Details of the Target

General Information of Target

Target ID LDTP06584
Target Name Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)
Gene Name CPSF6
Gene ID 11052
Synonyms
CFIM68; Cleavage and polyadenylation specificity factor subunit 6; Cleavage and polyadenylation specificity factor 68 kDa subunit; CPSF 68 kDa subunit; Cleavage factor Im complex 68 kDa subunit; CFIm68; Pre-mRNA cleavage factor Im 68 kDa subunit; Protein HPBRII-4/7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGVDHIDIYADVGEEFNQEAEYGGHDQIDLYDDVISPSANNGDAPEDRDYMDTLPPTV
GDDVGKGAAPNVVYTYTGKRIALYIGNLTWWTTDEDLTEAVHSLGVNDILEIKFFENRAN
GQSKGFALVGVGSEASSKKLMDLLPKRELHGQNPVVTPCNKQFLSQFEMQSRKTTQSGQM
SGEGKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPP
LGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPV
PGYGPPPGPPPPQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPA
FFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGREMDTARTPLSEAEFEEIMNR
NRAISSSAISRAVSDASAGDYGSAIETLVTAISLIKQSKVSADDRCKVLISSLQDCLHGI
ESKSYGSGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDR
ERDREREYRHR
Target Bioclass
Other
Family
RRM CPSF6/7 family
Subcellular location
Nucleus
Function
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export.; (Microbial infection) Binds HIV-1 capsid-nucleocapsid (HIV-1 CA-NC) complexes and might thereby promote the integration of the virus in the nucleus of dividing cells (in vitro).
Uniprot ID
Q16630
Ensemble ID
ENST00000266679.8
HGNC ID
HGNC:13871

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.E492K DBIA    Probe Info 
HEC1 SNV: p.M53T DBIA    Probe Info 
JHH4 SNV: p.Y548H DBIA    Probe Info 
JURKAT SNV: p.T372I Compound 10    Probe Info 
KMCH1 SNV: p.P240S DBIA    Probe Info 
MEWO SNV: p.R326C; p.S425L DBIA    Probe Info 
NCIH358 SNV: p.S425L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.04  LDD0402  [1]
TH211
 Probe Info  		Y395(20.00)  LDD0257  [2]
Probe 1
 Probe Info  		Y52(7.00); Y74(122.03); Y76(278.26); Y395(18.61)  LDD3495  [3]
DBIA
 Probe Info  		C159(1.13)  LDD3310  [4]
SAHA-CA-4PAP
 Probe Info  		5.50  LDD0269  [5]
AHL-Pu-1
 Probe Info  		C159(3.01)  LDD0169  [6]
HHS-475
 Probe Info  		Y390(0.85); Y441(0.94)  LDD0264  [7]
5E-2FA
 Probe Info  		H150(0.00); H478(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C159(0.00); C476(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C159(0.00); C476(0.00)  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C159(0.00); C476(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
BTD
 Probe Info  		N.A.  LDD0004  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		C476(0.00); C159(0.00)  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
aHNE
 Probe Info  		N.A.  LDD0001  [14]
Compound 10
 Probe Info  		C159(0.00); C476(0.00)  LDD2216  [17]
Compound 11
 Probe Info  		C159(0.00); C476(0.00)  LDD2213  [17]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
SF
 Probe Info  		Y395(0.00); Y384(0.00); Y76(0.00); Y390(0.00)  LDD0028  [18]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1c-yne
 Probe Info  		N.A.  LDD0228  [20]
Acrolein
