Details of the Target

General Information of Target

Target ID LDTP00013
Target Name Ubiquitin-like modifier-activating enzyme 6 (UBA6)
Gene Name UBA6
Gene ID 55236
Synonyms
MOP4; UBE1L2; Ubiquitin-like modifier-activating enzyme 6; Ubiquitin-activating enzyme 6; EC 6.2.1.45; Monocyte protein 4; MOP-4; Ubiquitin-activating enzyme E1-like protein 2; E1-L2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
Target Bioclass
Enzyme
Family
Ubiquitin-activating E1 family
Function
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
Uniprot ID
A0AVT1
Ensemble ID
ENST00000322244.10
HGNC ID
HGNC:25581
ChEMBL ID
CHEMBL2321622

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.D1050G DBIA    Probe Info 
HCC15 SNV: p.D725Y DBIA    Probe Info 
HCT15 Substitution: p.A224I DBIA    Probe Info 
MEWO SNV: p.P772S DBIA    Probe Info 
MFE319 SNV: p.L847F DBIA    Probe Info 
SF295 SNV: p.K800E DBIA    Probe Info 
SW756 SNV: p.E161K DBIA    Probe Info 
WM2664 Insertion: p.L390TfsTer31 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.53  LDD0402  [1]
A-EBA
 Probe Info  		3.59  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y710(20.00); Y523(11.48); Y979(6.26)  LDD0257  [4]
TH216
 Probe Info  		Y873(18.72); Y663(7.28)  LDD0259  [4]
ONAyne
 Probe Info  		K800(0.81)  LDD0274  [5]
STPyne
 Probe Info  		K1003(9.05); K1006(5.93); K1014(2.99); K295(0.14)  LDD0277  [5]
BTD
 Probe Info  		C178(2.47)  LDD1699  [6]
Probe 1
 Probe Info  		Y49(48.13); Y443(26.37); Y523(86.39); Y921(17.95)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
DA-P3
 Probe Info  		4.56  LDD0181  [9]
AHL-Pu-1
 Probe Info  		C721(2.58)  LDD0169  [10]
HHS-465
 Probe Info  		Y132(1.03)  LDD2237  [11]
DBIA
 Probe Info  		C178(0.98); C546(0.93)  LDD0078  [12]
5E-2FA
 Probe Info  		N.A.  LDD2235  [13]
ATP probe
 Probe Info  		K652(0.00); K644(0.00); K86(0.00); K95(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C721(0.00); C581(0.00); C311(0.00); C96(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C682(0.00); C347(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		C311(0.00); C96(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C721(0.00); C581(0.00); C311(0.00); C96(0.00)  LDD0037  [15]
NAIA_4
 Probe Info  		C347(0.00); C433(0.00); C546(0.00); C625(0.00)  LDD2226  [18]
WYneN
 Probe Info  		C347(0.00); C174(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C546(0.00); C347(0.00)  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
Compound 10
 Probe Info  		C347(0.00); C721(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C347(0.00); C721(0.00)  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C347(0.00); C178(0.00)  LDD0005  [19]
TFBX
 Probe Info  		N.A.  LDD0148  [21]
VSF
 Probe Info  		C17(0.00); C546(0.00); C347(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C17(0.00); C178(0.00); C721(0.00); C347(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		N.A.  LDD2175  [23]
1c-yne
 Probe Info  		K544(0.00); K839(0.00); K830(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		C682(0.00); C721(0.00); C546(0.00)  LDD0217  [25]
Methacrolein
 Probe Info  		C546(0.00); C699(0.00)  LDD0218  [25]
W1
 Probe Info  		C347(0.00); C682(0.00); C625(0.00)  LDD0236  [26]
NAIA_5
 Probe Info  		C721(0.00); C96(0.00); C581(0.00); C311(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		13.12  LDD0475  [27]
FFF probe2
 Probe Info  		20.00  LDD0463  [27]
FFF probe3
 Probe Info  		5.64  LDD0465  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C347(0.91)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C347(1.00)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C682(0.65)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C347(0.75)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C178(1.01); C347(0.99); C174(1.18)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C178(1.29); C347(1.36)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C178(1.02); C347(0.84)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C347(0.69)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C347(0.79)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C721(2.58)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C347(1.30); C546(0.87); C178(1.04); C449(0.92)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C347(1.70); C546(1.06); C178(1.07); C449(0.99)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C347(1.08); C546(1.01); C178(1.14); C449(0.76)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C347(1.04); C546(0.92); C178(1.11); C449(0.76)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C347(0.97); C546(0.98); C178(1.12); C449(0.84)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C347(1.26); C546(1.05); C178(1.22); C449(0.70)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C347(1.03); C546(1.00); C178(1.18); C449(0.97)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C347(1.18); C546(1.00); C178(1.18); C449(0.79)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C347(1.25); C546(1.08); C178(1.21); C449(0.76)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C347(1.11); C546(0.86); C178(1.06); C449(0.78)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C347(1.26); C546(0.93); C178(1.17); C449(0.76)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C347(1.11); C546(0.89); C178(1.03); C449(0.91)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C347(1.05); C546(1.21); C178(1.16); C449(0.65)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C347(1.17); C546(0.91); C178(1.10); C449(0.75)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C347(1.09); C546(0.85); C178(1.13); C449(0.71)