Details of the Target

General Information of Target

Target ID LDTP12837
Target Name Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)
Gene Name MAP3K20
Gene ID 51776
Synonyms
MLK7; MLTK; ZAK; Mitogen-activated protein kinase kinase kinase 20; EC 2.7.11.25; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNEEEQFVNIDLNDDNICSVCKLGTDKETLSFCHICFELNIEGVPKSDLLHTKSLRGHKD
CFEKYHLIANQGCPRSKLSKSTYEEVKTILSKKINWIVQYAQNKDLDSDSECSKNPQHHL
FNFRHKPEEKLLPQFDSQVPKYSAKWIDGSAGGISNCTQRILEQRENTDFGLSMLQDSGA
TLCRNSVLWPHSHNQAQKKEETISSPEANVQTQHPHYSREELNSMTLGEVEQLNAKLLQQ
IQEVFEELTHQVQEKDSLASQLHVRHVAIEQLLKNCSKLPCLQVGRTGMKSHLPINN
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Subcellular location
Cytoplasm
Function
Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation. Acts by catalyzing phosphorylation of MAP kinase kinases, leading to activation of the JNK (MAPK8/JNK1, MAPK9/JNK2 and/or MAPK10/JNK3) and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Activates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6. Involved in stress associated with adrenergic stimulation: contributes to cardiac decompensation during periods of acute cardiac stress. May be involved in regulation of S and G2 cell cycle checkpoint by mediating phosphorylation of CHEK2.; [Isoform ZAKalpha]: Key component of the stress-activated protein kinase signaling cascade in response to ribotoxic stress or UV-B irradiation. Acts as the proximal sensor of ribosome collisions during the ribotoxic stress response (RSR): directly binds to the ribosome by inserting its flexible C-terminus into the ribosomal intersubunit space, thereby acting as a sentinel for colliding ribosomes. Upon ribosome collisions, activates either the stress-activated protein kinase signal transduction cascade or the integrated stress response (ISR), leading to programmed cell death or cell survival, respectively. Dangerous levels of ribosome collisions trigger the autophosphorylation and activation of MAP3K20, which dissociates from colliding ribosomes and phosphorylates MAP kinase kinases, leading to activation of the JNK and MAP kinase p38 pathways that promote programmed cell death. Less dangerous levels of ribosome collisions trigger the integrated stress response (ISR): MAP3K20 activates EIF2AK4/GCN2 independently of its protein-kinase activity, promoting EIF2AK4/GCN2-mediated phosphorylation of EIF2S1/eIF-2-alpha. Also part of the stress-activated protein kinase signaling cascade triggering the NLRP1 inflammasome in response to UV-B irradiation: ribosome collisions activate MAP3K20, which directly phosphorylates NLRP1, leading to activation of the NLRP1 inflammasome and subsequent pyroptosis. NLRP1 is also phosphorylated by MAP kinase p38 downstream of MAP3K20. Also acts as a histone kinase by phosphorylating histone H3 at 'Ser-28' (H3S28ph).; [Isoform ZAKbeta]: Isoform that lacks the C-terminal region that mediates ribosome-binding: does not act as a sensor of ribosome collisions in response to ribotoxic stress. May act as an antagonist of isoform ZAKalpha: interacts with isoform ZAKalpha, leading to decrease the expression of isoform ZAKalpha.
TTD ID
T97821
Uniprot ID
Q9NYL2
DrugMap ID
TTTUZ3O
Ensemble ID
ENST00000338983.7
HGNC ID
HGNC:17797
ChEMBL ID
CHEMBL3886

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.R32Q DBIA    Probe Info 
COLO800 Insertion: . DBIA    Probe Info 
FADU SNV: p.T328A .
HCT116 Deletion: p.G767AfsTer65 DBIA    Probe Info 
HEC1B SNV: p.S584P .
JURKAT SNV: p.T752I .
KMCH1 SNV: p.Y120F DBIA    Probe Info 
KMS11 SNV: p.G25A DBIA    Probe Info 
KYSE510 SNV: p.L196F DBIA    Probe Info 
L428 SNV: p.D356N DBIA    Probe Info 
MFE319 Deletion: p.N222TfsTer4
SNV: p.A403V		 DBIA    Probe Info 
NCIH1155 Deletion: p.N646TfsTer186 DBIA    Probe Info 
NCIH661 SNV: p.G23C .
