General Information of Target

Target ID LDTP12405
Target Name Fructose-2,6-bisphosphatase TIGAR (TIGAR)
Gene Name TIGAR
Gene ID 57103
Synonyms
C12orf5; Fructose-2,6-bisphosphatase TIGAR; EC 3.1.3.46; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRPKEPSGSDGESDGPIDVGQEGQLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRIN
SSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAVDFRSIG
FRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFF
HSCPGLPALSNQLAILGRVPSPVLPGVSSPAYPIPALRTAPLRRATGIILPARRNVLPSR
GASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTPPGPTGSAAYVAVPTPNS
SSPGPAGRPAGAMLYHSWVSEITEIGAF
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family
Subcellular location
Cytoplasm
Function
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression.
Uniprot ID
Q9NQ88
Ensemble ID
ENST00000179259.6
HGNC ID
HGNC:1185
ChEMBL ID
CHEMBL4295958

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
15.00  LDD0402  [1]
TG42
 Probe Info 
4.07  LDD0043  [2]
TH211
 Probe Info 
Y208(20.00)  LDD0260  [3]
DA-P3
 Probe Info 
14.27  LDD0182  [4]
AHL-Pu-1
 Probe Info 
C114(2.44)  LDD0170  [5]
EA-probe
 Probe Info 
C114(2.92); C161(0.93); C114(15.00); C161(0.95)  LDD2210  [6]
HHS-482
 Probe Info 
Y92(0.94)  LDD0285  [7]
HHS-475
 Probe Info 
Y92(0.88)  LDD0264  [8]
HHS-465
 Probe Info 
Y92(9.10)  LDD2237  [9]
DBIA
 Probe Info 
C114(0.93)  LDD0078  [10]
ATP probe
 Probe Info 
N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info 
C215(0.00); C161(0.00); C114(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info 
N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info 
C215(0.00); C114(0.00); C161(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info 
N.A.  LDD0026  [14]
NAIA_4
 Probe Info 
C114(0.00); C161(0.00); C215(0.00)  LDD2226  [15]
TFBX
 Probe Info 
C114(0.00); C215(0.00)  LDD0027  [14]
WYneO
 Probe Info 
N.A.  LDD0022  [16]
Compound 10
 Probe Info 
N.A.  LDD2216  [17]
Compound 11
 Probe Info 
N.A.  LDD2213  [17]
ENE
 Probe Info 
N.A.  LDD0006  [16]
IPM
 Probe Info 
N.A.  LDD0005  [16]
NHS
 Probe Info 
N.A.  LDD0010  [16]
NPM
 Probe Info 
N.A.  LDD0016  [16]
STPyne
 Probe Info 
N.A.  LDD0009  [16]
VSF
 Probe Info 
N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info 
C161(0.00); C114(0.00)  LDD0018  [18]
1c-yne
 Probe Info 
N.A.  LDD0228  [19]
Acrolein
 Probe Info 
N.A.  LDD0217  [20]
AOyne
 Probe Info 
15.00  LDD0443  [21]
NAIA_5
 Probe Info 
C215(0.00); C76(0.00); C140(0.00)  LDD2223  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C114(2.44)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C161(4.12); C114(3.58)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C114(1.14); C161(1.37); C215(1.46); C254(0.98)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C114(1.23); C161(1.17); C215(2.02)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C114(0.94); C215(1.05)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C114(1.00); C215(0.93)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C114(1.04); C215(0.83)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C114(1.24); C215(0.89)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C114(1.04); C215(0.82)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C114(1.30); C215(1.04)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C114(1.15); C215(1.00)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C114(1.11); C215(0.80)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C114(0.91); C215(0.94)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C114(0.90); C215(0.86)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C114(1.07); C161(1.33); C215(1.66)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C114(1.02); C215(0.87)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C114(1.06); C215(0.81)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C114(1.13); C215(0.87)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C114(1.06); C215(1.12)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C114(1.13); C215(0.92)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C114(1.14); C215(0.98)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C114(1.56); C215(0.94)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C114(1.25); C215(1.24)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C114(1.10); C215(1.04)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C114(1.27); C215(0.99)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C114(1.04); C161(1.05); C215(1.16)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C114(1.25); C215(0.93)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C114(1.13); C215(1.58)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C114(1.31); C215(1.04)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C114(1.08); C215(1.12)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C114(1.05); C215(1.22)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C114(1.16); C215(0.98)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C114(1.31); C215(1.02)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C114(1.44); C215(1.07)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C114(1.32); C215(1.44); C254(1.31); C256(1.31)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C114(0.71); C215(1.03); C254(1.14); C256(1.14)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C114(1.03); C215(1.04); C254(0.95); C256(0.95)