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C347(1.05); C546(0.86); C178(1.17); C449(0.76)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C347(1.02); C546(1.00); C178(1.07); C449(0.98)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C347(0.90); C546(1.09); C178(1.09); C449(0.91)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C347(0.92); C546(1.18); C178(1.26); C449(0.86)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C347(1.31); C546(1.51); C178(1.19); C449(0.90)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C347(0.95); C546(1.10); C178(1.24); C449(0.97)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C347(0.87); C546(1.15); C178(1.35); C449(1.02)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C347(0.94); C546(1.09); C178(1.26); C449(0.97)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C347(1.00); C546(1.02); C178(1.03); C449(0.89)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C347(0.87); C546(1.17); C178(1.12); C449(1.01)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C347(0.82); C546(1.11); C178(0.98); C449(1.17)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C347(0.95); C546(1.17); C178(1.17); C449(0.96)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C347(0.85); C546(0.93); C178(1.07); C449(1.14)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C347(0.79); C546(0.96); C178(1.11); C449(1.19)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C347(0.91); C546(1.08); C178(1.08); C449(1.05)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C347(0.89); C546(1.15); C178(1.26); C449(0.96)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C347(0.84); C546(1.07); C178(1.37); C449(0.99)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C347(1.37); C546(1.00); C178(0.93); C449(0.81)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C347(1.17); C546(0.99); C178(1.04); C449(1.01)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C347(1.38); C546(1.04); C178(1.21); C449(0.78)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C347(1.03); C546(0.97); C178(0.99); C449(1.03)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C347(1.35); C546(1.27); C178(1.16); C449(1.11)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C347(1.23); C546(1.08); C178(1.22); C449(0.97)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C347(1.31); C546(1.14); C178(1.29); C449(0.87)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C347(1.36); C546(1.19); C178(1.01); C449(0.83)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C347(1.29); C546(1.22); C178(1.09); C449(0.86)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C347(1.24); C546(1.10); C178(1.05); C449(0.88)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C347(1.58); C546(1.27); C178(1.29); C449(0.78)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C347(1.31); C546(1.21); C178(1.16); C449(0.89)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C347(0.79); C546(1.12); C178(1.13); C449(0.85)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C347(1.52); C546(1.19); C178(1.21); C449(0.85)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C347(1.50); C546(1.27); C178(1.33); C449(0.91)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C347(1.15); C546(1.17); C178(1.27); C449(0.95)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C347(1.18); C546(1.07); C449(0.84); C455(0.84)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C449(0.69); C455(0.71); C546(1.17); C721(1.22)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C449(0.86); C455(0.94); C721(1.10); C178(1.18)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C455(0.61); C449(0.68); C721(0.98); C178(1.11)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C455(0.84); C449(0.98); C546(1.16); C721(1.26)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C449(0.51); C455(0.56); C546(1.34); C178(1.36)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C455(0.59); C449(0.64); C721(1.13); C178(1.27)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C347(0.84); C449(0.95); C455(0.95); C625(1.07)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C455(0.88); C449(0.97); C721(1.04); C546(1.07)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C449(0.87); C455(0.87); C546(1.14); C178(1.17)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C455(0.59); C449(0.71); C546(1.24); C178(1.27)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C455(0.45); C449(0.53); C721(1.32); C546(1.35)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C347(1.36); C546(1.13); C178(1.26); C449(0.71)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C347(1.20); C546(1.24); C178(1.26); C449(0.82)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C347(0.99); C546(1.07); C178(1.11); C449(0.84)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C347(0.90); C546(0.92); C178(1.08); C449(0.92)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C682(0.88); C699(1.00); C178(1.01); C546(1.05)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C449(0.95); C455(0.95); C682(1.06); C699(1.12)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C682(0.73); C699(1.05); C178(1.10); C347(1.12)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C178(0.92); C347(0.93); C449(0.97); C455(0.98)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C699(0.97); C682(1.00); C178(1.00); C546(1.05)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C347(0.93); C699(0.96); C178(0.99); C546(1.00)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C682(0.86); C347(0.97); C178(1.00); C699(1.00)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C682(0.85); C699(0.93); C178(0.96