 Probe Info  		C476(0.00); C159(0.00); H478(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C476(0.00); C159(0.00)  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
NAIA_5
 Probe Info  		C159(0.00); C476(0.00)  LDD2223  [16]
HHS-465
 Probe Info  		K79(0.00); Y74(0.00); Y384(0.00); Y390(0.00)  LDD2240  [23]
HHS-482
 Probe Info  		Y384(0.81); Y390(0.66); Y395(0.77); Y76(1.37)  LDD2239  [24]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.70  LDD0475  [25]
FFF probe3
 Probe Info  		6.05  LDD0465  [25]
FFF probe9
 Probe Info  		8.16  LDD0470  [25]
DA-2
 Probe Info  		N.A.  LDD0073  [26]
STS-1
 Probe Info  		N.A.  LDD0068  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C159(0.67); C466(0.26)  LDD2142  [28]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C159(0.86)  LDD2112  [28]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C159(0.62)  LDD2095  [28]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C159(0.97)  LDD2130  [28]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C159(0.90); C466(1.00); C476(1.10)  LDD2117  [28]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C159(1.29); C466(1.54)  LDD2152  [28]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C159(0.86); C466(1.13)  LDD2103  [28]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C466(0.27); C476(0.47)  LDD2132  [28]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C159(0.61)  LDD2131  [28]
 LDCM0026  4SU-RNA+native RNA HEK-293T C159(3.01)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C159(1.00); C476(0.88)  LDD1507  [29]
 LDCM0215  AC10 HEK-293T C159(0.99); C476(0.89)  LDD1508  [29]
 LDCM0226  AC11 HEK-293T C159(0.93); C476(0.94)  LDD1509  [29]
 LDCM0237  AC12 HEK-293T C159(0.89); C476(0.92)  LDD1510  [29]
 LDCM0259  AC14 HEK-293T C159(1.02); C476(0.96)  LDD1512  [29]
 LDCM0270  AC15 HEK-293T C159(0.95); C476(0.95)  LDD1513  [29]
 LDCM0276  AC17 HEK-293T C159(1.06); C476(0.90)  LDD1515  [29]
 LDCM0277  AC18 HEK-293T C159(1.05); C476(0.90)  LDD1516  [29]
 LDCM0278  AC19 HEK-293T C159(0.91); C476(0.84)  LDD1517  [29]
 LDCM0279  AC2 HEK-293T C159(1.01); C476(0.96)  LDD1518  [29]
 LDCM0280  AC20 HEK-293T C159(0.98); C476(0.96)  LDD1519  [29]
 LDCM0281  AC21 HEK-293T C159(1.04); C476(0.94)  LDD1520  [29]
 LDCM0282  AC22 HEK-293T C159(1.02); C476(1.00)  LDD1521  [29]
 LDCM0283  AC23 HEK-293T C159(1.04); C476(1.01)  LDD1522  [29]
 LDCM0284  AC24 HEK-293T C159(0.98); C476(0.96)  LDD1523  [29]
 LDCM0285  AC25 HEK-293T C159(1.03); C476(0.89)  LDD1524  [29]
 LDCM0286  AC26 HEK-293T C159(1.00); C476(0.89)  LDD1525  [29]
 LDCM0287  AC27 HEK-293T C159(0.95); C476(0.92)  LDD1526  [29]
 LDCM0288  AC28 HEK-293T C159(0.93); C476(1.04)  LDD1527  [29]
 LDCM0289  AC29 HEK-293T C159(1.02); C476(0.93)  LDD1528  [29]
 LDCM0290  AC3 HEK-293T C159(0.99); C476(0.98)  LDD1529  [29]
 LDCM0291  AC30 HEK-293T C159(1.06); C476(0.93)  LDD1530  [29]
 LDCM0292  AC31 HEK-293T C159(0.95); C476(0.94)  LDD1531  [29]
 LDCM0293  AC32 HEK-293T C159(0.90); C476(0.92)  LDD1532  [29]
 LDCM0294  AC33 HEK-293T C159(0.97); C476(1.00)  LDD1533  [29]
 LDCM0295  AC34 HEK-293T C159(0.97); C476(0.88)  LDD1534  [29]
