Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment9  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 102 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 20.0
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) C319 20.0
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 20.0
 LDTP15311  Deaminated glutathione amidase (NIT1) C165 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 20.0
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP13302  Nuclear prelamin A recognition factor (NARF) C99 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 20.0
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 20.0
 LDTP19750  RNA ligase 1 (RLIG1) C302 20.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 20.0
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) C66 20.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 20.0
 LDTP03937  Ubiquitin-like modifier-activating enzyme 7 (UBA7) C599 20.0
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 16.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 14.0
 LDTP09200  FAD synthase (FLAD1) C499 12.1
 LDTP02055  Thymidylate synthase (TYMS) C199 11.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 6.8
 LDTP10429  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) C309 6.8
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 6.6
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) C246 6.5
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) C130 6.2
 LDTP03786  Glutaredoxin-1 (GLRX) C23 5.7
 LDTP00042  Probable ribonuclease ZC3H12D (ZC3H12D) C367 5.2
 LDTP03496  Protein PML (PML) C213 4.5
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 4.5
 LDTP13719  Ubiquitin carboxyl-terminal hydrolase 22 (USP22) C171 4.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 4.3
 LDTP05943  Myotubularin-related protein 1 (MTMR1) C117 4.3
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 4.2
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 4.0
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 3.8
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 3.7
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 3.7
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 3.3
 LDTP06211  Caspase-8 (CASP8) C360 3.2
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100 2.9
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 2.8
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 2.8
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 2.7
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.6
 LDTP08808  E3 SUMO-protein ligase PIAS4 (PIAS4) C326 2.6
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) C267 2.6
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 2.6
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 2.6
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 2.6
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 2.6
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 2.5
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 2.5
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 2.4
 LDTP03258  Thymidylate kinase (DTYMK) C163 2.4
 LDTP03770  Alpha-adducin (ADD1) C68 2.3
 LDTP03401  Multifunctional protein CAD (CAD) C73 2.2
 LDTP02502  Thioredoxin (TXN) C32 2.1
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.0
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 2.0
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 2.0
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 2.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.9
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.8
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 1.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 1.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.8
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.8
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 1.8
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.8
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.7
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 1.7
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C190 1.6
 LDTP05954  GDP-L-fucose synthase (GFUS) C116 1.6
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 1.6
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.6
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 1.5
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.5
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 1.5
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.5
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.4
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 1.4
 LDTP03258  Thymidylate kinase (DTYMK) C117 1.4
 LDTP04374  Dynamin-2 (DNM2) C27 1.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.4
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.4
 LDTP13527  Aspartyl aminopeptidase (DNPEP) C144 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.3
 LDTP02493  Serine/threonine-protein kinase A-Raf (ARAF) C597 1.3
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.3
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.1
 LDTP11639  RNA exonuclease 4 (REXO4) C382 1.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.9
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 5.4
 LDTP04801  Gasdermin-D (GSDMD) C268 4.9
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 4.2
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.7
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 2.7
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 2.1
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 1.9
 LDTP00501  Exportin-1 (XPO1) C528 1.8
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) C151 1.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.6
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.4
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.4
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 0.8
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 13.8
 LDTP06475  Mothers against decapentaplegic homolog 2 (SMAD2) C81 5.6
 LDTP05362  Interferon regulatory factor 8 (IRF8) C306 5.5
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 2.5
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 2.4
 LDTP10262  THAP domain-containing protein 11 (THAP11) C48 2.3
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
Other
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 20.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP13515  Zinc finger protein 346 (ZNF346) C68 20.0
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 11.2
 LDTP07755  Dynamin-binding protein (DNMBP) C691 10.0
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 5.4
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C90 5.0
 LDTP07624  Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC1S3) C168 4.6
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 4.0
 LDTP17182  Uncharacterized protein C3orf38 (C3orf38) C308 4.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 4.0
 LDTP04092  Crk-like protein (CRKL) C249 4.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 3.8
 LDTP10252  Elongator complex protein 4 (ELP4) C218 3.7
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 3.7
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.5
 LDTP05867  Treacle protein (TCOF1) C1298 2.5
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.1
 LDTP06046  Ribosome biogenesis protein BOP1 (BOP1) C404 2.1
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 2.1
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 2.1
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 2.1
 LDTP04487  Cyclin-H (CCNH) C244 2.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.8
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 1.8
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.7
 LDTP05867  Treacle protein (TCOF1) C38 1.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.7
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 1.6
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.6
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.6
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.5
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.5
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.5
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.4
 LDTP15896  Ashwin (C2orf49) C10 1.4
 LDTP13580  Coronin-1C (CORO1C) C420 1.4
 LDTP09650  LIM domain only protein 7 (LMO7) C228 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C518 1.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.3
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C72 1.3
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.3
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 1.3
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.1
 LDTP04434  Host cell factor 1 (HCFC1) C1872 1.0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.