Details of the Target

General Information of Target

Target ID LDTP07088
Target Name Formin-binding protein 1-like (FNBP1L)
Gene Name FNBP1L
Gene ID 54874
Synonyms
C1orf39; TOCA1; Formin-binding protein 1-like; Transducer of Cdc42-dependent actin assembly protein 1; Toca-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSK
DEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGR
KAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTH
MADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKV
IPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTIS
ASKQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSTPNGSQFLTFSIEPV
HYCMNEIKTGKPRIPSFRSLKRGWSVKMGPALEDFSHLPPEQRRKKLQQRIDELNRELQK
ESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTG
GRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAI
GHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEK
NSKGS
Target Bioclass
Other
Family
FNBP1 family
Subcellular location
Cytoplasm
Function
Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.
Uniprot ID
Q5T0N5
Ensemble ID
ENST00000260506.12
HGNC ID
HGNC:20851

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC827 SNV: p.S422Ter DBIA    Probe Info 
HCT116 SNV: p.R57L DBIA    Probe Info 
IM95 SNV: p.I458V DBIA    Probe Info 
JURKAT SNV: p.N438Y .
TOV21G SNV: p.A311S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K109(2.02); K113(5.32); K321(7.83)  LDD0277  [1]
Probe 1
 Probe Info  		Y506(42.19); Y593(25.84)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C69(3.24)  LDD0170  [3]
HHS-475
 Probe Info  		Y593(0.86); Y566(1.11); Y435(1.31)  LDD0264  [4]
DBIA
 Probe Info  		C129(1.81)  LDD0080  [5]
1d-yne
 Probe Info  		N.A.  LDD0358  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C69(0.00); C129(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C247(0.00); C69(0.00); C129(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C247(0.00); C69(0.00); C129(0.00)  LDD0037  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		C69(0.00); C229(0.00)  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		C69(0.00); C54(0.00)  LDD0018  [11]
m-APA
 Probe Info  		N.A.  LDD0404  [12]
NAIA_5
 Probe Info  		C247(0.00); C129(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C69(3.24)  LDD0170  [3]
 LDCM0214  AC1 HCT 116 C129(0.48)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C129(1.31)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C129(0.96)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C129(1.00)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C129(0.82)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C129(1.12)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C129(0.94)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C129(1.09)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C129(0.91)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C129(0.93)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C129(0.88)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C129(0.97)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C129(1.05)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C129(0.89)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C129(0.88)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C129(0.94)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C129(0.90)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C129(1.12)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C129(0.96)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C129(1.08)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C129(1.06)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C129(1.13)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C129(1.27)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C129(1.14)  LDD0835  [5]
 LDCM0238  AC120 HCT 116 C129(1.23)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C129(0.80)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C129(1.14)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C129(0.80)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C129(0.89)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C129(1.20)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C129(1.01)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C129(1.19)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C129(1.12)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C129(0.91)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C129(0.92)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C129(0.91)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C129(0.87)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C129(0.87)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C129(0.92)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C129(0.86)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C129(0.94)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C129(0.91)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C129(0.87)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C129(0.90)  LDD0575  [5]
 LDCM0259  AC14 HEK-293T C129(0.93)  LDD0857  [5]
 LDCM0260  AC140 HCT 116 C129(0.89)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C129(0.83)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C129(0.79)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C129(0.79)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C129(1.21)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C129(1.03)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C129(1.17)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C129(0.89)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C129(0.95)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C129(1.18)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C129(1.05)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C129(1.09)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C129(0.83)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C129(0.92)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C129(1.10)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C129(0.98)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C129(1.02)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C129(1.13)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C129(1.12)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C129(0.92)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C129(1.04)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C129(1.00)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C129(0.53)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C129(1.00)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C129(0.90)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C129(0.92)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C129(0.91)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C129(0.98)  LDD0601  [5]
 LDCM0285  AC25 PaTu 8988t C129(1.13)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C129(1.00)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C129(1.09)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C129(1.04)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C129(1.05)  LDD1168  [5]
 LDCM0290  AC3 HCT 116 C129(0.48)  LDD0607  [5]
 LDCM0291  AC30 PaTu 8988t C129(1.13)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C129(1.13)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C129(1.10)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C129(1.14)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C129(1.35)  LDD1174  [5]
