Details of the Target

General Information of Target

Target ID LDTP03841
Target Name Hippocalcin-like protein 1 (HPCAL1)
Gene Name HPCAL1
Gene ID 3241
Synonyms
BDR1; Hippocalcin-like protein 1; Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYGD
ASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRSE
MLEIVQAIYKMVSSVMKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIRGAKSDPSIV
RLLQCDPSSASQF
Target Bioclass
Other
Family
Recoverin family
Subcellular location
Membrane
Function May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
Uniprot ID
P37235
Ensemble ID
ENST00000307845.8
HGNC ID
HGNC:5145
ChEMBL ID
CHEMBL4295755

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
SAA-alkyne
 Probe Info  		1.07  LDD0252  [2]
ONAyne
 Probe Info  		K151(7.57); K174(2.94)  LDD0274  [3]
STPyne
 Probe Info  		K151(3.23); K163(8.43); K174(9.32); K7(6.95)  LDD0277  [3]
Probe 1
 Probe Info  		Y31(22.22)  LDD3495  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
THZ1-DTB
 Probe Info  		C185(1.05)  LDD0460  [5]
HPAP
 Probe Info  		3.90  LDD0063  [6]
Alkyne-RA190
 Probe Info  		2.01  LDD0299  [7]
EA-probe
 Probe Info  		C185(0.77)  LDD2210  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
DBIA
 Probe Info  		C185(1.10)  LDD0078  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
BTD
 Probe Info  		N.A.  LDD0004  [13]
NAIA_4
 Probe Info  		0.00; C38(0.00)  LDD2226  [14]
NAIA_5
 Probe Info  		C185(0.00); C38(0.00)  LDD2225  [14]
IPM
 Probe Info  		N.A.  LDD2156  [15]
TFBX
 Probe Info  		C38(0.00); C185(0.00)  LDD0148  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		15.00  LDD0443  [17]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		18.05  LDD0472  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
Alk-rapa
 Probe Info  		6.44  LDD0213  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C38(0.54)  LDD2142  [20]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C38(0.79); C185(0.88)  LDD2112  [20]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C38(1.24)  LDD2117  [20]
 LDCM0214  AC1 HEK-293T C38(1.00); C185(1.02)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C38(0.94); C185(1.01)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C38(1.01); C185(1.02)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C38(0.98); C185(1.12)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C185(1.02)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C38(1.11); C185(1.07)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C38(1.16); C185(1.04)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C38(1.05); C185(1.00)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C38(0.93); C185(1.04)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C38(0.88); C185(1.07)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C38(1.12); C185(1.04)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C38(1.00); C185(0.92)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C185(1.02)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C38(1.21); C185(1.06)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C38(1.12); C185(1.05)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C38(1.06); C185(1.10)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C38(0.91); C185(0.98)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C38(0.96); C185(1.02)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C38(1.02); C185(0.98)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C38(1.00); C185(0.90)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C38(0.99); C185(1.04)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C185(0.96)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C38(1.07); C185(1.09)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C38(1.12); C185(0.95)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C38(1.44); C185(1.22)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C38(1.05); C185(1.11)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C38(1.18); C185(1.09)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C38(1.17); C185(1.18)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C38(0.98); C185(0.99)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C185(1.13)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C38(1.09); C185(1.05)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C38(1.07); C185(0.94)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C38(1.17); C185(1.11)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C38(1.04); C185(1.13)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C38(0.91); C185(1.05)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C38(1.14); C185(1.26)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C38(1.23); C185(1.14)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C38(1.06); C185(1.01)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C185(1.07)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C38(1.18); C185(1.07)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C38(1.25); C185(1.12)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C38(1.02); C185(1.11)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C38(1.14); C185(0.99)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C38(0.95); C185(1.10)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C38(1.02); C185(1.11)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C38(1.01); C185(1.12)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C38(1.16); C185(1.00)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