.98)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C728(1.04); C1003(1.55); C231(1.02); C186(0.97)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C728(0.95); C917(0.95); C1003(1.10); C231(1.13)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C728(0.98); C917(1.08); C1003(1.38); C186(0.97)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C728(0.97); C917(1.01); C1003(1.42); C186(1.01)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C728(0.90); C917(0.92); C1003(1.42); C231(0.97)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C728(0.97); C917(0.89); C1003(1.19); C186(1.06)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C728(1.01); C917(0.89); C1003(1.07); C186(0.99)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C728(0.97); C917(1.07); C1003(1.30); C186(1.12)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C728(1.11); C917(1.04); C1003(1.17); C186(0.96)  LDD1569  [25]
 LDCM0545  Acetamide MDA-MB-231 C1003(0.38)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C728(1.02); C917(1.06); C1003(1.09); C186(1.00)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C728(1.09); C1003(1.21); C186(0.96); C298(0.92)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C728(0.96); C917(0.98); C1003(1.09); C186(0.92)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C1003(0.42)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C186(1.31)  LDD2214  [26]
 LDCM0108  Chloroacetamide HeLa C1003(0.00); H877(0.00); H796(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C728(2.39); C1003(0.47)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C728(0.75); C917(1.08); C1003(1.25); C231(1.04)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C728(1.04); C917(1.21); C1003(0.53); C231(0.96)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C728(0.89); C917(0.99); C1003(1.29); C186(0.98)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C728(0.80); C917(0.94); C1003(1.39); C231(1.13)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C728(0.96); C917(0.84); C1003(1.07); C186(1.79)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C728(1.04); C917(1.13); C1003(1.30); C186(1.00)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C728(0.92); C917(1.01); C1003(1.15); C186(1.08)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C728(0.78); C917(0.91); C1003(1.27); C231(1.07)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C728(0.85); C917(0.90); C1003(1.05); C186(1.02)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C728(0.99); C917(0.95); C1003(1.24); C186(1.01)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C728(0.97); C917(0.94); C1003(1.22); C186(0.98)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C728(1.10); C917(0.97); C1003(1.13); C231(1.19)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C728(0.94); C917(1.05); C1003(0.67); C186(0.98)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C728(0.93); C917(0.92); C1003(1.07); C186(1.06)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C728(0.97); C917(1.06); C1003(1.10); C186(1.09)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C728(1.00); C917(1.00); C1003(1.43); C186(0.93)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C728(0.80); C917(1.06); C1003(1.28); C231(1.15)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C728(0.98); C917(0.94); C1003(1.15); C186(0.94)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C728(1.15); C917(1.21); C1003(1.24); C186(0.93)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C728(0.91); C917(1.01); C1003(1.21); C186(1.10)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C728(1.05); C917(0.98); C1003(1.23); C231(1.17)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C728(0.97); C917(0.95); C1003(1.08); C186(0.92)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C728(1.08); C917(1.01); C1003(1.07); C186(1.04)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C728(1.01); C917(1.09); C1003(0.67); C186(0.98)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C728(0.94); C917(0.90); C1003(1.16); C186(0.92)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C728(0.83); C917(0.87); C1003(1.24); C231(1.07)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C728(0.90); C917(0.85); C1003(1.19); C186(1.03)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C728(1.04); C917(1.02); C1003(1.00); C186(0.93)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C728(0.98); C917(0.79); C1003(1.19); C186(0.91)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C728(0.79); C917(0.77); C1003(1.76); C231(1.16)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C728(1.02); C917(0.91); C1003(1.30); C186(0.91)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C728(0.99); C917(0.78); C1003(1.34); C186(1.03)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C728(0.97); C917(0.89); C1003(1.29); C186(1.19)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C728(0.68); C917(1.04); C1003(1.49); C231(1.13)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C728(0.99); C917(0.96); C1003(1.16); C186(0.98)