SKN SNV: p.Q547Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K45(10.00)  LDD0277  [2]
AHL-Pu-1
 Probe Info  		C571(2.26)  LDD0168  [3]
DBIA
 Probe Info  		C571(1.46); C22(1.18); C285(0.99); C231(0.90)  LDD0078  [4]
ATP probe
 Probe Info  		K45(0.00); K46(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C285(0.00); C22(0.00); C242(0.00); C150(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C285(0.00); C273(0.00); C242(0.00); C150(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C285(0.00); C150(0.00); C242(0.00); C22(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		C22(0.00); C242(0.00)  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		14.20  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C571(2.26)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C571(13.01); C22(2.51)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C150(1.15); C22(1.12); C231(0.94); C242(0.83)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C150(1.09); C22(1.18); C231(0.93); C242(0.88)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C150(1.01); C22(0.86); C231(0.89); C242(0.71)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C150(0.98); C22(0.97); C231(0.85); C242(0.79)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C150(0.89); C22(0.88); C231(0.93); C242(0.78)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C150(1.11); C22(1.14); C231(0.79); C242(0.77)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C150(1.11); C22(1.08); C231(0.68); C242(0.70)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C150(1.07); C22(1.06); C231(0.72); C242(0.82)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C150(1.09); C22(1.06); C231(0.78); C242(0.76)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C150(0.98); C22(0.96); C231(0.80); C242(0.78)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C150(0.91); C22(1.06); C231(0.90); C242(0.73)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C150(0.95); C22(1.15); C231(0.83); C242(0.78)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C150(1.11); C22(1.20); C231(0.96); C242(0.84)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C150(0.92); C22(1.15); C231(0.83); C242(0.78)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C150(0.88); C22(1.09); C231(0.76); C242(0.70)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C150(0.91); C22(0.93); C231(0.75); C242(0.69)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C150(1.21); C22(1.11); C231(0.96); C242(0.85)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C150(1.24); C22(1.63); C231(0.84); C242(0.79)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C150(1.24); C22(1.77); C231(0.91); C242(0.94)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C150(1.34); C22(2.08); C231(0.88); C242(0.87)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C150(1.22); C22(1.61); C231(0.84); C242(0.89)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C150(1.17); C22(1.37); C231(0.92); C242(0.93)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C150(1.27); C22(1.40); C231(0.92); C242(0.86)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C150(1.20); C22(1.15); C231(1.01); C242(0.84)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C150(1.19); C22(1.19); C231(0.87); C242(0.73)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C150(1.24); C22(1.40); C231(0.94); C242(0.91)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C150(1.11); C22(1.28); C231(0.92); C242(0.89)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C150(1.02); C22(1.64); C231(0.98); C242(0.85)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C150(1.13); C22(1.27); C231(0.97); C242(1.00)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C150(1.16); C22(1.61); C231(0.92); C242(0.74)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C150(1.29); C22(2.17); C231(0.94); C242(1.05)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C150(1.28); C22(2.18); C231(0.92); C242(0.95)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C150(1.60); C22(1.25); C231(1.22); C242(1.39)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C150(0.94); C22(0.93); C231(1.17); C242(1.21)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C150(1.23); C22(1.23); C231(1.11); C242(1.01)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C150(1.06); C22(1.22); C231(1.07); C242(1.27)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C150(1.19); C22(0.85); C231(1.22); C242(1.36)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C150(1.21); C22(1.00); C231(1.14); C242(1.30)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C150(1.17); C22(1.20); C231(1.15); C242(1.26)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C150(1.16); C22(1.31); C231(1.22); C242(1.17)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C150(1.25); C22(0.93); C231(1.18); C242(1.17)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C150(1.26); C22(0.91); C231(1.14); C242(1.17)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C150(1.35); C22(0.95); C231(1.18); C242(1.17)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C150(1.24); C22(1.22); C231(1.26); C242(1.34)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C150(1.01); C22(1.21); C231(0.81); C242(0.83)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C150(1.36); C22(1.37); C231(1.24); C242(1.51)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