C185(1.08)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C38(1.17); C185(1.07)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C38(1.07); C185(1.06)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C38(0.93); C185(1.06)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C38(0.88); C185(1.05)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C38(1.15); C185(1.08)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C185(0.97)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C38(1.12); C185(1.08)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C38(1.07); C185(0.91)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C185(1.14)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C38(1.07); C185(1.06)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C38(1.06); C185(1.05)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C38(0.95); C185(1.06)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C38(0.99); C185(0.92)  LDD1569  [21]
 LDCM0520  AKOS000195272 MDA-MB-231 C38(0.78)  LDD2113  [20]
 LDCM0248  AKOS034007472 HEK-293T C38(1.06); C185(1.02)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C38(1.03); C185(1.10)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C38(1.08); C185(1.05)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 13.03  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C185(1.10)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C38(20.00); C185(1.26)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C38(0.96); C185(1.19)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C185(1.49)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C38(1.08); C185(1.11)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C38(0.90); C185(1.01)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C38(0.93); C185(1.09)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C38(1.11); C185(1.19)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C38(1.02); C185(1.06)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C38(1.01); C185(1.07)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C38(1.02); C185(1.06)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C38(1.15); C185(1.03)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C38(1.17); C185(1.01)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C38(0.91); C185(1.02)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C38(0.85); C185(1.33)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C38(0.85); C185(1.04)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C38(1.15); C185(1.03)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C38(0.93); C185(1.05)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C38(1.12); C185(1.05)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C38(0.97); C185(1.07)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C38(1.10); C185(0.96)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C38(1.19); C185(1.14)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C38(1.10); C185(1.09)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C38(0.99); C185(0.97)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C38(0.96); C185(1.04)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C38(0.88); C185(1.07)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C38(1.08); C185(1.05)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C38(0.96); C185(1.07)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C38(1.07); C185(1.06)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C38(0.90); C185(1.12)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C38(1.05); C185(1.17)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C38(0.61); C185(1.04)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C38(1.15); C185(1.04)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C38(0.78); C185(1.03)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C38(1.04); C185(1.04)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C38(0.84); C185(1.10)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C38(0.94); C185(1.01)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C38(1.46); C185(1.32)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C38(1.19); C185(1.08)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C38(0.75); C185(1.31)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C38(1.38); C185(1.04)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C38(0.82); C185(1.22)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C38(0.97); C185(1.11)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C38(0.76); C185(1.15)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C38(0.68); C185(1.13)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C185(1.07)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C38(0.91); C185(1.30)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C38(0.84); C185(1.12)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C38(0.80); C185(1.39)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C38(1.15); C185(1.07)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C38(1.00); C185(1.04)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C38(1.03); C185(1.04)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C38(1.29); C185(1.09)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C38(1.01); C185(1.05)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C38(1.24); C185(1.06)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C38(0.74); C185(1.11)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C38(0.76); C185