Details of the Target

General Information of Target

Target ID LDTP04787
Target Name Transmembrane protein 33 (TMEM33)
Gene Name TMEM33
Gene ID 55161
Synonyms
DB83; Transmembrane protein 33; Protein DB83; SHINC-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADTTPNGPQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALL
ANALTSALRLHQRLPHFQLSRAFLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSL
LHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFIACNEIFLMPATVFMLFSGQG
SLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHIIMKPACPLFVRRLCLQSIAFIS
RLAPTVP
Target Bioclass
Transporter and channel
Family
PER33/POM33 family
Subcellular location
Endoplasmic reticulum membrane
Function
Acts as a regulator of the tubular endoplasmic reticulum (ER) network by modulating intracellular calcium homeostasis. Mechanistically, stimulates PKD2 calcium-dependent activity. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling. Plays an essential role in VEGF-mediated release of Ca(2+) from ER stores during angiogenesis. Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. Participates in lipid metabolism by acting as a downstream effector of the pyruvate kinase/PKM. Forms a complex with RNF5 to facilitate polyubiquitination and subsequent degradation of SCAP on the ER membrane.
Uniprot ID
P57088
Ensemble ID
ENST00000504986.6
HGNC ID
HGNC:25541

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.73  LDD0402  [1]
CHEMBL5175495
 Probe Info  		7.34  LDD0196  [2]
ONAyne
 Probe Info  		K129(0.99)  LDD0274  [3]
BTD
 Probe Info  		C224(4.06)  LDD1699  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C224(0.99); C232(1.08)  LDD0531  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C232(0.00); C224(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C232(0.00); C224(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C224(0.00); C232(0.00); C37(0.00)  LDD0037  [9]
TFBX
 Probe Info  		C224(0.00); C232(0.00); C204(0.00)  LDD0027  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		K221(0.00); K148(0.00)  LDD0009  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C224(0.00); C232(0.00); C37(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.22  LDD1728  [14]
C040
 Probe Info  		9.19  LDD1740  [14]
C049
 Probe Info  		6.73  LDD1747  [14]
C056
 Probe Info  		20.97  LDD1753  [14]
C091
 Probe Info  		12.13  LDD1782  [14]
C092
 Probe Info  		17.75  LDD1783  [14]
C094
 Probe Info  		32.00  LDD1785  [14]
C112
 Probe Info  		22.32  LDD1799  [14]
C134
 Probe Info  		26.72  LDD1816  [14]
C143
 Probe Info  		12.82  LDD1825  [14]
C159
 Probe Info  		7.41  LDD1839  [14]
C160
 Probe Info  		8.00  LDD1840  [14]
C161
 Probe Info  		13.18  LDD1841  [14]
C196
 Probe Info  		11.00  LDD1872  [14]
C201
 Probe Info  		30.48  LDD1877  [14]
C218
 Probe Info  		10.85  LDD1892  [14]
C220
 Probe Info  		15.56  LDD1894  [14]
C225
 Probe Info  		5.43  LDD1898  [14]
C228
 Probe Info  		25.11  LDD1901  [14]
C231
 Probe Info  		36.50  LDD1904  [14]
C235
 Probe Info  		30.91  LDD1908  [14]
C238
 Probe Info  		11.96  LDD1911  [14]
C243
 Probe Info  		10.63  LDD1916  [14]
C246
 Probe Info  		17.51  LDD1919  [14]
C285
 Probe Info  		28.64  LDD1955  [14]
C293
 Probe Info  		18.64  LDD1963  [14]
C339
 Probe Info  		5.28  LDD2002  [14]
C343
 Probe Info  		13.18  LDD2005  [14]
C349
 Probe Info  		19.70  LDD2010  [14]
C350
 Probe Info  		34.06  LDD2011  [14]
C362
 Probe Info  		49.18  LDD2023  [14]
C364
 Probe Info  		16.11  LDD2025  [14]
C366
 Probe Info  		8.69  LDD2027  [14]
C367
 Probe Info  		6.02  LDD2028  [14]
C388
 Probe Info  		38.05  LDD2047  [14]
C431
 Probe Info  		15.56  LDD2086  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		13.66  LDD0477  [15]
FFF probe2
 Probe Info  		16.67  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
FFF probe9
 Probe Info  		12.91  LDD0470  [15]
JN0003
 Probe Info  		19.23  LDD0469  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
Alk-rapa
 Probe Info  		3.20  LDD0213  [17]
DA-2
 Probe Info  		N.A.  LDD0072  [18]
OEA-DA
 Probe Info  		10.98  LDD0046  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C224(1.37)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C224(1.29)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C204(1.05); C224(0.89)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C204(1.11)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C224(0.74)  LDD2103  [4]
 LDCM0214  AC1 HCT 116 C224(0.99); C232(1.08)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C224(1.26); C232(0.86)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C224(1.26); C232(0.81)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C224(1.21); C232(0.70)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C224(1.11); C232(0.76)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C224(0.95); C232(0.76)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C224(1.02); C232(0.67)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C224(1.07); C232(0.86)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C224(1.10); C232(0.71)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C224(1.02); C232(0.58)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C224(1.20); C232(0.79)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C224(1.15); C232(0.77)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C224(1.14); C232(0.81)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C224(1.02); C232(0.88)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C224(0.92); C232(0.77)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C224(0.95); C232(0.66)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C224(1.09); C232(1.13)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C224(1.02); C232(0.96)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C224(1.04); C232(0.89)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C224(1.02); C232(0.78)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C224(1.07); C232(0.92)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C224(1.17); C232(0.88)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C224(1.00); C232(0.81)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C224(0.96); C232(0.93)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C224(0.72); C232(1.03)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C224(1.19); C232(1.03)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C224(1.10); C232(0.89)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C224(1.09); C232(1.22)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C224(1.09); C232(1.06)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C224(1.16); C232(1.04)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C224(1.07); C232(1.05)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C224(1.19); C232(0.95)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C224(1.55); C232(1.62)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C224(1.69); C232(1.14)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C224(1.67); C232(1.13)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C224(1.43); C232(1.44)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C224(1.79); C232(1.04)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C224(1.87); C232(1.26)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C224(1.66); C232(1.12)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C224(1.82); C232(1.07)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C224(1.34); C232(1.04)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C224(1.32); C232(1.08)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C224(1.63); C232(1.20)