Details of the Target

General Information of Target

Target ID LDTP15677
Target Name Ribosomal protein eL42-like (RPL36AL)
Gene Name RPL36AL
Gene ID 6166
Synonyms
Ribosomal protein eL42-like; 60S ribosomal protein L36a-like; Large ribosomal subunit protein eL42-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSVLHFK
QLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCYSSVL
HLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGLEELV
SALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSKVESS
SESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICCWSAY
YNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL42 family
Subcellular location
Cytoplasm
Uniprot ID
Q969Q0
Ensemble ID
ENST00000298289.7
HGNC ID
HGNC:10346

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y48(9.22)  LDD0260  [2]
C-Sul
 Probe Info  		5.56  LDD0066  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		K6(0.63)  LDD0274  [5]
DBIA
 Probe Info  		C77(1.86)  LDD3429  [6]
BTD
 Probe Info  		C72(1.47); C77(1.22)  LDD1700  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C88(0.00); C72(0.00); C77(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C72(0.00); C88(0.00); C77(0.00)  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C88(0.00); C72(0.00); C77(0.00)  LDD0037  [9]
NAIA_5
 Probe Info  		C15(0.00); C88(0.00); C72(0.00); C77(0.00)  LDD2224  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		C72(0.00); C77(0.00)  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		C72(0.00); C77(0.00)  LDD0006  [13]
IPM
 Probe Info  		C77(0.00); C72(0.00)  LDD0005  [13]
SF
 Probe Info  		K6(0.00); Y26(0.00); K86(0.00); Y34(0.00)  LDD0028  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
TFBX
 Probe Info  		C88(0.00); C72(0.00); C15(0.00); C77(0.00)  LDD0148  [16]
VSF
 Probe Info  		C77(0.00); C72(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C88(0.00); C12(0.00); C72(0.00); C15(0.00)  LDD0018  [17]
W1
 Probe Info  		C72(0.00); C77(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
HHS-482
 Probe Info  		Y34(0.76)  LDD2239  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C77(0.83)  LDD2142  [7]
 LDCM0214  AC1 HEK-293T C77(0.99); C72(0.91); C77(0.91)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C77(0.86); C72(0.97); C77(0.97)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C77(0.94); C72(1.10); C77(1.10)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C77(0.99); C72(1.03); C77(1.03)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C77(0.94); C72(0.88); C77(0.88)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C77(0.97); C72(0.99); C77(0.99)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C77(1.06); C72(0.88); C77(0.88)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C77(1.04); C72(1.01); C77(1.01)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C77(1.16); C72(1.50); C77(1.50)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C77(0.83); C72(0.93); C77(0.93)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C77(0.99); C72(1.12); C77(1.12)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C77(1.00); C72(0.95); C77(0.95)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C77(0.97); C72(0.90); C77(0.90)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C77(1.00); C72(1.14); C77(1.14)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C72(0.94); C77(0.94)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C77(1.04); C72(0.99); C77(0.99)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C77(1.02); C72(1.08); C77(1.08)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C77(1.01); C72(1.09); C77(1.09)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C77(0.98); C72(0.98); C77(0.98)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C77(1.00); C72(0.95); C77(0.95)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C77(1.06); C72(1.01); C77(1.01)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C77(1.05); C72(0.90); C77(0.90)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C77(0.98); C72(1.03); C77(1.03)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C72(0.94); C77(0.94)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C77(0.93); C72(0.91); C77(0.91)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C77(1.02); C72(1.01); C77(1.01)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C77(1.14); C72(1.08); C77(1.08)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C77(0.93); C72(1.07); C77(1.07)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C77(1.04); C72(0.94); C77(0.94)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C77(0.94); C72(0.84); C77(0.84)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C77(0.91); C72(1.01); C77(1.01)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C77(0.85); C72(1.04); C77(1.04)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C72(0.99); C77(0.99)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C77(1.04); C72(0.95); C77(0.95)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C77(0.92); C72(1.04); C77(1.04)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C77(1.05); C72(1.06); C77(1.06)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C77(0.88); C72(1.06); C77(1.06)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C77(1.10); C72(1.02); C77(1.02)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