Details of the Target

General Information of Target

Target ID LDTP06475
Target Name Mothers against decapentaplegic homolog 2 (SMAD2)
Gene Name SMAD2
Gene ID 4087
Synonyms
MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE
LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR
KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV
PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS
MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD
GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP
NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK
GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
Target Bioclass
Transcription factor
Family
Dwarfin/SMAD family
Subcellular location
Cytoplasm
Function
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma.
Uniprot ID
Q15796
Ensemble ID
ENST00000262160.11
HGNC ID
HGNC:6768
ChEMBL ID
CHEMBL2396512

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.R321Q DBIA    Probe Info 
IGROV1 SNV: p.T67A; p.G343E DBIA    Probe Info 
OPM2 SNV: p.L87R DBIA    Probe Info 
OVK18 Deletion: p.Y366MfsTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y366(6.49)  LDD0257  [2]
BTD
 Probe Info  		C70(1.25)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C161(6.51)  LDD0168  [4]
HHS-475
 Probe Info  		Y366(0.99)  LDD0264  [5]
HHS-465
 Probe Info  		Y366(4.17)  LDD2237  [6]
DBIA
 Probe Info  		C70(0.96)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C149(0.00); C70(0.00); C161(0.00); C312(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C149(0.00); C70(0.00); C161(0.00); C312(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C149(0.00); C161(0.00); C312(0.00); C129(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		C312(0.00); C70(0.00); C374(0.00)  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
Compound 10
 Probe Info  		C161(0.00); C41(0.00); C70(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C312(0.00); C41(0.00); C70(0.00)  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		C70(0.00); C149(0.00)  LDD0236  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		C149(0.00); C70(0.00); C312(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y366(1.21)  LDD2239  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C70(0.54)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C161(6.51)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C161(2.05); C81(2.51)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C129(0.75); C149(0.98); C312(0.71); C374(0.91)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C149(0.88); C312(1.04); C380(1.03)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C129(0.78); C312(0.92); C374(0.58); C380(0.94)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C129(1.05); C312(0.79); C374(0.55); C380(0.93)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C129(1.07); C312(0.76); C374(0.50); C380(1.04)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C129(1.06); C312(0.81); C374(0.36); C380(1.15)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C129(0.82); C312(1.10); C374(0.48); C380(1.07)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C129(0.87); C312(0.89); C374(0.40); C380(1.09)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C129(0.78); C312(0.80); C374(0.39); C380(1.10)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C129(0.81); C312(0.90); C374(0.30); C380(0.71)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C129(0.78); C312(0.80); C374(0.51); C380(0.40)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C129(0.98); C312(0.76); C374(0.58); C380(0.40)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C149(0.88); C312(1.16); C380(0.99)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C129(0.81); C312(0.68); C374(0.66); C380(0.42)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C129(0.94); C312(0.78); C374(0.75); C380(0.42)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C129(0.86); C312(0.76); C374(0.36); C380(0.57)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C129(0.85); C149(0.83); C312(1.02); C374(0.80)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C129(0.81); C149(0.83); C312(0.87); C374(0.81)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C129(0.86); C149(1.15); C312(0.70); C374(0.68)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C129(0.83); C149(0.97); C312(0.98); C374(0.70)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C129(0.86); C149(1.27); C312(0.90); C374(0.76)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C129(0.90); C149(1.03); C312(1.04); C374(0.81)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C129(0.80); C149(1.04); C312(0.79); C374(0.71)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C149(0.98); C312(1.41); C380(0.99)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C129(0.91); C149(0.84); C312(0.81); C374(0.95)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C129(1.12); C149(1.46); C312(1.02); C374(1.05)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C129(0.91); C149(0.81); C312(1.07); C374(0.84)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C129(1.23); C149(1.16); C312(1.09); C374(1.07)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C129(0.94); C149(1.09); C312(1.10); C374(0.96)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C129(0.93); C149(0.91); C312(1.06); C374(0.95)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C129(0.81); C149(0.88); C312(1.00); C374(0.99)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C129(0.86); C149(0.94); C312(1.02); C374(0.87)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C129(0.93); C312(0.76); C374(0.57); C70(1.49)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C129(0.60); C312(1.30); C374(0.88); C70(0.84)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C129(0.59); C312(1.09); C374(0.62); C70(1.85)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C129(0.93); C312(1.08); C374(0.92); C70(1.02)