Details of the Target

General Information of Target

Target ID LDTP04895
Target Name Ras-related protein Rab-10 (RAB10)
Gene Name RAB10
Gene ID 10890
Synonyms
Ras-related protein Rab-10; EC 3.6.5.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKKTYDLLFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKL
QIWDTAGQERFHTITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVERMLL
GNKCDMDDKRVVPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILRKTPVKEPN
SENVDISSGGGVTGWKSKCC
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cytoplasmic vesicle membrane
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Also plays a specific role in asymmetric protein transport to the plasma membrane. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane. In epithelial cells, it regulates transport from the Golgi to the basolateral membrane. May play a role in the basolateral recycling pathway and in phagosome maturation. May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion. Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis. When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route.; (Microbial infection) Upon Legionella pneumophila infection promotes endoplasmic reticulum recruitment and bacterial replication. Plays a role in remodeling the Legionella-containing vacuole (LCV) into an endoplasmic reticulum-like vacuole.
Uniprot ID
P61026
Ensemble ID
ENST00000264710.5
HGNC ID
HGNC:9759
ChEMBL ID
CHEMBL4105971

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.77  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.32  LDD0196  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K102(9.20); K136(7.76)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K136(1.90)  LDD3494  [5]
BTD
 Probe Info  		C124(1.15)  LDD1700  [6]
HPAP
 Probe Info  		3.05  LDD0064  [7]
HHS-465
 Probe Info  		Y6(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C124(0.94)  LDD0531  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		Y6(0.00); Y78(0.00)  LDD0028  [14]
TFBX
 Probe Info  		C24(0.00); C124(0.00)  LDD0148  [15]
Acrolein
 Probe Info  		H110(0.00); C124(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
AOyne
 Probe Info  		9.50  LDD0443  [17]
MPP-AC
 Probe Info  		N.A.  LDD0428  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [18]
TPP-AC
 Probe Info  		N.A.  LDD0427  [18]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		5.35  LDD1733  [20]
C040
 Probe Info  		6.50  LDD1740  [20]
C056
 Probe Info  		17.15  LDD1753  [20]
C092
 Probe Info  		17.75  LDD1783  [20]
C220
 Probe Info  		14.03  LDD1894  [20]
C228
 Probe Info  		16.68  LDD1901  [20]
C231
 Probe Info  		12.47  LDD1904  [20]
C232
 Probe Info  		35.02  LDD1905  [20]
C235
 Probe Info  		23.10  LDD1908  [20]
C285
 Probe Info  		19.43  LDD1955  [20]
C289
 Probe Info  		30.27  LDD1959  [20]
C293
 Probe Info  		18.25  LDD1963  [20]
C349
 Probe Info  		11.47  LDD2010  [20]
C350
 Probe Info  		23.75  LDD2011  [20]
C362
 Probe Info  		37.01  LDD2023  [20]
C363
 Probe Info  		22.01  LDD2024  [20]
C388
 Probe Info  		42.81  LDD2047  [20]
FFF probe11
 Probe Info  		11.98  LDD0471  [21]
FFF probe13
 Probe Info  		10.18  LDD0475  [21]
FFF probe14
 Probe Info  		11.92  LDD0477  [21]
FFF probe2
 Probe Info  		6.23  LDD0463  [21]
FFF probe3
 Probe Info  		18.77  LDD0464  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
DA-2
 Probe Info  		N.A.  LDD0070  [23]
OEA-DA
 Probe Info  		4.15  LDD0046  [24]
STS-1
 Probe Info  		N.A.  LDD0068  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C124(0.79)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C124(0.74)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C124(0.74)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C124(1.14)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C124(0.98)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C124(1.37)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C124(0.95)  LDD2103  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C124(0.83)  LDD2131  [6]
 LDCM0214  AC1 HCT 116 C124(0.94)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C124(1.05)  LDD0532  [9]
 LDCM0226  AC11 HCT 116 C124(1.29)  LDD0543  [9]
 LDCM0230  AC113 HCT 116 C124(1.05)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C124(1.02)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C124(0.95)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C124(1.07)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C124(0.94)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C124(1.06)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C124(0.95)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C124(1.34)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C124(1.08)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C124(0.90)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C124(1.13)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C124(0.82)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C124(0.99)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C124(1.21)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C124(1.18)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C124(1.04)  LDD0562  [9]
 LDCM0259  AC14 HCT 116 C124(1.59)  LDD0576  [9]
 LDCM0263  AC143 HCT 116 C124(0.91)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C124(0.91)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C124(1.06)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C124(1.19)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C124(1.01)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C124(1.09)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C124(1.32)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C124(1.06)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C124(1.02)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C124(0.97)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C124(1.00)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C124(1.40)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C124(1.17)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C124(1.07)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C124(1.24)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C124(1.10)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C124(0.85)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C124(1.10)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C124(0.98)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C124(0.72)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C124(0.98)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C124(1.10)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C124(0.92)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C124(1.02)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C124(0.95)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C124(0.85)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C124(0.72)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C124(0.73)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C124(0.80)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C124(0.61)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C124(0.76)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C124(0.58)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C124(0.67)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C124(0.57)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C124(0.82)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C124(1.00)  LDD0612  [9]
 LDCM0296  AC35 HEK-293T C124(1.25)  LDD1535  [26]
 LDCM0297  AC36 HEK-293T C124(1.20)  LDD1536  [26]
 LDCM0298  AC37 HEK-293T C124(1.18)  LDD1537  [26]
 LDCM0299  AC38 HEK-293T C124(1.24)  LDD1538  [26]
 LDCM0300  AC39 HEK-293T C124(1.12)  LDD1539  [26]
 LDCM0301  AC4 HCT 116 C124(0.78)  LDD0618  [9]
 LDCM0302  AC40 HEK-293T C124(1.04)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C124(1.30)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C124(1.21)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C124(1.23)  LDD1544  [26]
 LDCM0306  AC44 HEK-293T C124(1.15)  LDD1545  [26]