C77(0.90); C72(0.88); C77(0.88)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C77(0.80); C72(1.18); C77(1.18)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C72(0.79); C77(0.79)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C77(0.91); C72(0.98); C77(0.98)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C77(0.90); C72(0.89); C77(0.89)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C77(0.83); C72(0.97); C77(0.97)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C77(0.98); C72(1.09); C77(1.09)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C77(0.89); C72(0.99); C77(0.99)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C77(1.02); C72(0.96); C77(0.96)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C77(0.81); C72(0.88); C77(0.88)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C77(0.89); C72(1.08); C77(1.08)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C72(1.16); C77(1.16)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C77(1.14); C72(0.92); C77(0.92)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C77(0.91); C72(1.10); C77(1.10)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C77(1.02); C72(1.02); C77(1.02)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C77(0.95); C72(1.03); C77(1.03)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C77(0.93); C72(1.02); C77(1.02)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C77(1.03); C72(1.01); C77(1.01)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C77(0.96); C72(0.98); C77(0.98)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C77(0.98); C72(0.94); C77(0.94)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C72(0.90); C77(0.90)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C77(0.91); C72(0.95); C77(0.95)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C72(0.80); C77(0.80)  LDD1569  [21]
 LDCM0520  AKOS000195272 MDA-MB-231 C72(0.83); C77(1.00)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C77(0.97); C72(0.87); C77(0.87)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C77(0.93); C72(0.88); C77(0.88)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C72(0.95); C77(0.95)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C88(1.22); C88(1.12); C88(0.78)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C72(0.80); C72(1.06); C77(1.06)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C77(0.98); C72(1.03); C77(1.03)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C72(0.96); C77(1.06)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C72(1.00); C72(1.02); C77(1.02)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C77(0.92); C72(1.00); C77(1.00)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C77(0.79); C72(1.12); C77(1.12)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C72(1.11); C77(0.84)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C72(0.95); C72(1.09); C77(1.09)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C77(1.09); C72(1.12); C77(1.12)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C77(0.83); C72(0.96); C77(0.96)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C72(1.00); C77(0.97)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C72(0.90); C72(1.11); C77(1.11)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C77(0.86); C72(0.89); C77(0.89)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C77(0.94); C72(1.13); C77(1.13)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C77(0.85); C72(0.92); C77(0.92)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C72(1.00); C77(0.90)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C72(1.00); C72(1.16); C77(1.16)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C77(0.88); C72(0.97); C77(0.97)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C77(0.92); C72(1.02); C77(1.02)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C72(1.10); C77(0.92)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C72(0.97); C72(0.96); C77(0.96)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C77(0.81); C72(1.19); C77(1.19)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C77(0.81); C72(1.03); C77(1.03)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C72(1.06); C77(1.06)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C72(1.06); C77(0.78)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C72(0.95); C72(1.05); C77(1.05)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C77(0.89); C72(1.10); C77(1.10)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C77(0.92); C72(0.98); C77(0.98)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C72(0.95); C77(0.77)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C72(1.00); C72(1.12); C77(1.12)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C77(0.89); C72(1.02); C77(1.02)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C77(0.98); C72(1.05); C77(1.05)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C72(1.11); C77(1.05)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C72(0.81); C72(1.08); C77(1.08)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C77(0.97); C72(1.07); C77(1.07)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C77(0.75); C72(0.97); C77(0.97)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C72(1.08); C77(0.92)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C77(0.90); C72(1.08); C77(1.08)