Details of the Target

General Information of Target

Target ID LDTP13302
Target Name Nuclear prelamin A recognition factor (NARF)
Gene Name NARF
Gene ID 26502
Synonyms
Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHDSNNVEKDITPSELPANPGCLHSKEHSIKATLIWRLFFLIMFLTIIVCGMVAALSAIR
ANCHQEPSVCLQAACPESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELN
FLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPILGAGECAYLNDKGASSARHYTER
KWICSKSDIHV
Target Bioclass
Enzyme
Family
NARF family
Subcellular location
Nucleus
Uniprot ID
Q9UHQ1
Ensemble ID
ENST00000309794.16
HGNC ID
HGNC:29916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.Y229Ter .
HT SNV: p.S196P .
JURKAT SNV: p.C6Y Compound 10    Probe Info 
KURAMOCHI SNV: p.V437G .
NCIH1155 SNV: p.A243V .
PANC1 Deletion: p.K231EfsTer20 .
SNU308 Insertion: p.L50FfsTer8 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.41  LDD0403  [1]
Johansson_61
 Probe Info  		_(5.78)  LDD1485  [2]
AHL-Pu-1
 Probe Info  		C172(3.27)  LDD0169  [3]
DBIA
 Probe Info  		C228(4.26)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C99(0.00); C172(0.00); C192(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C228(0.00); C172(0.00); C192(0.00); C99(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C172(0.00); C192(0.00); C99(0.00); C228(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
Compound 10
 Probe Info  		C172(0.00); C228(0.00); C99(0.00)  LDD2216  [8]
Compound 11
 Probe Info  		C172(0.00); C228(0.00); C99(0.00)  LDD2213  [8]
Phosphinate-6
 Probe Info  		C86(0.00); C99(0.00)  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		C228(0.00); C192(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C172(3.27)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C192(1.03); C228(1.15); C99(1.05)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C192(0.99); C228(1.11); C172(1.18); C99(1.20)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C192(0.96); C228(1.12); C172(1.06)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C192(1.01); C228(1.05); C172(1.04); C99(1.17)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C192(1.07); C228(1.12); C172(1.03); C99(0.85)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C192(1.06); C228(1.06); C172(1.03); C99(0.98)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C192(1.00); C228(1.01); C99(1.06)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C192(0.95); C228(1.16); C172(1.00); C99(1.16)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C192(0.90); C228(1.39); C172(1.20)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C192(0.97); C228(1.08); C172(0.97); C99(1.17)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C192(1.05); C228(1.03); C172(0.97); C99(0.97)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C192(1.01); C228(0.91); C99(1.17)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C192(1.05); C228(0.88); C172(0.88); C99(1.03)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C192(1.10); C228(0.99); C172(1.26); C99(1.10)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C192(0.99); C228(1.08); C172(1.03); C99(0.95)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C192(1.05); C228(1.18); C99(1.20)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C192(1.01); C228(1.02); C172(1.14); C99(1.10)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C192(1.00); C228(0.95); C172(1.05)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C192(0.97); C228(1.16); C172(0.95); C99(1.06)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C192(0.96); C228(1.05); C99(1.01)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C192(0.91); C228(1.17); C172(1.29)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C192(0.97); C228(1.09); C172(1.12); C99(1.04)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C192(0.96); C228(0.99); C172(1.08); C99(0.88)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C192(1.01); C228(1.05); C172(1.08); C99(0.99)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C192(1.06); C228(1.08); C99(0.98)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C192(0.98); C228(1.02); C172(0.97); C99(1.05)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C192(0.97); C228(1.14); C172(1.13)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C192(1.05); C228(1.11); C172(1.12); C99(0.90)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C192(0.99); C228(1.01); C99(1.23)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C192(1.06); C228(0.92); C172(1.02); C99(0.95)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C192(1.04); C228(1.00); C172(0.93); C99(0.95)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C192(0.99); C228(1.18); C172(1.10); C99(1.01)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C192(1.09); C228(1.12); C172(1.00); C99(0.93)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C192(1.07); C228(1.10); C99(1.10)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C192(0.88); C228(1.20); C172(1.24); C99(1.13)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C192(0.94); C228(1.14); C172(1.24)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C192(0.99); C228(1.21); C172(1.09); C99(0.97)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C192(0.95); C228(1.07); C99(0.94)