Details of the Target

General Information of Target

Target ID LDTP03907
Target Name Malate dehydrogenase, cytoplasmic (MDH1)
Gene Name MDH1
Gene ID 4190
Synonyms
MDHA; Malate dehydrogenase, cytoplasmic; EC 1.1.1.37; Aromatic alpha-keto acid reductase; KAR; EC 1.1.1.96; Cytosolic malate dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Target Bioclass
Enzyme
Family
LDH/MDH superfamily, MDH type 2 family
Subcellular location
Cytoplasm
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).
Uniprot ID
P40925
Ensemble ID
ENST00000233114.13
HGNC ID
HGNC:6970
ChEMBL ID
CHEMBL3560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BXPC3 SNV: p.E311D DBIA    Probe Info 
JHH7 SNV: p.Ter335SextTer19 .
NCIH2172 SNV: p.N151D DBIA    Probe Info 
SUPT1 SNV: p.G302C DBIA    Probe Info 
SW1116 SNV: p.D59N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0451  [1]
A-EBA
 Probe Info  		3.64  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
C-Sul
 Probe Info  		3.13  LDD0066  [4]
TH211
 Probe Info  		Y278(20.00); Y192(16.15); Y119(12.67)  LDD0257  [5]
TH214
 Probe Info  		Y192(6.51)  LDD0258  [5]
TH216
 Probe Info  		Y119(15.65); Y192(10.46); Y210(5.66)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K103(6.37); K107(9.46); K110(5.80); K118(10.00)  LDD0277  [7]
AZ-9
 Probe Info  		E222(1.01); E301(1.08)  LDD2208  [8]
ONAyne
 Probe Info  		K110(0.46)  LDD0275  [7]
m-APA
 Probe Info  		10.92  LDD0403  [9]
DBIA
 Probe Info  		C65(1.38); C48(1.23)  LDD3311  [10]
THZ1-DTB
 Probe Info  		C137(1.00)  LDD0460  [11]
BTD
 Probe Info  		C251(3.95); C154(2.25); C137(1.31)  LDD1700  [12]
AHL-Pu-1
 Probe Info  		C251(2.71)  LDD0172  [13]
HHS-482
 Probe Info  		Y192(0.83); Y210(1.09)  LDD0285  [14]
HHS-475
 Probe Info  		Y210(0.69)  LDD0264  [15]
HHS-465
 Probe Info  		Y210(10.00)  LDD2237  [16]
5E-2FA
 Probe Info  		N.A.  LDD2235  [17]
AMP probe
 Probe Info  		N.A.  LDD0200  [18]
ATP probe
 Probe Info  		K239(0.00); K107(0.00); K142(0.00); K118(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C251(0.00); C154(0.00); C137(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C137(0.00); C154(0.00); C251(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C251(0.00); C154(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C137(0.00); C154(0.00); C251(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C154(0.00); C137(0.00); C251(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K107(0.00); K298(0.00); K239(0.00)  LDD0035  [22]
IPM
 Probe Info  		C137(0.00); C154(0.00)  LDD0025  [23]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [23]
NAIA_4
 Probe Info  		C137(0.00); C154(0.00)  LDD2226  [24]
TFBX
 Probe Info  		C154(0.00); C137(0.00)  LDD0027  [23]
WYneN
 Probe Info  		N.A.  LDD0021  [25]
Compound 10
 Probe Info  		C137(0.00); C154(0.00)  LDD2216  [26]
NHS
 Probe Info  		K205(0.00); K318(0.00)  LDD0010  [25]
PF-06672131
 Probe Info  		N.A.  LDD0152  [27]
PPMS
 Probe Info  		N.A.  LDD0008  [25]
SF
 Probe Info  		K103(0.00); K118(0.00); K239(0.00)  LDD0028  [28]
Ox-W18
 Probe Info  		W184(0.00); W218(0.00)  LDD2175  [29]
1c-yne
 Probe Info  		K125(0.00); K142(0.00); K170(0.00); K179(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		C137(0.00); C154(0.00); C251(0.00)  LDD0217  [31]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [31]
Crotonaldehyde
 Probe Info  		C154(0.00); C251(0.00); C137(0.00)  LDD0219  [31]
Methacrolein
 Probe Info  		C137(0.00); C154(0.00); C251(0.00)  LDD0218  [31]
NAIA_5
 Probe Info  		C251(0.00); C154(0.00); C137(0.00)  LDD2223  [24]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		3.78  LDD0136  [32]
STS-2
 Probe Info  		2.67  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
DA-2
 Probe Info  		N.A.  LDD0071  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C251(0.58); C137(0.51)  LDD2142  [12]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C251(0.81); C137(0.59)  LDD2112  [12]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C154(0.51); C251(0.42); C137(0.38)  LDD2095  [12]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C251(1.18); C137(0.91)  LDD2130  [12]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C154(1.11); C251(1.46)  LDD2117  [12]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C154(1.27); C251(1.45); C137(1.16)  LDD2152  [12]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C137(1.06)  LDD2103  [12]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C154(0.33); C251(0.39)  LDD2132  [12]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C154(0.64); C251(0.70)  LDD2131  [12]
 LDCM0025  4SU-RNA HEK-293T C251(2.71)  LDD0172  [13]
 LDCM0214  AC1 HEK-293T C154(1.00); C137(0.90); C251(0.90)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C154(0.94); C137(0.88); C251(0.95)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C154(0.94); C137(1.02); C251(1.08)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C154(0.94); C137(0.99); C251(1.03)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C154(1.03); C137(1.04); C251(1.05)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C154(1.02); C137(1.02); C251(1.03)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C154(0.95); C137(0.97); C251(0.90)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C154(0.93); C137(0.95); C251(0.91)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C154(0.85); C137(0.86); C251(0.82)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C154(0.96); C137(0.91); C251(0.94)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C154(1.02); C137(1.04); C251(0.99)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C154(1.07); C137(1.07)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C154(1.00); C137(1.12); C251(1.00)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C154(0.99); C137(1.15); C251(0.86)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C154(1.01); C137(1.06)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C154(0.