Details of the Target

General Information of Target

Target ID LDTP04910
Target Name Ras-related protein Rap-1b (RAP1B)
Gene Name RAP1B
Gene ID 5908
Synonyms
Ras-related protein Rap-1b; EC 3.6.5.2; GTP-binding protein smg p21B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG
TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL
EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS
CQLL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Ras family
Subcellular location
Cell membrane
Function
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
Uniprot ID
P61224
Ensemble ID
ENST00000250559.14
HGNC ID
HGNC:9857

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.M67I DBIA    Probe Info 
CCK81 SNV: p.R2C DBIA    Probe Info 
PEO1 SNV: p.D33N DBIA    Probe Info 
PF382 SNV: p.D92N DBIA    Probe Info 
SUPT1 SNV: p.T61M DBIA    Probe Info 
SW620 SNV: p.G13D DBIA    Probe Info 
TOV21G SNV: p.Q182P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.82  LDD0402  [1]
A-EBA
 Probe Info  		4.84  LDD0215  [2]
AZ-9
 Probe Info  		D38(1.27)  LDD2208  [3]
Probe 1
 Probe Info  		Y32(74.18)  LDD3495  [4]
DBIA
 Probe Info  		C51(2.98)  LDD3312  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C141(0.94); C118(1.00)  LDD2089  [7]
MCL-4
 Probe Info  		1.70  LDD0049  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C118(0.00); C51(0.00); C141(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C51(0.00); C118(0.00); C141(0.00)  LDD0032  [11]
IPIAA_L
 Probe Info  		C141(0.00); C118(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C118(0.00); C51(0.00); C141(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0025  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		C118(0.00); C141(0.00)  LDD0027  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
AOyne
 Probe Info  		6.30  LDD0443  [17]
MPP-AC
 Probe Info  		N.A.  LDD0428  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
TPP-AC
 Probe Info  		N.A.  LDD0427  [18]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		7.15  LDD0464  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
DA-2
 Probe Info  		N.A.  LDD0070  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C141(1.02)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C141(0.55)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C141(0.91); C118(1.00)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C141(1.31)  LDD2117  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C141(0.75); C118(0.61)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C141(0.79); C118(1.18)  LDD2131  [7]
 LDCM0214  AC1 HEK-293T C141(1.01); C51(0.95)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C141(1.06); C51(0.91)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C141(1.04); C51(0.96)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C141(1.00); C51(1.02)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C141(1.02); C51(1.08)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C141(1.00); C51(0.98)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C141(1.05); C51(1.00)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C141(1.03); C51(1.04)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C141(1.13); C51(0.98)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C141(1.00); C51(0.89)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C141(1.01); C51(1.08)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C141(1.07); C51(1.03)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C141(1.00); C51(0.96)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C141(1.04); C51(0.93)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C141(0.99); C51(0.94)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C141(1.07); C51(1.00)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C141(1.12); C51(0.92)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C141(0.98); C51(0.87)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C141(1.01); C51(1.04)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C141(1.11); C51(0.97)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C141(1.04); C51(0.94)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C141(0.95); C51(0.98)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C141(1.01); C51(1.00)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C141(1.02); C51(0.90)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C141(0.93); C51(0.92)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C141(0.93); C51(1.10)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C141(0.95); C51(0.84)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C141(1.01); C51(0.97)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C141(1.02); C51(0.96)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C141(1.01); C51(0.96)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C141(0.91); C51(1.08)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C141(1.03); C51(1.07)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C141(0.97); C51(0.90)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C141(1.01); C51(1.07)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C141(0.98); C51(1.16)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C141(0.95); C51(1.12)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C141(0.98); C51(1.08)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C141(1.00); C51(1.02)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C141(0.92); C51(1.17)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C141(0.96); C51(1.11)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C141(0.92); C51(1.08)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C141(0.96); C51(0.94)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C141(1.12); C51(0.91)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C141(1.01); C51(0.96)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C141(0.98); C51(0.86)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C141(0.98); C51(1.06)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C141(1.05); C51(0.95)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C141(0.96); C51(0.93)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C141(0.92); C51(0.88)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C141(0.97); C51(1.05)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C141(1.04); C51(1.02)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C141(1.05); C51(0.90)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C141(1.00); C51(0.96)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C141(0.96); C51(1.30)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C141(1.02); C51(1.10)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C141(1.08); C51(0.97)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C141(0.93); C51(0.91)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C141(0.95); C51(0.87)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C141(1.01); C51(1.09)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C141(0.99); C51(1.09)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C141(0.98); C51(1.03)  LDD1569  [24]
