Details of the Target

General Information of Target

Target ID LDTP03216
Target Name Peptidyl-prolyl cis-trans isomerase B (PPIB)
Gene Name PPIB
Gene ID 5479
Synonyms
CYPB; Peptidyl-prolyl cis-trans isomerase B; PPIase B; EC 5.2.1.8; CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRLSERNMKVLLAAALIAGSVFFLLLPGPSAADEKKKGPKVTVKVYFDLRIGDEDVGRV
IFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYG
ERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVR
KVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Target Type
Successful
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family, PPIase B subfamily
Subcellular location
Virion; Endoplasmic reticulum lumen
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
TTD ID
T25847
Uniprot ID
P23284
DrugMap ID
TT6ZFQ4
Ensemble ID
ENST00000300026.4
HGNC ID
HGNC:9255
ChEMBL ID
CHEMBL2075

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.16  LDD0402  [1]
P2
 Probe Info  		10.00  LDD0449  [2]
P3
 Probe Info  		10.00  LDD0450  [2]
P8
 Probe Info  		1.64  LDD0451  [2]
A-EBA
 Probe Info  		3.40  LDD0215  [3]
CY-1
 Probe Info  		4.03  LDD0243  [4]
CY4
 Probe Info  		12.12  LDD0244  [4]
C-Sul
 Probe Info  		3.35  LDD0066  [5]
TH214
 Probe Info  		Y133(20.00)  LDD0258  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
YN-4
 Probe Info  		100.00  LDD0445  [7]
BTD
 Probe Info  		C202(6.19)  LDD1699  [8]
ONAyne
 Probe Info  		K98(0.00); K215(0.00); K116(0.00)  LDD0273  [9]
OPA-S-S-alkyne
 Probe Info  		K98(1.78); K186(3.18); K181(3.57); K116(6.61)  LDD3494  [10]
Probe 1
 Probe Info  		Y47(12.66); Y119(57.78)  LDD3495  [11]
HHS-475
 Probe Info  		Y88(0.69)  LDD0264  [12]
DBIA
 Probe Info  		C202(1.42)  LDD0080  [13]
AMP probe
 Probe Info  		N.A.  LDD0200  [14]
ATP probe
 Probe Info  		K129(0.00); K215(0.00); K209(0.00); K192(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		K84(0.00); K67(0.00); K215(0.00); K89(0.00)  LDD0035  [17]
WYneN
 Probe Info  		N.A.  LDD0021  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		N.A.  LDD0147  [20]
NHS
 Probe Info  		K209(0.00); K98(0.00); K84(0.00); K129(0.00)  LDD0010  [18]
OSF
 Probe Info  		N.A.  LDD0029  [21]
SF
 Probe Info  		K186(0.00); K67(0.00); K116(0.00); K84(0.00)  LDD0028  [21]
STPyne
 Probe Info  		K84(0.00); K116(0.00); K165(0.00)  LDD0009  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
1c-yne
 Probe Info  		K131(0.00); K116(0.00); K98(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C202(0.00); H132(0.00)  LDD0217  [23]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [23]
Crotonaldehyde
 Probe Info  		H132(0.00); C202(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C202(0.00); H132(0.00)  LDD0218  [23]
W1
 Probe Info  		Y133(0.00); H132(0.00)  LDD0236  [24]
MPP-AC
 Probe Info  		N.A.  LDD0428  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [26]
TER-AC
 Probe Info  		N.A.  LDD0426  [25]
TPP-AC
 Probe Info  		N.A.  LDD0427  [25]
HHS-465
 Probe Info  		K89(0.00); Y88(0.00); K186(0.00)  LDD2240  [27]
HHS-482
 Probe Info  		Y133(0.54)  LDD2239  [28]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [29]
DA-2
 Probe Info  		N.A.  LDD0071  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C202(0.38)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C202(0.61)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C202(0.54)  LDD2095  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C202(0.97)  LDD2117  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C202(0.89)  LDD2103  [8]
 LDCM0214  AC1 HCT 116 C202(0.96)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C202(1.02)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C202(1.37)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C202(0.91)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C202(0.84)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C202(0.55)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C202(0.69)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C202(0.75)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C202(0.69)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C202(0.51)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C202(0.78)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C202(0.81)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C202(0.96)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C202(0.72)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C202(0.74)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C202(0.62)  LDD0546  [13]
 LDCM0237  AC12 HCT 116 C202(0.82)  LDD0554  [13]
 LDCM0246  AC128 HCT 116 C202(0.58)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C202(1.06)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C202(1.14)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C202(1.41)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C202(1.10)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C202(1.17)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C202(0.81)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C202(0.85)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C202(1.38)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C202(0.95)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C202(1.02)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C202(1.09)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C202(1.31)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C202(1.13)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C202(0.85)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C202(0.93)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C202(1.10)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C202(1.19)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C202(1.12)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C202(1.32)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C202(1.21)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C202(0.18)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C202(0.95)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C202(0.96)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C202(1.49)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C202(1.80)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C202(0.77)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C202(0.15)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C202(1.09)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C202(1.94)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C202(1.10)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C202(1.04)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C202(0.73)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C202(0.63)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C202(0.84)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C202(0.67)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C202(0.78)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C202(0.73)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C202(0.76)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C202(0.54)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C202(0.63)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C202(0.85)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C202(0.80)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C202(0.89)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C202(0.90)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C202(0.86)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C202(0.64)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C202(0.82)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C202(0.90)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C202(0.72)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C202(0.75)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C202(0.69)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C202(1.24)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C202(1.33)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C202(1.27)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C202(1.09)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C202(1.15)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C202(1.60)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C202(0.66)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C202(1.14)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C202(0.92)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C202(1.24)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C202(0.83)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C202(0.65)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C202(1.00)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C202(0.97)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C202(1.67)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C202(0.15)