 LDCM0296  AC35 HEK-293T C159(0.94); C476(0.92)  LDD1535  [29]
 LDCM0297  AC36 HEK-293T C159(0.86); C476(0.94)  LDD1536  [29]
 LDCM0298  AC37 HEK-293T C159(1.00); C476(1.01)  LDD1537  [29]
 LDCM0299  AC38 HEK-293T C159(1.01); C476(0.99)  LDD1538  [29]
 LDCM0300  AC39 HEK-293T C159(0.93); C476(0.94)  LDD1539  [29]
 LDCM0301  AC4 HEK-293T C159(0.89); C476(1.04)  LDD1540  [29]
 LDCM0302  AC40 HEK-293T C159(0.91); C476(0.95)  LDD1541  [29]
 LDCM0303  AC41 HEK-293T C159(0.96); C476(0.92)  LDD1542  [29]
 LDCM0304  AC42 HEK-293T C159(0.93); C476(0.82)  LDD1543  [29]
 LDCM0305  AC43 HEK-293T C159(0.87); C476(0.94)  LDD1544  [29]
 LDCM0306  AC44 HEK-293T C159(0.88); C476(0.90)  LDD1545  [29]
 LDCM0307  AC45 HEK-293T C159(0.88); C476(0.93)  LDD1546  [29]
 LDCM0308  AC46 HEK-293T C159(0.93); C476(0.87)  LDD1547  [29]
 LDCM0309  AC47 HEK-293T C159(0.88); C476(0.90)  LDD1548  [29]
 LDCM0310  AC48 HEK-293T C159(0.82); C476(0.98)  LDD1549  [29]
 LDCM0311  AC49 HEK-293T C159(1.00); C476(0.88)  LDD1550  [29]
 LDCM0312  AC5 HEK-293T C159(0.99); C476(1.07)  LDD1551  [29]
 LDCM0313  AC50 HEK-293T C159(0.97); C476(1.03)  LDD1552  [29]
 LDCM0314  AC51 HEK-293T C159(0.93); C476(1.05)  LDD1553  [29]
 LDCM0315  AC52 HEK-293T C159(0.90); C476(0.92)  LDD1554  [29]
 LDCM0316  AC53 HEK-293T C159(0.97); C476(0.98)  LDD1555  [29]
 LDCM0317  AC54 HEK-293T C159(1.06); C476(0.92)  LDD1556  [29]
 LDCM0318  AC55 HEK-293T C159(0.94); C476(0.98)  LDD1557  [29]
 LDCM0319  AC56 HEK-293T C159(0.88); C476(0.94)  LDD1558  [29]
 LDCM0320  AC57 HEK-293T C159(0.95); C476(0.82)  LDD1559  [29]
 LDCM0321  AC58 HEK-293T C159(0.90); C476(0.89)  LDD1560  [29]
 LDCM0322  AC59 HEK-293T C159(0.91); C476(0.94)  LDD1561  [29]
 LDCM0323  AC6 HEK-293T C159(1.07); C476(0.91)  LDD1562  [29]
 LDCM0324  AC60 HEK-293T C159(0.89); C476(0.89)  LDD1563  [29]
 LDCM0325  AC61 HEK-293T C159(0.95); C476(0.89)  LDD1564  [29]
 LDCM0326  AC62 HEK-293T C159(0.98); C476(0.90)  LDD1565  [29]
 LDCM0327  AC63 HEK-293T C159(0.88); C476(0.88)  LDD1566  [29]
 LDCM0328  AC64 HEK-293T C159(0.88); C476(0.93)  LDD1567  [29]
 LDCM0334  AC7 HEK-293T C159(0.96); C476(0.99)  LDD1568  [29]
 LDCM0345  AC8 HEK-293T C159(0.90); C476(0.93)  LDD1569  [29]
 LDCM0545  Acetamide MDA-MB-231 C159(0.42)  LDD2138  [28]
 LDCM0520  AKOS000195272 MDA-MB-231 C159(0.75); C466(0.73)  LDD2113  [28]
 LDCM0248  AKOS034007472 HEK-293T C159(0.90); C476(1.01)  LDD1511  [29]
 LDCM0356  AKOS034007680 HEK-293T C159(1.02); C476(0.86)  LDD1570  [29]
 LDCM0275  AKOS034007705 HEK-293T C159(0.90); C476(0.99)  LDD1514  [29]
 LDCM0156  Aniline NCI-H1299 11.34  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C159(0.46); C466(0.70)  LDD2091  [28]
 LDCM0630  CCW28-3 231MFP C159(1.39)  LDD2214  [30]
 LDCM0108  Chloroacetamide HeLa C476(0.00); C159(0.00); H517(0.00); C466(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C159(2.32); C476(0.91); C159(0.90)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C159(0.97); C476(0.92)  LDD1571  [29]
 LDCM0368  CL10 HEK-293T C159(1.03); C476(0.78)  LDD1572  [29]
 LDCM0369  CL100 HEK-293T C159(0.97); C476(0.93)  LDD1573  [29]