 LDCM0296  AC35 HCT 116 C129(1.06)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C129(1.04)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C129(0.99)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C129(1.17)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C129(1.16)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C129(0.79)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C129(1.19)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C129(1.03)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C129(1.26)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C129(1.23)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C129(1.12)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C129(1.09)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C69(0.93)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C247(1.11)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C69(1.00)  LDD1549  [13]
 LDCM0312  AC5 HCT 116 C129(0.65)  LDD0629  [5]
 LDCM0314  AC51 HEK-293T C69(1.17)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C247(0.87)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C69(0.89)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C69(1.10)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C247(1.21)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C69(1.12)  LDD1558  [13]
 LDCM0320  AC57 PaTu 8988t C129(0.79)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C129(0.82)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C129(0.76)  LDD1201  [5]
 LDCM0323  AC6 HEK-293T C129(1.02)  LDD0921  [5]
 LDCM0324  AC60 PaTu 8988t C129(0.82)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C129(0.84)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C129(0.82)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C129(0.84)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C129(0.92)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C129(1.02)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C129(1.17)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C129(1.11)  LDD1210  [5]
 LDCM0332  AC68 HCT 116 C129(1.17)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C129(1.57)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C129(0.98)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C129(1.03)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C129(0.99)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C129(1.36)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C129(1.37)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C129(1.71)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C129(1.62)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C129(0.98)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C129(1.59)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C129(1.13)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C129(0.88)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C129(1.21)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C129(1.05)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C129(1.22)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C129(1.36)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C129(0.85)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C129(0.89)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C129(0.82)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C129(0.90)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C129(1.10)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C129(1.08)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C129(0.79)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C129(0.88)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C129(0.89)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C129(0.90)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C129(0.91)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C129(0.85)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C129(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C129(0.76)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C129(0.90)  LDD0681  [5]
 LDCM0365  AC98 HEK-293T C129(1.00)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C129(0.93)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C129(1.09)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C129(1.18)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C129(0.99)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [12]
 LDCM0020  ARS-1620 HCC44 C129(1.07)  LDD2171  [5]
 LDCM0632  CL-Sc Hep-G2 C129(1.84); C247(1.03)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C129(0.72)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C129(0.75)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C129(0.59)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C129(1.09)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C129(1.08)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C129(1.21)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C129(1.23)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C129(0.92)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C129(1.23)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C129(0.94)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C129(0.97)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C129(1.00)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C129(1.30)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C129(0.93)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C129(0.77)  LDD0698  [5]
 LDCM0382  CL112 PaTu 8988t C129(0.96)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C129(1.01)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C129(0.96)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C129(1.10)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C129(0.85)  LDD1265  [5]
 LDCM0387  CL117 HCT 116 C129(1.66)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C129(0.90)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C129(0.91)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C129(1.19)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C129(0.99)  LDD0708  [5]
 LDCM0393  CL122 HEK-293T C69(1.12)  LDD1597  [13]
 LDCM0395  CL124 HEK-293T C69(0.99)  LDD1599  [13]
 LDCM0396  CL125 PaTu 8988t C129(0.89)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C129(1.06)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C129(0.96)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C129(0.72)  LDD1278  [5]
 LDCM0400  CL13 HCT 116 C129(1.10)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C129(0.96)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C129(0.83)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C129(0.90)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C129(0.94)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C129(0.93)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C129(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C129(1.01)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C129(0.95)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C129(0.89)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C129(1.01)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C129(1.09)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C129(0.97)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C129(0.84)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C129(0.98)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C129(1.03)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C129(0.79)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C129(0.86)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C129(1.00)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C129(0.87)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C129(0.88)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C129(0.86)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C129(0.82)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C129(0.93)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C129(1.10)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C129(0.89)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C129(1.10)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C129(0.89)  LDD1307  [5]