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C224(1.88); C232(0.91)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C224(0.96); C232(1.16)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C224(1.99); C232(0.91)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C224(1.67); C232(1.10)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C224(1.59); C232(1.03)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C232(0.79); C224(0.80)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C232(0.72); C224(1.15)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C232(0.73); C224(1.06)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C232(0.65); C224(0.87)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C232(0.77); C224(0.83)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C232(0.52); C224(0.89)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C232(0.60); C224(0.91)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C224(1.12); C232(1.18)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C232(0.73); C224(0.86)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C232(0.84); C224(1.11)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C232(0.72); C224(0.74)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C232(0.58); C224(1.02)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C224(0.92); C232(0.71)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C224(1.25); C232(0.70)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C224(0.88); C232(0.92)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C224(1.11); C232(1.05)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C232(0.91); C224(1.10)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C224(0.75); C232(0.78)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C232(1.02); C224(1.06)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C232(1.09); C224(1.22)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C224(1.04); C232(1.36)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C224(0.94); C232(1.10)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C232(0.89); C224(1.04)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C232(0.91); C224(0.97)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C224(0.99); C232(1.52)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C224(1.14); C232(1.59)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C224(1.16); C232(1.25)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C224(1.10); C232(1.59)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C232(0.90); C224(1.05)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C232(1.15); C224(1.16)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C232(1.29); C224(1.32)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C224(1.09); C232(1.32)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C232(1.11); C224(1.30)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C232(0.89); C224(1.16)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C224(1.09); C232(1.45)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C224(0.93); C232(1.12)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C232(0.63); C224(0.80)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C232(0.94); C224(0.95)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C224(1.00); C232(1.01)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C224(0.96); C232(1.24)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C232(0.55); C224(0.92)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C232(0.89); C224(1.44)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C232(0.75); C224(1.00)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C232(0.68); C224(0.95)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C232(0.88); C224(0.98)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C232(0.84); C224(1.03)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C232(0.80); C224(1.03)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C232(0.90); C224(1.02)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C232(1.01); C224(1.12)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C232(0.83); C224(1.07)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C232(0.82); C224(1.47)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C224(1.10); C232(1.12)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C232(1.05); C224(1.26)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C224(1.24); C232(1.28)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C224(1.23); C232(1.24)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C224(1.31); C232(1.32)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C232(1.17); C224(1.25)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C224(1.04); C232(1.26)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C232(1.15); C224(1.27)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C232(1.06); C224(1.47)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C232(1.06); C224(1.09)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C224(0.97); C232(1.25)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C232(0.95); C224(1.12)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C232(0.98); C224(1.06)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C232(0.97); C224(1.05)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C232(0.92); C224(1.10)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C232(1.23); C224(1.31)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C232(1.07); C224(1.22)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C232(0.94); C224(1.46)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C232(0.87); C224(1.00)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C232(1.12); C224(1.30)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C232(0.71); C224(1.08)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C232(0.76); C224(1.12)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C232(0.89); C224(1.38)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C232(0.87); C224(0.96)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C232(0.72); C224(1.11)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C232(0.83); C224(1.08)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C232(1.00); C224(1.08)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C232(0.85); C224(1.30)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C232(0.83); C224(1.34)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C232(0.88); C224(1.36)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C232(0.86); C224(1.15)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C232(0.85); C224(1.28)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C232(0.88); C224(1.12)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C232(0.86); C224(1.33)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C224(0.83); C232(0.91)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C232(0.95); C224(1.11)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C232(0.78); C224(0.84)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C232(0.74); C224(1.32)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C232(0.59); C224(0.95)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C232(0.56); C224(1.03)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C232(0.52); C224(0.97)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C232(0.71); C224(1.06)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C232(0.82); C224(0.93)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C232(0.76); C224(1.07)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C232(0.76); C224(1.11)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C232(0.92); C224(1.14)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C232(0.66); C224(1.06)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C232(0.63); C224(1.19)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C232(0.65); C224(0.85)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C232(0.70); C224(0.93)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C232(0.83); C224(0.95)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C232(0.70); C224(1.17)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C232(0.63); C224(1.00)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C232(0.53); C224(1.19)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C232(0.82); C224(1.12)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C204(0.53)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C224(1.09); C232(0.93)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C232(0.88); C224(1.09)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C232(0.98); C224(1.20)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C224(1.28)  LDD2171  [7]
