Details of the Target

General Information of Target

Target ID LDTP05273
Target Name Spectrin beta chain, non-erythrocytic 1 (SPTBN1)
Gene Name SPTBN1
Gene ID 6711
Synonyms
SPTB2; Spectrin beta chain, non-erythrocytic 1; Beta-II spectrin; Fodrin beta chain; Spectrin, non-erythroid beta chain 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTTVATDYDNIEIQQQYSDVNNRWDVDDWDNENSSARLFERSRIKALADEREAVQKKTF
TKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKAL
QFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALL
LWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNL
AEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIET
EKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKG
NLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKL
EQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQA
VVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYI
MDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEG
YKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKI
LSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERII
YIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQ
SLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRL
RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNN
QASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNY
HLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAE
KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSR
TQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFL
RQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT
LEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKN
RETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFM
AELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDAN
KAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ
SQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW
VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA
EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK
AKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLY
AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERF
REFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI
LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV
RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV
RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR
KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL
SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP
PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNGATEQRTS
SKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSR
SWHNVYCVINNQEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLN
DGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSES
SPGKREKDKEKDKEKRFSLFGKKK
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Spectrin family
Subcellular location
Cytoplasm, cytoskeleton; Cell membrane
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.
TTD ID
T27826
Uniprot ID
Q01082
DrugMap ID
TTS9BDA
Ensemble ID
ENST00000333896.5
HGNC ID
HGNC:11275

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P896T DBIA    Probe Info 
AN3CA SNV: p.D255Y DBIA    Probe Info 
HCC1954 SNV: p.R107Ter DBIA    Probe Info 
HCT116 SNV: p.L1948F DBIA    Probe Info 
HCT15 SNV: p.T1581A; p.D1880N DBIA    Probe Info 
HT Deletion: p.N1053TfsTer42
SNV: p.K401T		 DBIA    Probe Info 
J82 SNV: p.D1942G DBIA    Probe Info 
LNCaP clone FGC SNV: p.W1044Ter DBIA    Probe Info 
MCC26 SNV: p.S1057F DBIA    Probe Info 
MFE319 SNV: p.K737E DBIA    Probe Info 
MIAPACA2 SNV: p.I1033M; p.E1205K DBIA    Probe Info 
NCIH716 Deletion: p.D1909GfsTer37
SNV: p.E2077D		 .
PC3 SNV: p.M133T; p.R1432W .
RPMI8226 SNV: p.Q235K DBIA    Probe Info 
SHP77 SNV: p.Q914L DBIA    Probe Info 
SKMEL24 SNV: p.E1116K DBIA    Probe Info 
SNGM SNV: p.R523L DBIA    Probe Info 
SW620 SNV: p.I2306V DBIA    Probe Info 
TE1 SNV: p.Q1871R DBIA    Probe Info 
TOV21G SNV: p.G205S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0451  [1]
A-EBA
 Probe Info  		5.91  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y1874(20.00); Y2249(20.00); Y2268(20.00)  LDD0260  [4]
C-Sul
 Probe Info  		7.17  LDD0066  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K1156(1.14); K1459(0.66); K1815(7.47); K1824(1.34)  LDD0274  [7]
STPyne
 Probe Info  		K1011(10.00); K102(4.20); K105(7.88); K1063(9.38)  LDD0277  [7]
AZ-9
 Probe Info  		E1009(0.69)  LDD2208  [8]
OPA-S-S-alkyne
 Probe Info  		K668(0.19); K1459(0.59); K1684(1.83); K714(2.12)  LDD3494  [9]
Probe 1
 Probe Info  		Y556(24.10); Y796(5.73); Y1114(88.80); Y1303(9.15)  LDD3495  [10]
AF-1
 Probe Info  		1.66  LDD0421  [11]
BTD
 Probe Info  		C1900(4.21); C604(2.30); C112(2.27); C1970(1.65)  LDD1700  [12]
AHL-Pu-1
 Probe Info  		C1389(2.98)  LDD0168  [13]
HHS-475
 Probe Info  		Y1137(0.70); Y232(0.77); Y1805(0.79); Y1303(0.80)  LDD0264  [14]
DBIA
 Probe Info  		C1900(1.01); C183(0.95)  LDD0078  [15]
5E-2FA
 Probe Info  		H961(0.00); H2311(0.00); H1649(0.00); H774(0.00)  LDD2235  [16]
ATP probe
 Probe Info  		K1815(0.00); K1653(0.00); K1878(0.00); K1884(0.00)  LDD0199  [17]
m-APA
 Probe Info  		H961(0.00); H2311(0.00); H1724(0.00); H1649(0.00)  LDD2231  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1389(0.00); C183(0.00); C964(0.00); C2262(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [19]
IPIAA_H
 Probe Info  		C2227(0.00); C1389(0.00); C112(0.00); C619(0.00)  LDD0030  [20]
IPIAA_L
 Probe Info  		C112(0.00); C1389(0.00); C624(0.00); C1900(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		C1389(0.00); C183(0.00); C964(0.00); C2262(0.00)  LDD0037  [18]
IPM
 Probe Info  		C604(0.00); C1900(0.00)  LDD0025  [21]
NAIA_4
 Probe Info  		N.A.  LDD2226  [22]
TFBX
 Probe Info  		C604(0.00); C112(0.00); C1900(0.00)  LDD0027  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [23]