); C625(0.97)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C682(0.79); C721(0.94); C178(1.00); C546(1.03)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C699(0.34); C546(0.93); C625(1.04); C449(1.10)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C699(0.31); C721(0.99); C546(1.04); C449(1.06)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C699(0.47); C546(0.95); C449(1.05); C455(1.05)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C699(0.30); C546(0.94); C449(1.01); C455(1.01)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C699(0.39); C721(1.00); C625(1.11); C546(1.14)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C178(0.95); C455(1.01); C449(1.03); C546(1.06)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C699(0.31); C625(1.00); C546(1.11); C347(1.16)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C699(0.24); C546(0.99); C449(1.04); C455(1.04)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C699(0.23); C546(1.12); C449(1.15); C455(1.15)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C699(0.26); C625(0.90); C546(0.90); C449(1.08)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C699(0.22); C625(0.97); C449(1.00); C455(1.00)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C924(0.82); C178(0.87); C699(0.90); C347(0.93)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C546(0.87); C924(0.88); C178(0.94); C449(0.98)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C546(0.90); C721(0.93); C347(0.96); C178(1.04)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C178(0.95); C546(0.97); C347(0.98); C449(0.98)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C924(0.76); C721(0.93); C546(0.99); C347(1.04)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C546(0.93); C178(0.99); C455(1.05); C449(1.06)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C924(0.79); C699(0.93); C546(0.98); C449(1.03)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C449(0.96); C455(0.96); C546(1.01); C721(1.06)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C699(0.94); C449(0.99); C455(0.99); C178(1.00)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C924(0.86); C699(0.93); C449(0.99); C455(0.99)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C924(0.88); C721(1.03); C347(1.03); C449(1.03)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C699(0.86); C924(0.93); C682(1.08); C546(1.09)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C682(0.89); C721(0.97); C546(1.01); C347(1.09)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C682(0.80); C721(0.85); C546(1.04); C699(1.15)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C721(0.63); C682(0.73); C546(1.06); C178(1.09)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C682(0.95); C721(1.12); C699(1.13); C178(1.13)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C455(0.97); C449(0.97); C546(1.02); C178(1.10)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C682(0.72); C546(1.07); C178(1.15); C721(1.16)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C721(0.67); C682(0.79); C546(0.96); C178(1.05)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C682(0.85); C721(1.03); C546(1.05); C178(1.16)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C682(0.73); C721(1.01); C178(1.02); C699(1.03)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C682(0.91); C546(1.06); C699(1.07); C178(1.11)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C682(0.89); C699(1.05); C546(1.09); C721(1.16)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C682(0.72); C699(0.98); C178(1.16); C546(1.21)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C699(0.29); C449(0.46); C455(0.46); C468(0.94)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C699(0.23); C449(0.37); C455(0.37); C468(0.81)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C699(0.26); C449(0.49); C455(0.49); C468(0.90)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C625(0.95); C449(1.04); C455(1.04); C178(1.09)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C699(0.23); C449(0.39); C455(0.39); C468(0.68)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C699(0.28); C449(0.37); C455(0.37); C468(0.81)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C699(0.23); C449(0.43); C455(0.43); C682(0.96)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C699(0.29); C449(0.44); C455(0.44); C468(0.67)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C699(0.20); C449(0.38); C455(0.38); C682(0.90)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C699(0.40); C449(0.49); C455(0.49); C682(0.95)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C699(0.34); C449(0.53); C455(0.53); C682(1.02)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C699(0.16); C449(0.26); C455(0.26); C468(0.84)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C468(0.83); C473(0.83); C625(0.84); C449(0.87)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C449(0.70); C455(0.70); C699(0.78); C625(0.79)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C625(0.86); C449(0.90); C455(0.90); C178(0.96)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C468(0.76); C473(0.76); C721(0.87); C625(0.89)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C625(0.87); C546(0.92); C449(0.95); C455(0.95)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C699(0.82); C625(0.91); C546(0.95); C468(1.07)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C546(1.09); C347(1.64); C468(0.79); C473(0.79)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C449(0.78); C455(0.78); C468(0.79); C473(0.79)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C468(