C150(1.30); C22(1.04); C231(1.22); C242(1.21)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C150(1.08); C22(0.90); C231(1.12); C242(1.19)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C242(0.74); C273(0.89); C231(0.92); C22(1.22)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C231(0.83); C242(0.85); C273(0.93); C150(1.20)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C273(0.87); C242(0.91); C231(0.92); C150(1.26)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C231(0.77); C273(0.93); C242(0.97); C150(1.25)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C242(0.85); C273(0.85); C231(0.93); C150(1.20)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C231(0.84); C273(1.01); C242(1.19); C150(1.44)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C231(0.77); C273(0.99); C242(1.16); C150(1.49)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C242(0.88); C231(0.94); C571(0.99); C150(1.06)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C231(0.83); C273(0.88); C242(0.92); C571(1.03)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C273(0.79); C242(0.87); C231(0.92); C571(1.06)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C231(0.72); C273(0.87); C242(0.94); C150(1.32)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C231(0.80); C273(1.06); C242(1.21); C150(1.82)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C150(1.25); C22(2.09); C231(0.86); C242(0.92)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C150(1.24); C22(1.52); C231(0.79); C242(0.94)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C150(1.14); C22(1.25); C231(0.87); C242(1.00)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C150(1.08); C22(1.19); C231(0.87); C242(0.99)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C242(0.91); C231(0.98); C150(1.05); C22(1.12)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C231(0.85); C242(0.89); C285(1.16); C150(1.16)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C231(0.93); C242(0.94); C150(0.99); C571(1.05)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C242(0.93); C231(0.94); C273(0.98); C22(1.07)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C242(0.91); C231(0.95); C150(0.98); C285(0.98)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C242(0.87); C231(0.95); C150(1.03); C285(1.09)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C242(0.93); C150(1.02); C231(1.06); C285(1.08)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C242(0.86); C231(1.02); C150(1.02); C22(1.06)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C242(0.93); C150(0.96); C22(1.03); C571(1.04)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C242(0.82); C273(0.84); C231(0.92); C150(1.11)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C273(0.71); C242(0.78); C231(0.89); C150(1.25)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C273(0.78); C242(0.82); C231(0.84); C150(1.16)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C242(0.77); C273(0.77); C231(0.88); C150(1.33)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C273(0.77); C242(0.78); C231(0.83); C150(1.26)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C231(0.75); C242(0.82); C285(1.08); C273(1.08)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C273(0.80); C242(0.85); C231(0.86); C150(1.25)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C273(0.68); C242(0.74); C231(0.83); C150(1.27)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C273(0.75); C242(0.80); C231(0.83); C150(1.30)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C273(0.76); C242(0.78); C231(0.80); C150(1.38)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C242(0.74); C231(0.81); C273(0.91); C150(1.35)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C571(0.86); C150(0.92); C242(0.97); C22(0.99)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C22(0.73); C273(0.86); C571(0.87); C150(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C571(0.83); C273(0.91); C22(0.92); C150(0.99)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C22(0.93); C150(0.96); C273(0.97); C242(1.02)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C273(0.91); C231(1.08); C571(1.09); C150(1.10)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C242(0.91); C273(0.94); C231(0.97); C285(1.11)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C571(0.90); C273(0.98); C231(1.05); C22(1.09)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C273(0.81); C285(1.03); C242(1.04); C150(1.04)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C273(0.88); C150(0.98); C242(1.05); C22(1.10)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C273(0.78); C22(0.86); C242(1.03); C231(1.04)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C571(0.85); C273(0.88); C22(0.92); C150(0.99)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C571(0.80); C273(0.87); C22(1.05); C150(1.07)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C273(0.72); C242(0.93); C231(0.96); C150(1.05)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C273(0.64); C242(0.95); C150(1.05); C231(1.08)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C273(0.77); C231(0.94); C242(0.95); C150(1.11)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C273(0.72); C242(1.05); C231(1.06); C150(1.21)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C571(0.89); C242(0.97); C273(1.05); C285(1.08)