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C77(0.98); C72(1.06); C77(1.06)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C77(0.94); C72(1.07); C77(1.07)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C77(0.98); C72(0.84); C77(0.84)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C77(0.85); C72(1.05); C77(1.05)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C77(1.29); C72(1.25); C77(1.25)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C77(0.90); C72(0.93); C77(0.93)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C77(0.82); C72(1.08); C77(1.08)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C72(0.80); C77(0.80)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C72(0.89); C72(1.02); C77(1.02)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C77(0.88); C72(0.96); C77(0.96)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C77(0.83); C72(1.01); C77(1.01)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C72(0.98); C77(0.99)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C77(0.90); C72(0.94); C77(0.94)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C77(0.79); C72(1.08); C77(1.08)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C77(0.92); C72(1.03); C77(1.03)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C77(1.06); C72(1.04); C77(1.04)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C77(0.92); C72(0.99); C77(0.99)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C77(1.33); C72(1.26); C77(1.26)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C77(1.03); C72(1.02); C77(1.02)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C77(0.90); C72(1.18); C77(1.18)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C72(0.78); C77(0.78)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C72(0.90); C72(1.03); C77(1.03)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C77(0.91); C72(1.02); C77(1.02)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C72(1.14); C77(0.95)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C72(0.96); C77(0.86)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C77(0.97); C72(1.04); C77(1.04)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C77(0.98); C72(0.95); C77(0.95)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C77(1.04); C72(1.05); C77(1.05)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C77(0.98); C72(0.98); C77(0.98)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C77(1.26); C72(1.04); C77(1.04)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C77(1.04); C72(0.90); C77(0.90)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C77(0.96); C72(1.06); C77(1.06)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C72(0.84); C77(0.84)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C72(0.99); C72(1.09); C77(1.09)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C77(1.02); C72(0.95); C77(0.95)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C77(0.81); C72(1.10); C77(1.10)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C72(1.01); C77(1.03)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C77(0.95); C72(0.92); C77(0.92)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C77(0.89); C72(1.02); C77(1.02)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C77(1.03); C72(1.03); C77(1.03)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C77(0.95); C72(1.06); C77(1.06)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C77(1.30); C72(0.98); C77(0.98)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C77(0.97); C72(0.91); C77(0.91)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C77(0.88); C72(1.10); C77(1.10)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C77(0.91); C72(1.09); C77(1.09)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C72(1.14); C77(1.14)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C72(0.94); C72(1.00); C77(1.00)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C77(0.74); C72(0.97); C77(0.97)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C77(0.82); C72(1.12); C77(1.12)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C72(0.99); C77(0.92)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C77(0.96); C72(0.91); C77(0.91)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C77(1.00); C72(1.04); C77(1.04)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C77(1.05); C72(1.09); C77(1.09)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C77(0.91); C72(1.05); C77(1.05)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C77(1.35); C72(1.00); C77(1.00)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C77(1.09); C72(1.05); C77(1.05)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C77(0.94); C72(1.01); C77(1.01)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C77(0.86); C72(1.06); C77(1.06)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C72(1.17); C77(1.17)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C72(0.86); C72(1.02); C77(1.02)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C77(0.89); C72(1.23); C77(1.23)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C72(1.06); C77(1.10)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C77(0.96); C72(0.90); C77(0.90)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C77(0.96); C72(1.16); C77(1.16)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C77(0.96); C72(1.08