0.69); C473(0.69); C449(0.84); C455(0.84)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C625(0.78); C468(0.88); C473(0.88); C449(0.96)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C625(0.80); C468(0.85); C473(0.85); C449(0.91)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C625(0.86); C449(0.90); C455(0.90); C721(0.95)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C449(0.84); C455(0.84); C625(0.97); C546(1.02)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C449(0.96); C455(0.96); C625(0.98); C178(1.05)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C625(0.88); C449(0.97); C455(0.97); C468(0.98)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C468(0.38); C473(0.38); C625(0.90); C721(0.92)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C468(0.62); C473(0.62); C699(0.84); C625(0.89)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C449(0.45); C455(0.45); C699(0.68); C347(1.11)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C449(0.47); C455(0.47); C699(0.76); C546(1.15)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C449(0.64); C455(0.64); C699(0.94); C347(1.20)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C449(0.80); C455(0.80); C546(1.10); C347(1.15)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C449(0.75); C455(0.75); C347(0.97); C546(1.00)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C449(0.79); C455(0.79); C699(0.83); C347(1.05)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C449(0.54); C455(0.54); C699(0.90); C347(0.97)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C347(1.00); C546(1.07); C449(1.10); C455(1.10)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C449(0.49); C455(0.49); C699(0.94); C347(1.10)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C449(0.61); C455(0.61); C699(0.88); C347(1.11)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C449(0.76); C455(0.76); C699(0.92); C546(1.17)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C449(0.64); C455(0.64); C699(0.88); C546(1.03)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C449(0.64); C455(0.64); C347(1.03); C546(1.07)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C449(0.52); C455(0.52); C546(1.05); C178(1.17)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C449(0.55); C455(0.55); C699(1.12); C546(1.28)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C455(0.54); C449(0.62); C546(0.96); C625(0.97)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C455(0.80); C449(0.84); C625(0.88); C178(0.97)  LDD0683  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C347(0.86); C449(1.08)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C347(0.84); C546(1.06); C178(0.99); C449(0.96)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C449(0.70); C455(0.70); C625(0.99); C546(1.08)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C449(0.85); C455(0.85); C347(1.03); C625(1.04)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C178(0.98); C546(0.93)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C682(1.10); C178(0.41); C347(0.47); C156(0.87)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C433(1.56)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C682(0.00); C721(0.00); C455(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C17(1.49); C347(1.14); C721(0.97); C347(0.77)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C625(0.84); C178(0.90); C699(0.94); C449(0.94)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C449(0.49); C455(0.49); C468(0.68); C473(0.68)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C455(0.88); C449(0.88); C546(0.91); C178(1.15)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C625(0.98); C449(1.06); C455(1.06); C546(1.09)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C449(0.68); C455(0.68); C178(0.90); C625(0.90)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C178(0.92); C625(0.94); C347(0.96); C546(0.99)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C449(0.82); C455(0.82); C625(0.90); C178(1.02)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C682(0.91); C699(0.95); C449(0.95); C455(0.95)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C682(0.88); C449(1.04); C455(1.04); C699(1.21)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C682(0.92); C449(1.09); C455(1.09); C699(1.15)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C699(0.99); C682(1.02); C625(1.16); C449(1.16)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C682(0.92); C449(0.94); C455(0.94); C178(1.09)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C449(0.46); C455(0.46); C468(0.56); C473(0.56)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C682(0.90); C699(1.03); C178(1.10); C449(1.11)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C449(0.74); C455(0.74); C682(0.86); C625(0.91)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C699(0.47); C625(0.84); C546(0.90); C721(1.10)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C699(0.26); C625(1.01); C449(1.02); C455(1.02)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C699(0.56); C625(0.88); C449(1.02); C455(1.02)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C699(0.40); C546(0.97); C625(0.98); C721(0.99)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C699(0.43); C546(0.96); C625(1.04); C449(1.09)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C699(0.57); C924(0.63); C449(0.99); C455(0.99)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C924(0.93); C699(0.94); C449(0.96); C455(0.96)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C924(0.61); C699(0.79); C449(0.89); C455(0.89)