 LDCM0307  AC45 HEK-293T C124(1.21)  LDD1546  [26]
 LDCM0308  AC46 HCT 116 C124(0.78)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C124(0.87)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C124(1.22)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C124(0.32)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C124(0.85)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C124(0.50)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C124(1.08)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C124(1.03)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C124(0.48)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C124(0.42)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C124(0.31)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C124(0.32)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C124(1.31)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C124(1.29)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C124(1.17)  LDD1561  [26]
 LDCM0323  AC6 HCT 116 C124(0.82)  LDD0640  [9]
 LDCM0324  AC60 HEK-293T C124(1.13)  LDD1563  [26]
 LDCM0325  AC61 HEK-293T C124(1.25)  LDD1564  [26]
 LDCM0326  AC62 HEK-293T C124(1.17)  LDD1565  [26]
 LDCM0327  AC63 HEK-293T C124(1.07)  LDD1566  [26]
 LDCM0328  AC64 HEK-293T C124(1.08)  LDD1567  [26]
 LDCM0332  AC68 HCT 116 C124(0.91)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C124(1.06)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C124(1.00)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C124(0.83)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C124(1.28)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C124(0.74)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C124(0.82)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C124(1.22)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C124(0.77)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C124(1.12)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C124(0.79)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C124(0.95)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C124(0.80)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C124(0.98)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C124(1.34)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C124(0.79)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C124(1.03)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C124(1.08)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C124(1.10)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C124(1.13)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C124(1.05)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C124(1.03)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C124(1.00)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C124(1.05)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C124(1.05)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C124(1.00)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C124(1.06)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C124(1.07)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C124(1.15)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C124(1.06)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C124(1.08)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C124(0.94)  LDD0681  [9]
 LDCM0545  Acetamide MDA-MB-231 C124(0.49)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C124(0.72)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C124(1.11)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C124(1.28)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C124(0.84)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H110(0.00); C124(0.00); H72(0.00); C24(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C124(20.00)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C124(1.12)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C124(0.85)  LDD1572  [26]
 LDCM0369  CL100 HCT 116 C124(0.89)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C124(0.95)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C124(0.92)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C124(1.27)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C124(1.17)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C124(1.18)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C124(1.39)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C124(1.00)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C124(0.89)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C124(0.99)  LDD0695  [9]
 LDCM0379  CL11 HEK-293T C124(0.73)  LDD1583  [26]
 LDCM0380  CL110 HCT 116 C124(0.77)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C124(0.76)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C124(0.83)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C124(0.59)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C124(0.62)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C124(0.75)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C124(0.94)  LDD0703  [9]
 LDCM0387  CL117 HEK-293T C124(1.25)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C124(1.24)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C124(1.23)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C124(0.71)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C124(1.20)  LDD1595  [26]
 LDCM0392  CL121 HCT 116 C124(0.63)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C124(0.58)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C124(0.42)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C124(0.53)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C124(1.39)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C124(1.17)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C124(1.24)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C124(1.20)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C124(1.24)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C124(1.22)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C124(1.30)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C124(1.18)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C124(1.31)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C124(1.24)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C124(1.22)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C124(1.24)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C124(0.85)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C124(0.90)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C124(0.82)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C124(0.68)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C124(0.67)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C124(1.12)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C124(1.13)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C124(1.22)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C124(1.20)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C124(1.16)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C124(1.09)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C124(1.07)  LDD1623  [26]
 LDCM0420  CL31 HCT 116 C124(1.19)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C124(0.83)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C124(0.94)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C124(0.68)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C124(0.87)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C124(1.30)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C124(0.83)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C124(0.82)  LDD0745  [9]
 LDCM0429  CL4 HEK-293T C124(1.08)  LDD1633  [26]
 LDCM0430  CL40 HCT 116 C124(1.04)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C124(1.03)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C124(0.42)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C124(0.74)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C124(1.02)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C124(0.74)  LDD0752  [9]
 LDCM0436  CL46 HEK-293T C124(0.78)  LDD1640  [26]
 LDCM0437  CL47 HEK-293T C124(0.71)  LDD1641  [26]