 LDCM0545  Acetamide MDA-MB-231 C118(0.71)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C141(1.06); C51(0.98)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C141(1.00); C51(0.86)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C141(1.01); C51(1.07)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C141(0.63); C118(1.18)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C141(0.00); C118(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C141(1.04); C51(1.15)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C141(1.11); C51(1.23)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C141(1.11); C51(1.07)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C141(1.03); C51(1.11)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C141(0.99); C51(1.13)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C141(0.98); C51(0.89)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C141(1.21); C51(1.01)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C141(1.03); C51(1.07)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C141(0.96); C51(1.23)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C141(1.09); C51(1.04)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C141(1.17); C51(0.96)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C141(1.14); C51(1.18)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C141(0.98); C51(1.11)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C141(1.17); C51(1.02)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C141(1.04); C51(1.10)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C141(1.14); C51(0.96)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C141(0.90); C51(0.97)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C141(1.10); C51(0.98)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C141(1.04); C51(0.97)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C141(0.98); C51(0.82)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C141(1.04); C51(0.96)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C141(0.92); C51(1.03)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C141(1.04); C51(1.10)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C141(1.00); C51(1.19)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C141(1.00); C51(0.99)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C141(0.99); C51(1.01)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C141(0.94); C51(1.06)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C141(1.06); C51(1.15)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C141(1.16); C51(0.88)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C141(0.96); C51(1.12)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C141(1.02); C51(1.14)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C141(1.05); C51(1.11)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C141(1.10); C51(0.92)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C141(1.00); C51(1.11)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C141(1.04); C51(1.06)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C141(1.30); C51(1.23)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C141(1.21); C51(1.09)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C141(1.11); C51(1.04)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C141(1.01); C51(1.06)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C141(1.00); C51(1.06)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C141(0.97); C51(1.03)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C141(0.94); C51(1.12)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C141(1.28); C51(0.95)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C141(0.94); C51(1.15)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C141(0.87); C51(0.92)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C141(1.00); C51(1.17)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C141(1.22); C51(0.99)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C141(0.97); C51(0.87)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C141(1.01); C51(1.07)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C141(1.23); C51(0.92)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C141(1.01); C51(1.01)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C141(1.08); C51(1.07)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C141(1.05); C51(1.01)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C141(1.04); C51(0.96)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C141(0.99); C51(1.17)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C141(1.25); C51(1.11)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C141(0.95); C51(1.03)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C141(0.93); C51(0.97)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C141(0.98); C51(1.04)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C141(1.15); C51(1.10)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C141(1.08); C51(1.11)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C141(1.17); C51(0.90)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C141(1.06); C51(0.96)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C141(1.18); C51(1.01)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C141(1.14); C51(1.24)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C141(1.04); C51(0.88)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C141(1.03); C51(0.94)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C141(0.98); C51(0.81)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C141(0.93); C51(0.97)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C141(1.01); C51(1.05)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C141(0.95); C51(0.94)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C141(1.08); C51(1.15)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C141(1.00); C51(1.06)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C141(1.05); C51(0.98)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C141(1.14); C51(1.05)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C141(1.14); C51(0.85)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C141(1.18); C51(1.08)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C141(0.99); C51(1.03)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C141(0.96); C51(1.13)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C141(1.21); C51(0.67)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C141(0.87); C51(1.09)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C141(0.98); C51(1.00)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C141(1.34); C51(1.14)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C141(0.92); C51(0.98)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C141(1.07); C51(1.06)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C141(0.97); C51(1.05)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C141(1.00); C51(0.88)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C141(1.18); C51(1.01)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C141(1.06); C51(0.92)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C141(1.00); C51(0.94)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C141(0.98); C51(0.90)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C141(1.04); C51(1.15)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