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C192(1.04); C228(0.95); C172(0.99); C99(0.97)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C192(0.97); C228(1.19); C172(1.02); C99(1.02)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C192(1.02); C228(1.22); C172(1.02); C99(0.97)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C192(1.02); C228(1.26); C99(1.10)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C192(0.91); C228(1.08); C99(1.23)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C192(0.93); C228(1.06); C172(1.11); C99(1.07)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C192(1.02); C228(1.13); C172(1.04)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C192(1.07); C228(1.10); C172(0.98); C99(0.99)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C192(0.98); C228(1.08); C99(1.04)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C192(1.06); C228(1.06); C172(1.01); C99(0.93)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C192(1.05); C228(1.03); C172(1.06); C99(1.01)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C192(1.02); C228(1.03); C172(1.10); C99(0.94)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C192(1.00); C228(1.20); C99(1.23)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C192(0.93); C228(1.04); C172(1.17); C99(1.16)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C192(0.92); C228(1.04); C172(1.06)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C192(0.94); C228(1.17); C172(1.02); C99(0.94)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C192(0.99); C228(1.18); C172(0.97); C99(0.98)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C192(0.91); C228(1.10); C99(1.24)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C192(0.90); C228(1.09); C172(0.99); C99(0.92)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C192(0.94); C228(1.01); C172(1.05); C99(0.96)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C192(1.01); C228(1.12); C172(1.21); C99(1.05)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C192(1.02); C228(0.98); C172(0.91); C99(1.07)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C192(1.01); C228(1.17); C172(1.02); C99(1.01)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C192(0.95); C228(1.10); C99(1.03)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C192(1.06); C228(1.14); C99(1.12)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C192(1.04); C228(1.13); C172(0.99); C99(0.89)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 13.41  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C228(2.63); C172(0.45)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C192(0.99); C228(1.20); C172(1.41)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C192(1.52); C228(1.45); C172(1.80); C99(1.52)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C192(0.93); C228(0.86); C172(1.04)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C192(1.00); C228(0.65); C172(1.27)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C192(1.47); C228(1.02); C172(0.92)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C192(0.98); C228(1.10); C99(1.10)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C192(0.96); C228(0.91); C172(1.07)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C192(1.00); C228(0.83); C172(1.35)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C192(1.01); C228(0.31); C172(0.86)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C192(0.99); C228(1.01); C99(1.01)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C192(1.04); C228(0.93); C172(1.11)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C192(0.95); C228(0.73); C172(1.29)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C192(2.03); C228(0.99); C172(1.09); C99(1.83)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C192(1.76); C228(0.94); C172(1.07)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C192(0.94); C228(1.10); C99(1.43)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C192(1.16); C228(0.84); C172(1.09)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C192(1.05); C228(1.03); C172(1.14)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C192(1.00); C228(0.97); C172(0.98)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C192(1.03); C228(0.81); C99(1.44)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C192(0.99); C228(1.17); C172(1.09)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C192(0.98); C228(1.06); C172(1.17)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C192(1.01); C228(1.15); C172(1.01)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C192(0.92); C228(0.79); C99(1.30)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C192(1.41); C228(0.93); C172(0.92); C99(1.46)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C192(1.06); C228(1.17); C172(1.21)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C192(0.99); C228(0.72); C172(1.27)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C192(1.09); C228(1.04); C172(1.10)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C192(1.05); C228(1.05); C99(1.34)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C192(1.00); C228(1.16); C172(1.01)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C192(0.90); C228(0.91); C172(1.23)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