Details of the Target

General Information of Target

Target ID LDTP10002
Target Name Ribonuclease P/MRP protein subunit POP5 (POP5)
Gene Name POP5
Gene ID 51367
Synonyms
Ribonuclease P/MRP protein subunit POP5; hPop5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELI
LGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLH
EADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGI
CHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPG
DEVVQINEQVVVREERDMVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDS
PHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAIL
PAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFM
GPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPF
IFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSP
AQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQ
EQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQ
NRELYSEGLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL
Target Bioclass
Enzyme
Family
Eukaryotic/archaeal RNase P protein component 2 family
Subcellular location
Nucleus, nucleolus
Function Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.
Uniprot ID
Q969H6
Ensemble ID
ENST00000341039.6
HGNC ID
HGNC:17689

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C11(2.12)  LDD3352  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		C129(0.00); C11(0.00)  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		C49(0.00); C129(0.00); C11(0.00)  LDD0037  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C96(1.03); C129(1.26); C11(0.92)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C96(1.02); C129(0.79); C11(1.05)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C96(1.01)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C96(0.90)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C96(0.88)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C96(0.90)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C96(0.91)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C96(0.84)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C96(1.35)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C96(0.82)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C96(1.34)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C96(0.98)  LDD0823  [7]
 LDCM0226  AC11 HEK-293T C96(0.85); C129(1.02); C146(1.07); C11(0.98)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C96(1.02)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C96(1.29)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C96(1.18)  LDD0827  [7]
 LDCM0230  AC113 HEK-293T C96(0.98)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C96(0.99)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C96(0.82)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C96(1.07)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C96(0.99)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C96(1.01)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C96(0.95)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C96(1.05); C129(1.02); C146(1.03)  LDD1510  [6]
 LDCM0238  AC120 HEK-293T C96(0.90)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C96(1.00)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C96(0.96)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C96(0.84)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C96(0.83)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C96(1.11)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C96(1.17)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C96(1.43)  LDD0843  [7]
 LDCM0259  AC14 HEK-293T C96(0.97); C129(0.96); C11(1.10)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C96(1.19); C129(0.94); C11(0.93)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C96(1.04); C129(0.96); C11(0.91)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C96(1.04); C129(0.83); C11(0.99)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C96(0.96); C129(0.80); C146(1.21); C11(1.01)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C96(0.90); C129(0.89); C11(1.03)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C96(0.95); C129(1.00); C146(1.10)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C96(1.06); C129(1.00)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C96(0.83); C129(1.04); C11(0.99)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C96(1.07); C129(0.93); C11(0.95)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C96(1.03); C129(0.86); C11(1.01)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C96(0.95); C129(1.16); C11(0.94)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C96(0.95); C129(0.88); C11(0.96)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C96(0.84); C129(0.99); C146(1.10); C11(0.96)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C96(1.01); C129(1.00); C146(0.96)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C96(0.94); C129(1.06)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C96(0.91); C129(1.12); C146(1.03); C11(0.92)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C96(0.86); C129(0.86); C11(1.04)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C96(1.05); C129(0.94); C11(0.83)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C96(0.97); C129(1.01); C11(0.94)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C96(1.04); C129(1.14); C11(0.96)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C96(1.08); C129(0.85); C11(0.98)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C96(1.04); C129(0.91); C146(1.15); C11(1.00)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C96(0.98); C129(1.02); C146(1.02)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C96(1.03); C129(1.15)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C96(0.96); C129(1.00); C11(1.09)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C96(1.11); C129(0.91); C11(0.97)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C96(1.03); C129(1.05); C146(1.00)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C96(1.26); C129(0.87); C11(1.01)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C96(1.05); C129(0.99); C11(0.77)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C96(1.17); C129(0.91); C11(0.83)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C96(0.93); C129(1.01); C146(1.24); C11(0.95)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C96(0.97); C129(1.09); C146(1.14)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C96(1.12); C129(0.95)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C96(0.97); C129(0.92); C11(1.10)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C96(0.98