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C728(1.01); C917(1.15); C1003(1.00); C186(0.80)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C728(0.97); C917(1.00); C1003(1.08); C186(1.11)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C728(1.22); C1003(1.06); C186(0.89); C298(0.97)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C728(1.07); C917(1.03); C1003(0.95); C186(0.93)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C728(1.18); C1003(0.83); C231(1.26); C186(0.97)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C728(0.89); C917(1.06); C1003(1.24); C186(0.95)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C728(1.12); C917(0.93); C1003(0.78); C186(0.99)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C728(0.93); C917(1.16); C1003(0.57); C186(1.01)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C728(1.14); C917(0.92); C1003(0.62); C231(1.25)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C728(0.96); C917(0.96); C1003(0.66); C186(0.96)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C728(0.98); C917(1.01); C1003(0.62); C186(1.04)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C728(0.97); C917(0.94); C1003(1.41); C231(1.02)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C728(1.03); C917(0.97); C1003(1.18); C186(0.89)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C728(1.01); C917(1.05); C1003(1.02); C186(1.06)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C728(1.07); C917(0.96); C1003(1.08); C186(1.12)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C728(1.11); C1003(1.04); C186(0.99); C298(0.98)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C728(1.04); C917(0.99); C1003(1.14); C186(0.92)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C728(0.98); C917(0.84); C1003(0.92); C186(0.94)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C728(1.21); C1003(0.80); C231(0.97); C186(1.07)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C728(1.08); C917(0.99); C1003(0.77); C186(0.95)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C728(0.91); C917(1.05); C1003(0.49); C186(0.88)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C728(1.06); C917(0.86); C1003(0.59); C231(1.30)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C728(0.95); C917(0.90); C1003(0.65); C186(0.89)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C728(0.91); C917(0.99); C1003(0.61); C186(0.95)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C728(0.83); C917(0.91); C1003(1.44); C231(1.14)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C728(1.19); C917(1.07); C1003(1.01); C186(1.05)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C728(0.89); C917(0.89); C1003(1.12); C186(1.06)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C728(0.94); C917(1.18); C1003(1.04); C186(1.17)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C728(1.22); C1003(1.01); C186(0.88); C298(0.99)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C728(1.02); C917(0.81); C1003(0.72); C186(1.04)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C728(1.04); C1003(0.78); C231(1.00); C186(1.02)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C728(1.02); C917(0.82); C1003(0.77); C186(0.96)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C728(0.99); C917(1.30); C1003(0.61); C186(1.00)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C728(1.04); C917(0.91); C1003(0.61); C231(1.14)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C728(1.00); C917(0.90); C1003(0.62); C186(1.07)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C728(0.81); C917(0.91); C1003(0.54); C186(1.01)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C728(0.73); C917(0.90); C1003(1.56); C231(1.12)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C728(1.15); C1003(1.05); C186(0.93); C298(0.92)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C728(0.98); C917(0.98); C1003(1.09); C186(0.99)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C728(0.97); C917(1.04); C1003(1.02); C186(0.96)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C728(1.17); C1003(1.05); C186(0.82); C298(0.84)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C728(1.11); C917(0.80); C1003(0.90); C186(0.78)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C728(1.04); C1003(0.80); C231(1.12); C186(0.96)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C728(1.19); C917(0.71); C1003(0.72); C186(0.94)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C728(0.99); C917(1.12); C1003(0.62); C186(0.98)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C728(1.01); C917(0.84); C1003(0.57); C231(1.14)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C728(1.12); C917(0.83); C1003(0.66); C186(1.00)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C728(1.16); C917(0.86); C1003(0.94); C186(1.04)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C728(0.90); C917(1.06); C1003(0.58); C186(0.99)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C728(0.68); C917(1.08); C1003(1.79); C231(1.03)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C728(0.96); C917(0.91