Details of the Target

General Information of Target

Target ID LDTP03753
Target Name Cystathionine beta-synthase (CBS)
Gene Name CBS
Gene ID 102724560
Synonyms
Cystathionine beta-synthase; EC 4.2.1.22; Beta-thionase; Serine sulfhydrase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPA
SESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKD
RISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDV
LRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEI
LQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTT
YEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKA
AQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLS
APLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVG
KVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLL
NFVAAQERDQK
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Cysteine synthase/cystathionine beta-synthase family
Subcellular location
Cytoplasm
Function
Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
TTD ID
T85309
Uniprot ID
P35520
DrugMap ID
TTVZJ7G
Ensemble ID
ENST00000352178.9
HGNC ID
HGNC:1550
ChEMBL ID
CHEMBL3399911

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.70  LDD0215  [2]
Probe 1
 Probe Info  		Y223(9.41)  LDD3495  [3]
DBIA
 Probe Info  		C52(0.97); C109(0.86); C370(1.00); C165(0.94)  LDD1492  [4]
W1
 Probe Info  		C15(1.00)  LDD0239  [5]
5E-2FA
 Probe Info  		H65(0.00); H66(0.00); H67(0.00); H17(0.00)  LDD2235  [6]
IA-alkyne
 Probe Info  		C370(0.00); C15(0.00); C165(0.00); C431(0.00)  LDD0032  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		C103(0.00); C15(0.00); C109(0.00); C370(0.00)  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C15(0.00); C370(0.00)  LDD0005  [9]
NHS
 Probe Info  		K30(0.00); K322(0.00)  LDD0010  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [9]
SF
 Probe Info  		K82(0.00); K83(0.00)  LDD0028  [11]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		C15(0.00); C370(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		7.40  LDD0443  [14]
NAIA_5
 Probe Info  		C109(0.00); C165(0.00); C52(0.00); C370(0.00)  LDD2223  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.91  LDD0471  [17]
FFF probe13
 Probe Info  		17.14  LDD0475  [17]
FFF probe14
 Probe Info  		20.00  LDD0477  [17]
FFF probe15
 Probe Info  		5.96  LDD0478  [17]
FFF probe2
 Probe Info  		12.59  LDD0463  [17]
FFF probe3
 Probe Info  		7.01  LDD0464  [17]
FFF probe6
 Probe Info  		12.04  LDD0468  [17]
Diazir
 Probe Info  		N.A.  LDD0011  [9]
DA-2
 Probe Info  		N.A.  LDD0073  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C52(0.96); C109(0.97); C370(0.98); C165(1.01)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C52(0.96); C109(1.09); C370(0.95); C165(0.90)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C52(1.01); C109(1.10); C370(0.99); C165(0.99)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C52(0.98); C109(1.07); C370(0.92); C165(0.88)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C52(0.97); C109(1.15); C370(0.99); C165(1.05)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C52(0.91); C109(1.01); C370(0.99); C165(0.95)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C52(0.99); C109(0.96); C370(0.94); C165(0.97)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C52(0.99); C109(0.93); C370(0.94); C165(1.02)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C52(1.18); C109(1.08); C370(0.92); C165(0.89)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C52(0.97); C109(1.04); C370(1.06); C165(0.96)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C52(0.96); C109(0.99); C370(0.95); C165(0.89)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C52(1.00); C109(1.00); C370(0.92); C165(0.99)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C52(0.91); C109(0.99); C370(1.03); C165(1.01)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C52(0.92); C109(1.09); C370(0.99); C165(1.05)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C52(0.91); C109(0.95); C370(0.99); C165(0.95)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C52(0.95); C109(1.06); C370(0.90); C165(0.93)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C52(1.00); C109(1.03); C370(0.99); C165(1.04)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C52(1.05); C109(1.05); C370(0.95); C165(0.98)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C52(0.95); C109(1.01); C370(0.94); C165(0.95)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C52(1.03); C109(1.03); C370(1.03); C165(0.98)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C52(1.01); C109(0.99); C370(0.96); C165(0.94)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C52(1.01); C109(1.08); C370(0.95); C165(1.03)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C52(0.94); C109(1.06); C370(0.97); C165(0.91)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C52(0.94); C109(1.00); C370(1.00); C165(0.99)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C52(0.86); C109(0.99); C370(0.89); C165(0.97)