 LDCM0429  CL4 HCT 116 C129(0.98)  LDD0746  [5]
 LDCM0430  CL40 PaTu 8988t C129(0.98)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C129(1.08)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C129(1.36)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C129(1.67)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C129(1.02)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C129(0.76)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C129(1.28)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C129(1.11)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C129(0.90)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C129(1.50)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C129(0.71)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C129(1.05)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C129(1.44)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C129(1.27)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C129(1.10)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C129(1.28)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C129(1.25)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C129(1.13)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C129(1.18)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C129(1.53)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C129(1.69)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C129(0.78)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C129(1.11)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C129(1.00)  LDD1051  [5]
 LDCM0454  CL62 HEK-293T C129(0.97)  LDD1052  [5]
 LDCM0455  CL63 HEK-293T C129(1.12)  LDD1053  [5]
 LDCM0456  CL64 HEK-293T C129(0.90)  LDD1054  [5]
 LDCM0457  CL65 HEK-293T C129(0.98)  LDD1055  [5]
 LDCM0458  CL66 HEK-293T C129(0.95)  LDD1056  [5]
 LDCM0459  CL67 HEK-293T C129(1.19)  LDD1057  [5]
 LDCM0460  CL68 HEK-293T C129(0.98)  LDD1058  [5]
 LDCM0461  CL69 HEK-293T C129(1.05)  LDD1059  [5]
 LDCM0462  CL7 HCT 116 C129(1.18)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C129(1.20)  LDD1061  [5]
 LDCM0464  CL71 HEK-293T C129(1.19)  LDD1062  [5]
 LDCM0465  CL72 HEK-293T C129(1.10)  LDD1063  [5]
 LDCM0466  CL73 HEK-293T C129(0.97)  LDD1064  [5]
 LDCM0467  CL74 HEK-293T C129(1.10)  LDD1065  [5]
 LDCM0469  CL76 HCT 116 C129(0.76)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C129(0.70)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C129(0.94)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C129(1.38)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C129(1.13)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C129(0.69)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C129(0.86)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C129(1.19)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C129(0.70)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C129(1.06)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C129(0.83)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C129(0.92)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C129(1.15)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C129(1.11)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C129(1.61)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C129(1.29)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C129(1.53)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C129(0.51)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C129(0.68)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C129(0.71)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C129(0.54)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C129(0.44)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C129(0.72)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C129(0.34)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C129(0.49)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C129(0.75)  LDD0811  [5]
 LDCM0572  Fragment10 MDA-MB-231 C69(2.89)  LDD1389  [14]
 LDCM0573  Fragment11 MDA-MB-231 C69(1.27)  LDD1467  [14]
 LDCM0574  Fragment12 MDA-MB-231 C69(20.00)  LDD1468  [14]
 LDCM0575  Fragment13 MDA-MB-231 C69(1.10)  LDD1395  [14]
 LDCM0576  Fragment14 MDA-MB-231 C69(1.47)  LDD1471  [14]
 LDCM0579  Fragment20 MDA-MB-231 C69(20.00)  LDD1402  [14]
 LDCM0580  Fragment21 MDA-MB-231 C69(1.18)  LDD1404  [14]
 LDCM0582  Fragment23 MDA-MB-231 C69(0.68)  LDD1408  [14]
 LDCM0584  Fragment25 MDA-MB-231 C69(0.87)  LDD1411  [14]
 LDCM0578  Fragment27 MDA-MB-231 C69(1.10)  LDD1401  [14]
 LDCM0586  Fragment28 MDA-MB-231 C69(1.15)  LDD1415  [14]
 LDCM0587  Fragment29 MDA-MB-231 C69(1.15)  LDD1417  [14]
 LDCM0588  Fragment30 MDA-MB-231 C69(1.12)  LDD1419  [14]
 LDCM0590  Fragment32 MDA-MB-231 C69(14.34)  LDD1423  [14]
 LDCM0468  Fragment33 HEK-293T C129(0.93)  LDD1066  [5]
 LDCM0593  Fragment35 MDA-MB-231 C69(0.61)  LDD1429  [14]
 LDCM0594  Fragment36 MDA-MB-231 C69(1.14)  LDD1431  [14]
 LDCM0596  Fragment38 MDA-MB-231 C69(1.83)  LDD1433  [14]
 LDCM0566  Fragment4 MDA-MB-231 C69(20.00)  LDD1378  [14]
 LDCM0598  Fragment40 MDA-MB-231 C69(1.07)  LDD1436  [14]
 LDCM0599  Fragment41 MDA-MB-231 C69(1.38)  LDD1438  [14]
 LDCM0601  Fragment43 MDA-MB-231 C69(20.00)  LDD1441  [14]
 LDCM0603  Fragment45 MDA-MB-231 C69(5.43)  LDD1482  [14]
 LDCM0608  Fragment50 MDA-MB-231 C69(6.57)  LDD1449  [14]
 LDCM0427  Fragment51 PaTu 8988t C129(1.14)  LDD1306  [5]
 LDCM0610  Fragment52 MDA-MB-231 C69(1.24)  LDD1452  [14]
 LDCM0611  Fragment53 MDA-MB-231 C69(1.01)  LDD1454  [14]
 LDCM0614  Fragment56 MDA-MB-231 C69(1.06)  LDD1458  [14]
 LDCM0568  Fragment6 MDA-MB-231 C69(0.75)  LDD1382  [14]
 LDCM0570  Fragment8 MDA-MB-231 C69(3.55)  LDD1462  [14]
 LDCM0571  Fragment9 MDA-MB-231 C69(1.57)  LDD1387  [14]
 LDCM0116  HHS-0101 DM93 Y593(0.86); Y566(1.11); Y435(1.31)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y435(0.84); Y566(1.17); Y593(1.26)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y435(0.75); Y593(0.98); Y566(1.20)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y435(0.92); Y566(0.99); Y593(1.46)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y435(0.63); Y593(1.09); Y566(1.50)  LDD0268  [4]
 LDCM0022  KB02 HCT 116 C129(1.81)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C129(2.14)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C129(3.12)  LDD0082  [5]
 LDCM0021  THZ1 HCT 116 C129(1.07)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8) . P78325
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Disheveled-associated activator of morphogenesis 1 (DAAM1) Formin homology family Q9Y4D1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.