C192(1.01); C228(1.28); C172(1.12)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C192(0.89); C228(1.20); C99(1.34)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C192(0.91); C228(1.08); C172(1.02)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C192(0.98); C228(1.49); C172(1.35)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C192(1.23); C228(0.86); C172(1.12)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C192(1.19); C228(1.21); C99(1.51)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C192(1.22); C228(0.97); C172(1.09)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C192(1.21); C228(1.39); C99(2.12)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C192(1.19); C228(1.03); C172(1.12); C99(1.29)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C192(1.36); C228(1.05); C172(1.44)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C192(1.06); C228(1.08); C172(1.05)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C192(1.73); C228(0.92); C172(1.05); C99(1.13)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C192(1.25); C228(0.99); C99(2.46)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C192(1.76); C228(1.10); C172(1.05); C99(1.35)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C192(1.88); C228(1.05); C172(1.10); C99(0.98)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C192(1.43); C228(0.98); C172(1.22); C99(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C192(1.25); C228(1.06); C172(0.96)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C192(1.06); C228(1.02); C172(0.98)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C192(1.05); C228(1.10); C99(1.23)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C192(1.05); C228(1.05); C172(1.01)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C192(1.09); C228(1.00); C99(1.20)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C192(1.19); C228(1.01); C99(1.30)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C192(1.10); C228(1.07); C172(1.02); C99(1.03)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C192(1.17); C228(0.98); C172(1.06)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C192(1.45); C228(0.90); C172(1.00); C99(1.79)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C192(1.81); C228(1.00); C99(3.12)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C192(1.59); C228(1.16); C172(1.03); C99(1.35)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C192(1.80); C228(1.02); C172(0.90); C99(1.17)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C192(1.25); C228(0.90); C172(1.07); C99(1.61)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C192(0.99); C228(1.04); C172(1.19)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C192(1.06); C228(1.59); C99(1.78)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C192(0.99); C228(1.06); C172(1.13)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C192(1.02); C228(1.08); C172(0.96)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C192(1.14); C228(0.98); C99(1.36)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C192(1.01); C228(1.08); C172(0.97); C99(1.48)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C192(1.00); C228(0.97); C172(1.08)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C192(1.36); C228(1.04); C172(0.98); C99(1.13)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C192(1.21); C228(0.89); C99(2.66)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C192(1.57); C228(0.89); C172(0.90); C99(1.38)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C192(1.73); C228(0.95); C172(0.95); C99(1.51)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C192(1.22); C228(1.02); C172(0.98); C99(1.06)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C192(0.87); C228(1.07); C172(1.26)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C192(1.10); C228(1.07); C99(1.35)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C192(1.00); C228(0.80); C172(1.10)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C192(1.00); C228(1.00); C172(1.09)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C192(1.02); C228(1.08); C99(1.99)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C192(1.05); C228(1.08); C172(1.18); C99(2.57)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C192(1.11); C228(1.10); C172(1.13)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C192(1.30); C228(1.07); C172(1.06); C99(2.16)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C192(1.01); C228(1.47); C99(2.63)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C192(1.38); C228(0.98); C172(0.84); C99(1.30)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C192(1.81); C228(1.06); C172(0.89); C99(1.36)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C192(0.95); C228(1.00); C172(1.06); C99(1.88)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C192(1.21); C228(0.83); C172(1.15); C99(2.14)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C192(0.90); C228(1.00); C172(1.10)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C192(0.99); C228(1.05); C172(1.16)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C192(0.97); C228(1.05); C99(1.32)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C192(1.03); C228(0.90); C172(1.15)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