 LDCM0370  CL101 HEK-293T C159(0.94); C476(0.84)  LDD1574  [29]
 LDCM0371  CL102 HEK-293T C159(0.81); C476(0.84)  LDD1575  [29]
 LDCM0372  CL103 HEK-293T C159(0.92); C476(1.02)  LDD1576  [29]
 LDCM0373  CL104 HEK-293T C159(0.95); C476(1.06)  LDD1577  [29]
 LDCM0374  CL105 HEK-293T C159(0.99); C476(0.97)  LDD1578  [29]
 LDCM0375  CL106 HEK-293T C159(0.95); C476(0.91)  LDD1579  [29]
 LDCM0376  CL107 HEK-293T C159(1.03); C476(0.99)  LDD1580  [29]
 LDCM0377  CL108 HEK-293T C159(1.05); C476(1.05)  LDD1581  [29]
 LDCM0378  CL109 HEK-293T C159(1.00); C476(0.87)  LDD1582  [29]
 LDCM0379  CL11 HEK-293T C159(0.87); C476(0.90)  LDD1583  [29]
 LDCM0380  CL110 HEK-293T C159(0.82); C476(0.85)  LDD1584  [29]
 LDCM0381  CL111 HEK-293T C159(0.95); C476(0.86)  LDD1585  [29]
 LDCM0382  CL112 HEK-293T C159(1.04); C476(0.84)  LDD1586  [29]
 LDCM0383  CL113 HEK-293T C159(0.95); C476(0.97)  LDD1587  [29]
 LDCM0384  CL114 HEK-293T C159(0.78); C476(0.82)  LDD1588  [29]
 LDCM0385  CL115 HEK-293T C159(0.89); C476(0.98)  LDD1589  [29]
 LDCM0386  CL116 HEK-293T C159(0.99); C476(0.92)  LDD1590  [29]
 LDCM0387  CL117 HEK-293T C159(0.88); C476(0.93)  LDD1591  [29]
 LDCM0388  CL118 HEK-293T C159(0.86); C476(0.89)  LDD1592  [29]
 LDCM0389  CL119 HEK-293T C159(0.90); C476(1.02)  LDD1593  [29]
 LDCM0390  CL12 HEK-293T C159(0.95); C476(0.92)  LDD1594  [29]
 LDCM0391  CL120 HEK-293T C159(0.87); C476(1.02)  LDD1595  [29]
 LDCM0392  CL121 HEK-293T C159(0.95); C476(0.92)  LDD1596  [29]
 LDCM0393  CL122 HEK-293T C159(0.89); C476(0.96)  LDD1597  [29]
 LDCM0394  CL123 HEK-293T C159(0.82); C476(0.90)  LDD1598  [29]
 LDCM0395  CL124 HEK-293T C159(0.89); C476(0.96)  LDD1599  [29]
 LDCM0396  CL125 HEK-293T C159(0.81); C476(0.82)  LDD1600  [29]
 LDCM0397  CL126 HEK-293T C159(0.90); C476(0.84)  LDD1601  [29]
 LDCM0398  CL127 HEK-293T C159(0.89); C476(0.94)  LDD1602  [29]
 LDCM0399  CL128 HEK-293T C159(0.88); C476(0.77)  LDD1603  [29]
 LDCM0400  CL13 HEK-293T C159(0.90); C476(0.94)  LDD1604  [29]
 LDCM0401  CL14 HEK-293T C159(0.85); C476(0.96)  LDD1605  [29]
 LDCM0402  CL15 HEK-293T C159(0.83); C476(0.88)  LDD1606  [29]
 LDCM0403  CL16 HEK-293T C159(1.01); C476(1.20)  LDD1607  [29]
 LDCM0404  CL17 HEK-293T C159(0.98); C476(0.85)  LDD1608  [29]
 LDCM0405  CL18 HEK-293T C159(1.05); C476(0.85)  LDD1609  [29]
 LDCM0406  CL19 HEK-293T C159(0.95); C476(0.91)  LDD1610  [29]
 LDCM0407  CL2 HEK-293T C159(0.93); C476(0.95)  LDD1611  [29]
 LDCM0408  CL20 HEK-293T C159(0.99); C476(0.95)  LDD1612  [29]
 LDCM0409  CL21 HEK-293T C159(0.89); C476(0.79)  LDD1613  [29]
 LDCM0410  CL22 HEK-293T C159(1.02); C476(0.97)  LDD1614  [29]
 LDCM0411  CL23 HEK-293T C159(0.84); C476(0.96)  LDD1615  [29]
 LDCM0412  CL24 HEK-293T C159(0.97); C476(0.88)  LDD1616  [29]
 LDCM0413  CL25 HEK-293T C159(0.87); C476(0.96)  LDD1617  [29]
 LDCM0414  CL26 HEK-293T C159(1.01); C476(1.00)  LDD1618  [29]
 LDCM0415  CL27 HEK-293T C159(1.04); C476(1.01)  LDD1619  [29]
 LDCM0416  CL28 HEK-293T C159(1.08); C476(0.93)  LDD1620  [29]
 LDCM0417  CL29 HEK-293T C159(1.16); C476(1.15)  LDD1621  [29]
 LDCM0418  CL3 HEK-293T C159(0.96); C476(0.98)  LDD1622  [29]