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C273(0.59); C242(0.96); C231(1.06); C285(1.21)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C273(0.61); C242(0.96); C150(1.05); C285(1.07)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C273(0.70); C242(0.97); C150(1.09); C231(1.10)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C273(0.61); C242(0.93); C231(0.97); C150(1.04)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C273(0.73); C231(0.99); C285(1.01); C242(1.02)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C273(0.63); C242(1.04); C231(1.09); C150(1.24)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C273(0.66); C242(1.08); C231(1.16); C150(1.33)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C273(0.70); C242(0.93); C571(1.05); C231(1.07)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C273(0.73); C242(0.90); C231(1.10); C571(1.20)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C242(0.93); C231(1.02); C571(1.06); C273(1.07)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C231(0.88); C242(0.90); C285(1.08); C150(1.08)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C273(0.79); C231(0.88); C242(0.94); C150(1.31)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C273(0.76); C242(0.89); C231(0.94); C571(1.02)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C273(0.82); C242(0.98); C231(1.04); C571(1.08)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C273(0.74); C242(0.91); C571(1.05); C231(1.12)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C231(0.99); C273(1.01); C242(1.06); C571(1.29)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C231(0.99); C273(1.00); C242(1.01); C571(1.12)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C273(0.74); C571(0.92); C242(0.97); C231(1.08)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C231(0.94); C273(1.01); C242(1.02); C571(1.11)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C273(0.90); C231(0.92); C571(1.07); C285(1.08)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C273(0.91); C231(1.04); C242(1.15); C285(1.17)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C242(0.90); C150(0.93); C231(1.01); C571(1.12)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C273(0.90); C242(1.02); C285(1.03); C231(1.07)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C273(0.93); C22(1.01); C231(1.07); C150(1.08)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C273(0.77); C571(0.99); C242(1.03); C231(1.12)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C273(0.77); C231(1.03); C571(1.15); C242(1.17)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C273(0.94); C231(1.10); C571(1.21); C242(1.27)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C273(0.74); C571(0.93); C231(1.02); C242(1.15)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C273(0.93); C571(1.02); C231(1.04); C285(1.10)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C273(0.73); C231(0.99); C242(1.04); C150(1.16)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C273(0.75); C285(0.97); C22(0.99); C242(1.01)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C273(0.72); C231(0.98); C22(1.08); C242(1.13)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C242(0.86); C231(0.87); C571(0.98); C285(1.09)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C273(0.86); C571(1.04); C242(1.05); C22(1.05)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C273(0.77); C571(0.96); C22(1.02); C242(1.02)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C273(0.82); C242(1.00); C231(1.09); C571(1.10)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C242(0.91); C273(1.03); C231(1.06); C150(1.38)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C242(0.96); C273(1.01); C231(1.02); C285(1.25)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C242(0.90); C231(0.97); C273(0.99); C285(1.08)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C273(1.00); C231(1.06); C242(1.06); C285(1.09)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C273(0.91); C231(1.00); C571(1.06); C242(1.06)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C273(0.92); C231(1.03); C242(1.10); C285(1.18)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C273(0.92); C231(0.93); C242(1.14); C571(1.29)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C242(1.00); C571(1.05); C273(1.06); C285(1.21)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C242(1.01); C273(1.05); C231(1.07); C150(1.23)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C242(0.94); C273(0.96); C231(1.14); C150(1.18)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C285(0.88); C242(0.92); C273(1.01); C231(1.04)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C273(0.90); C285(1.05); C231(1.07); C150(1.22)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C273(0.72); C231(0.90); C285(1.07); C242(1.12)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C273(0.86); C231(1.00); C150(1.11); C242(1.19)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C273(0.97); C231(1.05); C242(1.11); C285(1.30)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C231(0.75); C273(0.76); C242(0.79); C150(1.08)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C285(0.61); C231(0.79); C22(0.84); C273(0.86)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C150(1.05); C22(1.13); C231(1.06); C242(0.93)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C242(0.91); C231(0.98); C150(1.00); C571(1.01)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C242(0.94); C231(1.07); C285(1.12); C571(1.24)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 11.22  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C571(1.46); C22(1.18); C285(0.99); C231(0.90)  LDD0078  [4]