WYneO
 Probe Info  		C1389(0.00); C604(0.00)  LDD0022  [23]
aHNE
 Probe Info  		N.A.  LDD0001  [23]
Compound 10
 Probe Info  		C1389(0.00); C1900(0.00); C604(0.00)  LDD2216  [24]
Compound 11
 Probe Info  		N.A.  LDD2213  [24]
NHS
 Probe Info  		K1981(0.00); K1913(0.00); K1991(0.00); K842(0.00)  LDD0010  [23]
PF-06672131
 Probe Info  		C112(0.00); C1389(0.00)  LDD0152  [25]
SF
 Probe Info  		Y777(0.00); K2269(0.00); Y1983(0.00); Y232(0.00)  LDD0028  [26]
VSF
 Probe Info  		N.A.  LDD0007  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [27]
Ox-W18
 Probe Info  		N.A.  LDD2175  [28]
1c-yne
 Probe Info  		K1421(0.00); K62(0.00); K1633(0.00)  LDD0228  [29]
1d-yne
 Probe Info  		K1011(0.00); K1571(0.00)  LDD0357  [29]
Acrolein
 Probe Info  		H1851(0.00); H559(0.00); C1389(0.00); C1970(0.00)  LDD0217  [30]
Crotonaldehyde
 Probe Info  		C1900(0.00); H1537(0.00)  LDD0219  [30]
Methacrolein
 Probe Info  		C1389(0.00); C1970(0.00); C1900(0.00); C604(0.00)  LDD0218  [30]
W1
 Probe Info  		C604(0.00); C112(0.00); C1389(0.00); C1900(0.00)  LDD0236  [31]
NAIA_5
 Probe Info  		C604(0.00); C964(0.00); C1970(0.00); C1900(0.00)  LDD2223  [22]
TPP-AC
 Probe Info  		N.A.  LDD0427  [32]
HHS-465
 Probe Info  		K1209(0.00); K1809(0.00); Y1805(0.00); Y1983(0.00)  LDD2240  [33]
HHS-482
 Probe Info  		Y1805(0.92); Y1874(1.45); Y232(0.87); Y777(0.78)  LDD2239  [34]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		17.15  LDD1845  [35]
FFF probe13
 Probe Info  		13.25  LDD0475  [36]
FFF probe2
 Probe Info  		6.50  LDD0463  [36]
FFF probe3
 Probe Info  		9.42  LDD0464  [36]
JN0003
 Probe Info  		12.02  LDD0469  [36]
STS-2
 Probe Info  		N.A.  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
DA-2
 Probe Info  		N.A.  LDD0071  [39]
STS-1
 Probe Info  		N.A.  LDD0069  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1900(0.46); C1970(0.35); C112(0.56); C604(0.45)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1970(0.61); C112(0.69)  LDD2112  [12]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1900(0.96); C1970(0.23)  LDD2095  [12]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C604(0.64)  LDD2130  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1900(0.97); C112(1.08); C604(1.05)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1900(1.38); C112(1.61)  LDD2152  [12]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C604(0.95)  LDD2103  [12]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1970(0.34); C112(0.38)  LDD2132  [12]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1970(0.37); C112(0.55)  LDD2131  [12]
 LDCM0025  4SU-RNA HEK-293T C1389(2.98)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA DM93 C1389(2.55)  LDD0171  [13]
 LDCM0214  AC1 HCT 116 C1389(1.15); C1900(1.16); C604(1.00); C619(0.90)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C1389(1.03); C604(1.02); C619(0.90); C624(0.93)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C1389(0.88); C1900(0.80); C619(0.74); C624(0.80)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C1389(0.96); C1900(0.72); C619(0.74); C624(0.73)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C1389(0.87); C1900(0.85); C619(0.84); C624(0.87)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C1389(0.79); C1900(0.67); C619(0.86); C624(0.88)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C1389(0.88); C1900(0.98); C619(0.84); C624(0.89)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C1389(0.85); C1900(0.70); C619(0.86); C624(0.83)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C1389(0.91); C1900(0.80); C619(0.73); C624(0.74)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C1389(0.78); C1900(0.69); C619(0.94); C624(0.86)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C1389(0.79); C1900(0.95); C619(0.84); C624(0.80)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C1389(0.83); C1900(0.90); C619(0.81); C624(0.79)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C1389(1.10); C604(0.84); C619(0.87); C624(0.88)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C1389(0.91); C1900(0.71); C619(0.83); C624(0.79)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C1389(0.81); C1900(0.79); C619(1.17); C624(1.18)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C1389(0.85); C1900(0.85); C619(0.77); C624(0.71)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C1389(1.04); C1900(0.95); C604(1.02); C619(0.94)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C1389(1.09); C1900(0.93); C604(0.86); C619(1.08)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C1389(1.18); C1900(0.94); C604(0.98); C619(1.00)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C1389(1.11); C1900(1.05); C604(0.90); C619(1.12)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C1389(1.04); C1900(0.95); C604(1.26); C619(1.02)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C1389(1.05); C1900(0.91); C604(0.82); C619(0.94)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C1389(1.08); C1900(1.02); C604(0.93); C619(0.90)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C1389(0.95); C604(0.89); C619(0.87); C624(0.94)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C1389(0.92); C1900(0.93); C604(0.92); C619(1.13)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C1389(1.08); C1900(0.83); C604(1.29); C619(0.98)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C1389(1.11); C1900(0.81); C604(0.90); C619(1.14)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C1389(1.01); C1900(0.93); C604(0.99); C619(0.80)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C1389(1.01); C1900(0.94); C604(1.06); C619(1.10)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C1389(1.17); C1900(0.89); C604(0.92); C619(1.05)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C1389(1.21); C1900(0.93); C604(0.90); C619(1.15)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C1389(1.24); C1900(0.88); C604(0.92); C619(1.16)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C1389(1.30); C604(1.25); C619(1.65); C624(1.65)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C1389(1.24); C604(1.19); C619(1.49); C624(1.44)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C1389(1.23); C604(1.04); C619(1.00); C624(0.99)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C1389(1.06); C604(1.02); C619(1.27); C624(1.25)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C1389(1.17); C604(1.00); C619(1.32); C624(1.32)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C1389(1.27); C604(0.99); C619(1.26); C624(1.24)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C1389(1.26); C604(0.93); C619(1.18); C624(1.13)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C1389(1.34); C604(1.02); C619(1.22); C624(1.19)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C1389(1.13); C604(0.90); C619(1.23); C624(1.18)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C1389(1.22); C604(1.01); C619(1.18); C624(1.16)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C1389(1.29); C604(0.92); C619(1.07); C624(1.03)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C1389(1.32); C604(0.86); C619(1.24); C624(1.20)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C1389(1.06); C604(1.01); C619(1.02); C624(1.05)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C1389(1.30); C604(0.83); C619(1.19); C624(1.11)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C1389(1.29); C604(0.81); C619(1.08); C624(1.02)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C1389(1.21); C604(1.03); C619(1.11); C624(1.10)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C624(0.85); C619(0.89); C604(0.91); C861(1.01)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C624(0.77); C619(0.81); C861(0.93); C1900(1.01)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C624(0.78); C619(0.89); C1900(0.89); C861(0.96)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C1900(0.82); C619(0.94); C624(0.97); C861(0.99)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C619(0.87); C624(0.91); C604(0.98); C861(1.02)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C1900(0.94); C861(0.95); C624(1.18); C619(1.29)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C861(0.91); C624(0.92); C619(0.94); C1900(1.08)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C619(0.89); C861(0.89); C624(0.94); C604(0.98)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C861(0.93); C1389(0.98); C604(1.05); C1900(1.06)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C619(0.92); C861(0.93); C624(0.96); C1900(1.04)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C861(0.85); C619(0.87); C624(0.91); C1900(1.02)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C861(0.88); C1900(0.92); C624(1.04); C619(1.05)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C1389(1.17); C1900(1.01); C604(1.13); C619(0.99)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C1389(1.14); C1900(1.10); C604(1.37); C619(0.92)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C1389(1.16); C1900(1.03); C604(1.19); C619(0.81)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C1389(1.02); C1900(0.98); C604(1.21); C619(0.98)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C861(0.84); C624(0.92); C619(0.94); C1389(1.09)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C861(0.72); C604(0.76); C624(1.03); C1389(1.15)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C624(0.82); C861(0.83); C604(0.85); C619(0.93)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C624(0.96); C619(0.96); C604(0.98); C1389(1.17)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C624(0.81); C604(0.91); C861(0.92); C619(0.92)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C861(0.74); C624(0.94); C619(0.97); C1389(1.09)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C861(0.86); C624(0.93); C619(0.98); C604(1.05)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C861(0.82); C604(0.89); C624(0.90); C619(0.94)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C624(0.88); C861(0.90); C604(0.93); C619(0.94)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C604(0.81); C619(0.90); C624(0.92); C861(0.93)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C604(0.78); C624(0.79); C619(0.80); C861(0.97)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C604(0.82); C619(0.83); C624(0.88); C861(1.01)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C604(0.71); C619(0.86); C861(0.94); C624(0.95)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C604(0.69); C624(0.96); C861(0.96); C619(0.97)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C619(0.97); C624(0.97); C604(1.04); C861(1.09)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C604(0.70); C624(0.85); C619(0.85); C861(0.96)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C604(0.61); C619(0.83); C624(0.88); C861(0.91)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C604(0.74); C624(0.87); C619(0.90); C861(0.96)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C604(0.80); C861(0.84); C619(0.86); C624(0.93)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C604(0.84); C619(0.86); C861(0.89); C624(0.97)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C1389(0.97); C604(1.06); C1900(1.17); C619(1.30)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