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C52(0.96); C109(1.05); C370(0.93); C165(0.91)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C52(0.91); C109(0.97); C370(1.08); C165(0.91)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C52(0.90); C109(0.99); C370(0.93); C165(0.99)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C52(0.95); C109(1.05); C370(0.94); C165(1.05)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C52(0.90); C109(1.11); C370(1.01); C165(0.97)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C52(0.90); C109(1.01); C370(1.00); C165(0.96)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C52(0.97); C109(0.95); C370(0.99); C165(0.96)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C52(0.89); C109(0.98); C370(0.96); C165(1.06)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C52(0.94); C109(1.00); C370(0.92); C165(0.99)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C52(1.03); C109(1.01); C370(0.97); C165(0.91)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C52(0.98); C109(1.04); C370(1.08); C165(0.92)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C52(0.85); C109(1.00); C370(0.90); C165(0.99)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C52(0.95); C109(1.05); C370(0.93); C165(0.97)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C52(0.94); C109(1.13); C370(0.96); C165(1.00)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C52(0.93); C109(1.06); C370(1.04); C165(1.05)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C52(0.97); C109(1.07); C370(1.02); C165(1.00)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C52(1.00); C109(1.04); C370(0.94); C165(0.95)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C52(0.95); C109(0.99); C370(1.02); C165(1.07)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C52(1.01); C109(1.07); C370(0.98); C165(0.98)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C52(1.00); C109(1.08); C370(0.94); C165(0.92)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C52(0.92); C109(1.03); C370(0.90); C165(0.93)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C52(0.96); C109(0.98); C370(0.93); C165(1.01)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C52(0.99); C109(1.09); C370(0.95); C165(1.04)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C52(0.93); C109(1.04); C370(0.96); C165(1.04)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C52(0.88); C109(1.01); C370(1.03); C165(1.00)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C52(0.84); C109(0.96); C370(0.92); C165(0.94)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C52(0.91); C109(1.04); C370(0.94); C165(0.97)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C52(0.97); C109(1.02); C370(0.94); C165(0.98)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C52(1.02); C109(1.02); C370(0.95); C165(0.98)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C52(0.89); C109(0.94); C370(0.91); C165(0.92)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C52(0.92); C109(1.03); C370(0.92); C165(1.08)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C52(0.97); C109(1.03); C370(1.00); C165(0.99)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C52(0.87); C109(0.95); C370(1.05); C165(0.95)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C52(0.94); C109(1.04); C370(0.95); C165(0.97)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C52(0.88); C109(1.01); C370(0.99); C165(0.94)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C52(0.93); C109(0.99); C370(0.98); C165(0.94)  LDD1569  [4]
 LDCM0248  AKOS034007472 HEK-293T C52(0.92); C109(1.07); C370(0.95); C165(1.04)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C52(0.99); C109(1.01); C370(0.94); C165(1.03)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C52(0.96); C109(1.08); C370(1.02); C165(1.02)  LDD1514  [4]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C15(0.00); C431(0.00); C370(0.00); H66(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C15(2.47); C431(0.45)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C52(0.92); C109(0.92); C370(0.88); C165(1.01)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C52(0.93); C109(1.21); C370(1.09); C165(1.18)  LDD1572  [4]
 LDCM0369  CL100 HEK-293T C52(1.04); C370(0.99); C165(0.93); C431(1.01)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C52(1.03); C109(0.93); C370(0.85); C165(0.96)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C52(0.97); C109(1.15); C370(0.83); C165(1.04)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C52(0.91); C109(1.05); C370(0.99); C165(1.06)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C52(1.02); C370(1.06); C165(0.99); C431(0.95)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C52(0.89); C109(0.97); C370(1.03); C165(0.87)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C52(1.07); C109(1.10); C370(0.93); C165(1.09)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C52(0.99); C109(1.10); C370(0.98); C165(1.01)