); C129(1.04); C11(1.03)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C96(1.18); C129(0.99); C11(1.15)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C96(1.09); C129(1.08); C11(0.74)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C96(0.94); C129(1.09)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C96(1.01); C129(0.80); C11(0.87)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C96(0.86); C129(0.87); C146(1.09); C11(1.10)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C96(0.96); C129(1.00); C146(0.95)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C96(1.05); C129(0.97)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C96(0.94); C129(1.14); C11(1.01)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C96(1.14); C129(1.01); C11(1.05)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C96(0.97); C129(0.93); C11(1.07)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C96(1.06); C129(1.18); C11(0.81)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C96(0.94); C129(1.03); C11(0.99)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C96(0.90); C129(1.36); C146(0.99); C11(1.03)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C96(1.00); C129(1.05); C11(1.05)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C96(1.03); C129(1.03); C146(0.98)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C96(0.99); C129(1.09)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C96(0.95); C129(1.00); C11(1.14)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C96(1.11); C129(1.07); C11(0.95)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C96(0.98); C129(1.38); C11(1.02)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C96(0.97); C129(1.17); C11(0.97)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C96(0.95); C129(0.98); C11(1.00)  LDD1569  [6]
 LDCM0365  AC98 HEK-293T C96(0.85)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C96(1.11)  LDD0964  [7]
 LDCM0248  AKOS034007472 HEK-293T C96(1.09); C129(0.94)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C96(1.13); C129(1.01); C11(0.83)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C96(1.06); C129(0.98); C11(1.10)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C96(0.89)  LDD2171  [7]
 LDCM0367  CL1 HEK-293T C96(1.25); C129(0.86)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C96(1.42); C129(0.81); C11(1.14)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C96(0.95); C129(1.06); C146(1.05)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C96(1.06); C129(0.73)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C96(1.18); C129(0.88); C146(0.93); C11(0.97)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C96(1.09); C129(0.85); C146(1.06)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C96(1.01); C129(0.95); C146(0.87)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C96(0.90); C129(0.85)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C96(1.13); C129(0.87); C146(1.02); C11(0.88)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C96(1.05); C129(1.13); C146(0.96)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C96(1.04); C129(0.88); C146(1.16)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C96(1.21); C129(0.75)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C96(1.42); C129(0.55); C11(0.91)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C96(1.24); C129(0.73); C146(1.01); C11(0.90)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C96(1.18); C129(1.06); C146(1.18)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C96(0.99); C129(0.96); C146(1.08)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C96(1.01); C129(0.82)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C96(1.37); C129(0.81); C146(0.71); C11(1.07)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C96(1.00); C129(0.98); C146(1.02)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C96(1.00); C129(0.92); C146(1.02)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C96(1.03); C129(0.88)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C96(1.10); C129(0.82); C146(1.02); C11(0.93)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C96(1.00); C129(1.04); C146(1.01)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C96(1.40); C129(0.67); C11(1.04)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C96(0.94); C129(1.06); C146(0.93)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C96(0.95); C129(0.89)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C96(1.08); C129(0.98); C146(0.87); C11(0.97)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C96(1.42); C129(1.06); C146(1.03)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C96(1.10); C129(0.99); C146(0.93)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C96(0.84); C129(0.89)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C96(1.07); C129(1.31); C146(0.95); C11(1.04)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C96(1.00); C129(2.10); C146(0.99)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C96(0.97); C129(1.06); C146(0.93)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C96(1.00); C129(0.81)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C96(0.87); C129(0.72); C146(1.00); C11(1.02)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C96(1.39); C129(0.79); C146(1.25)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C96(0.99)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C96(0.76)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C96(0.77)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C96(0.94)  LDD1004  [7]
 LDCM0407  CL2 HEK-293T C96(0.99); C129(0.74); C146(0.95); C11(1.05)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C96(0.93)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C96(0.88)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C96(0.78)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C96(0.94)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C96(0.90)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C96(0.73)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C96(0.87)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C96(0.79)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C96(0.78)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C96(0.78)  LDD1015  [7]
 LDCM0418  CL3 HEK-293T C96(1.32); C129(0.86); C146(0.94)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C96(0.82)  LDD1017  [7]