94); C137(0.89); C251(0.84)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C154(1.02); C137(1.00); C251(1.06)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C154(0.94); C137(1.08); C251(0.94)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C154(1.05); C137(1.08); C251(1.03)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C154(1.11); C137(1.02)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C154(0.94); C137(0.97); C251(1.12)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C154(1.00); C137(1.19); C251(1.01)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C154(1.07); C137(1.09); C251(1.12)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C154(0.95); C137(0.95)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C154(0.93); C137(0.85); C251(0.83)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C154(1.01); C137(0.97); C251(1.00)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C154(1.00); C137(0.93); C251(0.95)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C154(1.02); C137(1.05); C251(1.03)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C154(1.15); C137(0.98)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C154(1.10); C137(1.10); C251(1.07)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C154(0.96); C137(0.96); C251(0.91)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C154(1.06); C137(1.05); C251(1.06)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C154(0.97); C137(0.97)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C154(0.92); C137(0.97); C251(0.85)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C154(0.96); C137(0.91); C251(0.99)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C154(0.97); C137(0.94); C251(1.13)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C154(0.97); C137(1.08); C251(1.03)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C154(1.10); C137(0.95)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C154(1.05); C137(1.06); C251(1.10)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C154(1.05); C137(1.11); C251(0.91)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C154(0.95); C137(1.04)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C154(0.91); C137(1.09); C251(0.92)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C154(1.03); C137(1.10)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C154(0.98); C137(0.99); C251(1.12)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C154(1.00); C137(0.96); C251(1.06)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C154(0.95); C137(0.99); C251(1.00)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C154(1.06); C137(1.02)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C154(1.06); C137(1.11); C251(1.06)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C154(1.03); C137(1.05); C251(0.95)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C154(1.01); C137(1.02)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C154(0.93); C137(0.95); C251(0.87)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C154(1.01); C137(0.97); C251(1.14)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C154(1.04); C137(1.08); C251(1.05)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C154(1.03); C137(0.95); C251(0.91)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C154(0.97); C137(1.00); C251(1.06)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C154(1.02); C137(1.15)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C154(1.02); C137(1.10); C251(0.96)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C154(0.96); C137(1.03); C251(1.03)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C154(1.01); C137(1.12)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C154(1.04); C137(1.04); C251(1.11)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C154(1.01); C137(0.97)  LDD1569  [35]
 LDCM0545  Acetamide MDA-MB-231 C154(0.67); C251(0.61)  LDD2138  [12]
 LDCM0520  AKOS000195272 MDA-MB-231 C251(0.96); C137(0.71)  LDD2113  [12]
 LDCM0248  AKOS034007472 HEK-293T C154(1.10); C137(1.07)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C154(0.89); C137(0.96); C251(0.88)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C154(0.97); C137(0.97)  LDD1514  [35]
 LDCM0156  Aniline NCI-H1299 10.92  LDD0403  [9]
 LDCM0498  BS-3668 MDA-MB-231 C154(0.75); C251(0.96); C137(0.54)  LDD2091  [12]
 LDCM0108  Chloroacetamide HeLa C137(0.00); C154(0.00); C251(0.00); H197(0.00)  LDD0222  [31]
 LDCM0367  CL1 HEK-293T C154(0.94); C137(0.97); C251(0.86)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C154(0.83); C137(0.94); C251(0.99)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C154(0.94); C137(0.92)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C154(0.91); C137(1.01); C251(0.98)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C154(0.93); C137(0.88); C251(0.96)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C154(0.93); C137(1.01); C251(1.01)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C154(1.01); C137(0.95)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C154(0.97); C137(0.99); C251(1.03)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C154(1.04); C137(0.95); C251(0.89)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C154(0.98); C137(1.14); C251(1.05)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C154(0.98); C137(1.03)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C154(0.94); C137(0.98); C251(1.03)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C154(1.12); C137(1.01); C251(0.79)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C154(0.86); C137(0.96); C251(0.91)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C154(0.91); C137(1.05); C251(0.95)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C154(0.98); C137(1.08)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C154(0.93); C137(0.95); C251(0.96)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C154(0.93); C137(1.05); C251(0.98)