 LDCM0419  CL30 HEK-293T C159(1.11); C476(0.98)  LDD1623  [29]
 LDCM0420  CL31 HEK-293T C159(1.08); C476(0.88)  LDD1624  [29]
 LDCM0421  CL32 HEK-293T C159(1.06); C476(1.15)  LDD1625  [29]
 LDCM0422  CL33 HEK-293T C159(0.80); C476(0.78)  LDD1626  [29]
 LDCM0423  CL34 HEK-293T C159(1.00); C476(0.93)  LDD1627  [29]
 LDCM0424  CL35 HEK-293T C159(0.92); C476(0.89)  LDD1628  [29]
 LDCM0425  CL36 HEK-293T C159(1.06); C476(0.90)  LDD1629  [29]
 LDCM0426  CL37 HEK-293T C159(0.87); C476(1.07)  LDD1630  [29]
 LDCM0428  CL39 HEK-293T C159(0.98); C476(1.06)  LDD1632  [29]
 LDCM0429  CL4 HEK-293T C159(0.97); C476(1.23)  LDD1633  [29]
 LDCM0430  CL40 HEK-293T C159(0.99); C476(0.99)  LDD1634  [29]
 LDCM0431  CL41 HEK-293T C159(1.03); C476(0.80)  LDD1635  [29]
 LDCM0432  CL42 HEK-293T C159(0.99); C476(0.95)  LDD1636  [29]
 LDCM0433  CL43 HEK-293T C159(0.98); C476(1.02)  LDD1637  [29]
 LDCM0434  CL44 HEK-293T C159(1.05); C476(1.00)  LDD1638  [29]
 LDCM0435  CL45 HEK-293T C159(0.94); C476(0.83)  LDD1639  [29]
 LDCM0436  CL46 HEK-293T C159(1.00); C476(0.86)  LDD1640  [29]
 LDCM0437  CL47 HEK-293T C159(0.91); C476(0.92)  LDD1641  [29]
 LDCM0438  CL48 HEK-293T C159(1.02); C476(0.91)  LDD1642  [29]
 LDCM0439  CL49 HEK-293T C159(0.84); C476(0.94)  LDD1643  [29]
 LDCM0440  CL5 HEK-293T C159(1.10); C476(0.89)  LDD1644  [29]
 LDCM0441  CL50 HEK-293T C159(0.81); C476(0.96)  LDD1645  [29]
 LDCM0443  CL52 HEK-293T C159(0.95); C476(0.94)  LDD1646  [29]
 LDCM0444  CL53 HEK-293T C159(1.03); C476(0.83)  LDD1647  [29]
 LDCM0445  CL54 HEK-293T C159(0.87); C476(0.77)  LDD1648  [29]
 LDCM0446  CL55 HEK-293T C159(1.03); C476(0.96)  LDD1649  [29]
 LDCM0447  CL56 HEK-293T C159(0.99); C476(0.94)  LDD1650  [29]
 LDCM0448  CL57 HEK-293T C159(0.86); C476(0.79)  LDD1651  [29]
 LDCM0449  CL58 HEK-293T C159(0.96); C476(0.89)  LDD1652  [29]
 LDCM0450  CL59 HEK-293T C159(0.79); C476(0.89)  LDD1653  [29]
 LDCM0451  CL6 HEK-293T C159(1.01); C476(0.87)  LDD1654  [29]
 LDCM0452  CL60 HEK-293T C159(0.91); C476(0.91)  LDD1655  [29]
 LDCM0453  CL61 HEK-293T C159(0.84); C476(1.05)  LDD1656  [29]
 LDCM0454  CL62 HEK-293T C159(0.83); C476(0.95)  LDD1657  [29]
 LDCM0455  CL63 HEK-293T C159(0.92); C476(0.98)  LDD1658  [29]
 LDCM0456  CL64 HEK-293T C159(0.86); C476(0.98)  LDD1659  [29]
 LDCM0457  CL65 HEK-293T C159(1.03); C476(0.99)  LDD1660  [29]
 LDCM0458  CL66 HEK-293T C159(0.96); C476(0.75)  LDD1661  [29]
 LDCM0459  CL67 HEK-293T C159(0.98); C476(0.93)  LDD1662  [29]
 LDCM0460  CL68 HEK-293T C159(0.95); C476(0.91)  LDD1663  [29]
 LDCM0461  CL69 HEK-293T C159(0.86); C476(0.88)  LDD1664  [29]
 LDCM0462  CL7 HEK-293T C159(1.04); C476(0.91)  LDD1665  [29]
 LDCM0463  CL70 HEK-293T C159(0.97); C476(0.90)  LDD1666  [29]
 LDCM0464  CL71 HEK-293T C159(0.83); C476(0.88)  LDD1667  [29]
 LDCM0465  CL72 HEK-293T C159(0.97); C476(0.92)  LDD1668  [29]
 LDCM0466  CL73 HEK-293T C159(0.92); C476(0.98)  LDD1669  [29]
 LDCM0467  CL74 HEK-293T C159(0.94); C476(0.96)  LDD1670  [29]
 LDCM0469  CL76 HEK-293T C159(0.95); C476(1.00)  LDD1672  [29]
 LDCM0470  CL77 HEK-293T C159(0.99); C476(0.83)  LDD1673  [29]
 LDCM0471  CL78 HEK-293T C159(1.07); C476(0.93)  LDD1674  [29]