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C114(0.91); C215(1.17); C254(1.34); C256(1.34)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C114(1.02); C215(1.24); C254(1.00); C256(1.00)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C114(1.09); C215(1.17); C254(1.24); C256(1.24)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C114(1.22); C215(0.84); C254(1.07); C256(1.07)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C114(1.15); C215(1.06); C254(1.11); C256(1.11)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C114(1.10); C215(1.06); C254(0.93); C256(0.93)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C114(0.99); C215(0.84); C254(1.01); C256(1.01)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C114(1.08); C215(0.79); C254(0.89); C256(0.89)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C114(1.10); C215(0.74); C254(0.89); C256(0.89)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C114(0.99); C161(1.17); C215(1.08)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C114(1.24); C215(0.85); C254(0.98); C256(0.98)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C114(1.12); C215(0.90); C254(0.91); C256(0.91)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C114(0.93); C215(1.01); C254(0.98); C256(0.98)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C215(0.89); C254(0.90); C256(0.90); C114(1.17)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C256(0.67); C215(1.01); C254(1.25); C114(1.38)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C256(0.85); C215(1.11); C114(1.16); C254(1.35)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C215(1.05); C256(1.11); C254(1.13); C114(1.46)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C256(0.80); C254(1.04); C215(1.29); C114(1.37)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C256(1.02); C215(1.12); C114(1.76); C254(1.98)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C215(0.96); C256(1.14); C254(1.44); C114(1.71)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C215(0.94); C114(1.15); C161(1.33)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C256(0.81); C215(0.88); C254(1.06); C114(1.16)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C215(0.87); C256(0.93); C114(1.13); C254(1.17)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C256(0.94); C215(0.95); C254(1.03); C114(1.39)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C256(1.01); C215(1.33); C254(1.46); C114(1.95)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C114(1.33); C215(1.04); C254(0.90); C256(0.99)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C114(1.36); C215(0.92); C254(1.23); C256(0.85)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C114(1.09); C215(0.89); C254(0.91); C256(1.09)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C114(1.04); C215(1.07); C254(1.13); C256(1.00)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C254(0.40); C256(0.40); C114(1.03); C215(1.30)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C254(0.36); C256(0.36); C215(1.29); C114(1.32)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C254(0.61); C256(0.61); C114(1.09); C215(1.32)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C215(1.07); C254(1.10); C256(1.10); C114(1.15)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C254(0.64); C256(0.64); C215(1.05); C114(1.08)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C254(0.50); C256(0.50); C114(0.99); C215(1.18)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C254(0.97); C256(0.97); C114(1.10); C215(1.26)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C254(0.69); C256(0.69); C215(1.11); C114(1.76)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C254(0.49); C256(0.49); C114(0.99); C215(1.21)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C215(0.96); C114(1.09); C161(1.15); C254(1.19)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C254(0.77); C256(0.77); C215(1.00); C114(1.23)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C254(0.95); C256(0.95); C215(0.98); C114(1.19)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C254(0.50); C256(0.50); C215(0.80); C161(1.37)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C254(0.65); C256(0.65); C215(0.87); C161(1.19)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C254(1.17); C256(1.17); C114(1.21); C215(1.29)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C254(0.67); C256(0.67); C215(0.79); C161(1.19)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C254(0.70); C256(0.70); C215(0.83); C114(1.19)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C254(0.56); C256(0.56); C215(0.91); C114(1.40)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C215(0.99); C254(1.03); C256(1.03); C114(1.28)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C215(0.86); C254(1.06); C256(1.06); C114(1.36)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C114(0.84); C215(1.05)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C215(0.82); C114(0.89)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C114(0.93); C215(1.15)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C215(0.86); C114(0.98)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C215(0.96); C114(1.01)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C254(1.10); C256(1.10); C114(1.29); C215(1.32)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C215(0.92); C114(1