Details of the Target

General Information of Target

Target ID LDTP06294
Target Name Lysine--tRNA ligase (KARS1)
Gene Name KARS1
Gene ID 3735
Synonyms
KARS; KIAA0070; Lysine--tRNA ligase; EC 2.7.7.-; EC 6.1.1.6; Lysyl-tRNA synthetase; LysRS
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTT
DNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDH
LTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGD
IIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFV
RQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAP
ELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSG
MVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKE
GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYG
LPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
Target Bioclass
Enzyme
Family
Class-II aminoacyl-tRNA synthetase family
Subcellular location
Cytoplasm, cytosol; Mitochondrion
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.; (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Uniprot ID
Q15046
Ensemble ID
ENST00000302445.8
HGNC ID
HGNC:6215
ChEMBL ID
CHEMBL5575

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC3 SNV: p.E150K DBIA    Probe Info 
JHH7 SNV: p.E37Ter .
RKO SNV: p.D123N DBIA    Probe Info 
SBC5 SNV: p.S138F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P3
 Probe Info  		10.00  LDD0450  [1]
A-EBA
 Probe Info  		2.70  LDD0215  [2]
CHEMBL5175495
 Probe Info  		5.18  LDD0196  [3]
C-Sul
 Probe Info  		2.34  LDD0066  [4]
TH211
 Probe Info  		Y76(20.00); Y77(16.49); Y95(15.31)  LDD0257  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K479(1.78)  LDD3494  [8]
Probe 1
 Probe Info  		Y231(19.17); Y253(20.56); Y369(26.54); Y373(13.06)  LDD3495  [9]
DBIA
 Probe Info  		C462(1.67)  LDD3311  [10]
THZ1-DTB
 Probe Info  		C427(1.04)  LDD0460  [11]
BTD
 Probe Info  		C434(1.75)  LDD1700  [12]
HPAP
 Probe Info  		3.67  LDD0063  [13]
5E-2FA
 Probe Info  		H100(0.00); H171(0.00); H120(0.00)  LDD2235  [14]
ATP probe
 Probe Info  		K175(0.00); K88(0.00); K421(0.00); K127(0.00)  LDD0199  [15]
m-APA
 Probe Info  		N.A.  LDD2231  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C434(0.00); C496(0.00); C427(0.00); C338(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C434(0.00); C496(0.00); C427(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		C338(0.00); C496(0.00); C427(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C338(0.00); C496(0.00); C427(0.00); C456(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C434(0.00); C496(0.00); C209(0.00); C427(0.00)  LDD0037  [16]
WYneN
 Probe Info  		C434(0.00); C427(0.00)  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		N.A.  LDD0147  [21]
NHS
 Probe Info  		K10(0.00); K175(0.00)  LDD0010  [19]
PF-06672131
 Probe Info  		C427(0.00); C434(0.00)  LDD0152  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
Acrolein
 Probe Info  		C496(0.00); H114(0.00); H374(0.00); H85(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C496(0.00); C434(0.00); C427(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C496(0.00); C427(0.00); C434(0.00)  LDD0218  [24]
NAIA_5
 Probe Info  		C534(0.00); C434(0.00); C496(0.00); C209(0.00)  LDD2223  [25]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		8.07  LDD0473  [26]
FFF probe3
 Probe Info  		6.52  LDD0464  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]
STS-1
 Probe Info  		N.A.  LDD0068  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C427(0.67)  LDD2142  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C427(1.15); C434(0.95)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C427(1.30); C434(1.28)  LDD2152  [12]
 LDCM0214  AC1 HEK-293T C427(0.89); C338(1.02); C534(1.05); C496(0.98)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C427(0.99); C338(1.03); C534(1.04); C496(1.19)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C427(1.05); C338(1.13); C534(0.97); C496(1.08)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C427(1.03); C534(0.95); C496(1.11); C209(1.01)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C427(1.07); C338(1.05); C534(1.10); C496(0.99)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C427(1.30); C338(1.16); C534(0.90); C496(1.02)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C427(0.95); C338(1.07); C534(1.01); C496(1.00)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C427(1.03); C338(0.99); C534(0.93); C496(1.21)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C427(0.90); C338(0.90); C534(0.93); C496(1.11)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C427(1.04); C338(1.07); C534(1.00); C496(1.25)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C427(1.00); C534(1.08); C496(1.11); C209(1.07)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C427(1.03); C338(1.17); C534(1.00); C496(0.96)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C427(1.08); C338(0.99); C534(1.10); C496(1.02)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C427(0.99); C338(1.15); C534(0.99); C496(1.01)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C427(1.01); C338(0.96); C534(1.01); C496(1.15)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C427(0.97); C338(1.08); C534(0.97); C496(1.01)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C427(1.09); C338(1.14); C534(1.03); C496(1.08)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C427(1.00); C338(0.98); C534(1.01); C496(0.98)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C427(1.03); C534(1.11); C496(1.22); C209(1.11)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C427(1.03); C338(1.23); C534(0.97); C496(0.91)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C427(1.00); C338(0.99); C534(0.91); C496(1.05)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C427(1.06); C338(1.00); C534(1.11); C496(1.04