Details of the Target

General Information of Target

Target ID LDTP03097
Target Name Ribose-phosphate pyrophosphokinase 3 (PRPS1L1)
Gene Name PRPS1L1
Gene ID 221823
Synonyms
PRPS3; PRPSL; Ribose-phosphate pyrophosphokinase 3; EC 2.7.6.1; Phosphoribosyl pyrophosphate synthase 1-like 1; PRPS1-like 1; Phosphoribosyl pyrophosphate synthase III; PRS-III
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIDESVRGEDVYIVQSGC
GEINDSLMELLIMINACKIASASRVTAVIPCFPYARQDKKDKSRSPISAKLVANMLSIAG
ADHIITMDLHASQIQGFFDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTS
IADQLNVDFALIHKERKKANEVDCIVLVGDVNDRVAILVDDMADTCVTICLAADKLLSAG
ATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISMILAEAI
RRTHNGESVSYLFSHVPL
Target Bioclass
Enzyme
Family
Ribose-phosphate pyrophosphokinase family
Function Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Uniprot ID
P21108
Ensemble ID
ENST00000506618.5
HGNC ID
HGNC:9463

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y94(20.00)  LDD0257  [1]
STPyne
 Probe Info  		K194(4.35); K282(5.88)  LDD0277  [2]
BTD
 Probe Info  		C165(1.15)  LDD1699  [3]
IPM
 Probe Info  		C91(0.00); C165(0.00)  LDD0241  [4]
DBIA
 Probe Info  		C91(0.92)  LDD3310  [5]
IA-alkyne
 Probe Info  		C284(20.00)  LDD0371  [6]
HHS-465
 Probe Info  		Y94(1.79)  LDD2237  [7]
PF-06672131
 Probe Info  		C91(0.00); C165(0.00)  LDD0152  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		6.10  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0073  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C284(1.41)  LDD2117  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C165(0.88)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C165(0.57)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C284(20.00)  LDD0371  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C284(20.00)  LDD0372  [6]
 LDCM0545  Acetamide MDA-MB-231 C165(1.07)  LDD2138  [3]
 LDCM0498  BS-3668 MDA-MB-231 C165(1.03)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0625  F8 Ramos C165(0.70)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C165(0.58)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C165(0.38)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C165(0.78)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C165(1.10)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C165(0.84)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C165(0.60)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C165(0.99)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C165(0.67)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C165(1.07)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C165(0.82)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C165(1.00)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C165(1.03)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C165(0.56)  LDD2201  [12]
 LDCM0468  Fragment33 Ramos C165(0.92)  LDD2202  [12]
 LDCM0596  Fragment38 Ramos C165(0.93)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C165(0.63)  LDD2184  [12]
 LDCM0610  Fragment52 Ramos C165(1.47)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C165(1.15)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C165(0.59)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C165(0.61)  LDD2188  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 Ramos C165(0.42)  LDD2182  [12]
 LDCM0023  KB03 Ramos C165(0.68)  LDD2183  [12]
 LDCM0024  KB05 COLO792 C91(0.92)  LDD3310  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C165(1.20)  LDD2121  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C165(0.91)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C284(0.59)  LDD2109  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C165(1.29)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C165(1.00)  LDD2123  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C165(0.64)  LDD2133  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C284(1.22)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C284(1.13)  LDD2137  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C165(1.56)  LDD2144  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C165(0.64)  LDD2148  [3]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578