 LDCM0420  CL31 HEK-293T C96(1.03)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C96(0.90)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C96(0.71)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C96(0.93)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C96(0.80)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C96(0.79)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C96(0.75)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C96(0.77)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C96(1.20); C129(0.99); C146(0.94)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C96(0.83)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C96(0.89)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C96(0.88)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C96(0.75)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C96(0.85)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C96(0.84)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C96(0.99)  LDD1034  [7]
 LDCM0437  CL47 HEK-293T C96(0.83)  LDD1035  [7]
 LDCM0438  CL48 HEK-293T C96(0.90)  LDD1036  [7]
 LDCM0439  CL49 HEK-293T C96(0.83)  LDD1037  [7]
 LDCM0440  CL5 HEK-293T C96(1.07); C129(1.04); C11(0.93)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C96(0.93)  LDD1039  [7]
 LDCM0442  CL51 HEK-293T C96(0.80)  LDD1040  [7]
 LDCM0443  CL52 HEK-293T C96(1.04)  LDD1041  [7]
 LDCM0444  CL53 HEK-293T C96(0.94)  LDD1042  [7]
 LDCM0445  CL54 HEK-293T C96(0.82)  LDD1043  [7]
 LDCM0446  CL55 HEK-293T C96(0.87)  LDD1044  [7]
 LDCM0447  CL56 HEK-293T C96(0.81)  LDD1045  [7]
 LDCM0448  CL57 HEK-293T C96(0.90)  LDD1046  [7]
 LDCM0449  CL58 HEK-293T C96(1.05)  LDD1047  [7]
 LDCM0450  CL59 HEK-293T C96(0.86)  LDD1048  [7]
 LDCM0451  CL6 HEK-293T C96(1.31); C129(0.79); C11(0.99)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C96(1.11)  LDD1050  [7]
 LDCM0453  CL61 HEK-293T C96(0.97); C129(0.88)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C96(1.01); C129(0.97); C146(1.09); C11(0.98)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C96(1.05); C129(1.01); C146(1.04)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C96(1.21); C129(1.01); C146(1.07)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C96(1.16); C129(0.97); C11(1.04)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C96(1.10); C129(0.96); C11(1.03)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C96(1.00); C129(0.88); C146(1.21); C11(0.97)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C96(1.14); C129(0.79); C146(0.94)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C96(1.25); C129(0.76)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C96(1.04); C129(0.90); C146(1.19); C11(1.03)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C96(1.06); C129(0.85); C11(1.14)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C96(1.26); C129(0.65); C11(1.03)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C96(1.23); C129(0.53); C11(1.02)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C96(0.87); C129(0.85)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C96(1.06); C129(0.99); C146(0.92); C11(0.89)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C96(1.10)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C96(1.04)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C96(2.08)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C96(1.68)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C96(1.23); C129(0.87); C146(0.80)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C96(1.15)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C96(0.91)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C96(0.82)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C96(0.80)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C96(1.46)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C96(1.04)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C96(1.73)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C96(1.46)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C96(0.90)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C96(0.96)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C96(1.32); C129(0.85)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C96(0.93)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C96(1.05); C129(1.42); C146(0.96); C11(0.89)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C96(1.13); C129(0.98); C146(1.25)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C96(1.44); C129(0.74)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C96(1.12); C129(0.79); C11(1.10)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C96(1.30); C129(0.83); C11(1.04)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C96(1.22); C129(1.23); C11(0.97)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C96(1.11); C129(0.89)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C96(1.01); C129(0.91); C146(1.08); C11(0.95)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C96(1.06); C129(1.27); C146(0.90)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C96(1.10); C129(0.84); C146(1.04)  LDD1698  [6]
 LDCM0573  Fragment11 Ramos C146(2.74)  LDD1392  [8]
 LDCM0574  Fragment12 MDA-MB-231 C146(1.91)  LDD1393  [8]
 LDCM0576  Fragment14 MDA-MB-231 C146(2.04)  LDD1397  [8]
 LDCM0580  Fragment21 MDA-MB-231 C146(1.40)  LDD1404  [8]
 LDCM0578  Fragment27 MDA-MB-231 C146(1.11)  LDD1401  [8]
 LDCM0468  Fragment33 HEK-293T C96(1.13); C129(1.09); C146(0.87)  LDD1671  [6]
 LDCM0594  Fragment36 MDA-MB-231 C146(1.96)  LDD1431  [8]
 LDCM0596  Fragment38 MDA-MB-231 C146(1.15)  LDD1433  [8]
 LDCM0602  Fragment44 MDA-MB-231 C146(0.81)  LDD1443  [8]
 LDCM0604  Fragment46 MDA-MB-231 C146(1.10)  LDD1445  [8]
 LDCM0427  Fragment51 HEK-293T C96(0.85)  LDD1025  [7]
 LDCM0022  KB02 MDA-MB-231 C146(20.00)  LDD1374  [8]
 LDCM0023  KB03 HEK-293T C96(0.95); C11(1.11); C129(1.08)  LDD1497  [6]
 LDCM0024  KB05 NCI-H1975 C11(2.12)  LDD3352  [1]
 LDCM0131  RA190 MM1.R C146(1.98)  LDD0304  [9]
 LDCM0021  THZ1 HCT 116 C96(0.89)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ribonuclease P protein subunit p29 (POP4) Eukaryotic/archaeal RNase P protein component 1 family O95707
Ribonuclease P protein subunit p30 (RPP30) Eukaryotic/archaeal RNase P protein component 3 family P78346
Ribonuclease P protein subunit p25 (RPP25) Histone-like Alba family Q9BUL9
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) CAMK Ser/Thr protein kinase family Q13554
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene c-Rel (REL) . Q04864
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acyl carrier protein, mitochondrial (NDUFAB1) Acyl carrier protein (ACP) family O14561
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.