)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C427(1.22); C338(1.09); C534(0.92); C496(1.12)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C427(1.05); C338(1.11); C534(1.04); C496(1.11)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C427(0.94); C338(1.13); C534(1.13); C496(0.89)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C427(1.00); C338(1.07); C534(0.99); C496(1.29)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C427(1.03); C338(1.03); C534(0.98); C496(1.11)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C427(1.04); C534(1.04); C496(1.24); C209(1.10)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C427(1.06); C338(1.30); C534(0.97); C496(1.06)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C427(1.03); C338(1.06); C534(1.12); C496(1.12)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C427(1.12); C338(1.11); C534(0.95); C496(1.02)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C427(1.03); C534(0.99); C496(1.21); C209(1.11)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C427(0.97); C338(0.99); C534(1.00); C496(1.03)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C427(0.89); C338(1.20); C534(1.11); C496(0.98)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C427(1.00); C338(1.09); C534(0.99); C496(1.10)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C427(1.02); C338(1.12); C534(1.08); C496(1.10)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C427(0.98); C534(0.99); C496(1.18); C209(1.08)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C427(0.97); C338(1.17); C534(0.92); C496(0.94)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C427(1.06); C338(1.18); C534(1.08); C496(1.03)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C427(1.15); C338(1.27); C534(1.11); C496(1.08)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C427(1.00); C338(1.29); C534(1.07); C496(1.07)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C427(0.91); C338(1.23); C534(1.07); C496(1.07)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C427(1.04); C338(1.16); C534(0.99); C496(0.90)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C427(1.06); C338(1.27); C534(1.04); C496(1.15)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C427(1.06); C338(1.13); C534(0.97); C496(1.06)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C427(0.96); C534(1.00); C496(1.16); C209(1.05)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C427(1.01); C338(1.22); C534(1.05); C496(1.00)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C427(1.07); C338(1.12); C534(1.07); C496(1.18)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C427(1.14); C338(1.43); C534(1.02); C496(1.06)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C427(1.01); C338(0.99); C534(1.06); C496(1.06)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C427(0.89); C338(1.06); C534(1.09); C496(1.16)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C427(1.07); C338(1.23); C534(1.08); C496(1.14)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C427(1.02); C338(1.25); C534(0.93); C496(0.93)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C427(0.98); C338(1.04); C534(1.01); C496(0.97)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C427(1.01); C534(0.93); C496(1.12); C209(1.03)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C427(0.97); C338(1.12); C534(1.05); C496(1.01)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C427(1.00); C338(1.04); C534(1.12); C496(1.10)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C427(1.17); C338(1.14); C534(0.94); C496(1.06)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C427(0.96); C338(1.06); C534(1.14); C496(1.07)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C427(1.44); C338(1.15); C534(0.99); C496(1.09)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C427(0.96); C338(0.90); C534(1.03); C496(1.01)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C427(0.60)  LDD2138  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C427(0.74)  LDD2113  [12]
 LDCM0248  AKOS034007472 HEK-293T C427(1.02); C338(1.30); C534(1.04); C496(1.03)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C427(0.97); C338(1.12); C534(1.04); C496(0.97)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C427(0.93); C338(1.01); C534(1.08); C496(1.04)  LDD1514  [31]
 LDCM0498  BS-3668 MDA-MB-231 C427(0.77); C434(0.85)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa C496(0.00); H114(0.00); C427(0.00); C434(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C427(1.20)  LDD2227  [25]
 LDCM0367  CL1 HEK-293T C427(0.92); C338(1.29); C534(1.03); C496(1.09)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C427(0.80); C338(0.86); C534(0.90); C496(1.02)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C427(0.89); C338(1.03); C534(1.07); C496(0.97)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C427(0.95); C338(1.25); C534(1.07); C496(1.01)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C427(1.02); C338(0.97); C534(0.98); C496(0.88)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C427(0.97); C338(1.23); C534(1.01); C496(0.94)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C427(1.02); C338(1.34); C534(0.94); C496(1.09)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C427(1.00); C338(1.18); C534(1.06); C496(0.97)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C427(1.03); C338(1.08); C534(1.03); C496(0.99)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C427(1.08); C338(1.29); C534(0.97); C496(1.01)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C427(0.98); C338(0.93); C534(0.95); C496(1.09)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C427(1.00); C338(1.18); C534(1.02); C496(0.96)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C427(1.09); C338(1.03); C534(1.06); C496(0.88)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C427(1.00); C338(1.00); C534(0.99); C496(0.66)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C427(0.96); C338(1.21); C534(1.26); C496(0.98)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C427(1.06); C338(0.87); C534(1.03); C496(1.37)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C427(1.02); C338(1.23); C534(1.27); C496(0.97)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C427(0.98); C338(1.01); C534(1.13); C496(1.22)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C427(0.96); C338(1.14); C534(0.93); C496(0.99)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C427(1.07); C338(0.88); C534(1.09); C496(1.05)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C427(0.97); C338(1.34); C534(1.13); C496(0.91)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C427(1.13); C338(1.13); C534(1.11); C496(1.08)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C427(1.10); C338(1.27); C534(1.04); C496(1.15)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C427(0.87); C338(1.06); C534(1.03); C496(1.17)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C427(1.14); C338(1.18); C534(0.99); C496(1.12)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C427(0.96); C338(1.26); C534(0.98); C496(1.11)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C427(1.10); C338(1.16); C534(1.09); C496(0.99)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C427(0.96); C338(1.14); C534(0.91); C496(1.12)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C427(1.14); C338(1.11); C534(1.00); C496(1.10)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C427(0.97); C338(1.41); C534(1.14); C496(1.02)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C427(1.12); C338(1.06); C534(0.99); C496(1.15)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C427(1.01); C338(1.07); C534(1.09); C496(1.10)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C427(0.86); C338(0.99); C534(1.06); C496(1.18)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C427(0.89); C338(1.13); C534(1.05); C496(1.01)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C427(1.11); C338(1.27); C534(1.34); C496(1.22)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C427(0.85); C338(1.20); C534(0.90); C496(0.99)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C427(1.16); C338(1.09); C534(1.05); C496(1.09)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C427(0.92); C338(0.96); C534(0.92); C496(0.99)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C427(0.98); C338(1.07); C534(1.12); C496(1.16)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C427(0.96); C338(1.08); C534(0.91); C496(1.06)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C427(1.13); C338(1.07); C534(1.03); C496(1.18)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C427(0.93); C534(0.96); C496(1.01); C209(0.88)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C427(0.89); C338(1.44); C534(1.01); C496(1.01)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C427(1.00); C338(1.10); C534(1.11); C496(1.23)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C427(1.00); C338(1.16); C534(1.12); C496(1.03)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C427(0.95); C338(1.08); C534(1.09); C496(1.08)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C427(0.98); C338(1.15); C534(1.03); C496(0.59)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C427(1.08); C338(1.26); C534(1.04); C496(1.01)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C427(1.05); C338(1.11); C534(1.19); C496(1.06)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C427(1.06); C338(0.91); C534(1.13); C496(1.12)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C427(0.99); C338(1.04); C534(1.01); C496(1.05)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C427(0.99); C338(1.04); C534(1.18); C496(1.13)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C427(1.11); C338(1.16); C534(1.00); C496(1.20)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C427(0.96); C338(1.13); C534(0.89); C496(1.11)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C427(0.98); C534(1.00); C496(1.10); C209(0.88)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C427(0.83); C338(1.10); C534(0.87); C496(0.93)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C427(1.01); C338(1.19); C534(1.13); C496(1.10)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C427(1.00); C338(1.11); C534(1.01); C496(1.01)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C427(0.96); C338(0.92); C534(1.00); C496(0.94)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C427(1.06); C338(1.40); C534(1.11); C496(0.91)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C427(0.91); C338(1.13); C534(1.04); C496(1.08)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C427(1.10); C338(1.03); C534(1.00); C496(1.03)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C427(1.17); C338(0.84); C534(0.98); C496(1.23)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C427(0.91); C338(1.06); C534(0.99); C496(0.96)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C427(1.14); C338(1.14); C534(1.05); C496(1.13)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C427(1.08); C338(1.06); C534(0.91); C496(1.12)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C427(0.98); C534(1.04); C496(1.16); C209(0.84)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C427(0.89); C338(1.02); C534(0.98); C496(0.88)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C427(1.01); C338(1.06); C534(1.05); C496(1.04)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C427(0.80); C338(1.14); C534(1.05); C496(0.91)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C427(0.92); C338(1.04); C534(