 LDCM0438  CL48 HEK-293T C124(0.57)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C124(1.29)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C124(1.16)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C124(1.16)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C124(1.15)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C124(1.28)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C124(1.15)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C124(1.05)  LDD1649  [26]
 LDCM0447  CL56 HEK-293T C124(0.89)  LDD1650  [26]
 LDCM0448  CL57 HEK-293T C124(0.97)  LDD1651  [26]
 LDCM0449  CL58 HEK-293T C124(0.96)  LDD1652  [26]
 LDCM0450  CL59 HEK-293T C124(0.71)  LDD1653  [26]
 LDCM0451  CL6 HEK-293T C124(1.13)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C124(0.64)  LDD1655  [26]
 LDCM0453  CL61 HCT 116 C124(0.95)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C124(0.82)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C124(0.92)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C124(0.86)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C124(0.98)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C124(0.63)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C124(0.95)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C124(0.87)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C124(0.82)  LDD0778  [9]
 LDCM0462  CL7 HEK-293T C124(1.09)  LDD1665  [26]
 LDCM0463  CL70 HCT 116 C124(1.00)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C124(1.10)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C124(1.27)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C124(1.07)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C124(1.13)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C124(0.77)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C124(0.83)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C124(0.83)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C124(0.85)  LDD0789  [9]
 LDCM0473  CL8 HEK-293T C124(0.81)  LDD1676  [26]
 LDCM0474  CL80 HCT 116 C124(0.92)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C124(0.82)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C124(0.67)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C124(0.71)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C124(0.70)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C124(0.68)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C124(0.73)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C124(0.72)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C124(0.85)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C124(0.79)  LDD0800  [9]
 LDCM0484  CL9 HEK-293T C124(0.92)  LDD1687  [26]
 LDCM0485  CL90 HCT 116 C124(0.80)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C124(0.80)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C124(0.83)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C124(1.15)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C124(0.97)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C124(0.81)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C124(0.82)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C124(0.87)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C124(0.93)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C124(0.93)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C124(1.21)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C124(1.19)  LDD1698  [26]
 LDCM0625  F8 Ramos C124(1.50)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C124(0.83)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C124(4.88)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C124(0.85)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C124(1.73)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C124(0.77)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C124(0.68)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C124(1.04)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C124(1.34)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C124(1.44)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C124(0.57)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C124(1.52)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C124(1.28)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C124(1.08)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C124(1.04)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C124(1.43)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C124(1.17)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C124(0.48)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C124(1.09)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C124(1.33)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C124(0.91)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C124(0.55)  LDD2188  [27]
 LDCM0107  IAA HeLa H110(0.00); H72(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C124(0.95)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C124(1.00)  LDD1497  [26]
 LDCM0024  KB05 SNU-869 C124(1.52)  LDD3446  [28]
 LDCM0109  NEM HeLa H110(0.00); H72(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C124(0.78)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C124(0.81)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C124(0.85)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C124(1.12)  LDD2094  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C124(0.82)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C124(1.00)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C124(0.70)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C124(1.05)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C124(1.48)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C124(0.64)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C124(1.05)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C124(0.53)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C124(1.01)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C124(1.05)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C124(1.14)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C124(0.89)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C124(0.63)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C124(0.38)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C124(12.60)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C124(1.66)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C124(0.95)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C124(1.08)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C124(0.48)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C124(0.88)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C124(0.99)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C124(0.85)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C124(0.85)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C124(0.96)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C124(1.21)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C124(1.00)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C124(1.15)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C124(0.86)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C124(0.62)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C124(0.86)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C124(2.13)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C24(2.19)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C124(0.84)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C124(1.44)  LDD2147  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C124(0.43)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C124(1.33)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C124(0.60)  LDD2206  [29]
 LDCM0014  Panhematin hPBMC 3.05  LDD0064  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein phosphatase 1H (PPM1H) PP2C family Q9ULR3
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Ras-related protein Rab-39A (RAB39A) Rab family Q14964
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RILP-like protein 2 (RILPL2) RILPL family Q969X0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.