Details of the Target

General Information of Target

Target ID LDTP16723
Target Name Putative high mobility group protein B1-like 1 (HMGB1P1)
Gene Name HMGB1P1
Synonyms
HMG1L1; HMGB1L1; Putative high mobility group protein B1-like 1; High mobility group protein B1 pseudogene 1; Putative high mobility group protein 1-like 1; HMG-1L1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCPLTLQVTGLMNVSEPNSSFAFVNEFILQGFTCEWTIQIFLFSLFTTTYALTITGNGAI
AFVLWCDWRLHTPMYMFLGNFSFLEIWYVSSTVPKMLVNFLSEKKNISFAGCFLQFYFFF
SLGTSECLLLTVMAFDQYLAICRPLLYPNIMTGHLCAKLVILCWVCGFLWFLIPIVLISQ
MPFCGPNIIDHVVCDPGPRFALDCVSAPRIQLFCYTLSSLVIFGNFLFIIGSYTLVLKAV
LGMPSSTGRHKAFSTCGSHLAVVSLCYSSLMVMYVSPGLGHSTGMQKIETLFYAMVTPLF
NPLIYSLQNKEIKAALRKVLGSSNII
Target Bioclass
Transcription factor
Family
HMGB family
Subcellular location
Nucleus
Function Binds preferentially single-stranded DNA and unwinds double-stranded DNA.
Uniprot ID
B2RPK0
Ensemble ID
ENST00000522557.2
HGNC ID
HGNC:4993

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D140(10.00)  LDD2209  [1]
BTD
 Probe Info  		C23(0.97)  LDD2090  [2]
HHS-475
 Probe Info  		Y78(1.00); Y155(1.00)  LDD0264  [3]
IPM
 Probe Info  		C23(0.64)  LDD1701  [2]
HHS-465
 Probe Info  		Y16(10.00); Y78(10.00)  LDD2237  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		E116(0.00); H117(0.00)  LDD0236  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0073  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0116  HHS-0101 DM93 Y78(1.00); Y155(1.00)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y155(0.70); Y78(0.89)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y78(0.86); Y155(0.91)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y78(0.93); Y155(0.93)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y155(0.83); Y78(1.04)  LDD0268  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0023  KB03 MDA-MB-231 C23(0.64)  LDD1701  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C23(0.97)  LDD2090  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C23(1.06)  LDD2099  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C23(1.16)  LDD2128  [2]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.