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C129(0.59); C312(1.31); C374(0.69); C70(1.22)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C129(0.66); C312(1.09); C374(0.63); C70(1.27)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C129(0.89); C312(0.79); C374(0.58); C70(1.09)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C129(0.73); C312(1.05); C374(0.54); C70(1.09)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C129(0.85); C312(1.02); C374(0.76); C70(1.21)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C129(0.84); C312(0.95); C374(0.73); C70(1.30)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C129(1.56); C312(0.74); C374(0.64); C70(1.41)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C129(0.84); C312(1.05); C374(0.70); C70(1.32)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C149(1.12); C312(1.10); C380(0.88)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C129(0.93); C312(0.96); C374(0.66); C70(1.30)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C129(0.97); C312(0.90); C374(0.72); C70(1.20)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C129(0.72); C312(1.20); C374(0.60); C70(1.25)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C312(0.68); C374(0.85); C149(0.88); C70(0.90)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C312(0.77); C374(0.77); C149(0.98); C70(1.07)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C149(0.82); C312(0.86); C374(0.89); C70(1.29)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C374(0.53); C312(0.62); C149(0.96); C70(1.52)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C374(0.69); C149(0.97); C312(1.01); C70(1.20)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C374(0.48); C312(0.90); C149(1.08); C70(1.49)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C374(0.61); C312(0.67); C149(0.69); C70(1.56)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C380(0.94); C312(1.05); C149(1.11)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C374(0.87); C312(0.97); C70(1.00); C149(1.54)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C312(0.69); C374(0.96); C70(1.14); C149(1.39)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C312(0.64); C374(0.69); C149(1.14); C70(1.18)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C374(0.50); C312(0.61); C149(0.88); C70(1.82)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C149(1.08); C312(0.62); C374(0.76); C70(1.28)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C149(1.20); C312(0.55); C374(0.83); C70(1.30)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C149(1.09); C312(0.58); C374(0.95); C70(1.03)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C149(1.13); C312(0.58); C374(1.34); C70(1.12)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C129(0.73); C436(1.06); C149(1.08); C380(1.08)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C436(0.61); C129(0.83); C149(1.03); C380(1.08)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C129(0.74); C436(0.86); C70(0.90); C312(0.95)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C374(0.70); C129(0.72); C312(0.89); C436(0.90)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C129(0.92); C436(1.00); C149(1.02); C380(1.10)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C436(0.76); C129(0.79); C149(0.81); C380(1.06)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C129(0.78); C149(0.94); C380(1.09); C436(1.18)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C129(0.75); C149(0.87); C436(0.93); C380(1.02)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C149(0.91); C129(0.94); C380(1.07); C436(1.13)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C436(0.82); C374(0.82); C312(0.96); C129(0.97)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C436(0.74); C374(0.76); C129(0.89); C312(1.07)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C436(0.79); C374(0.83); C129(0.96); C70(1.02)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C436(0.74); C129(0.75); C374(0.82); C312(0.88)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C374(0.73); C436(0.80); C129(0.82); C312(0.87)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C374(0.67); C129(0.74); C436(0.86); C70(0.88)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C374(0.76); C312(0.82); C436(0.82); C129(0.86)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C436(0.68); C374(0.74); C312(0.76); C70(0.89)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C436(0.59); C374(0.71); C312(0.79); C129(0.87)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C374(0.67); C436(0.67); C70(0.83); C312(0.91)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C374(0.68); C436(0.69); C312(0.94); C129(1.01)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C70(0.76); C149(0.84); C312(0.93); C129(1.05)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C149(0.68); C70(0.76); C129(1.00); C374(1.02)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C149(0.80); C129(0.90); C70(0.91); C374(0.92)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C70(0.84); C374(0.91); C129(0.94); C149(0.99)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C349(0.75); C362(0.75); C374(0.76); C129(0.98)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C129(0.70); C436(0.72); C374(0.73); C312(0.87)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C374(0.78); C349(0.83); C362(0.83); C312(0.85)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C149(0.63); C374(0.90); C349(0.90); C362(0.90)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C149(0.79); C374(0.81); C312(0.88); C70(0.98)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C374(0.66); C349(0.71); C362(0.71); C312(0.75)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C149(0.74); C374(0.80); C312(0.86); C70(0.94)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C374(0.67); C149(0.68); C312(0.79); C349(0.90)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C312(0.81); C129