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C52(0.98); C370(0.98); C165(0.95); C431(1.09)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C52(1.02); C109(1.06); C370(1.08); C165(0.99)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C52(0.93); C109(1.08); C370(1.09); C165(1.08)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C52(0.95); C109(1.10); C370(0.98); C165(0.92)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C52(0.99); C109(1.09); C370(0.92); C165(1.03)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C52(1.06); C370(1.00); C165(0.88); C431(0.96)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C52(0.96); C109(0.92); C370(0.99); C165(1.00)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C52(0.99); C109(1.13); C370(0.82); C165(1.05)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C52(1.01); C109(1.02); C370(0.95); C165(1.05)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C52(1.03); C370(0.95); C165(0.96); C431(1.01)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C52(0.91); C109(0.96); C370(0.78); C165(0.95)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C52(0.95); C109(1.08); C370(0.98); C165(1.06)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C52(0.96); C109(1.07); C370(0.94); C165(1.03)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C52(0.86); C109(1.01); C370(1.06); C165(1.00)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C52(0.97); C370(0.98); C165(0.98); C431(1.02)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C52(0.90); C109(0.95); C370(0.92); C165(1.01)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C52(1.05); C109(1.13); C370(0.94); C165(1.03)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C52(0.95); C109(1.04); C370(0.95); C165(0.95)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C52(1.00); C370(0.98); C165(1.00); C431(1.10)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C52(0.90); C109(1.06); C370(0.97); C165(0.99)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C52(0.95); C109(1.00); C370(0.78); C165(1.01)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C52(0.91); C109(0.97); C370(0.97); C165(0.98)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C52(0.96); C370(1.05); C165(0.90); C431(1.09)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C52(0.90); C109(0.99); C370(0.83); C165(0.95)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C52(1.01); C109(1.05); C370(0.82); C165(1.16)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C52(0.97); C109(1.12); C370(0.97); C165(0.99)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C52(0.90); C370(1.04); C165(0.94); C431(1.03)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C52(1.01); C109(1.09); C370(0.91); C165(0.98)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C52(0.90); C109(1.17); C370(0.95); C165(1.02)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C52(1.16); C109(1.16); C370(0.99); C165(1.04)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C52(1.03); C109(1.03); C370(0.83); C165(1.01)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C52(0.90); C109(1.08); C370(1.04); C165(1.03)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C52(0.89); C109(1.18); C370(1.02); C165(1.00)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C52(0.99); C109(1.19); C370(1.07); C165(1.19)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C52(0.95); C109(1.03); C370(1.07); C165(1.02)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C52(0.91); C109(1.08); C370(1.16); C165(1.01)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C52(0.85); C109(0.97); C370(0.99); C165(0.90)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C52(0.91); C109(1.07); C370(0.90); C165(1.08)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C52(0.93); C109(1.14); C370(0.87); C165(1.08)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C52(0.99); C370(1.11); C165(0.97); C431(0.98)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C52(1.04); C109(1.03); C370(1.03); C165(1.01)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C52(0.92); C109(1.00); C370(0.96); C165(1.07)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C52(1.05); C109(1.08); C370(1.04); C165(1.02)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C52(0.99); C109(1.13); C370(1.00); C165(1.01)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C52(1.02); C109(1.11); C370(1.04); C165(0.99)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C52(0.89); C109(1.21); C370(1.01); C165(1.03)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C52(1.05); C109(1.25); C370(1.04); C165(1.11)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C52(1.04); C109(1.17); C370(0.96); C165(1.06)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C52(1.00); C109(1.06); C370(1.08); C165(1.05)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C52(0.95); C109(0.92); C370(1.07); C165(1.04)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C52(1.10); C109(1.05); C370(0.89); C165(0.97)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C52(0.93); C370(0.95); C165(0.94); C431(1.12)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C52(0.99); C370(1.04); C165(1.04); C431(0.96)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C52(1.08); C109(1.05); C370(0.91); C165(0.95)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C52(1.05); C109(1.00); C370(1.01); C165(1.02)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C52(1.11); C109(1.10); C370(1.02); C165(1.08)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C52(1.03); C109(1.03); C370(0.98); C165(0.94)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C52(0.94); C109(1.09); C370(0.94); C165(1.04)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C52(1.18); C109(1.15); C370(1.11); C165(1.03)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C52(0.99); C109(1.08); C370(1.02); C165(1.14)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C52(0.93); C109(1.03); C370(1.12); C165(1.00)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C52(0.78); C109(0.94); C370(0.90); C165(0.94)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C52(0.90); C109(1.02); C370(0.92); C165(1.00)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C52(0.95); C109(1.14); C370(0.90); C165(1.00)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C52(1.01); C370(0.97); C165(1.00); C431(1.08)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C52(0.92); C109(1.12); C370(0.97); C165(1.06)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C52(0.93); C109(1.35); C370(1.04); C165(0.92)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C52(0.97); C109(1.14); C370(0.97); C165(1.08)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C52(0.98); C109(0.98); C370(0.96); C165(0.97)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C52(1.08); C109(1.19); C370(0.93); C165(0.99)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C52(1.10); C109(1.22); C370(1.06); C165(1.05)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C52(1.00); C109(1.09); C370(1.03); C165(1.09)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C52(0.96); C109(1.23); C370(0.99); C165(0.94)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C52(0.98); C109(1.09); C370(1.17); C165(1.06)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C52(0.87); C109(0.94); C370(0.89); C165(0.99)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C52(0.93); C109(1.09); C370(0.87); C165(1.07)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C52(0.97); C109(1.00); C370(0.92); C165(1.07)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C52(0.96); C370(1.10); C165(0.94); C431(0.97)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C52(0.90); C109(1.01); C370(0.88); C165(0.96)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C52(0.99); C109(1.01); C370(0.99); C165(0.98)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C52(1.12); C109(1.11); C370(0.94); C165(1.06)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C52(0.95); C109(1.06); C370(1.00); C165(1.04)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C52(0.96); C109(1.24); C370(1.07); C165(1.05)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C52(1.04); C109(1.02); C370(1.08); C165(0.98)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C52(1.06); C109(1.18); C370(1.01); C165(1.11)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C52(1.00); C109(1.17); C370(1.14); C165(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C52(0.95); C109(1.05); C370(1.10); C165(1.11)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C52(1.02); C109(0.94); C370(1.16); C165(0.97)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C52(1.05); C109(1.03); C370(0.87); C165(1.01)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C52(1.00); C370(0.97); C165(0.99); C431(1.01)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C52(0.95); C109(1.14); C370(0.94); C165(0.87)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C52(1.01); C109(1.10); C370(1.05); C165(1.02)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C52(1.02); C109(1.11); C370(0.93); C165(1.13)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C52(0.80); C109(1.17); C370(0.97); C165(0.90)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C52(1.02); C109(1.08); C370(0.99); C165(1.04)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C52(0.94); C109(1.12); C370(1.02); C165(1.11)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C52(1.03); C109(1.18); C370(1.08); C165(1.12)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C52(1.05); C109(1.18); C370(1.13); C165(1.09)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C52(1.05); C109(1.15); C370(1.05); C165(0.96)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C52(0.86); C109(0.95); C370(0.90); C165(0.96)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C52(0.90); C109(1.00); C370(0.84); C165(1.10)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C52(0.91); C109(0.91); C370(0.90); C165(1.12)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C52(0.92); C370(0.97); C165(0.98); C431(0.95)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C52(0.90); C109(1.04); C370(0.96); C165(1.01)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C52(0.89); C109(1.07); C370(0.99); C165(1.09)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C52(0.99); C109(1.17); C370(1.13); C165(0.87)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C52(0.96); C109(1.09); C370(1.16); C165(1.07)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C52(0.89); C109(1.01); C370(0.97); C165(0.92)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C52(0.89); C109(1.15); C370(1.03); C165(1.00)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C52(0.97); C109(1.06); C370(0.99); C165(1.07)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C52(0.99); C109(1.21); C370(0.97); C165(0.95)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C52(0.88); C109(1.16); C370(1.16); C165(0.95)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C52(0.95); C109(0.93); C370(0.90); C165(0.97)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C52(0.91); C109(1.05); C370(0.86); C165(1.07)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C52(1.01); C109(1.01); C370(0.98); C165(0.98)  LDD1697  [4]
 LDCM0191  Compound 21 HEK-293T 3.31  LDD0508  [17]
 LDCM0495  E2913 HEK-293T C52(0.88); C109(0.94); C370(0.96); C165(1.11)  LDD1698  [4]
 LDCM0625  F8 Ramos C370(0.60); C15(1.72); C165(0.68); C431(0.65)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C370(0.77); C15(3.16); C165(0.75); C431(0.64)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C370(4.74); C15(0.54); C165(20.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C370(0.99); C15(1.82); C165(0.65); C431(0.64)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C370(1.21); C15(0.87); C165(1.29); C431(0.98)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C370(0.98); C15(1.08); C431(2.69)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C370(0.93); C15(0.90); C165(0.65); C431(0.69)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C370(0.93); C15(0.84); C165(0.76); C431(0.82)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C370(1.14); C15(0.75); C165(1.37); C431(0.73)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C370(1.07); C15(0.87); C165(1.03); C431(0.67)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C370(0.74); C15(0.71); C165(0.75); C431(1.13)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C370(1.46); C15(1.44); C165(1.91); C431(1.14)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C370(1.60); C15(0.72); C431(1.07)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C370(0.72); C15(13.28); C165(0.68); C431(0.77)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C52(1.02); C109(1.03); C370(0.89); C165(1.02)  LDD1671  [4]
 LDCM0596  Fragment38 Ramos C370(1.27); C15(0.93); C165(0.92); C431(1.06)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C370(0.77); C15(1.41); C165(0.70); C431(0.82)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C52(0.91); C109(0.99); C370(0.79); C165(1.00)  LDD1631  [4]
 LDCM0610  Fragment52 Ramos C370(2.20); C15(1.24); C431(0.80)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C370(1.81); C15(1.35); C165(1.64); C431(0.84)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C370(0.66); C15(1.52); C165(0.52); C431(0.38)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C370(0.75); C15(1.45); C165(0.66); C431(0.86)  LDD2188  [19]
 LDCM0107  IAA HeLa H17(0.00); H67(0.00)  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C52(0.97); C109(0.86); C370(1.00); C165(0.94)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C52(1.00); C109(0.97); C370(0.91); C165(0.92)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C52(0.98); C109(0.85); C370(1.00); C165(0.91)  LDD1502  [4]
 LDCM0109  NEM HeLa N.A.  LDD0230  [13]
 LDCM0627  NUDT7-COV-1 HEK-293T C15(0.78)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C15(1.17)  LDD2207  [20]
 LDCM0112  W16 Hep-G2 C15(1.00)  LDD0239  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 5'-AMP-activated protein kinase gamma subunit family P54619
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) FKBP6 family O75344
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Galanin peptides (GAL) Galanin family P22466
Cytohesin-1 (CYTH1) . Q15438
Ubiquitin-associated and SH3 domain-containing protein A (UBASH3A) . P57075

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ademetionine Small molecular drug DB00118
Cysteine Small molecular drug DB00151
Pyridoxal Phosphate Small molecular drug DB00114
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ot-58 Recombinant protein D87TMY
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminooxyacetic Acid Small molecular drug D01BTV
Heme Small molecular drug D0UU1I
Serine Small molecular drug DB00133

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.