Details of the Target

General Information of Target

Target ID LDTP00192
Target Name ATP-dependent RNA helicase DDX39A (DDX39A)
Gene Name DDX39A
Gene ID 10212
Synonyms
DDX39; ATP-dependent RNA helicase DDX39A; EC 3.6.4.13; DEAD box protein 39; Nuclear RNA helicase URH49
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIV
DCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCH
TRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVR
NRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRK
FMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCM
ALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFN
YDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDIS
TYIEQSR
Target Bioclass
Enzyme
Family
DEAD box helicase family, DECD subfamily
Subcellular location
Nucleus
Function [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.
Uniprot ID
O00148
Ensemble ID
ENST00000242776.9
HGNC ID
HGNC:17821
ChEMBL ID
CHEMBL4105795

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.E3Ter DBIA    Probe Info 
CAOV3 SNV: p.R298C DBIA    Probe Info 
DOTC24510 SNV: p.R207Q DBIA    Probe Info 
HEC1 SNV: p.Y264H DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.M139T DBIA    Probe Info 
JURKAT SNV: p.R318W Compound 10    Probe Info 
NCIH446 SNV: p.E393D DBIA    Probe Info 
SNGM SNV: p.L80P DBIA    Probe Info 
SUPT1 SNV: p.S25N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.38  LDD0402  [1]
CHEMBL5175495
 Probe Info  		8.54  LDD0196  [2]
N1
 Probe Info  		7.66  LDD0242  [3]
TH211
 Probe Info  		Y38(11.83); Y265(6.44); Y264(6.40)  LDD0260  [4]
TH216
 Probe Info  		Y138(20.00); Y265(7.89)  LDD0259  [4]
ONAyne
 Probe Info  		K162(0.95); K269(0.64); K333(3.76)  LDD0274  [5]
Probe 1
 Probe Info  		Y138(40.32)  LDD3495  [6]
EA-probe
 Probe Info  		C62(0.83); C197(0.61)  LDD2210  [7]
HHS-475
 Probe Info  		Y38(0.75); Y265(1.06); Y264(1.08)  LDD0264  [8]
HHS-465
 Probe Info  		Y264(10.00); Y265(10.00); Y38(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C164(1.02)  LDD0078  [10]
5E-2FA
 Probe Info  		H42(0.00); H259(0.00); H166(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K383(0.00); K35(0.00); K155(0.00); K162(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C299(0.00); C238(0.00); C197(0.00); C164(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C164(0.00); C223(0.00); C62(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C197(0.00); C62(0.00); C223(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C299(0.00); C238(0.00); C197(0.00); C164(0.00)  LDD0037  [13]
BTD
 Probe Info  		N.A.  LDD0004  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C164(0.00); C197(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C238(0.00); C164(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C197(0.00); C164(0.00)  LDD0022  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [19]
Compound 10
 Probe Info  		C164(0.00); C223(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C164(0.00); C223(0.00)  LDD2213  [20]
IPM
 Probe Info  		C86(0.00); C238(0.00); C164(0.00); C197(0.00)  LDD0005  [16]
SF
 Probe Info  		K333(0.00); Y38(0.00); Y264(0.00); Y265(0.00)  LDD0028  [21]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C238(0.00); C62(0.00); C164(0.00); C197(0.00)  LDD0018  [22]
1c-yne
 Probe Info  		K221(0.00); K397(0.00); K240(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		C197(0.00); C164(0.00); H42(0.00); C74(0.00)  LDD0217  [23]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [23]
Crotonaldehyde
 Probe Info  		C197(0.00); H42(0.00); C164(0.00); H166(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C197(0.00); C164(0.00); H42(0.00); H166(0.00)  LDD0218  [23]
W1
 Probe Info  		C238(0.00); C197(0.00)  LDD0236  [24]
AOyne
 Probe Info  		10.70  LDD0443  [25]
NAIA_5
 Probe Info  		C299(0.00); C238(0.00); C197(0.00); C164(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y138(0.88); Y264(0.82); Y38(0.84)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.24  LDD0475  [26]
FFF probe3
 Probe Info  		5.04  LDD0465  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
DA-2
 Probe Info  		N.A.  LDD0073  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C238(0.99); C164(0.80)  LDD2142  [30]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C238(1.12); C164(0.82)  LDD2112  [30]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C238(0.55); C164(0.49)  LDD2095  [30]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C238(0.78); C164(0.76)  LDD2130  [30]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C238(0.95); C164(0.98)  LDD2117  [30]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C238(1.21); C164(1.42)  LDD2152  [30]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C238(0.97); C164(1.09)  LDD2103  [30]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C238(0.55); C164(1.07)  LDD2132  [30]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C164(0.51); C223(0.87)  LDD2131  [30]
