Details of the Target

General Information of Target

Target ID LDTP06628
Target Name Histone H2B type 2-E (H2BC21)
Gene Name H2BC21
Gene ID 8349
Synonyms
H2BFQ; HIST2H2BE; Histone H2B type 2-E; H2B-clustered histone 21; Histone H2B-GL105; Histone H2B.q; H2B/q
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2B family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Uniprot ID
Q16778
Ensemble ID
ENST00000369155.4
HGNC ID
HGNC:4760

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y41(11.42)  LDD0257  [1]
TH216
 Probe Info  		Y41(7.87)  LDD0259  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
HHS-475
 Probe Info  		Y84(1.13)  LDD0264  [3]
HHS-465
 Probe Info  		Y84(2.95)  LDD2237  [4]
2PCA
 Probe Info  		K58(0.00); R100(0.00); K109(0.00)  LDD0034  [5]
NHS
 Probe Info  		K47(0.00); K58(0.00); K35(0.00); K109(0.00)  LDD0010  [6]
SF
 Probe Info  		Y84(0.00); Y41(0.00); K35(0.00); K86(0.00)  LDD0028  [7]
STPyne
 Probe Info  		N.A.  LDD0009  [6]
W1
 Probe Info  		N85(0.00); N64(0.00); Q48(0.00); S57(0.00)  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BD-F
 Probe Info  		V67(0.00); E72(0.00)  LDD0024  [9]
DA-2
 Probe Info  		N.A.  LDD0071  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y84(1.13)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y84(1.00)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y84(1.27)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y84(1.26)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y84(1.74)  LDD0268  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
10 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.