C1389(1.05); C604(1.08); C1900(1.13); C619(1.28)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C604(1.09); C1389(1.13); C619(1.14); C624(1.14)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C604(1.02); C619(1.03); C624(1.03); C1900(1.05)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C604(1.01); C619(1.01); C624(1.01); C1389(1.09)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C619(0.90); C624(0.92); C604(1.05); C861(1.17)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C604(1.04); C619(1.05); C624(1.05); C1900(1.06)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C1900(0.97); C604(0.97); C1389(1.14); C619(1.16)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C604(0.99); C1900(1.11); C1389(1.17); C619(1.34)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C604(1.00); C619(1.05); C624(1.05); C1900(1.19)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C619(1.06); C624(1.06); C604(1.18); C1389(1.28)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C619(0.96); C624(0.96); C604(1.19); C1900(1.23)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C604(0.75); C1900(0.85); C1389(0.86); C624(0.89)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C604(0.74); C1389(0.88); C1900(0.90); C619(0.92)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C604(0.70); C1900(0.70); C1389(0.86); C624(1.03)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C604(0.61); C1900(0.75); C1389(0.79); C861(0.96)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C619(0.93); C624(0.95); C604(1.16); C861(1.18)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C604(0.66); C1900(0.69); C1389(0.88); C861(1.01)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C604(0.63); C1900(0.67); C1389(0.80); C619(1.01)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C604(0.61); C1900(0.72); C1389(0.81); C624(0.93)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C604(0.63); C1389(0.63); C1900(0.84); C861(1.06)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C1900(0.64); C604(0.66); C1389(0.80); C861(1.06)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C604(0.70); C1389(0.76); C1900(0.89); C861(1.04)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C604(0.64); C1389(0.81); C1900(0.85); C861(0.98)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C604(0.93); C624(0.97); C619(1.00); C1900(1.34)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C624(0.87); C604(0.88); C619(0.96); C1900(1.12)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C604(0.85); C619(0.90); C624(0.93); C1900(1.46)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C619(0.85); C624(0.91); C861(0.97); C1389(1.02)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C619(0.92); C604(0.98); C624(0.98); C1389(1.30)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C604(0.89); C624(0.96); C619(0.98); C1389(1.44)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C604(0.89); C624(0.91); C619(0.92); C1900(1.33)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C624(0.83); C619(0.84); C604(0.92); C1389(1.28)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C604(0.91); C619(0.97); C624(0.98); C1389(1.44)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C619(0.90); C624(0.92); C604(0.94); C1900(1.32)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C604(0.88); C619(0.90); C624(0.91); C1389(1.37)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C604(0.82); C619(0.97); C624(1.01); C1389(1.63)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C861(0.96); C1389(1.17); C604(1.21); C619(1.21)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C861(0.92); C604(1.10); C619(1.20); C624(1.20)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C619(0.85); C624(0.87); C861(0.96); C1389(0.97)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C861(0.92); C1900(1.03); C619(1.12); C624(1.12)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C1900(0.79); C1389(1.19); C604(1.24); C619(1.37)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C1900(0.63); C861(0.86); C619(1.04); C624(1.04)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C1900(0.87); C1389(1.04); C604(1.06); C861(1.09)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C1900(0.79); C861(0.97); C604(1.18); C619(1.23)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C861(0.82); C1900(0.84); C604(1.09); C1389(1.18)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C861(0.95); C1900(1.04); C1389(1.14); C604(1.17)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C1900(0.84); C604(1.04); C1389(1.08); C619(1.14)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C604(1.02); C1389(1.15); C861(1.16); C619(1.16)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C1900(0.71); C604(0.99); C861(1.01); C619(1.22)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C861(0.79); C619(0.82); C624(0.82); C604(0.95)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C1900(0.93); C619(1.13); C624(1.13); C1389(1.14)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C1900(0.85); C861(1.00); C604(1.05); C1389(1.14)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C861(0.52); C1900(0.90); C604(1.17); C1389(1.31)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C861(0.80); C624(0.81); C619(0.85); C604(1.09)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C624(0.90); C619(0.91); C861(0.99); C604(1.14)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C624(0.76); C619(0.79); C861(0.93); C604(0.97)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C624(0.76); C619(0.76); C861(0.84); C604(0.92)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C624(0.77); C619