Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment10  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 38 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP05480  Amidophosphoribosyltransferase (PPAT) C100 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) C145 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 20.0
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 13.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 12.0
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 11.0
 LDTP13719  Ubiquitin carboxyl-terminal hydrolase 22 (USP22) C171 9.3
 LDTP05859  Integrin-linked protein kinase (ILK) C346 8.3
 LDTP06211  Caspase-8 (CASP8) C360 5.8
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 3.9
 LDTP00481  Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) C98 3.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 2.8
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.8
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 2.7
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 2.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 2.1
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 2.1
 LDTP01220  Mitochondrial-processing peptidase subunit beta (PMPCB) C265 2.1
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.7
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.5
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.4
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.3
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 1.2
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 0.7
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 0.7
Transporter and channel
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 2.5
 LDTP04801  Gasdermin-D (GSDMD) C268 2.2
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.6
 LDTP00501  Exportin-1 (XPO1) C528 0.7
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 20.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 2.2
Other
Click to Show/Hide to Show 17 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 20.0
 LDTP07755  Dynamin-binding protein (DNMBP) C691 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP03994  Condensin-2 complex subunit D3 (NCAPD3) C541 6.5
 LDTP08483  DENN domain-containing protein 1C (DENND1C) C174 5.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 4.5
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C819 3.0
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 2.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.4
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 2.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 2.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.0
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.6
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.9

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.