); C77(1.08)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C77(0.87); C72(0.98); C77(0.98)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C77(0.89); C72(0.98); C77(0.98)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C77(1.11); C72(0.96); C77(0.96)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C77(1.03); C72(1.14); C77(1.14)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C77(0.86); C72(1.17); C77(1.17)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C72(0.83); C77(0.83)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C72(1.03); C72(1.07); C77(1.07)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C77(0.96); C72(0.87); C77(0.87)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C77(0.84); C72(1.06); C77(1.06)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C72(1.19); C77(0.80)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C77(0.98); C72(0.92); C77(0.92)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C77(1.38); C72(1.11); C77(1.11)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C77(0.91); C72(1.09); C77(1.09)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C77(0.98); C72(1.11); C77(1.11)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C77(0.86); C72(1.04); C77(1.04)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C77(1.20); C72(1.03); C77(1.03)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C77(0.93); C72(0.99); C77(0.99)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C77(0.94); C72(1.03); C77(1.03)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C72(0.94); C77(0.94)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C72(1.00); C72(0.97); C77(0.97)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C77(0.89); C72(0.77); C77(0.77)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C77(0.87); C72(1.10); C77(1.10)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C77(0.76); C72(0.97); C77(0.97)  LDD1698  [21]
 LDCM0625  F8 Ramos 1.60; C12(19.37)  LDD2187  [22]
 LDCM0572  Fragment10 MDA-MB-231 C88(1.94)  LDD1389  [23]
 LDCM0573  Fragment11 MDA-MB-231 C88(2.70)  LDD1391  [23]
 LDCM0574  Fragment12 MDA-MB-231 C88(1.88)  LDD1393  [23]
 LDCM0575  Fragment13 Ramos C88(0.66)  LDD1396  [23]
 LDCM0576  Fragment14 MDA-MB-231 C88(0.65)  LDD1397  [23]
 LDCM0577  Fragment15 MDA-MB-231 C88(1.36)  LDD1399  [23]
 LDCM0579  Fragment20 MDA-MB-231 C88(20.00)  LDD1402  [23]
 LDCM0580  Fragment21 Ramos 1.05; C12(0.54)  LDD2195  [22]
 LDCM0581  Fragment22 Ramos C88(0.94)  LDD1407  [23]
 LDCM0582  Fragment23 Ramos C88(2.81)  LDD1409  [23]
 LDCM0583  Fragment24 Ramos C88(1.56)  LDD1410  [23]
 LDCM0584  Fragment25 MDA-MB-231 C88(1.25)  LDD1411  [23]
 LDCM0585  Fragment26 Ramos C88(0.99)  LDD1412  [23]
 LDCM0578  Fragment27 MDA-MB-231 C88(0.88)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C88(1.04)  LDD1415  [23]
 LDCM0587  Fragment29 Ramos C88(1.37)  LDD1418  [23]
 LDCM0588  Fragment30 MDA-MB-231 C88(1.01)  LDD1419  [23]
 LDCM0589  Fragment31 MDA-MB-231 C88(1.71)  LDD1421  [23]
 LDCM0590  Fragment32 MDA-MB-231 C88(2.31)  LDD1423  [23]
 LDCM0468  Fragment33 HEK-293T C77(0.92); C72(1.05); C77(1.05)  LDD1671  [21]
 LDCM0592  Fragment34 MDA-MB-231 C88(0.90)  LDD1427  [23]
 LDCM0596  Fragment38 MDA-MB-231 C88(1.41)  LDD1433  [23]
 LDCM0566  Fragment4 Ramos C88(1.80)  LDD1379  [23]
 LDCM0599  Fragment41 MDA-MB-231 C88(1.02)  LDD1438  [23]
 LDCM0600  Fragment42 Ramos C88(1.18)  LDD1440  [23]
 LDCM0601  Fragment43 Ramos C88(1.57)  LDD1442  [23]
 LDCM0602  Fragment44 MDA-MB-231 C88(0.72)  LDD1443  [23]
 LDCM0604  Fragment46 MDA-MB-231 C88(1.01)  LDD1445  [23]
 LDCM0607  Fragment49 MDA-MB-231 C88(3.54)  LDD1448  [23]
 LDCM0608  Fragment50 MDA-MB-231 C88(2.20)  LDD1449  [23]
 LDCM0427  Fragment51 MDA-MB-231 C88(1.18)  LDD1450  [23]
 LDCM0610  Fragment52 Ramos 1.47; C12(0.60)  LDD2204  [22]
 LDCM0611  Fragment53 MDA-MB-231 C88(1.03)  LDD1454  [23]
 LDCM0613  Fragment55 MDA-MB-231 C88(0.94)  LDD1457  [23]
 LDCM0614  Fragment56 MDA-MB-231 C88(1.37)  LDD1458  [23]
 LDCM0568  Fragment6 MDA-MB-231 C88(1.25)  LDD1382  [23]
 LDCM0569  Fragment7 Ramos 1.00; C12(1.46)  LDD2186  [22]
 LDCM0571  Fragment9 MDA-MB-231 C88(1.28)  LDD1387  [23]
 LDCM0022  KB02 MDA-MB-231 C88(5.29)  LDD1374  [23]
 LDCM0023  KB03 MDA-MB-231 C88(2.65)  LDD1376  [23]
 LDCM0024  KB05 SK-MEL-30 C77(1.86)  LDD3429  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C77(0.75)  LDD2102  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C77(0.77)  LDD2092  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C72(1.32)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C77(0.95)  LDD2098  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C72(0.47); C77(0.90)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C72(0.72); C77(0.95)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C72(1.52); C77(1.30)  LDD2105  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C72(0.54); C77(0.61)  LDD2114  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C72(0.50); C77(0.66)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C72(0.73); C77(0.86)  LDD2134  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C72(1.47); C77(1.22)  LDD1700  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C77(0.77)  LDD2141  [7]
 LDCM0113  W17 Hep-G2 C77(1.45)  LDD0240  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.