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C154(1.00); C137(1.10); C251(1.11)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C154(1.04); C137(1.04)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C154(0.97); C137(0.95); C251(1.01)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C154(1.08); C137(1.13); C251(1.08)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C154(1.03); C137(1.09); C251(1.14)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C154(0.95); C137(0.92)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C154(0.94); C137(0.99)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C154(0.94); C137(1.02); C251(0.95)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C154(1.02); C137(0.96); C251(0.94)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C154(0.92); C137(1.11); C251(0.91)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C154(0.95); C137(0.96)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C154(1.03); C137(1.11); C251(0.94)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C154(0.99); C137(1.06); C251(1.05)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C154(0.95); C137(1.13); C251(1.03)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C154(1.03); C137(1.09)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C154(0.83); C137(0.85); C251(0.78)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C154(1.05); C137(0.84); C251(0.92)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C154(0.83); C137(0.97); C251(0.71)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C154(0.99); C137(0.97)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C154(0.80); C137(0.77); C251(0.69)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C154(0.97); C137(0.89); C251(1.00)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C154(0.88); C137(0.79); C251(0.99)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C154(1.03); C137(0.91); C251(0.89)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C154(0.95); C137(0.97); C251(0.98)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C154(0.91); C137(1.02)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C154(1.04); C137(1.12); C251(1.20)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C154(1.03); C137(1.00); C251(0.88)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C154(1.01); C137(0.95)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C154(0.89); C137(0.94); C251(0.84)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C154(0.95); C137(0.93); C251(0.99)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C154(0.94); C137(1.08); C251(1.02)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C154(0.89); C137(0.95)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C154(1.04); C137(0.91); C251(0.92)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C154(0.98); C137(1.10); C251(0.92)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C154(1.02); C137(1.02); C251(1.12)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C154(0.92); C137(0.87); C251(0.92)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C154(1.01); C137(1.03); C251(0.99)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C154(0.95); C137(1.03)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C154(1.03); C137(1.13); C251(1.15)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C154(0.95); C137(1.06); C251(1.03)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C154(1.03); C137(1.10)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C154(0.92); C137(0.95); C251(0.95)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C154(0.97); C137(1.03); C251(1.01)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C154(0.96); C137(0.91)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C154(0.99); C137(0.97)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C154(0.90); C137(1.00); C251(0.89)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C154(1.01); C137(1.02); C251(1.13)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C154(1.08); C137(1.06); C251(1.22)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C154(1.02); C137(1.02); C251(1.07)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C154(1.03); C137(1.02)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C154(1.10); C137(1.08); C251(1.25)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C154(1.07); C137(0.99); C251(0.89)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C154(0.99); C137(1.03)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C154(1.09); C137(1.06); C251(1.01)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C154(0.92); C137(0.83); C251(0.87)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C154(0.92); C137(0.88); C251(1.02)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C154(1.01); C137(0.88)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C154(0.93); C137(0.94); C251(0.81)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C154(0.91); C137(0.91); C251(0.98)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C154(1.09); C137(0.91); C251(1.10)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C154(1.01); C137(0.99); C251(1.14)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C154(1.02); C137(1.02)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C154(0.98); C137(1.01); C251(1.26)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C154(1.07); C137(1.08); C251(0.98)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C154(0.83); C137(0.75); C251(0.76)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C154(1.01); C137(1.08)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C154(0.96); C137(1.02); C251(0.96)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C154(0.97); C137(1.06); C251(1.05)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C154(0.98); C137(1.00); C251(1.02)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C154(0.92); C137(0.84)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