(0.82); C374(0.94); C349(0.95)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C129(0.78); C374(0.84); C349(0.87); C362(0.87)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C129(0.43); C349(0.43); C362(0.43); C374(0.55)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C374(0.60); C349(0.73); C362(0.73); C129(0.73)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C436(0.66); C129(0.67); C374(0.79); C312(0.83)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C374(0.67); C349(0.71); C362(0.71); C129(0.71)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C129(0.67); C70(0.84); C312(0.93); C380(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C129(0.84); C312(0.89); C70(0.93); C374(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C374(0.73); C129(0.79); C349(0.81); C362(0.81)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C129(0.82); C374(0.83); C70(0.92); C349(0.96)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C349(0.61); C362(0.61); C374(0.65); C129(0.78)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C374(0.65); C349(0.71); C362(0.71); C129(0.72)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C312(0.83); C129(0.88); C380(1.05); C70(2.04)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C312(0.82); C380(1.08); C129(1.18); C70(2.46)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C312(0.84); C380(1.05); C129(1.07); C70(2.48)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C312(0.85); C380(0.98); C149(1.03)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C312(0.71); C129(0.89); C380(1.03); C70(1.94)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C312(0.74); C129(0.98); C380(1.00); C70(1.89)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C312(0.78); C129(0.88); C380(1.01); C70(2.67)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C312(0.79); C129(0.80); C380(1.01); C70(2.17)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C129(0.73); C312(0.80); C380(0.98); C70(2.40)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C312(0.77); C380(1.00); C129(1.10); C70(2.02)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C312(0.83); C129(0.98); C380(1.04); C70(2.12)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C312(0.67); C129(0.89); C380(1.02); C70(2.32)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C436(0.64); C374(0.88); C380(0.97); C129(1.02)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C436(0.48); C374(0.86); C380(0.97); C70(1.09)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C149(0.87); C380(1.00); C312(1.02)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C436(0.41); C374(0.74); C129(0.91); C70(0.92)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C436(0.43); C374(0.96); C380(0.97); C129(1.00)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C436(0.50); C374(0.91); C380(1.05); C70(1.07)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C436(0.37); C374(0.71); C129(0.82); C312(1.04)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C436(0.40); C374(0.87); C129(0.94); C380(1.07)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C436(0.31); C374(0.73); C129(0.77); C312(1.03)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C436(0.56); C374(0.89); C129(0.95); C380(1.00)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C436(0.41); C374(0.79); C129(0.92); C380(0.96)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C436(0.38); C374(0.78); C129(0.85); C70(0.90)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C436(0.74); C374(0.84); C70(0.91); C380(1.04)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C380(0.96); C149(0.96); C312(1.00)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C436(0.65); C380(1.00); C129(1.03); C374(1.04)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C436(0.62); C374(0.83); C380(0.95); C129(1.08)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C436(0.44); C129(0.80); C374(0.91); C312(1.18)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C312(0.74); C149(0.86); C129(1.10); C70(1.77)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C312(0.84); C149(0.92); C129(1.09); C70(1.58)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C149(0.81); C312(0.91); C129(0.96); C70(1.53)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C149(0.90); C312(0.93); C129(1.07); C70(1.26)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C312(0.84); C129(0.99); C149(1.04); C70(1.07)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C149(0.92); C312(1.01); C129(1.02); C70(1.12)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C149(0.89); C312(0.89); C129(1.10); C70(1.38)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C129(0.79); C149(0.91); C70(0.94); C312(1.48)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C312(0.85); C129(0.92); C149(0.96); C70(1.53)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C129(0.90); C312(0.91); C149(0.95); C70(1.54)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C149(0.89); C129(0.98); C312(1.00); C70(1.21)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C129(0.76); C149(0.88); C70(1.21); C312(1.26)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C312(0.79); C129(0.89); C149(0.92); C70(1.03)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C129(0.73); C149(0.95); C312(1.20); C70(1.29)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C312(0.80); C129(0.88); C149(0.92); C70(1.64)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C374(0.17); C312(0.52); C129(0.73); C380(1.24)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C374(0.62); C312(0.77); C129(0.81); C380(0.90)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C149(0.98); C312(1.06); C380(1.03)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C380(0.96); C149(1.02); C312(1.04)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C312(0.87); C380(0.97); C149(1.02)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C70(0.96)