); C1003(1.11); C186(0.91)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C728(1.12); C917(0.96); C1003(1.32); C186(0.99)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C728(0.87); C917(1.00); C1003(1.05); C186(1.05)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C728(1.11); C1003(1.04); C186(0.93); C298(1.07)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C728(1.07); C917(0.81); C1003(0.88); C186(0.92)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C728(1.02); C1003(0.91); C231(1.31); C186(0.95)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C728(1.03); C917(0.91); C1003(0.70); C186(0.95)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C728(0.93); C917(0.97); C1003(0.58); C186(1.00)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C728(1.11); C1003(0.89); C231(1.28); C186(0.96)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C728(1.00); C917(0.93); C1003(0.63); C231(1.33)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C728(0.99); C917(0.79); C1003(0.64); C186(0.87)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C728(1.10); C917(0.95); C1003(0.67); C186(0.96)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C728(0.89); C917(0.88); C1003(1.56); C231(0.82)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C728(1.06); C917(0.81); C1003(1.24); C186(0.99)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C728(0.94); C917(0.97); C1003(1.18); C186(0.99)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C728(1.21); C1003(1.07); C186(0.97); C298(0.88)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C728(1.03); C917(0.90); C1003(1.05); C186(0.94)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C728(1.13); C1003(0.90); C231(1.09); C186(0.92)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C728(1.15); C917(0.81); C1003(0.62); C186(1.04)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C728(1.03); C917(0.85); C1003(0.72); C186(0.98)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C728(1.01); C917(0.95); C1003(0.64); C186(1.01)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C728(1.03); C917(0.88); C1003(0.67); C231(1.24)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C728(1.02); C917(0.83); C1003(0.69); C186(1.02)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C728(0.89); C917(0.90); C1003(0.66); C186(0.93)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C728(0.95); C917(0.92); C1003(2.52); C231(0.92)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C728(0.98); C917(0.82); C1003(1.72); C186(0.96)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C728(1.03); C917(0.85); C1003(1.50); C186(0.97)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C728(0.94); C917(0.75); C1003(1.58); C186(1.02)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C728(0.99); C1003(1.22); C186(1.00); C298(0.84)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C728(0.94); C917(1.11); C1003(0.60); C186(1.06)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C728(1.00); C917(0.75); C1003(0.92); C186(0.85)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C728(1.01); C1003(0.98); C231(1.05); C186(0.92)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C728(1.01); C917(0.80); C1003(0.92); C186(0.99)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C728(0.92); C917(1.32); C1003(0.79); C186(1.01)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C728(1.06); C917(0.83); C1003(0.77); C231(1.09)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C728(0.97); C917(0.87); C1003(0.74); C186(0.84)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C728(0.85); C917(0.65); C1003(0.89); C186(0.92)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C728(1.01); C917(0.94); C1003(1.40); C231(1.03)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C728(1.06); C917(0.98); C1003(1.16); C186(1.02)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C728(1.23); C917(0.97); C1003(1.05); C186(1.02)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C728(1.11); C917(1.16); C1003(1.14); C186(0.92)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C728(1.31); C1003(0.99); C231(0.62)  LDD1702  [7]
 LDCM0625  F8 Ramos C1003(1.39); C728(1.17)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C728(4.07)  LDD1390  [28]
 LDCM0573  Fragment11 MDA-MB-231 C728(0.81)  LDD1467  [28]
 LDCM0574  Fragment12 Ramos C1003(0.68); C728(0.80)  LDD2191  [27]
 LDCM0575  Fragment13 MDA-MB-231 C728(1.04)  LDD1395  [28]
 LDCM0576  Fragment14 MDA-MB-231 C728(1.25)  LDD1397  [28]
 LDCM0579  Fragment20 MDA-MB-231 C728(1.99)  LDD1402  [28]
 LDCM0580  Fragment21 MDA-MB-231 C728(4.33)  LDD1404  [28]
 LDCM0582  Fragment23 MDA-MB-231 C728(1.19)  LDD1408  [28]
 LDCM0583  Fragment24 Ramos C728(1.38)  LDD1410  [28]
 LDCM0584  Fragment25 MDA-MB-231 C728(0.86)  LDD1411  [28]
 LDCM0578  Fragment27 MDA-MB-231 C728(0.81)  LDD1401  [28]
 LDCM0586  Fragment28 MDA-MB-231 C728(0.81)  LDD1415  [28]
 LDCM0587  Fragment29 MDA-MB-231 C728(1.20)  LDD1417  [28]
 LDCM0588  Fragment30 Ramos C1003(1.27); C728(1.10)  LDD2199  [27]
 LDCM0589  Fragment31 MDA-MB-231 C728(0.66)  LDD1477  [28]