(0.77); C861(0.87); C604(0.90)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C861(0.78); C604(0.86); C624(0.88); C619(0.88)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C624(0.76); C619(0.77); C861(0.85); C604(0.93)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C624(0.77); C619(0.78); C604(0.84); C861(0.85)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C619(0.86); C624(0.86); C861(0.91); C604(1.07)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C624(0.72); C619(0.73); C604(0.86); C861(0.89)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C861(0.75); C624(0.76); C619(0.78); C604(0.92)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C619(0.80); C624(0.85); C861(1.13); C1389(1.27)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C861(0.77); C624(0.86); C619(0.86); C604(0.95)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C619(0.86); C624(0.90); C861(1.17); C1389(1.28)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C624(0.74); C619(0.74); C604(0.77); C861(0.88)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C624(0.88); C1900(0.89); C619(0.90); C1389(0.91)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C619(0.81); C624(0.84); C1389(0.89); C1900(0.97)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C112(0.46); C604(0.38)  LDD2138  [12]
 LDCM0166  Afatinib A431 1.66  LDD0421  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C1900(0.81); C1970(0.68); C112(0.74); C1389(1.28)  LDD2113  [12]
 LDCM0248  AKOS034007472 HCT 116 C1389(1.02); C604(1.04); C619(0.97); C624(1.01)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C861(0.85); C619(0.89); C604(0.94); C624(0.94)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C861(0.92); C604(0.93); C619(0.96); C624(1.01)  LDD0592  [15]
 LDCM0020  ARS-1620 HCC44 C1900(1.01); C183(0.95)  LDD0078  [15]
 LDCM0498  BS-3668 MDA-MB-231 C1900(0.78); C112(0.61)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa C1970(0.00); H2213(0.00); H1846(0.00); C2262(0.00)  LDD0222  [30]
 LDCM0367  CL1 HCT 116 C1389(0.82); C604(0.88); C619(1.05); C624(1.05)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C604(0.99); C861(1.04); C1389(1.13); C619(1.17)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C624(0.80); C619(0.81); C604(1.06); C861(1.14)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C619(0.93); C861(0.93); C1389(0.96); C624(0.99)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C619(0.89); C604(0.92); C624(0.94); C861(0.99)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C619(0.90); C604(0.92); C861(0.96); C624(0.96)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C861(0.81); C619(0.87); C624(0.93); C604(0.99)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C624(0.81); C861(0.81); C619(0.98); C604(1.01)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C861(0.80); C624(0.87); C604(1.03); C619(1.09)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C861(0.85); C624(0.92); C604(1.01); C619(1.13)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C861(0.78); C624(1.07); C619(1.17); C604(1.19)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C861(0.79); C624(0.80); C604(0.90); C619(0.96)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C604(0.86); C1389(1.10); C619(1.11); C624(1.11)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C861(0.79); C624(0.88); C604(0.99); C619(1.09)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C861(0.72); C604(0.87); C624(0.90); C619(0.96)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C604(0.67); C624(0.90); C619(0.90); C861(0.91)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C604(0.67); C861(0.84); C619(0.84); C624(0.88)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C604(0.58); C619(0.84); C624(0.89); C861(0.95)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C604(0.86); C624(0.88); C861(0.90); C619(0.91)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C604(0.85); C619(0.89); C624(0.90); C861(1.02)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C1900(1.00); C604(1.00); C1389(1.31); C619(1.54)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C619(1.00); C624(1.00); C604(1.04); C1389(1.14)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C604(1.07); C1900(1.08); C619(1.11); C624(1.11)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C604(0.95); C619(1.14); C624(1.14); C861(1.19)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C604(0.97); C1900(0.99); C619(1.04); C624(1.04)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C604(0.75); C1900(0.78); C1389(0.85); C861(1.03)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C1900(0.73); C604(0.75); C1389(0.79); C619(0.95)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C604(0.59); C1389(0.75); C1900(0.78); C861(0.93)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C1900(0.68); C604(0.72); C1389(0.85); C861(1.00)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C604(0.92); C619(0.95); C624(1.04); C1389(1.15)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C604(0.96); C624(0.97); C619(1.03); C1389(1.08)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C604(0.90); C619(0.95); C624(0.95); C1900(1.08)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C619(0.94); C624(0.94); C604(0.98); C1389(1.58)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C604(0.92); C619(1.05); C624(1.05); C861(1.07)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C604(0.83); C1389(0.95); C619(1.06); C624(1.06)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C861(0.73); C604(0.84); C1389(1.06); C619(1.08)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C619(0.91); C624(0.91); C1389(0.97); C1900(1.24)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C604(0.76); C619(0.80); C624(0.80); C1389(1.04)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C604(0.96); C619(1.07); C624(1.07); C1389(1.12)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C619(0.87); C624(0.87); C604(0.92); C1389(1.05)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C604(0.92); C619(0.94); C624(0.94); C1389(0.95)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C619(0.77); C624(0.77); C604(0.84); C1389(1.13)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C604(0.87); C619(0.94); C624(0.94); C1389(1.18)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C604(1.03); C619(1.35); C624(1.35); C1389(1.40)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C619(0.75); C624(0.75); C1389(1.13); C604(1.17)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C1389(1.30); C604(0.97); C619(0.95); C624(0.95)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C1389(1.20); C604(0.87); C619(0.81); C624(0.81)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C1389(1.05); C604(0.93); C619(0.89); C624(0.89)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C1389(1.13); C604(0.95); C619(0.86); C624(0.86)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C1389(1.24); C604(0.97); C619(0.85); C624(0.85)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C1389(1.40); C604(0.93); C619(0.92); C624(0.92)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C1389(0.99); C604(1.02); C619(1.03); C624(1.03)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C1389(1.12); C604(0.87); C619(0.84); C624(0.84)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C1389(1.08); C1900(0.78); C604(0.87); C619(0.77)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C1900(1.01); C604(0.98); C619(0.93); C624(0.95)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C1900(0.81); C604(0.90); C619(0.82); C624(0.83)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C1900(1.01); C604(0.94); C619(0.85); C624(0.88)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C1900(0.94); C604(0.85); C619(0.75); C624(0.77)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C1900(0.83); C604(0.91); C619(0.79); C624(0.80)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C1900(0.90); C604(1.00); C619(0.87); C624(0.88)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C1900(0.78); C604(0.92); C619(0.82); C624(0.82)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C1389(0.94); C604(0.82); C619(1.04); C624(1.04)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C1900(0.94); C604(0.82); C619(0.77); C624(0.77)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C1900(0.75); C604(0.95); C619(0.77); C624(0.77)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C1900(0.74); C604(1.05); C619(1.10); C624(1.11)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C1900(0.81); C604(0.94); C619(0.87); C624(0.88)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C1900(1.03); C604(0.94); C619(0.89); C624(0.88)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C1900(0.93); C604(0.96); C619(0.84); C624(0.84)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C1389(0.90); C1900(0.88); C604(0.86); C619(0.91)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C1389(0.92); C1900(0.70); C604(0.92); C619(0.96)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C1389(0.97); C1900(0.95); C604(1.01); C619(0.90)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C1389(0.97); C1900(0.77); C604(1.02); C619(0.94)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C1389(0.95); C604(0.93); C619(1.12); C624(1.12)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C1389(0.90); C1900(0.97); C604(0.81); C619(0.90)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C1389(0.89); C1900(0.96); C604(0.86); C619(0.97)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C1389(0.73); C1900(0.87); C604(0.77); C619(0.92)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C1389(0.81); C1900(0.98); C604(1.05); C619(0.84)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C1389(0.92); C1900(0.90); C604(0.93); C619(0.98)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C1389(0.92); C1900(0.63); C604(0.91); C619(0.91)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C1389(0.97); C1900(0.79); C604(0.93); C619(0.91)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C1389(0.95); C1900(1.09); C604(0.96); C619(1.00)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C1389(0.92); C1900(1.14); C604(0.93); C619(0.99)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C1389(0.94); C1900(0.88); C604(0.90); C619(0.99)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C1389(1.05); C604(0.87); C619(0.94); C624(0.94)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C1389(0.94); C1900(0.90); C604(0.99); C619(0.93)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C1389(1.08); C1900(1.21); C604(1.01); C619(0.82)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C1389(1.02); C1900(1.19); C604(0.95); C619(0.78)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C1389(1.16); C1900(1.05); C604(0.97); C619(0.74)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C1389(1.22); C1900(1.20); C604(0.96); C619(0.79)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C1389(1.06); C1900(1.22); C604(1.03); C619(0.76)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C1389(1.42); C1900(1.13); C604(0.95); C619(0.83)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C1389(1.10); C1900(1.04); C604(0.99); C619(0.80)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C1389(1.17); C1900(1.29); C604(1.04); C619