Details of the Target

General Information of Target

Target ID LDTP11639
Target Name RNA exonuclease 4 (REXO4)
Gene Name REXO4
Gene ID 57109
Synonyms
PMC2; XPMC2H; RNA exonuclease 4; EC 3.1.-.-; Exonuclease XPMC2; Prevents mitotic catastrophe 2 protein homolog; hPMC2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGKSGGSAGEITFLEALARSESKRDGGFKNNWSFDHEEESEGDTDKDGTNLLSVDEDE
DSETSKGKKLNRRSEIVANSSGEFILKTYVRRNKSESFKTLKGNPIGLNMLSNNKKLSEN
TQNTSLCSGTVVHGRRFHHAHAQIPVVKTAAQSSLDRKERKEYPPHVQKVEINPVRLSRL
QGVERIMKKTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQ
AITLNESTGPLLRTSIHQNSGGQKSQNTGLTTKKFYGNNVEKVPIDIIVNCDDSKHTYLQ
TNGKVILPGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSAC
SSPAPSTGKVEAALNENTCRAERELRSIPEDSELNTVTLPRKARMKDQFGNSIINTPLKR
RKVFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHD
PVEIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKGVNKLT
NLEEQYIILIFQNGLDPPANMVFESIINEIGIKNNISNFFAKIPFEEANGRLVACTRTYE
ESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFDEEEETGENHTIFIGPVEKLIVYPPP
PAKGGISVTNEDLHCLNEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQ
RERRNHETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPK
YEPNPHYHENAVIQKCSTVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDSN
PGQEESDPRYKRNICSVKYSVKKINHTASENEEFNKGESTSQKVADRTKSENGLQNESLS
STHHTDGLSKIRLNYSDESPEAGKMLEDELVDFSEDQDNQDDSSDDGFLADDNCSSEIGQ
WHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSFSKDVMKGSNPK
VPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKREEIRNIILKLQE
DQSKEKRKHKDTYSTEAPLGEGTEQYVNSISD
Target Bioclass
Enzyme
Family
REXO4 family
Subcellular location
Nucleus, nucleolus
Uniprot ID
Q9GZR2
Ensemble ID
ENST00000371935.6
HGNC ID
HGNC:12820