 LDCM0630  CCW28-3 231MFP C22(2.43)  LDD2214  [12]
 LDCM0108  Chloroacetamide HeLa C22(0.00); C242(0.00); C571(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C285(20.00)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C150(0.85); C285(0.91); C22(0.94); C231(1.07)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C571(0.90); C231(0.93); C150(0.99); C22(1.27)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C273(0.76); C242(0.81); C231(0.93); C285(1.07)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C231(0.80); C242(0.84); C150(1.07); C571(1.08)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C285(0.76); C571(0.86); C242(0.88); C231(0.91)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C242(0.86); C571(0.88); C231(0.88); C285(1.01)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C242(0.87); C231(0.92); C22(1.07); C285(1.10)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C242(0.88); C231(0.90); C285(1.03); C22(1.19)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C242(0.90); C285(0.92); C231(0.94); C150(1.28)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C242(0.95); C231(1.00); C285(1.12); C150(1.29)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C242(0.93); C231(1.05); C285(1.09); C150(1.36)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C242(0.88); C231(0.91); C285(0.98); C150(1.15)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C231(1.00); C150(1.09); C571(1.12); C285(1.31)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C231(0.86); C242(0.92); C285(1.16); C150(1.17)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C242(0.86); C231(0.88); C150(1.07); C285(1.25)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C242(0.93); C273(0.93); C231(0.95); C150(1.02)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C273(0.77); C242(0.78); C231(0.81); C150(1.31)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C242(0.74); C231(0.87); C273(0.93); C150(1.09)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C242(0.82); C231(0.84); C273(0.86); C22(1.14)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C273(0.82); C242(0.83); C231(0.86); C150(1.24)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C571(1.02); C273(1.02); C231(1.20); C150(1.20)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C273(0.88); C22(0.91); C150(1.04); C242(1.05)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C273(0.81); C231(1.00); C242(1.00); C150(1.04)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C571(0.90); C231(1.02); C150(1.05); C22(1.44)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C273(0.77); C22(0.81); C571(1.04); C242(1.06)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C231(0.77); C285(0.77); C150(0.82); C273(0.84)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C231(0.94); C273(0.97); C242(1.01); C150(1.07)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C273(0.66); C242(0.95); C150(1.01); C231(1.02)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C273(0.68); C242(1.03); C231(1.14); C150(1.28)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C273(0.88); C571(0.93); C242(0.94); C231(1.01)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C242(0.84); C273(0.93); C231(0.96); C150(1.01)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C273(0.74); C242(0.90); C231(0.96); C150(1.03)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C273(0.88); C231(0.97); C242(0.99); C571(1.10)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C231(0.91); C150(1.15); C571(1.22); C22(1.40)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C231(0.99); C150(0.99); C571(1.14); C285(1.20)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C231(0.90); C150(1.00); C571(1.04); C285(1.09)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C285(0.74); C150(0.90); C22(0.95); C242(1.04)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C242(0.87); C150(0.91); C571(1.01); C22(1.02)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C285(0.88); C242(0.89); C150(0.94); C231(0.94)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C242(0.93); C22(0.93); C150(0.98); C231(1.01)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C285(0.90); C150(0.94); C22(0.96); C231(1.00)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C242(0.92); C231(0.99); C150(1.09); C285(1.25)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C150(0.95); C242(1.01); C231(1.02); C285(1.35)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C150(0.81); C231(0.87); C242(1.20); C571(1.57)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C150(0.93); C242(0.99); C285(1.02); C231(1.10)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C231(1.04); C150(1.08); C242(1.15); C285(1.18)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C150(1.09); C22(1.13); C231(0.98); C242(1.08)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C150(1.09); C22(0.95); C231(0.95); C242(1.00)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C150(1.00); C22(1.06); C231(0.99); C242(1.03)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