 LDCM0214  AC1 HCT 116 C164(1.00); C197(1.16); C223(0.70)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C164(1.23); C197(1.13); C223(0.92); C238(1.13)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C164(0.73); C197(1.06); C223(0.82)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C164(0.75); C197(1.04); C223(1.07)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C164(0.71); C197(1.02); C223(1.07)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C164(0.75); C197(0.92); C223(0.94)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C164(0.71); C197(0.91); C223(1.04)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C164(0.83); C197(1.09); C223(0.87)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C164(0.76); C197(0.95); C223(0.88)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C164(0.79); C197(0.99); C223(0.96)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C164(0.67); C197(1.08); C223(0.87)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C164(0.72); C197(1.07); C223(1.07)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C164(1.03); C197(1.30); C223(0.95); C238(1.04)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C164(0.70); C197(0.95); C223(0.82)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C164(0.68); C197(0.97); C223(1.03)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C164(0.78); C197(0.89); C223(0.87)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C164(1.02); C197(1.02); C223(1.05)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C164(0.93); C197(0.81); C223(1.15)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C164(1.05); C197(0.74); C223(1.01)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C164(0.99); C197(0.85); C223(0.94)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C164(1.05); C197(0.92); C223(0.89)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C164(1.05); C197(0.89); C223(0.93)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C164(0.95); C197(0.82); C223(0.89)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C164(1.02); C197(0.99); C223(0.81); C238(1.32)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C164(0.68); C197(0.67); C223(2.27)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C164(1.14); C197(1.12); C223(1.06)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C164(1.07); C197(0.91); C223(0.86)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C164(1.01); C197(0.90); C223(1.32)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C164(1.08); C197(1.07); C223(1.00)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C164(1.07); C197(0.93); C223(1.21)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C164(0.98); C197(0.80); C223(1.07)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C164(1.02); C197(0.87); C223(0.90)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C164(1.55); C197(1.12); C223(1.06)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C164(1.55); C197(1.27); C223(0.87)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C164(1.53); C197(1.37); C223(0.74)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C164(1.39); C197(1.07); C223(1.08)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C164(1.78); C197(0.99); C223(0.61)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C164(1.47); C197(1.16); C223(0.78)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C164(1.44); C197(0.72); C223(1.01)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C164(1.62); C197(1.13); C223(0.78)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C164(1.20); C197(0.98); C223(0.83)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C164(1.16); C197(0.98); C223(0.82)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C164(1.54); C197(0.67); C223(1.12)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C164(1.28); C197(0.74); C223(0.72)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C164(1.18); C197(1.22); C223(1.98); C238(1.22)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C164(1.40); C197(0.66); C223(0.83)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C164(1.47); C197(0.72); C223(0.92)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C164(1.59); C197(1.01); C223(0.74)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C164(1.32); C197(0.92); C223(0.84)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C223(0.78); C197(1.02); C164(1.12)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C223(0.78); C164(1.27); C197(1.30)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C223(0.76); C164(1.03); C197(1.05)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C223(0.76); C164(0.99); C197(1.23)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C223(1.00); C197(1.17); C164(1.21)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C223(0.80); C197(1.03); C164(1.08)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C164(1.05); C197(1.13); C238(1.24); C223(1.45)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C223(0.71); C164(0.93); C197(0.98)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C223(0.85); C164(1.11); C197(1.14)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C164(0.91); C197(0.93); C223(0.97)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C223(0.90); C164(1.32); C197(1.43)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C164(0.94); C197(1.17); C223(0.85)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C164(0.94); C197(0.99); C223(0.62)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C164(1.03); C197(1.03); C223(0.91)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C164(1.30); C197(1.27); C223(1.10)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C223(0.70); C164(1.16); C197(1.47)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C223(0.81); C164(0.83); C197(1.68)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C223(0.60); C164(1.07); C197(1.28)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C223(0.87); C197(0.99); C164(1.17)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C164(1.09); C223(1.15); C197(1.21)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C164(0.91); C223(0.96); C197(1.47)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C164(1.03); C223(1.06); C197(1.32)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C223(0.93); C164(1.04); C197(1.38)