C154(0.92); C137(0.85); C251(0.85)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C154(0.97); C137(0.91); C251(1.01)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C154(1.02); C137(0.94); C251(1.10)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C154(1.03); C137(1.04); C251(1.07)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C154(1.08); C137(1.08)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C154(0.92); C137(0.78); C251(0.98)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C154(1.07); C137(1.01); C251(1.15)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C154(1.11); C137(1.04); C251(0.98)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C154(0.91); C137(1.00)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C154(0.98); C137(1.02); C251(0.97)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C154(1.09); C137(1.08); C251(1.00)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C154(1.07); C137(1.06)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C154(0.86); C137(0.96); C251(0.86)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C154(1.01); C137(0.99); C251(1.13)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C154(1.05); C137(1.15); C251(1.13)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C154(0.75); C137(0.81); C251(0.71)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C154(1.18); C137(1.16); C251(1.28)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C154(1.19); C137(0.99)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C154(1.19); C137(1.25); C251(1.34)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C154(1.12); C137(1.14); C251(1.01)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C154(1.05); C137(1.11)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C154(0.94); C137(1.00); C251(0.89)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C154(0.99); C137(0.98); C251(0.97)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C154(0.97); C137(1.17); C251(1.02)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C154(1.04); C137(0.95)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C154(1.01); C137(0.89); C251(0.95)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C154(0.96); C137(0.94)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C154(0.76); C137(0.82); C251(0.68)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C154(1.04); C137(1.03); C251(1.18)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C154(0.92); C137(0.98); C251(1.03)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C154(0.94); C137(1.21)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C154(1.08); C137(1.10); C251(1.14)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C154(0.89); C137(0.87); C251(0.71)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C154(0.98); C137(1.15)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C154(0.86); C137(0.94); C251(0.95)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C154(0.96); C137(0.90); C251(1.12)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C154(0.98); C137(1.10); C251(0.99)  LDD1697  [35]
 LDCM0495  E2913 HEK-293T C154(0.94); C137(0.99); C251(0.91)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C251(2.38)  LDD1702  [12]
 LDCM0625  F8 Ramos C154(0.96); C137(0.72); C251(0.70)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C154(0.53); C137(0.39); C251(1.01)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C154(0.36); C137(0.28)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C154(0.52); C137(0.37); C251(1.05)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C154(1.10); C137(0.83); C251(1.36)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C154(0.89); C137(0.81); C251(0.74)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C154(0.46); C137(0.34); C251(1.05)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C154(0.97); C137(0.63); C251(1.29)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C154(1.15); C137(0.85); C251(1.60)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C154(0.98); C137(0.74); C251(1.18)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C154(0.67); C137(2.00); C251(0.65)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C154(1.16); C137(0.86); C251(1.70)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C154(1.49); C137(1.01); C251(1.61)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C154(0.55); C137(0.41); C251(0.95)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C154(0.99); C137(1.20); C251(1.11)  LDD1671  [35]
 LDCM0596  Fragment38 Ramos C154(1.01); C137(1.36); C251(1.55)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C154(0.80); C137(0.83); C251(0.64)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C154(0.97); C137(1.00); C251(1.05)  LDD1631  [35]
 LDCM0610  Fragment52 Ramos C154(1.17); C137(3.93); C251(1.65)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C154(1.47); C137(1.24); C251(2.18)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C154(0.55); C137(0.55); C251(0.93)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C154(0.47); C137(0.34); C251(0.75)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y210(0.69)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y210(0.76)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y210(0.98)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y210(0.97)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y210(1.02)  LDD0268  [15]
 LDCM0107  IAA HeLa C137(0.00); C154(0.00); C251(0.00); H253(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y192(0.83); Y210(1.09)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y192(0.52); Y210(0.59)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y192(0.85); Y210(1.01)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y192(3.44); Y210(3.81)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y192(1.92); Y210(2.59)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y192(0.67); Y210(1.72)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y192(0.66); Y210(0.80)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y192(0.62); Y210(0.87)  LDD0292  [14]
