Details of the Target

General Information of Target

Target ID LDTP10036
Target Name BOS complex subunit NCLN (NCLN)
Gene Name NCLN
Gene ID 56926
Synonyms
BOS complex subunit NCLN; Nicalin; Nicastrin-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNP
YATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIV
LSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIR
IPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTV
SASRWKIPSSWRLLFGSGLPPALF
Target Bioclass
Transporter and channel
Family
Nicastrin family
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO.
Uniprot ID
Q969V3
Ensemble ID
ENST00000246117.9
HGNC ID
HGNC:26923

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.R403W .
CAL33 SNV: p.A466E .
CCK81 SNV: p.A66T .
HCT15 SNV: p.V119M .
JHH6 SNV: p.Y540F .
NCIH1666 SNV: p.I426F .
OVK18 SNV: p.Y225C; p.V490M .
PF382 SNV: p.I447V .
RKO SNV: p.S325P .
SNGM Deletion: p.W233GfsTer179 .
SW403 SNV: p.E173Ter .
T98G SNV: p.G242R .
TC71 SNV: p.A195T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.22  LDD0402  [1]
11RK72
 Probe Info  		3.06  LDD0327  [2]
11RK73
 Probe Info  		2.10  LDD0328  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K471(8.19); K491(10.00); K99(0.79)  LDD0277  [4]
DBIA
 Probe Info  		C84(3.02)  LDD3311  [5]
BTD
 Probe Info  		C84(1.84)  LDD1700  [6]
EA-probe
 Probe Info  		N.A.  LDD0440  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Ox-W18
 Probe Info  		N.A.  LDD2175  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
AOyne
 Probe Info  		14.70  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C072
 Probe Info  		12.04  LDD1768  [15]
C092
 Probe Info  		16.56  LDD1783  [15]
C100
 Probe Info  		12.04  LDD1789  [15]
C107
 Probe Info  		8.82  LDD1794  [15]
C112
 Probe Info  		17.03  LDD1799  [15]
C140
 Probe Info  		9.65  LDD1822  [15]
C169
 Probe Info  		86.22  LDD1849  [15]
C194
 Probe Info  		11.79  LDD1870  [15]
C196
 Probe Info  		11.47  LDD1872  [15]
C210
 Probe Info  		76.11  LDD1884  [15]
C213
 Probe Info  		16.34  LDD1887  [15]
C219
 Probe Info  		17.51  LDD1893  [15]
C220
 Probe Info  		75.58  LDD1894  [15]
C228
 Probe Info  		18.38  LDD1901  [15]
C231
 Probe Info  		12.55  LDD1904  [15]
C246
 Probe Info  		48.17  LDD1919  [15]
C288
 Probe Info  		38.05  LDD1958  [15]
C289
 Probe Info  		34.06  LDD1959  [15]
C293
 Probe Info  		19.29  LDD1963  [15]
C322
 Probe Info  		12.30  LDD1988  [15]
C356
 Probe Info  		8.88  LDD2017  [15]
C357
 Probe Info  		7.62  LDD2018  [15]
C364
 Probe Info  		18.90  LDD2025  [15]
C366
 Probe Info  		13.27  LDD2027  [15]
C388
 Probe Info  		93.05  LDD2047  [15]
C390
 Probe Info  		23.26  LDD2049  [15]
C400
 Probe Info  		7.62  LDD2059  [15]
C403
 Probe Info  		19.70  LDD2061  [15]
C413
 Probe Info  		21.41  LDD2069  [15]
C414
 Probe Info  		6.68  LDD2070  [15]
C429
 Probe Info  		70.03  LDD2084  [15]
FFF probe11
 Probe Info  		14.65  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe15
 Probe Info  		9.66  LDD0478  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		20.00  LDD0464  [16]
FFF probe4
 Probe Info  		17.25  LDD0466  [16]
FFF probe6
 Probe Info  		20.00  LDD0467  [16]
FFF probe9
 Probe Info  		12.62  LDD0470  [16]
JN0003
 Probe Info  		20.00  LDD0469  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
OEA-DA
 Probe Info  		9.67  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C84(0.96)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C84(1.32)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C84(0.85)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C84(1.14)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C84(1.03)  LDD2103  [6]
 LDCM0214  AC1 HEK-293T C310(0.81)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C310(1.12)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C310(1.10)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C310(0.90)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C310(1.05)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C310(1.09)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C310(0.97)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C310(0.96)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C310(0.90)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C310(1.10)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C310(0.96)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C310(0.98)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C310(1.10)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C310(1.01)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C310(1.07)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C310(0.86)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C310(1.21)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C310(1.00)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C310(0.90)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C310(1.02)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C310(1.01)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C310(1.09)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C310(0.94)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C310(0.96)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C310(1.08)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C310(1.21)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C310(0.98)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C310(1.08)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C310(1.08)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C310(1.03)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C310(0.84)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C310(0.78)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C310(1.06)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C310(1.09)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C310(1.02)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C310(0.92)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C310(1.04)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C310(0.98)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C310(0.94)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C310(0.82)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C310(1.04)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C310(1.06)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C310(0.93)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C310(0.98)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C310(0.94)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C310(0.97)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C310(1.04)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C310(1.04)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C310(0.95)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C310(1.05)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C310(0.95)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C310(0.91)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C310(0.92)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C310(0.97)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C310(0.82)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C310(0.96)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C310(1.06)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C310(1.04)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C310(1.06)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C310(1.02)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C310(0.94)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C310(0.96)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C310(0.97)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C310(1.07)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H482(0.00); H387(0.00)  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C310(0.82)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C310(1.19)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C310(0.93)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C310(0.66)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C310(0.98)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C310(1.01)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C310(1.09)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C310(0.83)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C310(0.89)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C310(1.06)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C310(0.97)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C310(0.84)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C310(0.94)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C310(1.05)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C310(1.13)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C310(0.97)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C310(1.02)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C310(0.92)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C310(1.05)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C310(1.13)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C310(0.96)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C310(1.