(1.13)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C38(0.56); C185(1.45)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C185(1.11)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C38(0.89); C185(1.15)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C38(0.86); C185(1.16)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C38(0.94); C185(1.09)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C38(1.28); C185(1.25)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C38(1.02); C185(1.08)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C38(1.23); C185(1.19)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C38(1.45); C185(1.21)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C38(1.12); C185(0.99)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C38(0.81); C185(0.95)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C38(0.79); C185(1.09)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C38(0.69); C185(1.03)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C185(1.10)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C38(0.86); C185(1.09)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C38(0.89); C185(1.25)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C38(0.77); C185(1.12)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C38(1.09); C185(1.15)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C38(1.16); C185(1.08)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C38(1.12); C185(1.02)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C38(1.22); C185(1.10)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C38(1.12); C185(1.01)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C38(0.80); C185(1.07)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C38(0.76); C185(1.16)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C38(0.69); C185(0.95)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C185(1.07)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C38(0.94); C185(1.19)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C38(0.92); C185(1.05)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C38(1.09); C185(1.40)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C38(0.91); C185(1.05)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C38(1.17); C185(1.04)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C38(1.17); C185(1.20)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C38(1.01); C185(1.08)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C38(1.20); C185(1.08)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C38(1.02); C185(1.10)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C38(0.81); C185(1.24)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C38(0.77); C185(1.19)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C38(0.71); C185(1.09)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C38(0.75); C185(1.05)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C185(1.25)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C38(0.96); C185(1.13)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C38(1.28); C185(1.46)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C38(0.83); C185(1.09)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C38(1.01); C185(1.09)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C38(1.00); C185(1.14)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C38(0.98); C185(1.06)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C38(1.06); C185(1.03)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C38(0.84); C185(1.02)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C38(0.51); C185(1.47)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C38(0.73); C185(1.00)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C38(0.79); C185(1.06)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C185(1.01)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C38(0.80); C185(1.07)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C38(0.85); C185(1.01)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C38(0.75); C185(1.13)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C38(1.48); C185(1.14)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C38(0.83); C185(1.17)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C38(1.14); C185(1.19)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C38(0.92); C185(1.15)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C38(0.65); C185(0.92)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C38(0.71); C185(1.31)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C38(0.90); C185(1.05)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C38(1.00); C185(1.26)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C38(0.84); C185(1.06)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C185(1.07)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C38(0.81); C185(1.67)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C38(0.94); C185(1.02)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C38(0.82); C185(1.03)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C38(1.01); C185(0.89)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C38(0.94); C185(1.12)  LDD1697  [21]
 LDCM0634  CY-0357 Hep-G2 C185(0.20)  LDD2228  [14]
 LDCM0495  E2913 HEK-293T C38(1.66); C185(1.17)  LDD1698  [21]
 LDCM0175  Ethacrynic acid HeLa C185(0.77)  LDD2210  [8]
 LDCM0572  Fragment10 MDA-MB-231 C185(4.41)  LDD1389  [22]
 LDCM0573  Fragment11 MDA-MB-231 C185(2.83)  LDD1391  [22]
 LDCM0574  Fragment12 MDA-MB-231 C185(9.15)  LDD1393  [22]