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C223(0.82); C164(1.12); C197(1.16)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C223(0.71); C197(0.93); C164(1.09)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C223(0.71); C197(0.78); C164(1.21)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C223(0.76); C197(0.89); C164(1.09)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C223(0.67); C164(0.96); C197(1.02)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C197(0.62); C223(0.73); C164(1.10)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C223(0.67); C164(1.20); C197(1.22)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C197(0.59); C223(0.88); C164(1.02)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C223(0.75); C197(0.90); C164(1.11)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C223(0.70); C197(0.73); C164(1.08)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C223(0.73); C197(1.00); C164(1.08)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C223(0.74); C197(0.86); C164(0.91)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C223(0.84); C164(0.88); C197(1.25)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C223(0.82); C197(0.96); C164(0.99)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C223(0.85); C164(1.17); C197(1.32)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C223(0.89); C197(1.02); C164(1.06)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C223(0.85); C164(0.99); C197(1.04)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C223(0.70); C197(1.08); C164(1.19)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C223(0.93); C164(1.05); C197(1.15)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C223(0.95); C164(1.04); C197(1.11)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C164(1.05); C197(1.11); C223(1.15)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C223(0.84); C164(1.09); C197(1.14)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C164(1.09); C223(1.09); C197(1.48)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C223(1.03); C164(1.10); C197(1.52)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C223(0.62); C197(0.75); C164(0.91)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C223(0.73); C197(1.02); C164(1.05)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C223(0.77); C197(0.83); C164(0.93)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C197(0.72); C164(0.75); C223(0.88)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C223(0.64); C197(1.04); C164(1.27)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C164(0.71); C197(0.81); C223(1.06)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C197(0.77); C164(1.06); C223(1.12)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C223(0.83); C197(0.85); C164(0.86)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C164(0.69); C197(0.88); C223(1.18)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C164(0.70); C197(0.72); C223(1.06)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C164(0.71); C223(0.71); C197(1.04)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C164(0.78); C197(0.87); C223(1.08)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C223(0.90); C197(0.94); C238(1.04); C164(1.11)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C238(0.82); C197(0.94); C223(1.06); C164(1.19)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C197(0.97); C223(0.97); C238(1.00); C164(1.10)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C238(0.99); C197(1.03); C223(1.11); C164(1.15)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C238(1.01); C223(1.03); C197(1.08); C164(1.20)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C223(1.01); C197(1.15); C238(1.21); C164(1.39)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C223(0.89); C197(1.11); C164(1.30); C238(1.40)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C223(0.91); C197(1.03); C164(1.17); C238(1.30)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C223(0.94); C164(1.13); C197(1.14); C238(1.35)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C223(0.84); C238(0.96); C197(1.13); C164(1.27)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C223(0.96); C238(1.03); C197(1.06); C164(1.16)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C197(1.02); C164(1.19); C238(1.19); C223(1.21)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C197(0.85); C164(0.98); C223(1.16)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C164(0.98); C197(0.98); C223(1.21)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C164(1.06); C223(1.06); C197(1.08); C238(1.11)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C197(0.61); C223(0.84); C164(0.93)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C164(0.96); C197(1.06); C223(1.08)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C197(0.70); C223(0.91); C164(0.95)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C197(0.65); C223(0.97); C164(1.16)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C197(0.80); C164(1.04); C223(1.29)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C197(0.88); C223(1.07); C164(1.43)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C223(0.99); C164(1.09); C197(1.11)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C197(0.86); C164(1.09); C223(1.13)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C197(0.90); C223(1.11); C164(1.16)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C197(0.71); C164(0.96); C223(0.98)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C197(0.89); C164(0.95); C223(1.16); C238(1.20)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