 LDCM0498  BS-3668 MDA-MB-231 C204(0.88)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C224(0.95); C232(1.27)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C232(1.05); C224(1.45)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C232(1.04); C224(1.20)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C224(0.98); C232(1.67)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C224(1.21); C232(1.82)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C224(1.07); C232(1.30)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C224(1.04); C232(1.30)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C232(0.69); C224(1.03)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C232(0.66); C224(1.18)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C232(0.59); C224(1.14)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C232(0.91); C224(1.10)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C232(0.83); C224(1.01)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C232(0.93); C224(1.41)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C232(0.79); C224(1.12)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C232(0.82); C224(0.93)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C232(0.92); C224(0.96)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C224(1.00); C232(1.15)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C224(1.01); C232(2.74)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C224(0.91); C232(1.05)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C232(0.92); C224(1.11)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C232(0.93); C224(0.97)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C232(0.90); C224(0.99)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C232(0.72); C224(0.94)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C232(0.99); C224(1.75)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C232(0.77); C224(1.19)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C224(0.72); C232(0.92)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C232(0.99); C224(1.22)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C224(1.10); C232(1.17)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C232(1.17); C224(1.31)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C224(1.10); C232(1.13)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C224(1.00); C232(1.07)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C224(1.03); C232(1.13)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C232(0.97); C224(1.06)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C224(1.31); C232(1.45)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C232(1.20); C224(1.45)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C224(1.40); C232(1.43)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C232(0.86); C224(0.86)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C224(0.95); C232(1.02)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C224(1.04); C232(1.09)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C232(0.90); C224(1.09)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C224(1.11); C232(1.45)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C224(1.03); C232(1.04)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C232(0.92); C224(1.06)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C232(0.98); C224(1.27)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C224(1.11); C232(1.22)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C224(1.09); C232(0.92)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C224(1.06); C232(0.81)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C224(0.94); C232(0.99)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C224(1.21); C232(0.85)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C224(0.98); C232(1.02)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C224(1.23); C232(0.85)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C224(1.11); C232(1.25)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C224(1.04); C232(1.16)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C224(0.92); C232(1.17)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C224(0.90); C232(1.02)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C224(0.90); C232(0.78)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C224(0.99); C232(0.92)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C224(0.94); C232(0.92)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C224(0.98); C232(0.89)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C224(1.09); C232(1.02)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C224(0.94); C232(1.02)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C224(1.20); C232(1.21)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C224(1.04); C232(0.96)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C224(1.07); C232(1.47)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C224(1.13); C232(1.53)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C224(1.08); C232(1.20)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C224(0.92); C232(1.01)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C224(1.00); C232(1.06)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C224(1.12); C232(1.65)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C224(1.19); C232(1.28)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C224(1.06); C232(1.68)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C224(1.14); C232(1.53)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C224(1.35); C232(1.65)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C224(0.99); C232(1.39)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C224(1.13); C232(1.26)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C224(1.11); C232(1.22)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C224(0.86); C232(1.69)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C224(1.00); C232(1.48)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C224(1.06); C232(1.65)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C224(0.92); C232(1.21)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C224(1.00); C232(1.40)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C224(1.13); C232(1.55)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C224(1.16); C232(1.19)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C224(1.15); C232(1.08)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C224(1.19); C232(1.30)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C224(1.04); C232(0.93)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