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C70(20.00); C149(1.06); C41(0.90)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C149(0.87); C312(0.87); C380(0.99); C129(1.00)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C436(0.45); C312(0.81); C380(0.98); C70(1.01)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C129(0.67); C436(0.70); C149(0.77); C312(0.82)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C149(0.90); C380(0.92); C312(0.93)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C149(0.66); C380(0.79); C312(0.96)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C380(0.89); C312(1.04); C149(1.07)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C149(0.89); C380(0.97); C312(1.08)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C129(0.76); C149(0.88); C436(0.90); C70(0.95)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C436(0.43); C129(0.72); C149(1.01); C380(1.14)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C436(0.69); C129(0.73); C149(0.94); C312(1.17)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C436(0.69); C129(0.83); C149(1.12); C70(1.21)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C436(0.79); C129(0.81); C149(0.82); C380(1.08)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C436(0.46); C312(0.86); C380(0.87); C149(0.99)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C129(0.59); C436(0.64); C149(0.75); C380(1.12)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C129(0.65); C436(0.68); C149(0.73); C70(0.95)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C129(0.88); C70(0.89); C436(0.90); C312(0.91)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C374(0.78); C436(0.79); C312(0.87); C129(1.06)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C436(0.71); C374(0.72); C312(0.84); C129(0.96)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C436(0.70); C374(0.77); C312(0.91); C129(1.01)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C374(0.73); C436(0.79); C129(1.00); C312(1.20)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C312(0.49); C349(0.54); C362(0.54); C374(0.57)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C149(0.73); C349(0.77); C362(0.77); C374(0.86)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C149(0.69); C312(0.78); C374(0.81); C129(1.07)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C436(0.52); C312(0.86); C380(0.93); C149(1.10)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C149(0.71); C129(0.80); C374(0.88); C349(0.90)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C374(0.67); C349(0.70); C362(0.70); C70(0.72)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C129(0.57); C349(0.59); C362(0.59); C374(0.60)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C129(0.53); C374(0.72); C349(0.72); C362(0.72)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C129(0.68); C374(0.71); C349(0.76); C362(0.76)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C129(0.96); C312(1.02); C380(1.03); C70(1.29)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C129(0.84); C312(0.92); C380(1.01); C70(1.53)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C312(0.87); C380(1.01); C129(1.04); C70(1.71)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C312(0.87); C129(0.95); C380(1.04); C70(2.19)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C436(0.41); C380(0.86); C312(0.91); C374(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C436(0.80); C380(0.90); C312(1.01); C149(1.05)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C436(0.39); C149(0.70); C380(0.82); C312(0.89)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C349(0.57); C362(0.57); C312(0.99); C436(1.07)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C349(0.37); C362(0.37); C436(0.76); C129(0.85)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C349(0.38); C362(0.38); C436(0.51); C312(0.90)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C349(0.45); C362(0.45); C436(0.76); C129(0.82)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C374(0.89); C380(0.93); C70(0.94); C149(0.96)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C436(0.59); C349(0.64); C362(0.64); C312(0.79)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C349(0.39); C362(0.39); C436(0.60); C312(0.90)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C349(0.38); C362(0.38); C436(0.61); C312(0.88)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C349(0.81); C362(0.81); C436(0.88); C129(1.03)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C129(1.28); C312(1.02); C349(0.44); C362(0.44)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C129(1.17); C312(1.03); C349(0.45); C362(0.45)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C129(1.24); C312(1.00); C349(0.60); C362(0.60)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C129(1.38); C312(0.94); C349(0.60); C362(0.60)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C129(1.20); C312(1.13); C349(0.38); C362(0.38)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C129(1.45); C312(0.90); C349(0.41); C362(0.41)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C129(1.11); C149(0.97); C312(0.95); C374(1.54)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C129(1.30); C312(1.03); C349(0.67); C362(0.67)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C129(0.88); C149(0.87); C312(1.02); C349(0.90)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C129(0.96); C149(0.78); C312(0.99); C349(0.64)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C129(0.90); C149(0.54); C312(1.26); C349(1.35)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C129(1.23); C149(0.73); C312(0.89); C349(0.96)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C129(0.75); C149(0.80); C312(1.00); C349(0.99)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C129(1.42); C149(0.80); C312(1.08); C349(0.89)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C129(0.93); C149(0.73