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C449(0.51); C455(0.51); C468(0.62); C473(0.62)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C721(0.89); C449(0.98); C455(0.98); C924(0.99)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C347(0.71); C178(1.06); C699(1.07); C682(1.11)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C682(0.72); C546(1.00); C721(1.04); C699(1.05)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C682(0.74); C546(0.92); C721(0.93); C699(1.05)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C682(0.82); C699(1.05); C721(1.11); C546(1.12)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C699(0.82); C449(0.88); C455(0.88); C682(0.95)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C699(0.29); C449(0.74); C455(0.74); C924(0.96)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C699(0.58); C449(0.77); C455(0.77); C468(0.95)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C699(0.42); C449(0.62); C455(0.62); C468(0.82)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C449(0.40); C455(0.40); C924(0.57); C468(0.60)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C625(0.64); C449(0.69); C455(0.69); C468(0.87)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C924(0.51); C449(0.51); C455(0.51); C699(0.55)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C924(0.86); C449(0.87); C455(0.87); C546(1.18)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C699(0.59); C546(0.88); C924(0.90); C449(0.99)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C699(0.49); C924(0.71); C347(1.12); C178(1.12)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C699(0.60); C924(0.66); C347(1.01); C449(1.13)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C625(0.80); C178(0.91); C449(0.91); C455(0.91)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C699(0.62); C924(1.02); C449(1.05); C455(1.05)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C699(0.30); C924(0.74); C449(0.94); C455(0.94)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C699(0.35); C924(0.71); C449(1.02); C455(1.02)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C699(0.71); C924(0.94); C721(0.96); C347(1.05)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C347(1.21); C546(1.67); C178(1.54); C449(0.95)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C347(1.98); C546(1.39); C178(1.33); C449(0.83)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C347(1.07); C546(1.47); C178(1.30); C449(0.77)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C347(1.26); C546(1.14); C178(1.23); C449(1.03)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C347(2.19); C546(1.39); C178(1.28); C449(0.88)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C347(1.07); C546(1.30); C178(1.30); C449(1.06)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C347(2.75); C546(0.97); C178(1.06); C449(0.94)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C347(0.87); C546(1.24); C178(1.20); C449(1.09)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C347(4.64); C546(0.95); C178(1.06); C449(0.72)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C347(2.58); C546(1.20); C178(1.05); C449(0.58)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C347(2.72); C546(0.98); C178(0.93); C449(0.62)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C347(8.06); C546(0.96); C178(1.12); C449(0.56)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C347(1.60); C546(0.86); C178(1.16); C449(0.60)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C347(1.60); C546(1.22); C178(1.11); C449(0.64)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C347(1.57); C546(0.95); C178(1.18); C449(0.64)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C347(1.10); C546(1.14); C178(1.09); C449(0.65)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C347(1.66); C546(1.05); C178(1.09); C449(0.80)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C347(5.29); C546(3.03); C178(1.08); C449(0.70)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C347(2.15); C546(1.03); C178(1.00); C449(0.68)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C347(2.38); C546(1.40); C178(1.38); C449(0.66)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C347(2.11); C546(0.99); C178(1.12); C449(0.62)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C347(5.29); C546(1.05); C178(1.08); C449(0.56)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C347(2.28); C546(1.38); C178(1.16); C449(0.58)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C347(2.82); C546(1.04); C178(0.86); C449(1.41)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C347(3.66); C546(1.09); C178(0.88); C449(1.47)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C347(1.94); C546(0.98); C178(0.89); C449(1.62)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C347(1.00); C546(1.09); C178(0.93); C449(1.16)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C347(1.13); C546(1.01); C178(1.11); C449(0.75)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C347(1.22); C546(0.94); C178(0.83); C449(1.68)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C347(1.26); C546(1.00); C178(0.90); C449(2.05)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C347(1.17); C546(1.04); C178(0.97); C449(1.50)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C347(1.12); C546(0.92); C178(0.84); C449(1.51)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C347(1.90); C546(1.10); C178(0.88); C449(1.50)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C347(1.30); C546(0.99); C178(0.84); C449(1.33)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C347(2.65); C546(1.12); C178(1.00); C449