 LDCM0472  CL79 HEK-293T C159(0.96); C476(1.03)  LDD1675  [29]
 LDCM0473  CL8 HEK-293T C159(0.78); C476(0.64)  LDD1676  [29]
 LDCM0474  CL80 HEK-293T C159(0.94); C476(1.11)  LDD1677  [29]
 LDCM0475  CL81 HEK-293T C159(0.93); C476(0.98)  LDD1678  [29]
 LDCM0476  CL82 HEK-293T C159(0.96); C476(1.01)  LDD1679  [29]
 LDCM0477  CL83 HEK-293T C159(0.82); C476(0.91)  LDD1680  [29]
 LDCM0478  CL84 HEK-293T C159(0.97); C476(0.83)  LDD1681  [29]
 LDCM0479  CL85 HEK-293T C159(0.74); C476(0.92)  LDD1682  [29]
 LDCM0480  CL86 HEK-293T C159(0.89); C476(0.97)  LDD1683  [29]
 LDCM0481  CL87 HEK-293T C159(0.85); C476(0.95)  LDD1684  [29]
 LDCM0482  CL88 HEK-293T C159(0.85); C476(1.00)  LDD1685  [29]
 LDCM0483  CL89 HEK-293T C159(0.94); C476(0.89)  LDD1686  [29]
 LDCM0484  CL9 HEK-293T C159(0.94); C476(0.95)  LDD1687  [29]
 LDCM0485  CL90 HEK-293T C159(0.76); C476(0.73)  LDD1688  [29]
 LDCM0486  CL91 HEK-293T C159(0.93); C476(0.97)  LDD1689  [29]
 LDCM0487  CL92 HEK-293T C159(0.86); C476(0.77)  LDD1690  [29]
 LDCM0488  CL93 HEK-293T C159(0.82); C476(0.88)  LDD1691  [29]
 LDCM0489  CL94 HEK-293T C159(1.00); C476(0.80)  LDD1692  [29]
 LDCM0490  CL95 HEK-293T C159(0.73); C476(0.73)  LDD1693  [29]
 LDCM0491  CL96 HEK-293T C159(0.87); C476(0.79)  LDD1694  [29]
 LDCM0492  CL97 HEK-293T C159(0.94); C476(0.85)  LDD1695  [29]
 LDCM0493  CL98 HEK-293T C159(0.89); C476(0.96)  LDD1696  [29]
 LDCM0494  CL99 HEK-293T C159(0.96); C476(0.95)  LDD1697  [29]
 LDCM0495  E2913 HEK-293T C159(1.02); C476(1.10)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C159(1.03)  LDD1702  [28]
 LDCM0625  F8 Ramos C159(2.36)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C159(0.99)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C159(0.07)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C159(0.70)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C159(1.06)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C159(0.82)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C159(0.91)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C159(0.83)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C159(1.01)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C159(1.26)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C159(0.67)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C159(1.10)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C159(0.89)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C159(1.54)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C159(0.96); C476(0.95)  LDD1671  [29]
 LDCM0596  Fragment38 Ramos C159(2.22)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C159(0.95)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C159(0.87); C476(1.04)  LDD1631  [29]
 LDCM0610  Fragment52 Ramos C159(0.99)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C159(1.35)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C159(0.89)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C159(0.68)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y390(0.85); Y441(0.94)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y390(0.65); Y441(0.70)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y441(0.83); Y390(1.11)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y390(0.67); Y441(0.89)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y390(0.63); Y441(1.29)  LDD0268  [7]