.12)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C215(0.88); C114(1.04)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C215(0.87); C114(1.41)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C215(0.83); C114(1.14)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C114(1.01); C215(1.15)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C215(1.05); C114(1.28)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C215(0.80); C161(1.07); C114(1.10); C254(1.27)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C114(1.02); C215(1.07); C254(1.23); C256(1.23)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C215(1.04); C254(1.19); C256(1.19); C114(1.20)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C215(1.01); C254(1.17); C256(1.17); C114(1.42)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C254(1.19); C256(1.19); C114(1.32); C215(1.40)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C215(1.02); C254(1.19); C256(1.19); C114(1.43)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C161(0.75); C114(0.99); C254(1.03); C256(1.03)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C161(0.99); C215(1.05); C254(1.09); C256(1.09)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C215(1.00); C254(1.14); C256(1.14); C114(1.95)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C254(0.89); C256(0.89); C215(1.08); C114(1.18)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C215(1.11); C114(1.34); C254(1.34); C256(1.34)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C215(1.09); C254(1.15); C256(1.15); C114(1.63)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C254(1.00); C256(1.00); C215(1.17); C114(1.38)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C254(0.88); C256(0.88); C215(0.97); C114(1.36)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C215(0.82); C254(1.15); C256(1.15); C114(1.49)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C215(1.14); C114(1.19); C161(1.34)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C215(0.82); C254(0.99); C256(0.99); C114(1.49)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C254(0.92); C256(0.92); C215(0.99); C114(1.29)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C215(0.72); C254(1.12); C256(1.12); C114(1.58)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C215(0.83); C254(1.33); C256(1.33); C114(1.53)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C215(0.97); C114(1.46); C254(1.59); C256(1.59)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C254(0.86); C256(0.86); C215(0.95); C114(1.65)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C254(0.96); C256(0.96); C215(1.15); C114(1.52)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C215(0.84); C254(1.11); C256(1.11); C114(1.83)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C215(0.92); C114(1.18); C254(1.39); C256(1.39)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C215(0.95); C254(1.19); C256(1.19); C114(1.26)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C114(1.11); C161(1.14); C215(1.17)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C254(0.83); C256(0.83); C215(0.88); C114(1.37)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C215(1.12); C114(1.24); C254(1.36); C256(1.36)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C215(0.86); C254(1.04); C256(1.04); C114(1.29)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C254(0.86); C256(0.86); C215(0.92); C114(1.78)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C215(1.10); C254(1.30); C256(1.30); C114(1.76)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C254(0.83); C256(0.83); C215(0.94); C114(1.86)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C254(1.02); C256(1.02); C215(1.08); C114(1.40)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C215(0.82); C254(1.00); C256(1.00); C114(1.44)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C215(0.87); C114(1.23); C254(1.36); C256(1.36)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C215(0.88); C254(1.06); C256(1.06); C114(1.26)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C215(1.02); C114(1.16); C161(1.37)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C215(0.94); C114(1.19); C254(1.32); C256(1.32)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C215(1.00); C254(1.22); C256(1.22); C114(1.42)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C215(0.92); C254(1.46); C256(1.46); C114(1.96)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C215(0.82); C114(1.71)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C215(0.78); C114(1.50)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C215(0.96); C114(1.36)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C215(0.95); C114(1.41)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C215(1.04); C114(1.12)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C215(1.09); C114(1.16)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C215(0.90); C114(1.24)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C114(1.07); C215(1.34)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C215(1.14); C114(1.65)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C215(0.92); C114(1.59)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C215(0.72); C114(1.22)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C215(0.87); C114(1.22)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C215(1.05); C114(1.21)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C215(0.81); C114(1.56)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C215(0.93); C114(2.08)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C215(0.85); C114(1.32)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C215(0.94); C114(0.97)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C114(1.02); C161(1.10); C215(1.66)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C114(1.09); C161(1.21); C215(1.53)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C215(1.31); C114(1.54); C161(2.00)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 