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC12 SNV: p.M391T .
KMS12BM Substitution: p.K10_R11delinsNC .
MDAMB231 SNV: p.L26V .
MOLT4 SNV: p.D203G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C248(1.30)  LDD3330  [2]
AHL-Pu-1
 Probe Info  		C382(20.00)  LDD0170  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C382(0.00); C248(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		C248(0.00); C274(0.00)  LDD0027  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		C248(0.00); C418(0.00); C382(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C382(20.00)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C418(2.01)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C418(0.82); C382(1.17)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C418(1.02); C382(1.30)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C382(1.08)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C418(1.16); C382(0.78)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C382(1.11)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C418(1.21); C382(0.94)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C418(0.99); C382(0.89)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C418(1.03); C382(1.01)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C382(0.88)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C418(1.36); C382(1.04)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C418(0.86); C382(0.89)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C382(1.00)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C382(1.08)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C418(1.01); C382(0.97)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C418(0.80); C382(0.99)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C418(0.94); C382(1.08)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C418(1.02); C382(1.37)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C382(0.93)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C418(1.01); C382(0.99)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C382(0.94)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C382(1.08)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C382(1.08)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C418(1.01); C382(0.89)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C418(1.13); C382(0.97)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C418(0.80); C382(1.19)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C418(1.05); C382(1.02)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C382(1.13)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C418(1.04); C382(1.05)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C382(0.97)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C382(0.94)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C418(1.21); C382(0.98)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C418(0.98); C382(0.98)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C418(0.95); C382(1.14)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C418(0.95); C382(1.16)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C418(1.11); C382(1.21)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C382(1.23)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C418(0.94); C382(0.85)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C382(1.12)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C382(1.12)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C418(0.88); C382(1.05)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C418(1.01); C382(0.93)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C418(0.80); C382(1.05)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C382(0.99)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C418(1.16); C382(1.01)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C382(1.09)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C418(1.07); C382(0.90)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C382(0.90)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C382(1.04)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C418(1.20); C382(0.91)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C418(1.23); C382(1.09)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C418(0.87); C382(1.09)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C418(0.83); C382(1.04)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C382(0.90)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C382(1.16)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C418(0.98); C382(1.06)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C382(0.97)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C382(0.92)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C418(1.09); C382(0.98)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C418(0.79); C382(1.17)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C418(0.97); C382(1.09)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C418(1.05); C382(1.14)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C382(0.93)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C418(0.88); C382(1.06)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C418(1.00); C382(1.08)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.57  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C382(1.43)  LDD2214  [16]
 LDCM0108  Chloroacetamide HeLa C248(0.00); C418(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C418(20.00); C382(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C418(0.96); C382(0.91)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C382(1.38)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C418(1.00)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C418(0.82); C382(0.94)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C418(0.97); C382(1.02)  LDD1575  [15]
 LDCM0373  CL104 HEK-293T C418(1.03)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C418(1.24); C382(0.99)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C418(0.91); C382(1.04)  LDD1579  [15]
 LDCM0377  CL108 HEK-293T C418(0.99)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C418(0.95); C382(0.94)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C418(1.05); C382(1.09)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C418(1.09); C382(1.12)  LDD1584  [15]
 LDCM0382  CL112 HEK-293T C418(1.18)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C418(0.94); C382(1.09)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C418(0.97); C382(1.09)  LDD1588  [15]
 LDCM0386  CL116 HEK-293T C418(1.07)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C418(0.88); C382(0.87)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C418(0.87); C382(1.12)  LDD1592  [15]
 LDCM0390  CL12 HEK-293T C418(1.06); C382(1.06)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C418(1.23)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C418(0.86); C382(0.80)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C418(0.92); C382(0.89)  LDD1597  [15]
 LDCM0395  CL124 HEK-293T C418(1.00)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C418(0.64); C382(0.85)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C418(0.81); C382(0.97)  LDD1601  [15]
 LDCM0399  CL128 HEK-293T C418(0.78)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C418(1.03); C382(1.00)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C418(1.00); C382(1.32)  LDD1605  [15]
 LDCM0403  CL16 HEK-293T C418(1.21)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C418(0.86); C382(1.40)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C418(1.28); C382(1.20)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C382(1.22)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C418(1.10); C382(1.29)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C418(0.85); C382(0.96)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C382(1.29)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C382(1.17)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C418(1.14); C382(1.08)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C418(0.87); C382(0.99)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C418(0.86); C382(1.02)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C418(0.94); C382(1.05)  LDD1618  [15]
 LDCM0416  CL28 HEK-293T C418(1.05)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C418(0.96); C382(1.12)  LDD1621  [15]
 LDCM0419  CL30 HEK-293T C418(1.06); C382(1.06)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C382(1.03)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C418(0.95); C382(1.07)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C382(1.19)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C382(1.00)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C418(0.92); C382(1.14)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C418(0.82); C382(1.11)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C418(0.87); C382(1.05)  LDD1630  [15]
 LDCM0429  CL4 HEK-293T C418(0.96)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C418(1.01)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C418(0.84); C382(1.17)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C418(1.09); C382(1.30)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C382(0.97)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C418(1.05); C382(1.36)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C382(1.39)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C382(1.25)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C418(0.99); C382(1.11)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C418(0.81); C382(0.98)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C418(0.91); C382(0.76)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C418(0.75); C382(1.14)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C418(0.99); C382(1.37)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C418(1.06)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C418(0.86); C382(1.20)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C418(1.07); C382(1.27)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C382(1.24)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C418(0.84); C382(1.02)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C382(1.26)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C382(0.96)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C418(0.95); C382(1.09)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C418(1.13); C382(0.97)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C418(0.95); C382(1.15)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C418(0.80); C382(0.94)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C418(1.21); C382(1.33)  LDD1657  [15]
 LDCM0456  CL64 HEK-293T C418(1.06)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C418(0.89); C382(0.98)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C418(1.10); C382(1.42)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C382(1.06)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C418(1.01); C382(0.96)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C382(1.05)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C382(1.17)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C382(1.01)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C418(0.87); C382(0.99)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C418(1.01); C382(1.14)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C418(0.91); C382(0.85)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C418(0.81); C382(1.08)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C418(1.06)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C418(0.97); C382(1.47)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C418(0.94); C382(1.10)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C382(0.98)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C418(0.70); C382(0.93)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C418(0.76); C382(1.05)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C382(1.01)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C382(0.91)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C418(0.93); C382(1.12)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C418(0.73); C382(0.99)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C418(0.66); C382(0.81)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C418(0.69); C382(1.14)  LDD1683  [15]
 LDCM0482  CL88 HEK-293T C418(0.85)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C418(0.76); C382(0.99)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C382(1.10)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C418(1.05); C382(1.16)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C382(0.92)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C418(0.92); C382(1.00)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C382(0.98)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C382(0.89)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C418(1.05); C382(1.31)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C418(0.62); C382(0.84)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C418(0.88); C382(1.11)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C418(0.91); C382(1.05)  LDD1696  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C382(2.65); C418(1.52)  LDD1702  [17]
 LDCM0625  F8 Ramos C418(1.37); C274(0.89); C382(1.00)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C418(1.66)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C418(0.89); C274(11.15)  LDD2190  [18]
 LDCM0574  Fragment12 MDA-MB-231 C382(20.00)  LDD1468  [19]
 LDCM0575  Fragment13 Ramos C382(0.86)  LDD1470  [19]
 LDCM0576  Fragment14 MDA-MB-231 C382(1.24)  LDD1471  [19]
 LDCM0579  Fragment20 Ramos C418(1.24)  LDD2194  [18]
 LDCM0582  Fragment23 Ramos C418(1.02)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C418(0.88)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C418(0.61); C274(0.64); C382(0.86)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C418(1.13)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C418(1.10)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C418(1.56)  LDD2201  [18]
 LDCM0468  Fragment33 Ramos C418(1.53)  LDD2202  [18]
 LDCM0596  Fragment38 Ramos C418(1.14)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C418(1.04); C274(0.95); C382(1.23)  LDD2184  [18]
 LDCM0603  Fragment45 MDA-MB-231 C382(20.00)  LDD1482  [19]
 LDCM0427  Fragment51 HEK-293T C418(0.94); C382(1.17)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C418(1.03)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C418(1.07)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C418(1.39); C382(1.93)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C382(0.96)  LDD1464  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 Ramos 5.49  LDD0431  [20]
 LDCM0023  KB03 HEK-293T C418(1.06); C382(1.03)  LDD1497  [15]
 LDCM0024  KB05 MIA PaCa-2 C248(1.30)  LDD3330  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C382(0.81)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C382(0.28)  LDD2207  [21]
 LDCM0170  Structure8 Ramos 5.61  LDD0433  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nitric oxide synthase 3 (NOS3) NOS family P29474
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
20 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.