C141(1.02); C51(1.17)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C141(1.09); C51(1.17)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C141(0.88); C51(1.07)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C141(0.92); C51(0.89)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C141(0.94); C51(1.03)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C141(1.13); C51(1.08)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C141(1.00); C51(1.16)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C141(1.07); C51(0.94)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C141(1.24); C51(0.96)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C141(1.17); C51(1.07)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C141(0.98); C51(0.96)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C141(1.26); C51(1.27)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C141(0.97); C51(1.02)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C141(0.96); C51(1.16)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C141(0.88); C51(1.05)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C141(0.98); C51(0.93)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C141(1.09); C51(1.24)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C141(1.12); C51(1.19)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C141(1.05); C51(0.96)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C141(1.09); C51(1.16)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C141(1.13); C51(0.96)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C141(1.09); C51(0.97)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C141(1.09); C51(0.99)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C141(1.48); C51(0.82)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C141(1.06); C51(1.07)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C141(1.05); C51(1.09)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C141(1.15); C51(1.01)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C141(0.93); C51(1.11)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C141(1.07); C51(0.89)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C141(1.14); C51(1.34)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C141(1.16); C51(1.08)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C141(1.03); C51(0.95)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C141(1.09); C51(1.18)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C141(1.08); C51(1.03)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C141(2.80)  LDD1702  [7]
 LDCM0625  F8 Ramos C141(2.38); C118(0.47)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C141(1.20); C118(0.68)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C141(20.00); C118(0.19)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C141(0.39); C118(0.72)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C141(0.40); C118(0.95)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C141(0.40); C118(0.79)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C141(0.37); C118(0.64)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C141(0.48); C118(1.23)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C141(0.70)  LDD2196  [25]
 LDCM0586  Fragment28 Ramos C141(0.78); C118(0.37)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C141(1.82); C118(0.89)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C141(0.61); C118(1.62)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C141(2.24); C118(0.82)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C141(1.04); C51(1.00)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C141(0.13)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C141(0.84); C118(0.65)  LDD2184  [25]
 LDCM0427  Fragment51 HEK-293T C141(0.91); C51(1.21)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C141(1.01)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C141(1.20); C118(0.86)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C141(0.59); C118(0.70)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C141(1.97); C118(0.63)  LDD2188  [25]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HEK-293T C118(0.90); C141(0.78); C51(0.91)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C118(1.00); C141(0.86); C51(0.96)  LDD1497  [24]
 LDCM0024  KB05 HMCB C51(2.98)  LDD3312  [5]
 LDCM0006  Micheliolide M9-ENL1 1.70  LDD0049  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C141(0.95); C118(0.96)  LDD2121  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C141(0.94); C118(1.00)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C141(1.46)  LDD2090  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C141(1.36); C118(1.18)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C141(0.97); C118(0.90)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C118(1.15)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C141(0.82); C118(0.69)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C141(0.81); C118(0.73)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C141(1.20); C118(1.97)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C118(0.54)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C141(0.95); C118(1.37)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C141(0.94)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C141(1.10); C118(1.06)  LDD2109  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C141(0.98)  LDD2114  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C141(1.02)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C141(1.35); C118(1.10)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C141(1.11); C118(1.29)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C141(0.98); C118(1.46)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C141(1.21)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C141(0.51); C118(0.70)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C141(1.35)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C141(1.51); C118(1.24)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C141(1.00); C118(1.47)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C141(1.12); C118(0.76)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C141(0.75)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C141(0.70); C118(0.86)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C141(1.81); C118(1.54)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C141(1.01); C118(1.20)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C141(0.81); C118(0.76)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C118(0.93)  LDD2151  [7]
 LDCM0131  RA190 MM1.R C141(1.08)  LDD0304  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) 2-oxoacid dehydrogenase family P36957
Serine/threonine-protein kinase Nek7 (NEK7) NEK Ser/Thr protein kinase family Q8TDX7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calreticulin (CALR) Calreticulin family P27797
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ral guanine nucleotide dissociation stimulator (RALGDS) . Q12967
Rap1 GTPase-activating protein 1 (RAP1GAP) . P47736
Ras association domain-containing protein 5 (RASSF5) . Q8WWW0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.