Details of the Target

General Information of Target

Target ID LDTP03409
Target Name Inositol-trisphosphate 3-kinase B (ITPKB)
Gene Name ITPKB
Gene ID 3707
Synonyms
Inositol-trisphosphate 3-kinase B; EC 2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase B; IP3K B; InsP 3-kinase B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPP
AESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLS
PPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPF
RSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGR
AAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASL
TMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPER
GGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALAS
VGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLP
CWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSD
ALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSS
SSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPF
VMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVV
KDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEA
PTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAF
REFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGK
TTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA
Target Bioclass
Enzyme
Family
Inositol phosphokinase (IPK) family
Subcellular location
Cytoplasm, cytoskeleton
Function Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
Uniprot ID
P27987
Ensemble ID
ENST00000272117.8
HGNC ID
HGNC:6179
ChEMBL ID
CHEMBL5165

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P187LfsTer44 .
COLO792 SNV: p.P545R .
EOL1 SNV: p.P179S DBIA    Probe Info 
G402 SNV: p.I896S .
HCT116 Insertion: p.K374EfsTer15 .
HCT15 SNV: p.W799Ter .
HEC1B SNV: p.D573Y .
HT1376 SNV: p.R698H .
LNCaP clone FGC SNV: p.P503H .
MEWO SNV: p.L453F; p.T782I DBIA    Probe Info 
NCIH196 SNV: p.D923N .
NCIH1993 SNV: p.Q941H .
NCIH2172 SNV: p.G206W DBIA    Probe Info 
OVK18 SNV: p.R498M .
PF382 SNV: p.I470T DBIA    Probe Info 
TOV21G SNV: p.R165H; p.Q577K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C493(7.81)  LDD0170  [1]
DBIA
 Probe Info  		C693(10.60)  LDD0204  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
NAIA_4
 Probe Info  		N.A.  LDD2226  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
IPM
 Probe Info  		N.A.  LDD0147  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0073  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C493(7.81)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C493(3.10)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C693(1.03)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C693(0.99)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C693(0.98)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C693(1.03)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C693(1.00)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C693(1.00)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C693(1.14)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C693(0.98)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C693(1.19)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C693(0.91)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C693(0.96)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C693(0.93)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C693(0.93)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C693(0.88)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C693(0.96)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C693(1.12)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C693(0.90)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C693(0.99)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C693(0.94)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C693(0.90)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C693(1.02)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C693(0.95)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C693(1.02)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C693(1.00)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C693(1.22)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C693(1.06)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C693(0.98)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C693(0.97)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C693(0.94)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C693(0.90)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C693(1.02)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C693(0.97)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C693(1.00)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C693(1.05)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C693(1.08)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C693(1.06)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C693(0.98)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C693(0.94)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C693(1.20)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C693(1.02)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C693(0.98)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C693(0.94)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C693(0.90)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C693(0.93)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C693(1.05)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C693(1.07)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C693(0.92)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C693(1.04)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C693(1.03)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C693(0.93)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C693(1.07)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C693(1.02)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C693(1.00)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C693(1.03)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C693(1.01)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C693(1.22)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C693(0.98)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C693(0.96)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C693(0.96)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C693(0.97)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C693(1.01)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C693(0.95)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C693(1.09)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C693(0.97)  LDD1514  [9]
 LDCM0102  BDHI 8 Jurkat C693(10.60)  LDD0204  [2]
 LDCM0367  CL1 HEK-293T C693(0.84)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C693(1.08)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C481(1.11)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C693(1.00)  LDD1574  [9]
 LDCM0372  CL103 HEK-293T C693(0.91)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C481(1.03)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C693(0.85)  LDD1578  [9]
 LDCM0376  CL107 HEK-293T C693(0.95)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C481(0.99)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C693(0.85)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C693(1.06)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C693(1.10)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C481(0.93)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C693(0.84)  LDD1587  [9]
 LDCM0385  CL115 HEK-293T C693(1.10)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C481(0.96)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C693(1.04)  LDD1591  [9]
 LDCM0389  CL119 HEK-293T C693(1.03)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C693(1.14)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C481(1.09)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C693(0.97)  LDD1596  [9]
 LDCM0394  CL123 HEK-293T C693(0.93)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C481(1.17)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C693(0.90)  LDD1600  [9]
 LDCM0398  CL127 HEK-293T C693(0.96)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C481(0.91)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C693(0.87)  LDD1604  [9]
 LDCM0402  CL15 HEK-293T C693(0.88)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C481(1.16)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C693(1.33)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C693(0.99)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C693(0.86)  LDD1610  [9]
 LDCM0408  CL20 HEK-293T C693(1.12)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C693(1.16)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C693(1.25)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C693(1.05)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C693(1.06)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C693(0.76)  LDD1617  [9]
 LDCM0415  CL27 HEK-293T C693(1.01)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C481(0.98)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C693(1.04)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C693(0.90)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C693(0.98)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C693(1.11)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C693(1.03)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C693(1.00)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C693(1.03)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C693(1.18)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C693(1.29)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C693(0.85)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C693(0.99)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C481(0.81)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C481(1.11)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C693(1.01)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C693(1.01)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C693(0.97)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C693(1.13)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C693(1.09)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C693(1.18)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C693(1.15)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C693(1.24)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C693(0.88)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C693(0.95)  LDD1644  [9]
 LDCM0443  CL52 HEK-293T C481(1.14)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C693(1.04)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C693(0.94)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C693(1.18)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C693(1.23)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C693(1.08)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C693(1.12)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C693(1.32)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C693(0.91)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C693(1.13)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C693(0.79)  LDD1656  [9]
 LDCM0455  CL63 HEK-293T C693(1.04)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C481(0.82)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C693(1.10)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C693(1.04)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C693(1.11)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C693(1.05)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C693(1.12)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C693(0.99)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C693(1.21)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C693(1.20)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C693(1.20)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C693(0.83)  LDD1669  [9]
 LDCM0469  CL76 HEK-293T C481(0.95)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C693(1.46)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C693(1.02)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C693(1.09)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C693(0.86)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C693(1.10)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C693(0.95)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C693(1.26)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C693(1.02)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C693(1.12)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C693(0.84)  LDD1682  [9]
 LDCM0481  CL87 HEK-293T C693(0.92)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C481(1.06)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C693(1.05)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C693(1.01)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C693(0.95)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C693(1.04)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C693(1.07)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C693(0.95)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C693(1.10)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C693(1.15)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C693(1.11)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C693(0.84)  LDD1695  [9]
 LDCM0494  CL99 HEK-293T C693(1.09)  LDD1697  [9]
 LDCM0634  CY-0357 Hep-G2 C267(0.83)  LDD2228  [4]
 LDCM0495  E2913 HEK-293T C693(1.11)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C693(0.95)  LDD1671  [9]
 LDCM0566  Fragment4 Ramos C693(0.46)  LDD2184  [10]
 LDCM0569  Fragment7 Ramos C693(0.92)  LDD2186  [10]
 LDCM0022  KB02 T cell C178(20.00)  LDD1703  [11]
 LDCM0023  KB03 Ramos C693(0.89)  LDD2183  [10]
 LDCM0024  KB05 IGR37 C693(2.51)  LDD3314  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intraflagellar transport protein 88 homolog (IFT88) . Q13099
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Protein SCAI (SCAI) SCAI family Q8N9R8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840