(0.94)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C1389(1.06); C1900(1.11); C604(0.98); C619(0.94)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C1389(1.12); C604(1.03); C619(1.08); C624(1.08)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C1389(1.27); C1900(0.99); C604(1.02); C619(0.85)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C1389(1.21); C1900(1.28); C604(0.90); C619(0.79)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C1389(1.06); C1900(1.31); C604(0.97); C619(0.89)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C1389(1.05); C1900(1.19); C604(0.82); C619(0.73)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C1389(1.17); C1900(1.20); C604(0.94); C619(0.71)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C1389(1.19); C1900(1.01); C604(1.07); C619(0.94)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C1389(1.03); C1900(0.75); C604(1.08); C619(0.89)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C1389(1.25); C1900(0.83); C604(0.94); C619(0.77)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C1389(1.43); C1900(0.99); C604(0.98); C619(0.78)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C1389(1.30); C604(0.78); C619(1.21); C624(1.21)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C1389(1.34); C1900(1.10); C604(1.03); C619(1.06)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C1389(1.29); C1900(0.96); C604(1.02); C619(0.84)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C1389(1.29); C1900(1.04); C604(1.00); C619(0.95)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C1389(1.39); C1900(0.97); C604(0.98); C619(0.87)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C1389(1.60); C1900(1.09); C604(0.88); C619(1.04)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C1389(1.12); C1900(0.90); C604(0.97); C619(0.78)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C1389(1.20); C1900(0.97); C604(1.00); C619(0.80)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C1389(1.17); C1900(0.94); C604(1.00); C619(0.84)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C1389(1.22); C1900(0.98); C604(0.97); C619(0.86)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C1389(1.51); C1900(0.87); C604(0.94); C619(1.04)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C1389(1.03); C604(0.92); C619(1.02); C624(1.02)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C1389(1.15); C1900(0.81); C604(0.84); C619(0.89)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C1389(1.16); C1900(1.03); C604(1.03); C619(0.95)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C1389(1.08); C1900(1.09); C604(1.02); C619(0.88)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C1389(1.02); C1900(1.26); C604(1.04); C619(0.91)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C1389(1.09); C1900(1.19); C604(0.98); C619(0.82)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C1389(1.18); C1900(1.15); C604(0.89); C619(0.89)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C1389(1.11); C1900(1.12); C604(0.98); C619(0.86)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C1389(1.17); C1900(1.28); C604(0.88); C619(0.88)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C1389(1.18); C1900(1.29); C604(0.96); C619(0.85)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C1389(1.17); C1900(1.28); C604(1.05); C619(0.83)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C1900(0.95); C604(1.00); C2262(1.05); C1389(0.85)  LDD1698  [41]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C604(1.20)  LDD1702  [12]
 LDCM0625  F8 Ramos C604(0.84)  LDD2187  [42]
 LDCM0572  Fragment10 Ramos C604(1.14)  LDD2189  [42]
 LDCM0574  Fragment12 Ramos C604(0.93)  LDD2191  [42]
 LDCM0576  Fragment14 Ramos C604(1.44)  LDD2193  [42]
 LDCM0579  Fragment20 Ramos C604(1.11)  LDD2194  [42]
 LDCM0580  Fragment21 Ramos C604(0.87)  LDD2195  [42]
 LDCM0582  Fragment23 Ramos C604(0.87)  LDD2196  [42]
 LDCM0578  Fragment27 Ramos C604(0.95)  LDD2197  [42]
 LDCM0588  Fragment30 Ramos C604(1.00)  LDD2199  [42]
 LDCM0590  Fragment32 Ramos C604(1.05)  LDD2201  [42]
 LDCM0468  Fragment33 HCT 116 C1389(1.11); C1900(1.12); C604(1.04); C619(0.81)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C604(1.03)  LDD2203  [42]
 LDCM0566  Fragment4 Ramos C604(1.64)  LDD2184  [42]
 LDCM0427  Fragment51 HCT 116 C1900(0.85); C604(0.98); C619(1.03); C624(1.04)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C604(1.28)  LDD2204  [42]
 LDCM0614  Fragment56 Ramos C604(1.94)  LDD2205  [42]
 LDCM0569  Fragment7 Ramos C604(2.48)  LDD2186  [42]
 LDCM0571  Fragment9 Ramos C604(1.08)  LDD2188  [42]
 LDCM0116  HHS-0101 DM93 Y1137(0.70); Y232(0.77); Y1805(0.79); Y1303(0.80)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y1730(0.61); Y232(0.68); Y1805(0.73); Y1303(1.01)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y1730(0.25); Y1303(0.46); Y232(0.69); Y1805(0.73)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y1303(0.43); Y1805(0.69); Y232(0.69); Y1190(0.84)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y1303(0.06); Y232(0.71); Y1730(0.80); Y1805(0.80)  LDD0268  [14]
 LDCM0107  IAA HeLa H464(0.00); H559(0.00); H1155(0.00); H1846(0.00)  LDD0221  [30]
 LDCM0022  KB02 HCT 116 C619(6.97); C624(6.97); C1900(1.79); C1389(1.52)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C619(6.71); C624(6.71); C1900(1.95); C1389(1.60)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C619(9.87); C624(9.87); C1900(2.58); C1389(1.71)  LDD0082  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C112(0.62)  LDD2121  [12]