); C312(0.94); C349(1.00)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C129(0.89); C149(0.72); C312(0.99); C349(0.62)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C129(0.92); C149(0.63); C312(0.83); C374(0.83)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C129(0.89); C149(0.91); C312(1.14); C349(1.08)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C129(1.47); C149(0.98); C312(1.08); C349(0.85)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C129(1.08); C149(0.59); C312(0.86); C349(0.86)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C129(1.29); C149(0.73); C312(0.89); C349(0.89)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C129(0.91); C149(0.62); C312(0.98); C349(0.68)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C129(0.97); C149(0.61); C312(1.01); C349(0.72)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C129(1.00); C312(1.02); C374(0.58); C380(0.91)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C129(1.04); C312(0.89); C374(0.56); C380(0.95)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C129(1.18); C312(1.03); C374(0.63); C380(0.96)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C129(1.15); C312(0.93); C374(0.78); C380(1.04)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C129(1.22); C149(1.18); C312(1.04); C374(1.02)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C129(1.23); C312(1.07); C374(0.84); C380(0.93)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C129(1.10); C312(1.09); C374(0.66); C380(0.97)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C129(1.33); C312(1.03); C374(0.69); C380(0.97)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C129(1.26); C312(0.98); C374(1.14); C380(0.88)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C129(1.30); C312(1.09); C374(0.75); C380(0.90)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C129(1.11); C312(1.04); C374(0.78); C380(0.96)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C129(1.33); C312(1.06); C374(0.77); C380(0.88)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C129(1.20); C312(1.03); C374(0.82); C380(0.85)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C129(1.38); C312(1.19); C374(0.66); C380(0.91)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C129(1.23); C312(1.18); C374(0.79); C380(0.95)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C129(1.11); C149(0.98); C312(0.75); C374(0.82)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C129(1.24); C312(0.89); C374(0.62); C380(0.95)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C129(0.94); C149(0.87); C312(0.92); C374(0.92)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C129(0.90); C149(0.91); C312(0.90); C374(0.90)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C129(0.98); C149(0.81); C312(0.75); C374(0.76)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C129(0.96); C149(0.91); C312(0.78); C374(0.68)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C129(1.02); C149(0.90); C312(0.96); C374(0.93)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C129(0.80); C149(0.91); C312(0.74); C374(0.65)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C129(1.18); C149(1.05); C312(0.80); C374(0.86)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C129(1.34); C149(0.93); C312(0.64); C374(0.58)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C129(1.05); C149(0.91); C312(0.59); C374(0.71)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C129(1.15); C149(0.98); C312(0.89); C374(0.82)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C129(0.98); C149(0.87); C312(0.76); C374(0.67)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C129(1.09); C149(0.96); C312(0.76); C374(0.78)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C129(1.23); C149(0.94); C312(0.81); C374(0.79)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C129(1.56); C149(0.80); C312(0.78); C374(0.73)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C129(1.48); C149(0.97); C312(0.78); C374(0.80)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C129(0.89); C312(0.84); C436(0.33); C70(0.80)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C129(1.54); C312(1.08); C436(0.45); C70(0.65)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C129(0.96); C312(0.99); C436(0.42); C70(1.84)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C129(0.94); C312(0.91); C436(0.38); C70(1.47)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C129(0.87); C149(1.11); C312(0.89); C374(0.99)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C129(0.91); C312(0.88); C436(0.24); C70(0.68)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C129(0.99); C312(1.08); C436(0.48); C70(1.01)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C129(0.82); C312(0.92); C436(0.27); C70(0.98)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C129(0.77); C312(0.93); C436(0.31); C70(0.92)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C129(0.85); C312(0.72); C436(0.24); C70(1.02)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C129(0.89); C312(0.92); C436(0.48); C70(0.74)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C129(0.89); C312(1.03); C436(0.65); C70(0.70)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C129(0.76); C312(1.06); C436(0.57); C70(1.23)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C129(0.79); C312(1.07); C436(0.38); C70(0.85)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C129(0.70); C312(0.84); C436(0.26); C70(2.03)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C129(1.18); C149(0.84); C312(1.02); C374(0.73)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C129(0.70); C312(1.26); C436(0.70); C70(0.37)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C129(0.96); C149(1.04); C312(0.77); C374(0.71)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C129(0.96); C149(1.02); C312(0.88); C374(1.14)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C129(0.90); C149(1.03); C312(0.98); C374(1.20)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C129(0.95); C149(0.95); C312(0.79); C374(1.65)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C129(0.81); C149(0.83); C312(0.81); C374(0.92)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C129(0.78); C149(1.10); C312(0.78); C374(0.80)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C129(0.78); C149(1.00); C312(0.75); C374(0.78)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C129(0.66); C149(0.80); C312(0.76); C374(0.58)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C129(0.69); C149(1.11); C312(0.73); C374(0.66)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C70(0.86); C129(1.00); C380(0.89); C436(1.01)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C380(2.22); C161(1.48); C70(1.30)  LDD1702  [3]
