Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment7  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 43 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 20.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 10.4
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 5.1
 LDTP04689  Adenosine kinase (ADK) C353 4.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 4.5
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 2.7
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.1
 LDTP02502  Thioredoxin (TXN) C32 2.0
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.0
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 2.0
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.6
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.6
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.5
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.3
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.2
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.1
 LDTP02672  Elongation factor 2 (EEF2) C136 1.1
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.1
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.1
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP04374  Dynamin-2 (DNM2) C27 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.9
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 0.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 0.7
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.6
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.3
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) C268 4.3
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 2.3
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 2.0
 LDTP00501  Exportin-1 (XPO1) C34 1.8
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP01574  Importin-7 (IPO7) C757 0.8
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.8
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.3
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.2
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 1.1
Other
Click to Show/Hide to Show 36 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 20.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 20.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.6
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 2.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 2.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.0
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 2.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.7
 LDTP02205  Tubulin beta chain (TUBB) C354 1.7
 LDTP04487  Cyclin-H (CCNH) C244 1.7
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.6
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.6
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.6
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.6
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.5
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP13580  Coronin-1C (CORO1C) C420 1.4
 LDTP02205  Tubulin beta chain (TUBB) C239 1.4
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.3
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.3
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 1.2
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.1
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.0
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.0
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 0.8
 LDTP03244  Cofilin-1 (CFL1) C80 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.