C192(1.01); C228(1.01); C99(1.50)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C192(1.09); C228(0.97); C172(1.07); C99(2.36)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C192(1.05); C228(1.05); C172(1.24)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C192(1.32); C228(1.00); C172(0.96); C99(2.47)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C192(1.21); C228(0.81); C99(2.43)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C192(1.20); C228(1.06); C172(1.16)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C192(1.37); C228(0.91); C172(1.11); C99(0.89)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C192(1.55); C228(0.85); C172(0.98); C99(1.46)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C192(1.18); C228(1.04); C172(1.19); C99(1.05)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C192(0.96); C228(1.13); C172(1.09)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C192(1.07); C228(0.88); C172(1.18)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C192(0.96); C228(1.06); C172(1.11)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C192(1.09); C228(1.16); C99(1.25)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C192(1.01); C228(0.98); C172(1.05); C99(1.14)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C192(1.08); C228(0.97); C172(1.11)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C192(1.22); C228(2.15); C172(1.34); C99(2.25)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C192(1.25); C228(1.07); C172(1.02); C99(1.00)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C192(1.20); C228(0.92); C99(1.53)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C192(1.36); C228(0.96); C172(0.90); C99(1.00)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C192(1.48); C228(1.17); C172(1.09); C99(1.16)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C192(1.45); C228(1.05); C172(1.27); C99(1.55)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C192(0.91); C228(1.09); C172(1.14)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C192(0.97); C228(1.28); C172(1.06)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C192(1.09); C228(1.13); C99(2.06)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C192(0.99); C228(1.05); C172(1.09)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C192(1.04); C228(1.03); C99(1.53)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C192(1.31); C228(0.91); C99(2.10)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C192(1.55); C228(1.26); C172(1.53); C99(3.24)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C192(1.05); C228(1.15); C172(1.13)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C192(1.30); C228(1.08); C172(1.09); C99(2.58)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C192(1.05); C228(1.21); C99(2.42)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C192(1.31); C228(1.04); C172(0.99); C99(1.66)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C192(1.14); C228(1.14); C172(0.90); C99(1.44)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C192(1.14); C228(1.16); C172(0.92); C99(1.84)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C192(0.99); C228(0.46); C172(1.40)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C192(1.00); C228(0.95); C172(1.17)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C192(0.91); C228(1.12); C99(1.48)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C192(0.93); C228(1.25); C99(1.52)  LDD1698  [11]
 LDCM0201  EV-3 T cell C99(5.21)  LDD0515  [12]
 LDCM0202  EV-93 T cell C99(16.46)  LDD0514  [12]
 LDCM0203  EV-96 T cell C228(5.66)  LDD0523  [12]
 LDCM0625  F8 Ramos C172(1.00)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C172(1.33)  LDD2190  [13]
 LDCM0575  Fragment13 Ramos C99(20.00)  LDD1470  [2]
 LDCM0576  Fragment14 Ramos C172(0.76); C99(1.39)  LDD2193  [13]
 LDCM0580  Fragment21 Ramos C172(0.64)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C172(0.75); C99(0.65)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C172(0.88); C99(1.00)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C172(0.64)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C172(0.52)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C172(0.99); C99(0.79)  LDD2200  [13]
 LDCM0468  Fragment33 HEK-293T C192(0.98); C228(0.98); C99(2.06)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C172(0.72); C99(0.56)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C172(0.72)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C192(1.02); C228(1.12); C172(1.16)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C172(0.69)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C172(0.51); C99(1.03)  LDD2205  [13]
 LDCM0615  Fragment63-R Jurkat _(5.30)  LDD1487  [2]
 LDCM0617  Fragment63-S Jurkat _(10.82)  LDD1490  [2]
 LDCM0569  Fragment7 Jurkat _(5.78)  LDD1485  [2]
 LDCM0571  Fragment9 Ramos C99(20.00)  LDD1464  [2]
 LDCM0022  KB02 HEK-293T C192(1.00); C228(1.06)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C228(4.26)  LDD0209  [4]
 LDCM0024  KB05 HEK-293T C192(0.98); C228(0.85)  LDD1502  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C99(0.07)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C99(0.07)  LDD2207  [14]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.