 LDCM0590  Fragment32 MDA-MB-231 C728(1.75)  LDD1423  [28]
 LDCM0468  Fragment33 MDA-MB-231 C728(6.43)  LDD1479  [28]
 LDCM0593  Fragment35 Ramos C728(1.38)  LDD1430  [28]
 LDCM0596  Fragment38 MDA-MB-231 C728(1.21)  LDD1433  [28]
 LDCM0566  Fragment4 MDA-MB-231 C728(1.47)  LDD1378  [28]
 LDCM0599  Fragment41 MDA-MB-231 C728(1.37)  LDD1438  [28]
 LDCM0601  Fragment43 MDA-MB-231 C728(8.59)  LDD1441  [28]
 LDCM0603  Fragment45 MDA-MB-231 C728(5.31)  LDD1444  [28]
 LDCM0604  Fragment46 MDA-MB-231 C728(0.88)  LDD1445  [28]
 LDCM0605  Fragment47 MDA-MB-231 C728(0.97)  LDD1446  [28]
 LDCM0606  Fragment48 MDA-MB-231 C728(1.47)  LDD1447  [28]
 LDCM0608  Fragment50 MDA-MB-231 C728(1.48)  LDD1449  [28]
 LDCM0427  Fragment51 HEK-293T C728(0.89); C917(1.05); C1003(1.23); C186(0.93)  LDD1631  [25]
 LDCM0610  Fragment52 MDA-MB-231 C728(1.11)  LDD1452  [28]
 LDCM0611  Fragment53 MDA-MB-231 C728(1.06)  LDD1454  [28]
 LDCM0614  Fragment56 MDA-MB-231 C728(0.91)  LDD1458  [28]
 LDCM0568  Fragment6 MDA-MB-231 C728(1.12)  LDD1382  [28]
 LDCM0569  Fragment7 MDA-MB-231 C728(1.52)  LDD1383  [28]
 LDCM0570  Fragment8 MDA-MB-231 C728(1.70)  LDD1385  [28]
 LDCM0571  Fragment9 MDA-MB-231 C728(1.45)  LDD1387  [28]
 LDCM0116  HHS-0101 DM93 Y1145(0.25); Y799(0.43); Y141(0.94)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y1145(0.61); Y141(1.05)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y1145(0.46); Y799(0.55); Y141(0.66); Y502(1.51)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y502(0.55); Y1145(0.72); Y141(1.01); Y799(1.09)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y502(0.74); Y1145(1.01); Y141(1.98)  LDD0268  [10]
 LDCM0107  IAA HeLa H877(0.00); H762(0.00); H1152(0.00); H848(0.00)  LDD0221  [22]
 LDCM0022  KB02 MDA-MB-231 C728(11.47)  LDD1374  [28]
 LDCM0023  KB03 Jurkat C728(10.40)  LDD0209  [9]
 LDCM0024  KB05 G361 C729(2.80)  LDD3311  [29]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1003(0.92)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1003(0.51)  LDD2121  [7]
 LDCM0109  NEM HeLa H877(0.00); H796(0.00); H1152(0.00); H848(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1003(0.57)  LDD2089  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1003(0.90)  LDD2092  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1003(1.25)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1003(0.79)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1003(0.82); C728(0.92)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1003(0.74)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1003(0.95)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1003(0.80)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1003(1.14)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1003(1.06); C231(1.37); C728(1.03)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1003(0.79)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1003(0.80); C728(1.00)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1003(0.88); C728(0.87)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1003(0.62)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1003(0.49)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1003(1.01)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1003(2.35)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1003(0.98)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1003(0.97)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1003(0.88); C728(1.06)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1003(0.99)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1003(0.86); C728(0.98)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1003(1.00)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1003(0.93); C728(1.05)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1003(0.80)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1003(0.71); C231(1.45)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1003(0.72); C728(0.96)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1003(1.07); C728(1.29)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1003(0.82); C728(0.94)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1003(0.98)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1003(0.90); C728(1.11)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1003(0.76); C728(0.87)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1003(1.10)  LDD2143  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1003(0.83)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1003(4.74)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1003(0.55)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1003(1.18)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1003(0.33)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1003(1.25)  LDD2151  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C186(1.04); C728(1.01)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C186(0.89); C728(0.62)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C728(1.21)  LDD0304  [31]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.