12.10  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C114(0.93)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C161(0.83)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C254(0.78); C256(0.78); C215(0.83); C114(1.04)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C254(0.51); C256(0.51); C215(0.89); C114(1.26)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C254(1.10); C256(1.10); C114(1.21); C215(1.33)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C215(1.05); C114(1.13); C161(1.51)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C161(1.12); C114(1.37); C215(2.76)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C161(1.01); C114(1.03); C215(2.41)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C114(1.04); C161(1.20); C215(1.90)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C254(0.35); C256(0.35); C215(1.01); C114(1.19)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C254(0.21); C256(0.21); C215(1.09); C114(1.42)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C254(0.33); C256(0.33); C215(1.08); C114(1.21)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C254(0.36); C256(0.36); C215(1.24); C114(1.33)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C254(0.31); C256(0.31); C215(1.16); C114(1.37)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C254(0.61); C256(0.61); C215(0.78); C114(1.38)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C254(0.47); C256(0.47); C215(1.27); C114(1.39)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C254(0.46); C256(0.46); C215(1.12); C114(1.20)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C215(0.89); C254(0.92); C256(0.92); C114(0.99)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C254(0.65); C256(0.65); C215(0.85); C114(1.27)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C254(0.68); C256(0.68); C215(0.88); C114(1.46)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C215(0.82); C254(0.88); C256(0.88); C114(1.26)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C254(0.84); C256(0.84); C215(0.97); C114(1.18)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C215(0.79); C114(1.54)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C215(0.85); C114(1.06)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C215(1.00); C114(1.12)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C254(0.60); C256(0.60); C215(0.99); C114(1.39)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C215(0.90); C114(1.02)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C161(0.66); C114(0.68); C215(0.85); C254(1.13)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C215(0.94); C254(1.04); C256(1.04); C114(1.20)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C215(0.78); C114(1.30); C254(1.32); C256(1.32)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C215(0.77); C254(1.16); C256(1.16); C114(1.53)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C215(0.82); C254(0.98); C256(0.98); C114(1.16)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C254(0.68); C256(0.68); C215(0.77); C114(1.20)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C215(0.84); C254(0.96); C256(0.96); C114(1.14)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C254(1.10); C256(1.10); C215(1.20); C114(1.30)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C254(0.70); C256(0.70); C215(1.07); C114(1.28)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C254(0.50); C256(0.50); C215(0.96); C114(1.26)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C254(0.58); C256(0.58); C215(0.85); C114(1.44)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C215(1.01); C114(1.10)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C215(0.89); C114(1.32)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C114(1.00); C215(1.12)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C114(1.01); C215(1.27)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C254(0.68); C256(0.68); C215(0.76); C114(0.98)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C215(1.17); C114(1.30)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C215(1.04); C114(1.53)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C215(1.03); C114(2.03)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C215(0.97); C114(1.05)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C114(1.15); C215(1.23)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C114(1.18); C215(0.94)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C114(1.05); C215(1.08)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C114(1.04); C215(1.19)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C114(1.26); C215(1.31)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C114(1.13); C215(1.13)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