C224(1.06); C232(0.84)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C224(1.00); C232(0.71)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C224(1.04); C232(0.78)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C224(0.95); C232(0.86)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C224(1.05); C232(0.69)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C224(1.00); C232(0.86)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C224(1.03); C232(0.86)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C224(0.90); C232(1.00)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C224(1.37); C232(0.91)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C224(1.14); C232(0.90)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C224(0.95); C232(0.76)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C224(1.04); C232(0.78)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C224(0.94); C232(0.97)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C224(1.07); C232(0.95)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C224(0.93); C232(1.07)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C224(0.98); C232(1.25)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C224(0.86); C232(0.91)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C224(0.94); C232(0.83)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C224(1.50); C232(1.45)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C224(1.00); C232(0.84)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C224(0.96); C232(0.95)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C224(1.03); C232(1.27)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C224(0.96); C232(0.89)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C224(1.00); C232(0.88)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C224(0.88); C232(0.92)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C224(0.76); C232(1.04)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C224(1.08); C232(0.87)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C224(1.08); C232(1.01)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C224(0.98); C232(1.10)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C224(1.23); C232(1.03)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C224(0.97); C232(1.07)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C224(0.98); C232(1.05)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C224(0.96); C232(0.77)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C224(1.21); C232(1.03)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C224(1.08); C232(1.12)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C224(1.10); C232(0.64)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C224(1.06); C232(1.16)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C224(1.06); C232(1.47)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C224(1.27); C232(0.77)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C224(1.24); C232(0.77)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C224(1.21); C232(1.09); C162(1.01)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C224(68.05)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C224(2.12); C232(0.50)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C232(0.52)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C224(0.04); C232(0.23)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C232(2.11)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C224(0.70); C232(0.63)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C232(6.62)  LDD2193  [21]
 LDCM0580  Fragment21 Ramos C224(0.76); C232(0.75)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C224(3.10); C232(0.54)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C224(0.94); C232(0.64)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C224(3.07); C232(3.03)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C224(0.64); C232(0.37)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C224(1.06); C232(0.88)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C232(0.74)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C224(1.01); C232(0.76)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C224(5.93); C232(0.66)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C224(14.53); C232(1.91)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C224(1.07); C232(1.40)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C224(1.50); C232(0.44)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C224(0.36); C232(0.36)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C224(6.72); C232(0.96)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C224(8.70)  LDD2188  [21]
 LDCM0015  HNE MDA-MB-231 C224(1.10); C232(0.90)  LDD0346  [21]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C224(0.89); C232(1.04)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C224(0.95); C232(0.92)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C232(2.99)  LDD3310  [22]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C224(1.03)  LDD2102  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C204(0.96)  LDD2089  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C224(0.66)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C204(0.73); C224(0.69)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C224(0.82)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C204(0.52); C224(1.21)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C204(0.78); C224(0.56)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C224(1.87)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C224(0.51)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C224(1.09)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C224(0.68)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C204(0.98)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C224(1.03)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C224(0.79)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C204(0.84); C224(0.76)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C224(0.62)  LDD2115  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C224(1.40)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C224(2.46)  LDD2119  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C204(0.93)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C204(0.88)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C204(0.83)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C204(0.86); C224(0.59)  LDD2129  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C224(0.74)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C204(0.85); C224(0.95)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C204(1.27)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C204(0.64); C224(0.70)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C204(0.99); C224(0.59)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C224(0.83)  LDD2141  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C224(7.66)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C204(0.88); C224(0.82)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C224(0.83)  LDD2148  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C204(0.76)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C224(1.45); C232(0.87); C204(0.84)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C204(1.31); C232(0.86); C232(0.75); C224(0.72)  LDD2207  [23]
 LDCM0090  Rapamycin JHH-7 3.20  LDD0213  [17]
 LDCM0021  THZ1 HCT 116 C224(1.28)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melatonin receptor type 1A (MTNR1A) G-protein coupled receptor 1 family P48039

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.