C164(0.97); C223(1.10); C197(1.28)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C164(0.85); C197(0.85); C223(1.32)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C197(0.93); C164(1.15); C223(1.22)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C223(0.70); C238(0.92); C197(0.94); C164(1.02)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C223(0.72); C164(0.87); C238(0.92); C197(1.02)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C223(0.53); C164(0.92); C238(0.98); C197(1.04)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C223(0.69); C238(0.89); C164(0.91); C197(0.99)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C223(0.59); C238(0.87); C164(1.01); C197(1.02)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C223(0.65); C238(0.81); C164(0.98); C197(1.00)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C223(0.61); C238(0.89); C164(0.92); C197(1.02)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C223(0.43); C238(0.82); C164(1.14); C197(1.31)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C223(0.57); C164(1.02); C197(1.10); C238(1.22)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C223(0.51); C164(0.95); C197(1.11); C238(1.14)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C223(0.51); C164(0.77); C197(1.03); C238(1.06)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C223(0.46); C164(0.80); C197(1.13); C238(1.18)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C223(0.43); C238(0.86); C164(0.99); C197(1.00)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C223(0.46); C164(1.01); C197(1.09); C238(1.26)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C223(0.40); C164(0.77); C238(0.83); C197(1.10)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C223(0.76); C164(0.77); C197(1.00)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C164(0.70); C223(0.84); C197(0.91)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C238(0.45); C164(0.47)  LDD2138  [30]
 LDCM0520  AKOS000195272 MDA-MB-231 C164(0.84); C197(1.01)  LDD2113  [30]
 LDCM0248  AKOS034007472 HCT 116 C164(1.13); C197(1.22); C223(0.96); C238(1.27)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C223(0.90); C238(0.97); C197(1.25); C164(1.28)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C197(1.04); C164(1.17); C223(1.24); C238(1.37)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.36  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C164(1.02)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C238(0.53); C164(0.50); C223(1.04)  LDD2091  [30]
 LDCM0630  CCW28-3 231MFP C197(1.69)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa H42(0.00); C164(0.00); H166(0.00); C197(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C62(20.00); C238(20.00); C238(2.77); C164(2.68)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C197(1.00); C164(1.04); C223(1.26)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C197(1.22); C164(1.34); C223(1.38)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C223(0.69); C164(1.10); C197(1.13)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C238(1.14); C197(1.15); C164(1.16); C223(1.82)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C238(1.24); C197(1.33); C164(1.38); C223(1.85)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C197(1.03); C164(1.08); C238(1.21); C223(1.43)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C238(1.15); C164(1.19); C197(1.23); C223(1.57)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C164(1.06); C223(1.11); C197(1.59)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C164(1.06); C223(1.24); C197(1.74)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C164(1.13); C223(1.27); C197(1.67)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C223(0.99); C164(1.05); C197(1.50)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C164(0.97); C223(0.97); C197(1.20)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C164(1.19); C197(1.27); C223(1.34)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C223(0.70); C164(0.92); C197(1.05)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C223(0.64); C164(0.89); C197(1.04)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C197(0.75); C164(0.90); C223(0.93)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C197(0.64); C223(0.82); C164(0.94)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C197(0.60); C223(0.83); C164(1.04)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C197(0.66); C223(0.70); C164(0.87)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C223(0.68); C197(0.79); C164(1.11)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C197(0.90); C223(0.91); C164(1.07)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C223(0.73); C197(1.07); C164(1.08)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C223(0.74); C164(0.97); C197(1.07)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C223(1.32); C197(1.36); C164(1.52)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C223(0.72); C197(1.01); C164(1.09)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C164(0.82); C223(0.94); C197(1.05)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C197(0.83); C164(0.84); C223(1.18)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C164(0.70); C223(0.80); C197(0.88)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C223(0.62); C164(0.71); C197(0.84)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C223(0.82); C238(1.00); C197(1.06); C164(1.11)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C238(0.89); C197(0.91); C164(1.00); C223(1.00)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C223(0.98); C197(0.98