Details of the Target

General Information of Target

Target ID LDTP02058
Target Name Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)
Gene Name RPN2
Gene ID 6185
Synonyms
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; RIBIIR; Ribophorin II; RPN-II; Ribophorin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIVGLSS
LGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSEDS
SVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSI
VEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAI
FSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPL
TQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIA
NTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQL
VDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYT
LYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTV
VSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMF
QTLKYLAILGSVTFLAGNRMLAQQAVKRTAH
Target Bioclass
Transporter and channel
Family
SWP1 family
Subcellular location
Endoplasmic reticulum
Function
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Uniprot ID
P04844
Ensemble ID
ENST00000237530.11
HGNC ID
HGNC:10382

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Y459H DBIA    Probe Info 
CAL33 SNV: p.I470V .
FADU SNV: p.A252V DBIA    Probe Info 
MCC13 SNV: p.M337I .
MFE319 SNV: p.A18T DBIA    Probe Info 
MOLT4 SNV: p.R289W IA-alkyne    Probe Info 
NCIH446 SNV: p.A209T DBIA    Probe Info 
RAMOS SNV: p.E276K .
SW1116 SNV: p.T108S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.50  LDD0197  [1]
CHEMBL5175495
 Probe Info  		10.84  LDD0196  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
C-Sul
 Probe Info  		4.95  LDD0066  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
BTD
 Probe Info  		C72(3.34)  LDD1699  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
DBIA
 Probe Info  		C100(4.08)  LDD3319  [8]
Alkyne-RA190
 Probe Info  		2.84  LDD0299  [9]
IPM
 Probe Info  		C72(5.28)  LDD1702  [6]
5E-2FA
 Probe Info  		H170(0.00); H264(0.00); H221(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K442(0.00); K311(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H170(0.00); H264(0.00)  LDD2231  [10]
1d-yne
 Probe Info  		N.A.  LDD0358  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C72(0.00); C100(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
NHS
 Probe Info  		K442(0.00); K627(0.00)  LDD0010  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
1c-yne
 Probe Info  		K154(0.00); K38(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		H283(0.00); H268(0.00); H170(0.00); H27(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		H283(0.00); C72(0.00); H528(0.00); H268(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
AOyne
 Probe Info  		5.60  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C293
 Probe Info  		21.26  LDD1963  [19]
FFF probe11
 Probe Info  		11.24  LDD0471  [20]
FFF probe12
 Probe Info  		12.46  LDD0473  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		20.00  LDD0477  [20]
FFF probe2
 Probe Info  		15.05  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
FFF probe6
 Probe Info  		5.25  LDD0467  [20]
FFF probe9
 Probe Info  		18.12  LDD0470  [20]
JN0003
 Probe Info  		20.00  LDD0469  [20]
STS-1
 Probe Info  		1.17  LDD0137  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
Diazir
 Probe Info  		N.A.  LDD0011  [15]
Photonaproxen
 Probe Info  		N.A.  LDD0156  [23]
DA-2
 Probe Info  		N.A.  LDD0073  [24]
OEA-DA
 Probe Info  		8.67  LDD0046  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C72(0.74)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C72(0.83)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C72(0.41)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C72(0.89)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C72(0.85)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C72(1.06)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C72(0.98)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C72(0.86)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C72(0.67)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C100(1.28)  LDD1507  [26]
 LDCM0215  AC10 HEK-293T C100(1.04)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C100(1.05)  LDD1509  [26]
 LDCM0276  AC17 HEK-293T C100(0.98)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C100(0.95)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C100(1.24)  LDD1517  [26]
 LDCM0279  AC2 HEK-293T C100(1.10)  LDD1518  [26]