C114(0.96); C215(0.91); C254(0.66); C256(0.66)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C114(0.98); C215(1.17)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C114(1.20); C215(1.06); C254(0.68); C256(0.68)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C114(1.22); C215(0.85); C254(0.34); C256(0.34)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C114(1.25); C215(0.78); C254(0.32); C256(0.32)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C114(1.57); C215(0.90); C254(0.43); C256(0.43)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C114(1.22); C215(1.04); C254(0.46); C256(0.46)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C114(1.29); C215(0.89); C254(0.47); C256(0.47)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C114(1.54); C215(1.09); C254(0.59); C256(0.59)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C114(1.55); C215(1.10); C254(0.53); C256(0.53)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C114(0.98); C215(0.84); C254(0.86); C256(0.86)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C114(1.22); C215(0.88); C254(0.56); C256(0.56)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C114(1.24); C215(0.91); C254(0.76); C256(0.76)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C114(1.94); C215(0.99); C254(0.33); C256(0.33)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C114(1.57); C215(0.99); C254(0.38); C256(0.38)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C114(1.40); C215(1.01); C254(0.45); C256(0.45)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C114(1.66); C215(0.91); C254(0.59); C256(0.59)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C114(0.94); C161(0.85); C215(0.85); C254(1.34)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C114(0.92); C161(1.07); C215(0.90); C254(1.28)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C114(0.96); C161(0.63); C215(0.84); C254(1.66)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C114(1.00); C161(1.67); C215(0.93); C254(1.15)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C114(1.08); C215(1.02); C254(0.97); C256(0.97)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C114(0.97); C161(0.88); C215(0.98); C254(1.11)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C114(1.00); C161(1.08); C215(0.95); C254(1.27)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C114(0.98); C161(1.54); C215(0.94); C254(1.17)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C114(1.02); C161(0.98); C215(0.71); C254(1.06)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C114(0.97); C161(0.74); C215(0.87); C254(1.37)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C114(0.91); C161(0.82); C215(0.82); C254(1.48)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C114(0.94); C161(1.02); C215(0.95); C254(1.10)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C114(1.06); C161(1.83); C215(0.76); C254(1.25)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C114(0.90); C161(0.94); C215(0.89); C254(1.42)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C114(0.93); C161(0.98); C215(0.92); C254(1.26)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C114(1.22); C215(0.96); C254(0.56); C256(0.56)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C114(0.96); C161(1.32); C215(0.88); C254(1.10)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C114(1.38); C215(1.19); C254(0.85); C256(0.85)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C114(1.22); C215(1.04); C254(0.89); C256(0.89)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C114(1.71); C215(0.86); C254(0.57); C256(0.57)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C114(1.32); C215(0.99); C254(0.67); C256(0.67)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C114(1.17); C215(1.07); C254(1.04); C256(1.04)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C114(1.10); C215(1.04); C254(0.68); C256(0.68)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C114(1.11); C215(1.10); C254(0.58); C256(0.58)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C114(1.12); C215(1.19); C254(0.45); C256(0.45)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C114(1.33); C215(0.94); C254(0.58); C256(0.58)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C114(1.36); C215(0.93); C254(0.61); C256(0.61)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C114(1.18); C215(1.08); C254(0.48); C256(0.48)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C114(1.42); C215(1.01); C254(0.55); C256(0.55)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C114(1.30); C215(1.17); C254(0.99); C256(0.99)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C114(1.46); C215(1.38); C254(0.58); C256(0.58)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C114(1.13); C215(1.09); C254(0.63); C256(0.63)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C114(1.15); C215(0.92)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C114(1.17); C215(0.80)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C114(1.14); C215(1.06)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C114(1.25); C215(0.91)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C114(1.95); C215(0.80); C254(0.44); C256(0.44)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C114(1.06); C215(1.03)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C114(1.20); C215(0.99)