 LDCM0107  IAA HeLa C476(0.00); H478(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C159(1.03); C476(0.91)  LDD1492  [29]
 LDCM0023  KB03 HEK-293T C159(1.03); C476(0.85)  LDD1497  [29]
 LDCM0024  KB05 COLO792 C159(1.13)  LDD3310  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C159(0.90); C466(1.51)  LDD2102  [28]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C159(0.45); C466(0.71)  LDD2121  [28]
 LDCM0109  NEM HeLa H517(0.00); H478(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C159(0.56); C466(0.86)  LDD2089  [28]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C159(0.92); C466(0.93)  LDD2090  [28]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C159(0.78)  LDD2092  [28]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C159(1.01); C466(0.81)  LDD2093  [28]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C159(1.03)  LDD2094  [28]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C159(0.59); C466(0.08)  LDD2096  [28]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C159(0.78); C466(0.77)  LDD2097  [28]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C159(0.82); C466(0.39)  LDD2098  [28]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C159(0.78); C466(1.04); C476(0.85)  LDD2099  [28]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C159(0.92)  LDD2100  [28]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C159(1.14); C466(0.74)  LDD2101  [28]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C159(0.63); C466(0.44); C476(0.28)  LDD2104  [28]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C159(1.47); C476(1.00)  LDD2105  [28]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C159(0.57); C466(0.45)  LDD2106  [28]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C159(0.88); C466(1.03)  LDD2107  [28]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C159(0.69); C466(0.22)  LDD2108  [28]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C159(0.91); C466(0.50); C476(0.58)  LDD2109  [28]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C159(1.38)  LDD2110  [28]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C159(0.86); C466(1.09)  LDD2111  [28]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C159(0.86)  LDD2114  [28]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C159(0.66); C466(0.39)  LDD2115  [28]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C159(1.23); C466(0.19)  LDD2116  [28]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C159(0.61); C466(0.23)  LDD2118  [28]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C159(2.34); C466(2.22)  LDD2119  [28]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C159(0.92); C466(0.98)  LDD2120  [28]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C159(0.86); C466(0.10)  LDD2122  [28]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C159(0.81); C466(0.70); C476(0.96)  LDD2123  [28]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C159(0.68); C466(0.10)  LDD2124  [28]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C159(0.62); C466(0.75); C476(0.93)  LDD2125  [28]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C159(0.48); C466(0.10)  LDD2126  [28]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C159(1.01); C466(1.00)  LDD2127  [28]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C159(0.95); C466(1.06)  LDD2128  [28]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C159(0.74); C466(0.90)  LDD2129  [28]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C159(0.66); C466(0.42)  LDD2133  [28]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C159(0.70); C466(0.33)  LDD2134  [28]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C159(0.92); C466(1.28); C476(1.38)  LDD2135  [28]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C159(1.01); C466(1.06); C476(1.60)  LDD2136  [28]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C159(0.96); C466(1.00)  LDD2137  [28]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C466(2.35); C159(1.15)  LDD1700  [28]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C159(0.60); C466(0.70); C476(1.23)  LDD2140  [28]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C159(0.64); C466(0.45)  LDD2141  [28]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C159(1.05); C466(1.14)  LDD2143  [28]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C159(3.09); C466(3.21)  LDD2144  [28]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C159(6.45)  LDD2145  [28]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C159(0.85); C466(0.81); C476(0.91)  LDD2146  [28]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C159(3.52); C466(4.95)  LDD2147  [28]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C159(0.75); C466(0.40)  LDD2148  [28]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C159(1.02); C466(0.11)  LDD2149  [28]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C159(0.29); C466(0.58)  LDD2150  [28]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C466(0.12)  LDD2151  [28]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C159(1.88); C466(1.38)  LDD2153  [28]
 LDCM0627  NUDT7-COV-1 HEK-293T C159(1.05); C159(0.83)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C159(0.89); C159(0.67)  LDD2207  [32]
 LDCM0131  RA190 MM1.R C159(1.08)  LDD0304  [33]
 LDCM0096  SAHA K562 5.50  LDD0269  [5]
 LDCM0112  W16 Hep-G2 C159(0.66)  LDD0239  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) Cyclophilin-type PPIase family Q9Y3C6
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) Nudix hydrolase family O43809
Ubiquitin carboxyl-terminal hydrolase 21 (USP21) Peptidase C19 family Q9UK80
Ubiquitin thioesterase OTUB2 (OTUB2) Peptidase C65 family Q96DC9
Phospholipid scramblase 1 (PLSCR1) Phospholipid scramblase family O15162
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) . Q9H0M0
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Cytoplasmic protein NCK2 (NCK2) . O43639
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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