1.02); C496(0.98)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C427(1.10); C338(1.32); C534(1.17); C496(1.00)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C427(1.03); C338(0.97); C534(1.15); C496(0.97)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C427(1.19); C338(1.06); C534(1.06); C496(1.22)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C427(0.99); C338(1.01); C534(1.04); C496(1.38)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C427(0.89); C338(0.97); C534(1.05); C496(1.06)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C427(0.98); C338(1.07); C534(0.98); C496(1.08)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C427(1.11); C338(1.05); C534(1.05); C496(1.18)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C427(1.06); C534(0.95); C496(1.29); C209(0.92)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C427(0.87); C338(1.17); C534(0.99); C496(0.92)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C427(1.00); C338(1.31); C534(1.13); C496(1.25)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C427(1.01); C338(1.23); C534(1.12); C496(1.09)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C427(0.87); C338(1.10); C534(1.02); C496(1.14)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C427(0.89); C338(1.15); C534(0.97); C496(1.05)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C427(1.09); C338(1.43); C534(1.12); C496(1.05)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C427(1.21); C338(1.09); C534(1.13); C496(1.18)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C427(1.10); C338(1.36); C534(1.02); C496(1.15)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C427(1.00); C338(1.03); C534(0.97); C496(1.37)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C427(0.91); C338(1.24); C534(1.13); C496(1.18)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C427(0.98); C338(1.16); C534(1.06); C496(1.10)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C427(1.06); C338(1.20); C534(0.88); C496(1.11)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C427(1.08); C534(1.05); C496(1.30); C209(0.89)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C427(0.97); C338(1.35); C534(1.01); C496(1.05)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C427(0.97); C338(1.00); C534(1.06); C496(1.18)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C427(0.97); C338(1.09); C534(1.18); C496(1.13)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C427(0.93); C338(1.17); C534(1.10); C496(0.91)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C427(0.95); C338(1.00); C534(1.04); C496(0.97)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C427(0.99); C338(1.20); C534(1.10); C496(1.04)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C427(1.20); C338(1.19); C534(1.13); C496(1.03)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C427(1.18); C338(1.09); C534(0.99); C496(1.09)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C427(0.86); C338(0.98); C534(1.00); C496(1.03)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C427(1.11); C338(1.23); C534(1.00); C496(1.17)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C427(1.09); C338(1.27); C534(0.96); C496(1.12)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C427(0.84); C534(0.91); C496(1.01); C209(0.74)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C427(1.11); C534(0.93); C496(1.23); C209(0.92)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C427(0.97); C338(1.39); C534(1.08); C496(0.88)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C427(1.07); C338(1.17); C534(1.02); C496(1.11)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C427(1.18); C338(1.17); C534(1.05); C496(1.10)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C427(0.95); C338(1.01); C534(1.09); C496(0.95)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C427(1.01); C338(1.25); C534(1.28); C496(1.02)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C427(1.17); C338(1.02); C534(1.03); C496(1.04)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C427(0.97); C338(1.20); C534(1.00); C496(1.05)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C427(1.08); C338(0.95); C534(1.07); C496(1.16)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C427(0.88); C338(1.06); C534(1.10); C496(0.89)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C427(0.95); C338(1.16); C534(1.02); C496(0.87)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C427(0.88); C338(0.88); C534(0.91); C496(1.10)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C427(1.16); C338(1.28); C534(0.94); C496(1.15)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C427(0.95); C534(0.97); C496(1.23); C209(0.91)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C427(0.95); C338(1.14); C534(0.85); C496(0.91)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C427(0.99); C338(0.97); C534(0.99); C496(1.08)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C427(0.71); C338(0.99); C534(0.84); C496(0.96)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C427(0.86); C338(0.93); C534(1.00); C496(0.93)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C427(0.94); C338(1.04); C534(0.95); C496(0.89)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C427(1.13); C338(1.14); C534(1.04); C496(1.21)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C427(0.86); C338(1.13); C534(1.07); C496(0.91)  LDD1697  [31]
 LDCM0191  Compound 21 HEK-293T 3.56  LDD0508  [26]
 LDCM0190  Compound 34 HEK-293T 3.09  LDD0510  [26]
 LDCM0193  Compound 36 HEK-293T 3.24  LDD0511  [26]
 LDCM0495  E2913 HEK-293T C427(0.94); C338(1.32); C534(1.06); C496(1.01)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C427(2.42); C434(1.16)  LDD1702  [12]