C150(1.02); C22(1.03); C231(1.01); C242(0.98)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C150(1.16); C22(1.29); C231(1.01); C242(1.04)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C150(0.92); C22(1.27); C231(0.96); C285(0.93)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C150(1.10); C22(0.96); C231(1.07); C242(1.00)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C150(1.01); C22(1.03); C231(0.86); C242(0.93)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C150(0.89); C22(1.16); C231(0.77); C242(0.64)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C150(0.86); C22(1.07); C231(0.80); C242(0.74)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C150(1.11); C22(1.80); C231(0.89); C242(1.04)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C150(0.85); C22(1.23); C231(0.87); C242(1.07)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C150(0.95); C22(1.16); C231(0.86); C242(0.89)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C150(0.93); C22(1.43); C231(0.88); C242(1.17)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C150(0.94); C22(1.46); C231(0.91); C242(0.67)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C150(0.84); C22(1.08); C231(0.93); C285(0.91)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C150(0.89); C22(1.26); C231(0.92); C242(0.84)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C150(0.94); C22(1.10); C231(0.83); C242(1.10)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C150(0.98); C22(1.50); C231(1.05); C242(1.26)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C150(1.09); C22(1.33); C231(0.94); C242(0.81)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C150(1.00); C22(1.25); C231(0.81); C242(0.79)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C150(1.08); C22(2.38); C231(0.92); C242(0.95)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C150(0.97); C22(0.84); C231(1.01); C242(0.95)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C150(0.96); C22(1.09); C231(0.98); C242(0.91)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C150(0.96); C22(0.97); C231(1.01); C242(1.03)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C150(1.02); C22(1.11); C231(1.02); C242(1.08)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C150(0.98); C22(1.07); C231(0.98); C285(1.01)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C150(0.96); C22(1.05); C231(1.01); C242(0.98)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C150(1.01); C22(1.09); C231(1.11); C242(0.93)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C150(0.98); C22(1.15); C231(1.02); C242(1.00)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C150(0.98); C22(1.12); C231(0.99); C242(0.93)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C150(0.91); C22(0.92); C231(1.04); C242(0.98)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C150(0.88); C22(1.02); C231(1.02); C242(0.98)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C150(0.95); C22(1.07); C231(1.01); C242(0.96)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C150(0.93); C22(0.91); C231(0.97); C242(0.95)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C150(0.90); C22(1.07); C231(1.01); C242(0.93)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C150(1.01); C22(0.99); C231(1.14); C242(0.94)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C150(0.93); C22(1.18); C231(0.91); C285(1.13)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C150(0.98); C22(1.02); C231(1.10); C242(0.91)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C150(1.04); C22(1.34); C231(1.11); C242(0.96)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C150(1.09); C22(1.17); C231(0.93); C242(0.98)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C150(1.09); C22(1.33); C231(0.96); C242(0.89)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C150(1.25); C22(1.64); C231(1.07); C242(0.90)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C150(1.12); C22(1.24); C231(1.16); C242(0.99)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C150(1.19); C22(1.55); C231(1.02); C242(0.96)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C150(1.31); C22(1.28); C231(1.06); C242(0.89)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C150(1.10); C22(1.35); C231(0.92); C242(0.89)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C150(1.00); C22(1.19); C231(0.91); C242(0.78)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C150(1.11); C22(1.29); C231(1.02); C285(2.05)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C150(1.12); C22(1.29); C231(0.93); C242(0.87)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C150(1.19); C22(1.50); C231(1.21); C242(0.88)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C150(1.05); C22(1.16); C231(1.02); C242(1.01)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C150(1.08); C22(1.72); C231(1.04); C242(0.87)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C150(1.17); C22(1.38); C231(1.03); C242(0.98)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C150(0.87); C22(1.32); C231(0.81); C242(0.89)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C150(0.95); C22(1.53); C231(0.84); C242(0.93)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C150(1.01); C22(1.37); C231(0.93); C242(1.05)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C150(0.94); C22(1.46); C231(0.82); C242(0.91)