); C238(1.02); C164(1.08)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C238(0.92); C197(1.02); C223(1.09); C164(1.18)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C197(1.20); C223(1.26); C164(1.29)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C197(1.07); C223(1.10); C164(1.26)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C223(0.93); C197(1.20); C164(1.29)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C223(0.70); C164(0.86); C197(1.05)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C223(0.81); C164(0.94)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C223(0.68); C164(1.18)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C223(0.88); C164(1.15)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C197(0.98); C164(1.10); C223(1.28)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C223(0.86); C164(1.30)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C223(0.79); C164(1.15)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C164(1.52); C223(2.01)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C164(1.06); C223(1.16)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C223(0.76); C164(1.27)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C164(1.13); C223(0.77)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C164(0.98); C223(0.88)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C164(1.26); C223(0.79)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C164(1.10); C223(0.67)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C164(1.26); C223(0.84)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C164(1.19); C197(1.00); C223(1.38)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C164(0.98); C223(0.78)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C164(0.96); C197(1.00); C223(0.97)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C164(1.04); C197(1.14); C223(0.78)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C164(0.94); C197(1.00); C223(0.54)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C164(1.07); C197(1.15); C223(0.56)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C164(0.97); C197(1.01); C223(1.24)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C164(1.03); C197(0.89); C223(0.85)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C164(1.14); C197(0.92); C223(0.96)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C164(0.99); C197(0.97); C223(0.75)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C164(0.99); C197(0.94); C223(1.12)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C164(0.96); C197(0.88); C223(0.66)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C164(1.13); C197(1.00); C223(0.96)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C164(1.18); C197(0.96); C223(1.22)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C164(1.04); C197(1.02); C223(0.61)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C164(1.00); C197(1.07); C223(0.72)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C164(1.03); C197(1.16); C223(0.63)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C164(1.08); C197(1.34); C223(0.74)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C164(1.03); C197(1.20); C223(0.95)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C164(1.10); C197(1.28); C223(1.07)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C164(1.11); C197(1.18); C223(0.84)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C164(1.15); C197(1.05); C223(0.98)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C164(1.01); C197(1.13); C223(1.13)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C164(1.00); C197(1.26); C223(0.78)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C164(0.98); C197(1.17); C223(0.88)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C164(0.98); C197(0.97); C223(2.34)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C164(1.01); C197(1.12); C223(1.04)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C164(0.89); C197(1.20); C223(0.88)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C164(0.98); C197(1.08); C223(1.31)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C164(0.96); C197(1.18); C223(1.40)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C164(1.00); C197(1.18); C223(0.96)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C164(1.02); C197(1.03); C223(0.99)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C164(1.16); C197(1.03); C223(0.80)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C164(1.00); C197(0.92); C223(1.00)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C164(1.07); C197(1.11); C223(0.92); C238(1.02)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C164(0.92); C197(1.09); C223(0.89); C238(1.04)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C164(1.14); C197(1.04); C223(1.13); C238(1.04)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C164(1.08); C197(1.17); C223(0.91); C238(1.05)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C164(1.08); C197(1.11); C223(1.12); C238(1.16)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C164(1.08); C197(1.32); C223(1.02); C238(1.31)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C164(0.98); C197(1.25); C223(1.24); C238(1.19)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C164(1.06); C197(1.17); C223(2.57); C238(1.29)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C164(0.99); C197(1.05); C223(1.00); C238(1.01)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C164(1.34); C197(1.25); C223(0.87)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C164(0.97); C197(1.09); C223(1.22); C238(1.17)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