(1.27)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C347(2.23); C546(0.95); C178(0.85); C449(1.51)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C347(1.21); C546(1.10); C178(0.85); C449(1.38)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C347(1.10); C546(0.93); C178(0.89); C449(1.49)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C347(1.44); C546(1.08); C178(1.17); C449(0.45)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C347(1.21); C546(0.99); C178(0.89); C449(1.30)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C347(1.75); C546(0.94); C178(1.02); C449(0.90)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C347(4.09); C546(0.99); C178(1.05); C449(0.88)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C347(2.03); C546(1.01); C178(1.19); C449(0.68)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C347(1.94); C546(1.12); C178(1.19); C449(0.70)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C347(1.91); C546(1.06); C178(1.04); C449(0.86)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C347(2.56); C546(1.18); C178(1.38); C449(0.66)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C347(1.33); C546(1.09); C178(1.20); C449(0.63)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C347(6.83); C546(1.09); C178(1.14); C449(0.78)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C347(5.57); C546(0.85); C178(0.97); C449(0.62)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C347(1.30); C546(1.28); C178(1.16); C449(0.53)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C347(1.66); C546(1.00); C178(1.10); C449(0.68)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C347(2.36); C546(1.03); C178(1.18); C449(0.85)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C347(1.57); C546(1.10); C178(1.01); C449(0.91)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C347(2.29); C546(1.00); C178(1.07); C449(0.82)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C347(2.05); C546(0.96); C178(1.07); C449(0.65)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C347(1.36); C546(0.93); C178(0.91); C449(0.80)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C347(1.88); C546(0.86); C178(0.93); C449(1.05)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C347(1.55); C546(0.86); C178(1.05); C449(0.91)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C347(1.63); C546(0.89); C178(1.21); C449(0.86)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C347(5.90); C546(1.14); C178(1.22); C449(0.47)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C347(1.23); C546(0.89); C178(0.94); C449(0.82)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C347(1.33); C546(0.91); C178(1.18); C449(1.06)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C347(1.54); C546(1.02); C178(1.26); C449(0.96)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C347(1.65); C546(0.90); C178(1.29); C449(0.87)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C347(2.11); C546(0.95); C178(1.50); C449(0.65)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C347(1.50); C546(1.01); C178(1.12); C449(0.89)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C347(1.50); C546(0.94); C178(0.98); C449(1.13)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C347(11.64); C546(0.92); C178(1.06); C449(1.08)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C347(1.39); C546(0.90); C178(1.22); C449(1.02)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C347(2.01); C546(0.95); C178(1.62); C449(0.72)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C347(3.44); C546(1.11); C178(1.06); C449(0.67)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C347(3.51); C546(6.50); C178(0.80); C449(1.16)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C347(1.33); C546(0.95); C178(0.99); C449(0.87)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C347(5.23); C546(0.75); C178(0.88); C449(0.77)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C347(3.40); C546(0.77); C178(0.82); C449(0.90)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C347(2.80); C546(0.84); C178(0.90); C449(0.90)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C347(3.10); C546(0.81); C178(0.96); C449(0.78)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C347(1.49); C546(0.94); C178(1.00); C449(0.91)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C347(1.16); C546(0.99); C178(0.99); C449(0.77)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C347(1.42); C546(1.09); C178(1.02); C449(0.84)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C347(2.11); C546(0.94); C178(1.05); C449(0.94)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C546(0.92)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C178(1.03); C682(1.05); C156(1.13); C546(1.02)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C347(2.82); C156(1.59); C174(1.41); C178(1.20)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 32.63  LDD0183  [9]
 LDCM0625  F8 Ramos C721(1.15); C347(2.75)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C347(20.00)  LDD1466  [32]
 LDCM0573  Fragment11 MDA-MB-231 C347(1.57)  LDD1467  [32]
 LDCM0574  Fragment12 Ramos C721(0.42)  LDD2191  [31]
 LDCM0575  Fragment13 MDA-MB-231 C347(1.30)  LDD1469  [32]
 LDCM0576  Fragment14 Ramos C721(0.62); C347(0.70); C625(1.03)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C721(0.35); C347(1.83)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C721(1.07); C347(0.85)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C721(1.42); C347(0.65)  LDD2196  [31]
 LDCM0578  Fragment27 MDA-MB-231 C347(0.78)  LDD1474  [32]