 LDCM0625  F8 Ramos C70(1.82); C312(0.66); C129(0.74); C41(1.46)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C70(0.67); C312(0.51); C380(0.57); C129(0.07)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C70(2.76); C312(0.10); C129(0.18)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C70(0.45); C312(0.57); C380(0.56); C129(0.09)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C70(0.99); C312(1.13); C380(1.00); C129(0.51)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C70(0.78); C312(1.02); C129(0.40); C41(1.03)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C70(0.59); C312(0.46); C380(0.47); C129(0.11)  LDD2194  [18]
 LDCM0580  Fragment21 MDA-MB-231 C81(1.29)  LDD1473  [19]
 LDCM0582  Fragment23 Ramos C70(0.70); C312(0.37); C380(0.93); C129(0.08)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C70(0.90); C312(0.92); C380(1.08); C129(0.52)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C70(0.65); C312(1.45); C380(0.24); C129(0.19)  LDD2198  [18]
 LDCM0587  Fragment29 Ramos C81(1.32)  LDD1476  [19]
 LDCM0588  Fragment30 Ramos C70(1.16); C312(0.85); C380(0.94); C129(0.20)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C70(0.83); C312(1.22); C380(1.05); C129(0.24)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C70(0.59); C312(0.52); C380(0.60); C129(0.08)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C129(1.08); C149(0.90); C312(0.79); C374(0.81)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C70(0.74); C312(0.73); C380(0.97); C129(0.56)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C70(0.58); C312(0.68); C129(0.65); C41(0.78)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C129(1.03); C149(0.64); C312(0.89); C349(0.75)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C70(1.13); C312(0.88); C380(1.27); C129(0.30)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C70(1.28); C312(0.85); C380(1.19); C129(1.41)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C70(0.58); C312(0.58); C129(0.30); C41(0.75)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C81(5.59)  LDD1464  [19]
 LDCM0116  HHS-0101 DM93 Y366(0.99)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y366(0.70)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y366(0.74)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y366(0.74)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y366(1.85)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C374(1.55); C70(1.30); C312(1.76); C149(2.11)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C374(1.94); C70(1.50); C312(2.40); C149(1.53)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C374(1.94); C70(1.65); C312(1.13); C149(0.79)  LDD0082  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C70(0.60)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C70(0.65); C161(0.90)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C70(0.45)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C70(0.78)  LDD2111  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C70(0.49)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C70(0.67)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C70(0.76)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C70(0.83)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C70(0.78); C380(0.79)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C70(0.86)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C70(1.25)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C380(0.49)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C70(0.70)  LDD2146  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C41(0.76)  LDD2207  [20]
 LDCM0131  RA190 MM1.R C70(1.65)  LDD0304  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein phosphatase 1A (PPM1A) PP2C family P35813
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) Ser/Thr protein kinase family O15111
Myotubularin-related protein 4 (MTMR4) Protein-tyrosine phosphatase family Q9NYA4
Transforming protein RhoA (RHOA) Rho family P61586
E3 ubiquitin-protein ligase TRIM33 (TRIM33) TRIM/RBCC family Q9UPN9
E3 ubiquitin-protein ligase SMURF2 (SMURF2) . Q9HAU4
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Secretogranin-1 (CHGB) Chromogranin/secretogranin protein family P05060
Cellular tumor antigen p53 (TP53) P53 family P04637
Ankyrin-3 (ANK3) . Q12955
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Tumor protein 63 (TP63) P53 family Q9H3D4
Forkhead box protein H1 (FOXH1) . O75593
Oligodendrocyte transcription factor 1 (OLIG1) . Q8TAK6
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dedicator of cytokinesis protein 9 (DOCK9) DOCK family Q9BZ29
Neurofilament medium polypeptide (NEFM) Intermediate filament family P07197
Ski oncogene (SKI) SKI family P12755
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Disabled homolog 2 (DAB2) . P98082
Ran-binding protein 3 (RANBP3) . Q9H6Z4
Zinc finger FYVE domain-containing protein 9 (ZFYVE9) . O95405
Zinc finger RNA-binding protein (ZFR) . Q96KR1

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dexfosfoserine Small molecular drug DB04522

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.