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C202(1.87)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C202(0.26)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C202(2.07)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C202(1.10)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C202(0.54)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C202(0.57)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C202(0.17)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C202(0.07)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C202(0.91)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C202(0.96)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C202(0.69)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C202(0.81)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C202(0.90)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C202(1.05)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C202(0.72)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C202(1.07)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C202(0.68)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C202(0.79)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C202(1.05)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C202(0.16)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C202(1.22)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C202(0.98)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C202(0.92)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C202(1.06)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C202(1.05)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C202(1.27)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C202(0.82)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C202(0.49)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C202(0.91)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C202(0.90)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C202(0.94)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C202(1.18)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C202(1.34)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C202(0.87)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C202(0.88)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C202(1.04)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C202(0.57)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C202(0.48)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C202(0.64)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C202(0.86)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C202(0.79)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C202(0.87)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C202(0.91)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C202(0.80)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C202(5.45)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C202(0.44)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C202(0.61)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C202(0.89)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C202(1.39)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C202(1.02)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C202(0.87)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C202(0.82)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C202(0.39)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C202(0.81)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C202(0.56)  LDD2138  [8]
 LDCM0248  AKOS034007472 HCT 116 C202(1.13)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C202(0.83)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C202(0.83)  LDD0592  [13]
 LDCM0498  BS-3668 MDA-MB-231 C202(0.85)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C202(0.00); H132(0.00)  LDD0222  [23]
 LDCM0367  CL1 HCT 116 C202(0.83)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C202(0.66)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C202(1.13)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C202(0.86)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C202(0.98)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C202(0.75)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C202(0.91)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C202(0.62)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C202(0.54)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C202(0.53)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C202(0.26)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C202(0.58)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C202(0.38)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C202(0.64)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C202(0.77)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C202(0.71)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C202(0.84)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C202(0.93)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C202(0.89)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C202(0.95)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C202(0.34)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C202(1.18)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C202(1.08)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C202(0.25)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C202(1.22)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C202(0.68)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C202(1.15)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C202(0.48)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C202(0.27)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C202(0.86)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C202(0.81)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C202(0.84)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C202(0.82)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C202(0.82)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C202(1.00)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C202(0.35)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C202(0.74)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C202(0.85)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C202(1.02)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C202(0.83)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C202(1.05)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C202(0.67)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C202(0.48)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C202(0.26)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C202(0.95)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C202(0.49)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C202(0.58)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C202(0.82)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C202(1.02)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C202(0.70)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C202(0.71)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C202(0.85)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C202(0.86)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C202(0.87)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C202(0.87)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C202(0.74)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C202(0.40)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C202(0.36)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C202(0.68)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C202(0.38)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C202(0.53)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C202(0.81)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C202(0.59)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C202(0.63)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C202(0.26)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C202(0.31)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C202(0.71)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C202(0.62)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C202(0.98)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C202(0.83)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C202(1.68)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C202(1.07)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C202(0.87)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C202(1.21)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C202(1.67)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C202(2.04)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C202(0.65)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C202(0.87)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C202(1.45)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