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C150(1.11); C22(1.60); C231(1.03); C285(0.81)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C150(1.01); C22(1.33); C231(0.82); C242(1.03)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C150(1.01); C22(1.37); C231(0.87); C242(0.95)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C150(1.11); C22(1.74); C231(0.95); C242(1.16)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C150(1.00); C22(1.71); C231(0.88); C242(0.99)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C150(0.98); C22(1.90); C231(1.06); C242(0.95)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C150(0.97); C22(1.44); C231(0.91); C242(0.98)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C150(1.06); C22(1.14); C231(0.98); C242(0.87)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C150(0.95); C22(1.44); C231(1.04); C242(0.94)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C150(0.91); C22(1.55); C231(0.96); C242(0.98)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C150(0.93); C22(1.92); C231(1.08); C242(1.21)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C150(0.93); C22(1.31); C231(0.93); C285(1.08)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C150(0.93); C22(1.23); C231(0.99); C242(1.03)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C150(1.12); C22(1.10); C231(0.86); C242(0.94)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C150(1.03); C22(1.11); C231(0.94); C242(0.97)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C150(1.01); C22(1.33); C231(0.88); C242(0.95)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C150(1.10); C22(1.15); C231(0.89); C242(0.88)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C150(1.06); C22(1.23); C231(0.85); C242(0.85)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C150(1.22); C22(1.14); C231(0.89); C242(0.89)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C150(1.07); C22(1.07); C231(0.95); C242(0.97)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C150(1.06); C22(1.08); C231(0.90); C242(0.94)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C150(1.16); C22(1.02); C231(0.88); C242(0.95)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C150(1.13); C285(0.85); C273(1.00); C22(1.07)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C231(2.42); C150(1.24)  LDD1702  [14]
 LDCM0572  Fragment10 MDA-MB-231 C22(1.21)  LDD1465  [15]
 LDCM0573  Fragment11 MDA-MB-231 C22(0.66)  LDD1467  [15]
 LDCM0574  Fragment12 MDA-MB-231 C22(0.68)  LDD1468  [15]
 LDCM0575  Fragment13 MDA-MB-231 C22(5.24)  LDD1395  [15]
 LDCM0576  Fragment14 MDA-MB-231 C22(1.63)  LDD1397  [15]
 LDCM0579  Fragment20 MDA-MB-231 C22(20.00)  LDD1402  [15]
 LDCM0580  Fragment21 MDA-MB-231 C22(2.00)  LDD1404  [15]
 LDCM0581  Fragment22 MDA-MB-231 C22(1.04)  LDD1406  [15]
 LDCM0582  Fragment23 MDA-MB-231 C22(1.36)  LDD1408  [15]
 LDCM0584  Fragment25 MDA-MB-231 C22(0.75)  LDD1411  [15]
 LDCM0578  Fragment27 MDA-MB-231 C22(1.14)  LDD1401  [15]
 LDCM0586  Fragment28 MDA-MB-231 C22(1.39)  LDD1415  [15]
 LDCM0587  Fragment29 MDA-MB-231 C22(1.17)  LDD1417  [15]
 LDCM0588  Fragment30 MDA-MB-231 C22(1.06)  LDD1419  [15]
 LDCM0590  Fragment32 MDA-MB-231 C22(2.12)  LDD1423  [15]
 LDCM0468  Fragment33 HCT 116 C150(1.27); C22(1.17); C231(1.05); C242(0.84)  LDD0785  [4]
 LDCM0592  Fragment34 MDA-MB-231 C22(0.84)  LDD1427  [15]
 LDCM0596  Fragment38 MDA-MB-231 C22(1.18)  LDD1433  [15]
 LDCM0566  Fragment4 MDA-MB-231 C22(20.00)  LDD1378  [15]
 LDCM0599  Fragment41 MDA-MB-231 C22(1.49)  LDD1438  [15]
 LDCM0601  Fragment43 MDA-MB-231 C22(2.90)  LDD1441  [15]
 LDCM0602  Fragment44 MDA-MB-231 C22(0.82)  LDD1443  [15]
 LDCM0603  Fragment45 MDA-MB-231 C22(20.00)  LDD1444  [15]
 LDCM0427  Fragment51 HCT 116 C150(0.91); C22(1.73); C231(1.08); C242(0.97)  LDD0744  [4]
 LDCM0612  Fragment54 MDA-MB-231 C22(1.11)  LDD1456  [15]
 LDCM0613  Fragment55 MDA-MB-231 C22(1.18)  LDD1457  [15]
 LDCM0614  Fragment56 MDA-MB-231 C22(1.13)  LDD1458  [15]
 LDCM0569  Fragment7 MDA-MB-231 C22(3.13)  LDD1383  [15]
 LDCM0570  Fragment8 MDA-MB-231 C22(1.44)  LDD1462  [15]
 LDCM0571  Fragment9 MDA-MB-231 C22(20.00)  LDD1387  [15]
 LDCM0022  KB02 HCT 116 C22(20.00); C571(3.47); C150(8.34)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C22(1.69); C571(2.10); C150(2.47)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C22(20.00); C571(2.22); C150(1.17)  LDD0082  [4]
 LDCM0131  RA190 MM1.R C22(1.36)  LDD0304  [16]
 LDCM0021  THZ1 HCT 116 C150(1.12); C231(0.99)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) AGC Ser/Thr protein kinase family O75582
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial zinc finger protein induced by tumor necrosis factor alpha (ZNF71) Krueppel C2H2-type zinc-finger protein family Q9NQZ8
Zinc finger protein 1 homolog (ZFP1) Krueppel C2H2-type zinc-finger protein family Q6P2D0
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 567 (ZNF567) Krueppel C2H2-type zinc-finger protein family Q8N184
Zinc finger protein 660 (ZNF660) Krueppel C2H2-type zinc-finger protein family Q6AZW8
Zinc finger protein ZFP2 (ZFP2) Krueppel C2H2-type zinc-finger protein family Q6ZN57

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dasatinib Small molecular drug DB01254
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid16539403c15b Small molecular drug D06BDC

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.