 LDCM0625  F8 Ramos C427(0.62); C496(0.92); C434(0.74)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C427(0.45); C496(0.43); C434(0.51)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C427(0.72); C496(0.12)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C427(0.65); C496(0.62); C434(0.71)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C427(1.29); C496(1.24); C434(1.15)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C427(0.72); C496(1.23); C434(0.57)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C427(0.56); C496(0.51); C434(0.50)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C427(1.09); C496(0.93); C434(0.90)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C427(0.66); C496(0.82); C434(0.91)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C427(1.20); C496(1.22); C434(1.09)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C427(0.63); C496(0.55); C434(0.54)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C427(1.08); C496(1.09); C434(1.21)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C427(1.28); C496(0.94); C434(1.26)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C427(0.45); C496(0.61); C434(0.55)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C427(1.05); C338(1.38); C534(1.12); C496(1.04)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C427(1.03); C496(1.02); C434(1.10)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C427(0.64); C496(0.46); C434(0.51)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C427(1.18); C338(1.19); C534(1.05); C496(1.28)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C427(1.34); C496(1.42); C434(1.48)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C427(1.44); C496(1.16); C434(2.12)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C427(0.37); C496(0.39); C434(0.41)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C427(0.52); C496(0.52); C434(0.49)  LDD2188  [32]
 LDCM0107  IAA HeLa H114(0.00); H374(0.00); C496(0.00); C427(0.00)  LDD0221  [24]
 LDCM0022  KB02 HEK-293T C496(1.18); C427(0.92); C209(0.98); C534(0.96)  LDD1492  [31]
 LDCM0023  KB03 Jurkat C434(4.54)  LDD0315  [17]
 LDCM0024  KB05 G361 C462(1.67)  LDD3311  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C434(0.96)  LDD2102  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C427(1.09); C434(1.41)  LDD2121  [12]
 LDCM0109  NEM HeLa H114(0.00); H171(0.00); H374(0.00); C496(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C434(1.15)  LDD2089  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C427(1.34)  LDD2090  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C434(0.91)  LDD2093  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C427(0.92); C434(0.91)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C434(0.82)  LDD2098  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C427(1.12); C434(0.98)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C427(0.61); C434(0.80)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C427(0.76); C434(0.97)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C427(0.88); C434(0.65)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C434(1.03)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C434(0.64)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C427(1.08); C434(0.95)  LDD2107  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C427(0.81); C434(0.58)  LDD2109  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C427(1.28); C434(0.98)  LDD2111  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C434(0.70)  LDD2115  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C434(0.09)  LDD2118  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C434(1.46)  LDD2119  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C427(0.12)  LDD2122  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C427(0.89); C434(0.87)  LDD2123  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C427(0.39)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C434(0.74)  LDD2125  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C434(1.00)  LDD2127  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C427(1.31); C434(0.96)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C434(0.67)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C427(0.60); C434(0.82)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C434(0.96)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C427(1.32); C434(1.00)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C427(0.97); C434(0.92)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C434(1.75)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C434(0.66)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C434(0.85)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C434(1.18)  LDD2143  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C427(2.14); C434(2.30)  LDD2144  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C434(0.84)  LDD2146  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C427(0.54); C434(0.50)  LDD2148  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C427(0.59); C434(0.46)  LDD2150  [12]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C427(1.89)  LDD2153  [12]
 LDCM0014  Panhematin K562 3.67  LDD0063  [13]
 LDCM0021  THZ1 HeLa S3 C427(1.04)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional glutamate/proline--tRNA ligase (EPRS1) Class-I aminoacyl-tRNA synthetase family P07814
Lysine--tRNA ligase (KARS1) Class-II aminoacyl-tRNA synthetase family Q15046
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein uS2 (RPSA) Universal ribosomal protein uS2 family P08865
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lysine Small molecular drug DB00123

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD042888
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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