C164(0.89); C197(1.14); C223(1.19); C238(1.29)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C164(0.94); C197(1.19); C223(1.43); C238(1.05)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C164(0.98); C197(1.08); C223(1.40); C238(1.07)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C164(1.01); C197(1.11); C223(1.29); C238(1.18)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C164(1.02); C197(0.77); C223(1.25)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C164(0.96); C197(0.69); C223(3.27)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C164(1.08); C197(0.77); C223(1.07)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C164(1.11); C197(0.77); C223(1.22)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C164(1.30); C197(0.90); C223(1.33)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C164(1.04); C197(0.81); C223(1.20)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C164(1.03); C197(0.76); C223(0.85)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C164(1.14); C197(0.85); C223(1.01)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C164(1.13); C197(0.83); C223(1.23)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C164(1.22); C197(0.89); C223(1.18)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C164(1.08); C197(0.83); C223(1.08)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C164(0.98); C197(0.85); C223(1.28)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C164(1.01); C197(0.87); C223(1.02)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C164(1.05); C197(0.84); C223(1.19)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C164(1.14); C197(0.92); C223(1.46)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C164(1.19); C197(1.06); C223(1.09)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C164(0.95); C197(0.87); C223(1.59)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C164(1.11); C197(0.94); C223(0.80)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C164(0.89); C197(0.83); C223(0.89)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C164(1.08); C197(1.04); C223(0.91)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C164(1.01); C197(0.91); C223(0.82)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C164(1.00); C197(0.84); C223(0.83)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C164(1.08); C197(0.88); C223(0.73)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C164(1.00); C197(0.78); C223(0.84)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C164(1.10); C197(1.05); C223(0.61)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C164(1.08); C197(1.16); C223(0.65)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C238(0.84); C164(1.02); C197(0.75); C223(0.87)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C238(6.05); C164(5.06); C197(2.56)  LDD1702  [30]
 LDCM0175  Ethacrynic acid HeLa C62(0.83); C197(0.61)  LDD2210  [7]
 LDCM0625  F8 Ramos C238(1.25); C197(0.92); C164(1.89); C299(0.76)  LDD2187  [33]
 LDCM0572  Fragment10 Ramos C238(2.95); C197(0.57); C164(2.10); C299(0.78)  LDD2189  [33]
 LDCM0573  Fragment11 Ramos C238(0.10); C197(1.15); C164(0.00); C223(0.13)  LDD2190  [33]
 LDCM0574  Fragment12 Ramos C238(2.89); C197(0.89); C164(3.24); C299(1.14)  LDD2191  [33]
 LDCM0575  Fragment13 Ramos C238(1.07); C197(0.78); C164(0.97)  LDD2192  [33]
 LDCM0576  Fragment14 Ramos C238(1.78); C197(0.96); C164(2.02); C223(1.04)  LDD2193  [33]
 LDCM0579  Fragment20 Ramos C238(7.05); C197(1.23); C164(5.14); C299(1.34)  LDD2194  [33]
 LDCM0580  Fragment21 Ramos C238(1.06); C197(0.87); C164(0.96); C299(2.56)  LDD2195  [33]
 LDCM0582  Fragment23 Ramos C238(0.80); C197(0.71); C164(0.85); C299(2.09)  LDD2196  [33]
 LDCM0578  Fragment27 Ramos C238(0.84); C197(0.84); C164(0.85)  LDD2197  [33]
 LDCM0586  Fragment28 Ramos C238(0.78); C197(0.96); C164(0.75); C223(1.19)  LDD2198  [33]
 LDCM0588  Fragment30 Ramos C238(1.21); C197(0.59); C164(1.27); C299(0.92)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C238(1.06); C197(0.74); C164(1.05)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C238(3.16); C197(0.46); C164(5.38); C299(1.20)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C164(0.97); C197(1.09); C223(1.03); C238(1.08)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C238(1.00); C197(0.70); C164(1.27)  LDD2203  [33]
 LDCM0566  Fragment4 Ramos C238(2.88); C197(1.15); C164(2.74); C223(1.42)  LDD2184  [33]
 LDCM0427  Fragment51 HCT 116 C164(0.97); C197(0.61); C223(0.61)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C238(1.10); C197(0.58); C164(1.21)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C238(1.40); C197(0.81); C164(1.07); C299(1.09)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C238(4.32); C197(2.14); C164(3.73); C299(0.61)  LDD2186  [33]
 LDCM0571  Fragment9 Ramos C238(9.99); C197(0.97); C164(3.99); C299(0.99)  LDD2188  [33]
 LDCM0116  HHS-0101 DM93 Y38(0.75); Y265(1.06); Y264(1.08)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y38(0.69); Y265(0.87); Y264(1.05)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y38(0.63); Y265(0.73); Y264(1.07)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y38(0.77); Y264(1.10); Y265(1.36)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y38(0.80); Y264(0.86); Y265(1.76)  LDD0268  [8]
 LDCM0107  IAA HeLa H42(0.00); H191(0.00); C197(0.00); H72(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C164(1.02)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C164(2.03)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C164(1.46)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C238(0.95)  LDD2102  [30]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C238(0.48); C164(0.58)  LDD2121  [30]