 LDCM0022  KB02 HEK-293T C251(1.01); C154(1.07); C137(1.00)  LDD1492  [35]
 LDCM0023  KB03 HEK-293T C251(0.93); C154(1.02); C137(0.96)  LDD1497  [35]
 LDCM0024  KB05 G361 C65(1.38); C48(1.23)  LDD3311  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C251(1.14); C137(1.15)  LDD2102  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C154(0.93); C251(0.96); C137(0.56)  LDD2121  [12]
 LDCM0109  NEM HeLa C137(0.00); H187(0.00); C251(0.00); C154(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C154(0.92); C251(1.07); C137(0.65)  LDD2089  [12]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C251(0.94); C137(1.06)  LDD2090  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C251(1.30)  LDD2092  [12]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C154(1.22); C251(1.32); C137(0.96)  LDD2093  [12]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C251(2.93)  LDD2094  [12]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C154(0.53); C251(0.94); C137(0.63)  LDD2097  [12]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C251(0.95)  LDD2098  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C251(1.47); C137(0.74)  LDD2099  [12]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C251(0.56); C137(0.37)  LDD2100  [12]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C154(1.95); C251(1.06); C137(0.89)  LDD2101  [12]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C251(0.52)  LDD2104  [12]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C251(1.54); C137(1.13)  LDD2105  [12]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C251(0.66); C137(0.60)  LDD2106  [12]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C154(0.99); C251(1.05); C137(0.81)  LDD2107  [12]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C251(0.82); C137(0.56)  LDD2108  [12]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C154(0.69); C251(0.68); C137(0.48)  LDD2109  [12]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C137(0.59)  LDD2110  [12]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C154(1.13); C251(1.37); C137(0.84)  LDD2111  [12]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C251(0.61); C137(0.72)  LDD2114  [12]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C154(0.95); C251(0.57); C137(0.53)  LDD2115  [12]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C251(0.03); C137(0.54)  LDD2116  [12]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C251(0.04); C137(0.61)  LDD2118  [12]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C154(2.32); C251(2.15); C137(2.68)  LDD2119  [12]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C154(0.71); C251(0.38); C137(0.95)  LDD2120  [12]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C137(0.33)  LDD2122  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C154(0.95); C137(0.74)  LDD2123  [12]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C154(0.36); C251(0.02); C137(0.25)  LDD2124  [12]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C154(1.00); C251(0.90); C137(0.67)  LDD2125  [12]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C137(0.25)  LDD2126  [12]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C154(1.11); C251(1.23); C137(0.88)  LDD2127  [12]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C251(0.60); C137(0.96)  LDD2128  [12]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C154(1.22); C251(1.19); C137(1.01)  LDD2129  [12]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C154(0.88); C251(0.67); C137(0.57)  LDD2133  [12]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C251(0.53); C137(0.48)  LDD2134  [12]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C154(1.62); C251(1.85); C137(1.03)  LDD2135  [12]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C154(1.27); C251(1.44); C137(0.82)  LDD2136  [12]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C154(1.01); C251(1.10); C137(0.78)  LDD2137  [12]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C251(3.95); C154(2.25); C137(1.31)  LDD1700  [12]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C154(0.90); C251(1.03); C137(0.56)  LDD2140  [12]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C154(0.21); C251(0.57); C137(0.47)  LDD2141  [12]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C154(0.81); C251(0.38)  LDD2143  [12]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C154(2.62); C251(2.19); C137(1.96)  LDD2144  [12]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C154(0.12); C251(0.19); C137(0.13)  LDD2145  [12]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C154(0.99); C251(1.14); C137(0.87)  LDD2146  [12]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C154(2.02); C251(1.22); C137(2.95)  LDD2147  [12]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C251(0.52); C137(0.50)  LDD2148  [12]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C137(0.35)  LDD2149  [12]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C251(0.77); C137(0.43)  LDD2150  [12]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C251(0.03)  LDD2151  [12]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C154(1.49); C251(2.57); C137(1.35)  LDD2153  [12]
 LDCM0131  RA190 MM1.R C251(1.37); C137(1.20)  LDD0304  [37]
 LDCM0021  THZ1 HeLa S3 C137(1.00)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 1 (TERF1) . P54274

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nicotinamide Adenine Dinucleotide Phosphate . DB03461

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
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Mass spectrometry data entry: PXD028270
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Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD001377 , PXD005252
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