 LDCM0109  NEM HeLa H1851(0.00); H1846(0.00); H2250(0.00); H494(0.00)  LDD0223  [30]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C112(0.60); C604(0.75)  LDD2089  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C112(0.89); C604(0.94)  LDD2092  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C112(1.15); C1389(0.74)  LDD2093  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C112(1.44)  LDD2094  [12]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1900(0.04); C112(0.49); C604(0.73)  LDD2096  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C112(0.83)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C112(0.85); C604(0.87)  LDD2098  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1970(2.02); C112(1.20); C1389(1.71); C604(1.24)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1970(0.45); C2262(0.54)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1970(0.62); C112(0.51); C604(0.83)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1970(0.23); C112(0.65)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C112(0.84); C604(1.32)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1970(0.25); C112(0.31); C604(0.33)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1900(0.92); C1970(1.45); C112(1.13); C1389(1.16)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1970(0.38); C112(0.63)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C112(0.82); C1389(0.74)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1970(0.36); C112(0.59)  LDD2110  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1900(1.69); C112(1.29); C1389(1.30); C604(1.21)  LDD2111  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1970(0.46); C1389(0.64)  LDD2114  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1970(0.44); C112(0.48); C604(0.54)  LDD2115  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C112(0.53)  LDD2116  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1900(0.16); C112(0.65); C604(0.76)  LDD2118  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1900(2.48); C112(2.17); C1389(1.87); C604(2.58)  LDD2119  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C112(0.70); C604(0.97)  LDD2120  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1970(0.22); C112(0.55)  LDD2122  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1900(1.10); C1970(0.93); C1389(1.34); C604(1.25)  LDD2123  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1900(0.06); C1970(0.25); C112(0.51)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1900(1.18); C1970(0.93); C112(1.03); C1389(1.05)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1900(0.06); C112(0.54); C604(0.76); C2262(0.10)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1900(1.22); C1970(0.97); C112(1.10); C604(1.13)  LDD2127  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C112(0.88); C604(1.02)  LDD2128  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C112(1.26); C1389(1.00)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C112(0.84)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1970(0.40); C112(0.42); C1389(0.34); C604(0.59)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1900(0.73); C112(1.12); C1389(1.34); C604(1.32)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1900(1.37); C1970(1.56); C112(1.34); C604(1.24)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1900(0.90); C1970(1.22); C112(1.23); C604(1.12)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1900(4.21); C604(2.30); C112(2.27); C1970(1.65)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1900(1.63); C1970(1.51); C112(1.03); C1389(1.02)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1970(0.47); C112(0.48); C604(0.69)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C112(1.03); C604(1.09)  LDD2143  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1900(2.99); C112(2.99); C1389(2.28)  LDD2144  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1900(0.11); C1970(0.09); C604(4.72); C2262(0.18)  LDD2145  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1900(1.12); C1970(0.95); C112(1.11)  LDD2146  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C112(2.48)  LDD2147  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1970(0.27); C112(0.59); C604(0.60)  LDD2148  [12]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C112(0.54)  LDD2149  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1900(1.09); C112(0.45)  LDD2150  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1900(0.12); C112(0.51)  LDD2151  [12]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C112(1.00); C604(2.19)  LDD2153  [12]
 LDCM0131  RA190 MM1.R C1900(1.45)  LDD0304  [43]
 LDCM0021  THZ1 HCT 116 C1389(0.95); C112(0.87)  LDD2173  [15]
 LDCM0110  W12 Hep-G2 K1913(0.60); R1915(0.60); C604(0.73); C1389(13.53)  LDD0237  [31]
 LDCM0111  W14 Hep-G2 C1389(4.45)  LDD0238  [31]
 LDCM0113  W17 Hep-G2 C1389(5.84)  LDD0240  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) Spectrin family Q13813
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-413 Antibody D01QKZ
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1d-myo-inositol 145-trisphosphate Small molecular drug DB03401
Calcium . DB01373

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
31 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
32 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
33 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
34 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
35 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
40 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
41 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
42 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
43 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.