 LDCM0109  NEM HeLa H42(0.00); H259(0.00); H191(0.00); H372(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C238(0.60); C164(0.49)  LDD2089  [30]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C238(1.22); C164(0.73)  LDD2090  [30]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C238(0.81); C164(0.65)  LDD2092  [30]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C238(0.97); C164(0.98)  LDD2093  [30]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C238(0.97); C164(0.81)  LDD2094  [30]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C164(0.70)  LDD2096  [30]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C238(0.95); C164(0.99)  LDD2097  [30]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C238(1.10); C164(1.04); C197(0.98)  LDD2098  [30]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C238(0.78); C164(1.01)  LDD2099  [30]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C238(1.27); C164(1.02)  LDD2100  [30]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C238(0.87); C164(1.03)  LDD2101  [30]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C164(0.86)  LDD2104  [30]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C238(1.27); C164(1.37)  LDD2105  [30]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C238(0.90); C164(0.75)  LDD2106  [30]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C238(0.86); C164(0.86)  LDD2107  [30]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C238(0.91); C164(0.99)  LDD2108  [30]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C238(0.86); C164(0.82); C223(1.04)  LDD2109  [30]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C238(1.87)  LDD2110  [30]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C238(0.90); C164(1.01)  LDD2111  [30]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C238(1.02); C164(0.66)  LDD2114  [30]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C164(0.58); C197(0.78)  LDD2115  [30]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C238(0.58); C164(1.25)  LDD2116  [30]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C238(0.72); C164(1.17)  LDD2118  [30]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C238(2.68); C197(1.73)  LDD2119  [30]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C238(0.91); C164(0.80)  LDD2120  [30]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C238(0.63); C164(1.03)  LDD2122  [30]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C238(0.88); C164(0.96); C223(1.23); C197(1.30)  LDD2123  [30]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C164(1.26)  LDD2124  [30]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C238(0.73); C164(0.74); C223(1.55)  LDD2125  [30]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C238(1.19); C164(2.07)  LDD2126  [30]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C238(1.06); C164(0.99); C223(1.48); C197(3.16)  LDD2127  [30]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C238(0.94); C164(1.00)  LDD2128  [30]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C238(0.90); C164(1.07)  LDD2129  [30]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C238(0.75); C164(0.67); C197(0.36)  LDD2133  [30]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C238(0.44); C164(0.58); C197(0.59)  LDD2134  [30]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C238(1.12); C164(1.13); C197(1.33)  LDD2135  [30]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C238(1.54); C164(1.25)  LDD2136  [30]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C238(0.96); C164(0.93); C223(1.00)  LDD2137  [30]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C238(1.40); C164(1.24)  LDD1700  [30]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C238(0.65); C164(0.74)  LDD2140  [30]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C238(0.70); C164(0.74); C197(0.91)  LDD2141  [30]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C238(0.98); C164(1.03)  LDD2143  [30]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C238(2.55); C164(2.11)  LDD2144  [30]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C238(13.81)  LDD2145  [30]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C238(0.81); C164(0.81); C197(1.09)  LDD2146  [30]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C238(2.95); C164(2.82)  LDD2147  [30]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C238(0.55); C164(0.57)  LDD2148  [30]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C238(0.65); C164(1.43)  LDD2149  [30]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C238(0.46); C164(0.53)  LDD2150  [30]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C238(1.10); C164(1.43)  LDD2151  [30]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C238(2.10); C164(1.94)  LDD2153  [30]
 LDCM0627  NUDT7-COV-1 HEK-293T C238(1.11); C197(0.96)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C223(0.90); C197(0.77); C164(0.73); C238(0.70)  LDD2207  [34]
 LDCM0131  RA190 MM1.R C197(1.04)  LDD0304  [35]
 LDCM0021  THZ1 HCT 116 C223(1.26)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
ATP-dependent RNA helicase DDX39A (DDX39A) DEAD box helicase family O00148
Spliceosome RNA helicase DDX39B (DDX39B) DEAD box helicase family Q13838
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
SAP domain-containing ribonucleoprotein (SARNP) . P82979
Telomeric repeat-binding factor 1 (TERF1) . P54274

References

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2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
35 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.