 LDCM0575  Fragment13 MDA-MB-231 C185(1.64)  LDD1395  [22]
 LDCM0576  Fragment14 MDA-MB-231 C185(16.43)  LDD1397  [22]
 LDCM0579  Fragment20 MDA-MB-231 C185(17.20)  LDD1402  [22]
 LDCM0580  Fragment21 MDA-MB-231 C185(1.86)  LDD1404  [22]
 LDCM0581  Fragment22 MDA-MB-231 C185(1.07)  LDD1406  [22]
 LDCM0582  Fragment23 MDA-MB-231 C185(3.56)  LDD1408  [22]
 LDCM0584  Fragment25 MDA-MB-231 C185(1.11)  LDD1411  [22]
 LDCM0578  Fragment27 MDA-MB-231 C185(0.93)  LDD1401  [22]
 LDCM0586  Fragment28 MDA-MB-231 C185(1.45)  LDD1415  [22]
 LDCM0587  Fragment29 MDA-MB-231 C185(1.11)  LDD1417  [22]
 LDCM0588  Fragment30 MDA-MB-231 C185(0.98)  LDD1419  [22]
 LDCM0590  Fragment32 MDA-MB-231 C185(2.13)  LDD1423  [22]
 LDCM0468  Fragment33 MDA-MB-231 C185(0.98)  LDD1425  [22]
 LDCM0592  Fragment34 MDA-MB-231 C185(1.07)  LDD1427  [22]
 LDCM0594  Fragment36 MDA-MB-231 C185(1.65)  LDD1431  [22]
 LDCM0596  Fragment38 MDA-MB-231 C185(1.25)  LDD1433  [22]
 LDCM0566  Fragment4 MDA-MB-231 C185(4.31)  LDD1378  [22]
 LDCM0598  Fragment40 MDA-MB-231 C185(1.08)  LDD1436  [22]
 LDCM0599  Fragment41 MDA-MB-231 C185(2.70)  LDD1438  [22]
 LDCM0601  Fragment43 MDA-MB-231 C185(1.96)  LDD1441  [22]
 LDCM0602  Fragment44 MDA-MB-231 C185(0.78)  LDD1443  [22]
 LDCM0603  Fragment45 MDA-MB-231 C185(20.00)  LDD1444  [22]
 LDCM0604  Fragment46 MDA-MB-231 C185(0.79)  LDD1445  [22]
 LDCM0605  Fragment47 MDA-MB-231 C185(1.21)  LDD1446  [22]
 LDCM0606  Fragment48 MDA-MB-231 C185(1.42)  LDD1447  [22]
 LDCM0607  Fragment49 MDA-MB-231 C185(5.94)  LDD1448  [22]
 LDCM0608  Fragment50 MDA-MB-231 C185(3.23)  LDD1449  [22]
 LDCM0427  Fragment51 MDA-MB-231 C185(1.06)  LDD1450  [22]
 LDCM0610  Fragment52 MDA-MB-231 C185(1.29)  LDD1452  [22]
 LDCM0611  Fragment53 MDA-MB-231 C185(1.10)  LDD1454  [22]
 LDCM0612  Fragment54 MDA-MB-231 C185(1.04)  LDD1456  [22]
 LDCM0613  Fragment55 MDA-MB-231 C185(0.95)  LDD1457  [22]
 LDCM0614  Fragment56 MDA-MB-231 C185(1.18)  LDD1458  [22]
 LDCM0568  Fragment6 MDA-MB-231 C185(1.17)  LDD1382  [22]
 LDCM0569  Fragment7 MDA-MB-231 C185(3.56)  LDD1383  [22]
 LDCM0570  Fragment8 MDA-MB-231 C185(2.67)  LDD1385  [22]
 LDCM0571  Fragment9 MDA-MB-231 C185(10.78)  LDD1387  [22]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 MDA-MB-231 C185(17.21)  LDD1374  [22]
 LDCM0023  KB03 MDA-MB-231 C185(13.74)  LDD1376  [22]
 LDCM0024  KB05 MIA PaCa-2 C185(9.87)  LDD3330  [23]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C38(0.99)  LDD2102  [20]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C38(0.98)  LDD2092  [20]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C38(0.87)  LDD2097  [20]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C38(2.56)  LDD2098  [20]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C38(0.66)  LDD2100  [20]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C38(0.93)  LDD2101  [20]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C38(1.30)  LDD2105  [20]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C38(0.67)  LDD2106  [20]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C38(0.87)  LDD2107  [20]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C38(0.71)  LDD2108  [20]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C38(0.62)  LDD2109  [20]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C38(0.45); C185(0.79)  LDD2114  [20]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C38(0.86)  LDD2123  [20]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C38(0.89)  LDD2125  [20]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C38(0.82)  LDD2127  [20]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C38(0.76)  LDD2128  [20]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C38(1.12)  LDD2129  [20]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C38(0.52)  LDD2134  [20]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C38(0.96)  LDD2135  [20]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C38(1.07)  LDD2136  [20]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C38(1.00)  LDD2137  [20]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C38(1.00)  LDD2141  [20]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C38(2.20)  LDD2153  [20]
 LDCM0014  Panhematin K562 3.90  LDD0063  [6]
 LDCM0131  RA190 MM1.R 2.01  LDD0299  [7]
 LDCM0090  Rapamycin JHH-7 6.44  LDD0213  [19]
 LDCM0021  THZ1 HeLa S3 C185(1.05)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase 3 (CA3) Alpha-carbonic anhydrase family P07451
Tyrosine--tRNA ligase, cytoplasmic (YARS1) Class-I aminoacyl-tRNA synthetase family P54577
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Procollagen galactosyltransferase 2 (COLGALT2) Glycosyltransferase 25 family Q8IYK4
Phospholipase A and acyltransferase 2 (PLAAT2) H-rev107 family Q9NWW9
Tryptase gamma (TPSG1) Peptidase S1 family Q9NRR2
Ephrin type-B receptor 3 (EPHB3) Tyr protein kinase family P54753
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
High mobility group protein 20A (HMG20A) . Q9NP66
Transcription factor GATA-5 (GATA5) . Q9BWX5
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Myeloid-derived growth factor (MYDGF) MYDGF family Q969H8
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Serpin I2 (SERPINI2) Serpin family O75830
Brorin (VWC2) . Q2TAL6
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2) . Q9BXJ5
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
8 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
20 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840