Details of the Target

General Information of Target

Target ID LDTP15391
Target Name Probable phosphoglycerate mutase 4 (PGAM4)
Gene Name PGAM4
Gene ID 441531
Synonyms
PGAM3; Probable phosphoglycerate mutase 4; EC 5.4.2.11; EC 5.4.2.4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALPQMCDGSHLASTLRYCMTVSGTVVLVAGTLCFAWWSEGDATAQPGQLAPPTEYPVPE
GPSPLLRSVSFVCCGAGGLLLLIGLLWSVKASIPGPPRWDPYHLSRDLYYLTVESSEKES
CRTPKVVDIPTYEEAVSFPVAEGPPTPPAYPTEEALEPSGSRDALLSTQPAWPPPSYESI
SLALDAVSAETTPSATRSCSGLVQTARGGS
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Uniprot ID
Q8N0Y7
Ensemble ID
ENST00000458128.3
HGNC ID
HGNC:21731

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
THZ1-DTB
 Probe Info  		C55(1.00)  LDD0460  [1]
HHS-475
 Probe Info  		Y133(0.74); Y119(0.84); Y92(0.97)  LDD0264  [2]
HHS-465
 Probe Info  		Y119(4.96); Y133(7.45); Y92(10.00)  LDD2237  [3]
Acrolein
 Probe Info  		N.A.  LDD0217  [4]
AOyne
 Probe Info  		6.60  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y133(0.74); Y119(0.84); Y92(0.97)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y133(0.70); Y119(0.81); Y92(0.90)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y133(0.81); Y92(0.89); Y119(0.99)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y133(0.80); Y92(1.06); Y119(5.68)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y133(0.88); Y119(1.14); Y92(1.18)  LDD0268  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0021  THZ1 HeLa S3 C55(1.00)  LDD0460  [1]

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.