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C114(1.45); C215(1.01)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C114(1.51); C215(0.85)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C114(1.78); C215(0.83)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C114(1.21); C215(0.93)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C114(1.17); C215(0.97)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C114(1.32); C215(0.90)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C114(1.30); C215(0.95)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C114(1.79); C215(1.01)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C114(1.22); C215(0.80); C254(0.56); C256(0.56)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C114(1.08); C215(0.89)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C114(1.34); C161(1.36); C215(0.89); C254(0.96)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C114(1.14); C161(1.57); C215(0.90); C254(1.03)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C114(1.08); C161(1.39); C215(1.37); C254(1.33)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C114(1.38); C161(1.76); C215(1.40); C254(1.45)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C114(1.64); C161(1.84); C215(0.92); C254(1.40)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C114(1.30); C161(1.28); C215(1.02); C254(1.16)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C114(1.47); C161(1.71); C215(0.96); C254(1.17)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C114(1.28); C161(1.59); C215(1.03); C254(1.01)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C114(1.23); C161(1.56); C215(1.14); C254(1.23)  LDD0811  [10]
 LDCM0634  CY-0357 Hep-G2 C161(2.16); C215(1.07); C114(0.56)  LDD2228  [15]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C161(7.54)  LDD0526  [22]
 LDCM0175  Ethacrynic acid HeLa C114(2.92); C161(0.93); C114(15.00); C161(0.95)  LDD2210  [6]
 LDCM0625  F8 Ramos C114(1.21); C161(1.71)  LDD2187  [23]
 LDCM0572  Fragment10 MDA-MB-231 C161(4.60); C114(2.13)  LDD1465  [24]
 LDCM0573  Fragment11 MDA-MB-231 C161(0.90); C114(0.78)  LDD1467  [24]
 LDCM0574  Fragment12 Ramos C114(5.17); C161(0.58)  LDD2191  [23]
 LDCM0575  Fragment13 MDA-MB-231 C161(1.13); C114(1.05)  LDD1469  [24]
 LDCM0576  Fragment14 MDA-MB-231 C161(20.00); C114(2.17)  LDD1471  [24]
 LDCM0579  Fragment20 Ramos C114(1.09); C161(0.70)  LDD2194  [23]
 LDCM0580  Fragment21 MDA-MB-231 C161(0.95); C114(0.87)  LDD1473  [24]
 LDCM0582  Fragment23 Ramos C114(0.87); C161(0.42)  LDD2196  [23]
 LDCM0578  Fragment27 MDA-MB-231 C161(0.58); C114(0.43)  LDD1474  [24]
 LDCM0586  Fragment28 Ramos C114(0.78); C161(1.12)  LDD2198  [23]
 LDCM0587  Fragment29 Ramos C161(1.29); C114(0.94)  LDD1476  [24]
 LDCM0588  Fragment30 Ramos C114(1.21); C161(0.42)  LDD2199  [23]
 LDCM0589  Fragment31 MDA-MB-231 C161(1.01)  LDD1477  [24]
 LDCM0590  Fragment32 Ramos C114(11.04); C161(1.20)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C114(1.38); C215(1.21); C254(0.79); C256(0.79)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C114(0.72); C161(0.36)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C114(1.40); C161(1.89)  LDD2184  [23]
 LDCM0599  Fragment41 MDA-MB-231 C114(0.59)  LDD1481  [24]
 LDCM0603  Fragment45 MDA-MB-231 C161(20.00); C114(4.57)  LDD1482  [24]
 LDCM0427  Fragment51 HCT 116 C114(2.00); C215(0.90); C254(0.41); C256(0.41)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C114(0.93); C161(0.48)  LDD2204  [23]
 LDCM0614  Fragment56 MDA-MB-231 C161(1.39)  LDD1484  [24]
 LDCM0569  Fragment7 Ramos C114(1.91); C161(3.85)  LDD2186  [23]
 LDCM0571  Fragment9 MDA-MB-231 C161(2.58); C114(1.88)  LDD1463  [24]
 LDCM0116  HHS-0101 DM93 Y92(0.88)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y92(0.86)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y92(0.85)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y92(0.89)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y92(1.05)  LDD0268  [8]
 LDCM0123  JWB131 DM93 Y92(0.94)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y92(0.59)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y92(1.16)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y92(1.89)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y92(1.77)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y92(0.90)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y92(0.64)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y92(0.82)  LDD0292  [7]
 LDCM0022  KB02 HCT 116 C114(2.51); C254(2.47); C256(2.47)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C114(1.51); C254(5.80); C256(5.80)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C114(20.00); C254(2.50); C256(2.50)  LDD0082  [10]
 LDCM0030  Luteolin HEK-293T 14.27  LDD0182  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0627  NUDT7-COV-1 HEK-293T C161(0.84); C114(0.39); C114(0.13)  LDD2206  [25]
 LDCM0032  Oleacein HEK-293T 9.37  LDD0184  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C161(2.88); C114(0.81); C114(0.66)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C114(1.19); C161(1.10)  LDD0304  [26]
 LDCM0170  Structure8 Ramos 4.87  LDD0433  [27]
 LDCM0021  THZ1 HCT 116 C114(1.05)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hexokinase-2 (HK2) Hexokinase family P52789
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
27 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.