14)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C310(1.10)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C310(1.07)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C310(1.04)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C310(0.88)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C310(0.90)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C310(0.94)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C310(0.82)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C310(0.98)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C310(1.04)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C310(0.95)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C310(1.02)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C310(0.95)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C310(0.96)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C310(1.02)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C310(0.95)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C310(0.83)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C310(1.01)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C310(0.82)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C310(1.11)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C310(0.79)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C310(0.99)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C310(1.24)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C310(0.96)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C310(1.22)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C310(0.88)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C310(0.81)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C310(1.19)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C310(1.17)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C310(0.94)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C310(1.15)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C310(1.00)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C310(0.95)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C310(1.03)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C310(0.96)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C310(0.76)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C310(1.06)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C310(0.94)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C310(0.90)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C310(0.93)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C310(0.98)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C310(1.10)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C310(1.10)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C310(1.07)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C310(1.11)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C310(0.99)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C310(0.94)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C310(0.88)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C310(0.99)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C310(1.04)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C310(1.01)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C310(1.14)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C310(1.06)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C310(1.04)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C310(0.89)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C310(1.24)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C310(1.34)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C310(0.89)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C310(0.94)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C310(0.87)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C310(0.94)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C310(1.03)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C310(0.96)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C310(0.96)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C310(1.02)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C310(1.04)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C310(0.92)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C310(1.20)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C310(1.34)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C310(0.86)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C310(0.81)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C310(0.94)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C310(1.04)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C310(1.13)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C310(0.84)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C310(1.11)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C310(0.95)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C310(0.94)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C310(1.37)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C310(1.03)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C310(1.24)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C310(1.07)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C310(1.25)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C310(0.83)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C310(1.02)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C310(0.92)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C310(0.82)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C310(0.94)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C310(0.76)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C310(1.05)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C310(0.92)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C310(1.18)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C310(1.07)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C310(1.02)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C310(1.25)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C310(1.55)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C310(1.08)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C310(0.97)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C310(1.05)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C310(1.19)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C310(1.06)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C310(0.89)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C310(1.11)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C310(1.14)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C310(0.96)  LDD1698  [20]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [7]
 LDCM0468  Fragment33 HEK-293T C310(0.92)  LDD1671  [20]
 LDCM0427  Fragment51 HEK-293T C310(1.19)  LDD1631  [20]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 G361 C84(2.49)  LDD2477  [5]
 LDCM0023  KB03 G361 C84(3.33)  LDD2894  [5]
 LDCM0024  KB05 G361 C84(3.02)  LDD3311  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C84(1.26)  LDD2102  [6]
 LDCM0109  NEM HeLa H347(0.00); H482(0.00); H372(0.00); H481(0.00)  LDD0223  [13]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C84(1.01)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C84(1.33)  LDD2093  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C84(2.03)  LDD2098  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C84(1.55)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C84(0.48)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C84(0.87)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C84(1.59)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C84(0.90)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C84(1.25)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C84(0.91)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C84(3.02)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C84(1.11)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C84(0.75)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C84(0.58)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C84(1.12)  LDD2116  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C84(1.40)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C84(1.06)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C84(0.88)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C84(1.02)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C84(2.47)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C84(1.13)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C84(1.06)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C84(1.87)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C84(0.98)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C84(1.84)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C84(0.90)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C84(0.70)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C84(1.27)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C84(1.54)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C84(0.94)  LDD2146  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C84(1.88)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402