C202(1.01)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C202(1.37)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C202(1.14)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C202(1.39)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C202(1.19)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C202(1.19)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C202(0.89)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C202(0.85)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C202(0.80)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C202(0.66)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C202(0.93)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C202(0.40)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C202(0.78)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C202(1.12)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C202(0.82)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C202(0.66)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C202(0.71)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C202(0.66)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C202(0.86)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C202(0.68)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C202(0.77)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C202(1.01)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C202(0.64)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C202(0.77)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C202(0.47)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C202(0.30)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C202(1.40)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C202(0.74)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C202(0.17)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C202(0.30)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C202(0.06)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C202(0.93)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C202(1.25)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C202(20.00)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C202(0.35)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C202(0.05)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C202(0.70)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C202(1.00)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C202(0.64)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C202(0.94)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C202(0.87)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C202(0.62)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C202(0.98)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C202(1.11)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C202(1.04)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C202(1.77)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C202(1.14)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C202(0.85)  LDD1698  [31]
 LDCM0625  F8 Ramos C202(0.64)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C202(0.56)  LDD2189  [32]
 LDCM0574  Fragment12 Ramos C202(0.51)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C202(0.67)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C202(0.62)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C202(0.62)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C202(0.64)  LDD2195  [32]
 LDCM0578  Fragment27 Ramos C202(0.96)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C202(1.05)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C202(0.70)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C202(1.19)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C202(0.59)  LDD2201  [32]
 LDCM0468  Fragment33 HCT 116 C202(0.67)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C202(1.39)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C202(0.37)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C202(0.15)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C202(0.97)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C202(0.58)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C202(0.81)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C202(0.41)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y88(0.69)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y88(0.62); Y133(0.71)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y88(0.71)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y133(0.57); Y88(0.78)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y133(0.34); Y88(0.48)  LDD0268  [12]
 LDCM0107  IAA HeLa H132(0.00); C202(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C202(1.42)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C202(1.35)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C202(1.56)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C202(0.91)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C202(0.94)  LDD2121  [8]
 LDCM0109  NEM HeLa C202(0.00); H132(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C202(0.86)  LDD2089  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C202(0.78)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C202(4.39)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C202(0.30)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C202(0.93)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C202(0.98)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C202(1.41)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C202(0.44)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C202(0.46)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C202(1.48)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C202(0.41)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C202(1.29)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C202(0.61)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C202(0.73)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C202(0.62)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C202(1.23)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C202(0.52)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C202(0.47)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C202(0.76)  LDD2116  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C202(0.82)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C202(0.90)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C202(0.41)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C202(1.04)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C202(0.48)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C202(1.20)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C202(0.34)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C202(1.06)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C202(0.38)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C202(0.40)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C202(1.18)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C202(1.44)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C202(1.02)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C202(1.73)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C202(1.07)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C202(0.56)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C202(0.41)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C202(2.37)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C202(0.12)  LDD2145  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C202(0.55)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C202(0.91)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C202(0.44)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C202(1.51)  LDD2153  [8]
 LDCM0131  RA190 MM1.R C202(1.01)  LDD0304  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein disulfide-isomerase A4 (PDIA4) Protein disulfide isomerase family P13667
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Stromal interaction molecule 1 (STIM1) . Q13586
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C4 (HOXC4) Antp homeobox family P09017
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
DNA-binding protein inhibitor ID-2 (ID2) . Q02363
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Dymeclin (DYM) Dymeclin family Q7RTS9
Centromere protein V (CENPV) Gfa family Q7Z7K6
Heat shock 70 kDa protein 6 (HSPA6) Heat shock protein 70 family P17066
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-proline Small molecular drug D0DZ3X
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1,4-dithiothreitol Small molecular drug D01GMJ
14-dithiothreitol Small molecular drug DB04447
Proline Small molecular drug DB00172

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
11 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
28 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.