 LDCM0586  Fragment28 Ramos C721(0.70); C347(1.83); C625(1.04)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C721(0.71); C347(1.17)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C347(1.88)  LDD1478  [32]
 LDCM0590  Fragment32 Ramos C721(0.38)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C347(4.65); C546(1.16); C178(1.10); C449(0.85)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C721(0.86); C347(0.90)  LDD2203  [31]
 LDCM0566  Fragment4 MDA-MB-231 C347(20.00)  LDD1461  [32]
 LDCM0599  Fragment41 MDA-MB-231 C347(0.64)  LDD1481  [32]
 LDCM0427  Fragment51 HCT 116 C347(5.27); C546(1.17); C178(1.32); C449(0.64)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C347(1.21)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C721(1.08); C347(1.29)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C721(0.49); C347(2.62); C625(0.94)  LDD2186  [31]
 LDCM0571  Fragment9 MDA-MB-231 C347(3.33)  LDD1463  [32]
 LDCM0107  IAA HeLa H91(0.00); C455(0.00)  LDD0221  [25]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C347(20.00); C625(1.18)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C347(20.00); C625(1.22)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C347(4.58); C625(0.97)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 8.92  LDD0182  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C347(0.92)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C347(0.59)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C682(0.97); C347(0.53)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C682(0.99); C347(1.09)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C682(0.90); C178(1.12); C347(0.74)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C178(1.03); C347(1.11); C174(1.39)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C682(0.80); C347(1.21)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C178(0.79); C347(0.84)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C682(0.85)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C682(1.21); C178(1.25); C347(0.69)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C178(0.87); C347(0.92)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C347(0.99)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C174(0.78); C449(0.78); C455(0.59)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C347(0.91)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C178(0.64); C347(1.27)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C347(0.77)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C178(0.77); C347(1.04); C174(1.22)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C347(0.94)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C682(0.77); C178(0.79); C347(0.78); C156(0.83)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C347(1.44)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C682(1.10); C347(1.04); C174(1.45)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C347(0.77)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C174(0.72)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C347(1.02)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C178(1.36); C347(1.25)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C178(2.12); C174(2.38)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C347(0.79); C455(1.41)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C682(0.51); C178(0.97); C347(1.03)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C682(1.19); C347(1.08)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C178(0.94); C347(1.20)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C682(0.95); C347(1.00); C174(1.03); C455(0.97)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C178(1.01); C347(1.02)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C156(0.76); C455(1.08)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C682(0.72); C347(0.86)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C682(0.97); C178(0.90)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C455(0.76)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C455(0.78)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C682(1.17); C178(1.42); C347(0.95)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C178(0.86); C347(1.20)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C682(0.95); C178(0.77); C347(1.22)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C174(2.75); C347(1.26); C178(0.77)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C178(0.77); C347(0.79); C174(1.00)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C347(1.02)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C682(1.04); C174(3.36)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C347(9.62)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C178(1.12); C347(0.80); C174(1.22); C156(1.12)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C347(3.65)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C682(0.54); C347(0.86)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C682(0.47); C347(1.06)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C347(0.37); C625(0.92)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C682(0.45); C178(1.12); C347(1.14)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C347(1.34)  LDD2153  [6]
 LDCM0032  Oleacein HEK-293T 4.91  LDD0184  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C17(0.89); C347(0.67)  LDD2207  [33]
 LDCM0029  Quercetin HEK-293T 4.56  LDD0181  [9]
 LDCM0131  RA190 MM1.R C347(0.98)  LDD0304  [34]
 LDCM0021  THZ1 HCT 116 C178(1.17); C347(1.11); C546(1.28)  LDD2173  [12]
 LDCM0112  W16 Hep-G2 C347(1.98)  LDD0239  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
34 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.