 LDCM0284  AC24 HEK-293T C100(0.99)  LDD1523  [26]
 LDCM0285  AC25 HEK-293T C100(1.08)  LDD1524  [26]
 LDCM0286  AC26 HEK-293T C100(1.11)  LDD1525  [26]
 LDCM0287  AC27 HEK-293T C100(1.05)  LDD1526  [26]
 LDCM0290  AC3 HEK-293T C100(0.95)  LDD1529  [26]
 LDCM0293  AC32 HEK-293T C100(0.94)  LDD1532  [26]
 LDCM0294  AC33 HEK-293T C100(1.31)  LDD1533  [26]
 LDCM0295  AC34 HEK-293T C100(1.09)  LDD1534  [26]
 LDCM0296  AC35 HEK-293T C100(1.03)  LDD1535  [26]
 LDCM0302  AC40 HEK-293T C100(1.23)  LDD1541  [26]
 LDCM0303  AC41 HEK-293T C100(1.03)  LDD1542  [26]
 LDCM0304  AC42 HEK-293T C100(0.98)  LDD1543  [26]
 LDCM0305  AC43 HEK-293T C100(1.17)  LDD1544  [26]
 LDCM0310  AC48 HEK-293T C100(1.06)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C100(1.07)  LDD1550  [26]
 LDCM0313  AC50 HEK-293T C100(0.97)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C100(1.10)  LDD1553  [26]
 LDCM0319  AC56 HEK-293T C100(1.16)  LDD1558  [26]
 LDCM0320  AC57 HEK-293T C100(1.26)  LDD1559  [26]
 LDCM0321  AC58 HEK-293T C100(1.06)  LDD1560  [26]
 LDCM0322  AC59 HEK-293T C100(0.89)  LDD1561  [26]
 LDCM0328  AC64 HEK-293T C100(1.34)  LDD1567  [26]
 LDCM0345  AC8 HEK-293T C100(1.03)  LDD1569  [26]
 LDCM0520  AKOS000195272 MDA-MB-231 C72(0.64)  LDD2113  [6]
 LDCM0356  AKOS034007680 HEK-293T C100(1.02)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C100(1.09)  LDD1514  [26]
 LDCM0498  BS-3668 MDA-MB-231 C72(0.58)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa H170(0.00); H283(0.00); C72(0.00); H27(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C100(1.06)  LDD1571  [26]
 LDCM0369  CL100 HEK-293T C100(1.01)  LDD1573  [26]
 LDCM0370  CL101 HEK-293T C100(1.00)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C100(0.99)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C100(1.12)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C100(1.06)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C100(0.95)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C100(1.14)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C100(1.01)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C100(1.01)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C100(0.98)  LDD1582  [26]
 LDCM0380  CL110 HEK-293T C100(1.01)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C100(1.06)  LDD1585  [26]
 LDCM0382  CL112 HEK-293T C100(1.05)  LDD1586  [26]
 LDCM0383  CL113 HEK-293T C100(0.98)  LDD1587  [26]
 LDCM0384  CL114 HEK-293T C100(1.03)  LDD1588  [26]
 LDCM0385  CL115 HEK-293T C100(1.08)  LDD1589  [26]
 LDCM0386  CL116 HEK-293T C100(1.05)  LDD1590  [26]
 LDCM0387  CL117 HEK-293T C100(0.92)  LDD1591  [26]
 LDCM0388  CL118 HEK-293T C100(1.03)  LDD1592  [26]
 LDCM0389  CL119 HEK-293T C100(1.07)  LDD1593  [26]
 LDCM0390  CL12 HEK-293T C100(1.23)  LDD1594  [26]
 LDCM0391  CL120 HEK-293T C100(1.00)  LDD1595  [26]
 LDCM0392  CL121 HEK-293T C100(0.90)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C100(1.10)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C100(1.17)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C100(1.12)  LDD1599  [26]
 LDCM0396  CL125 HEK-293T C100(1.07)  LDD1600  [26]
 LDCM0397  CL126 HEK-293T C100(1.06)  LDD1601  [26]
 LDCM0398  CL127 HEK-293T C100(1.26)  LDD1602  [26]
 LDCM0399  CL128 HEK-293T C100(1.09)  LDD1603  [26]
 LDCM0400  CL13 HEK-293T C100(1.08)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C100(1.04)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C100(1.07)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C100(1.04)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C100(1.07)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C100(1.10)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C100(1.03)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C100(1.12)  LDD1611  [26]
 LDCM0412  CL24 HEK-293T C100(1.17)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C100(0.97)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C100(1.09)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C100(1.00)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C100(1.00)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C100(1.12)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C100(1.00)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C100(1.07)  LDD1623  [26]
 LDCM0420  CL31 HEK-293T C100(1.02)  LDD1624  [26]
 LDCM0425  CL36 HEK-293T C100(1.17)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C100(1.05)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C100(1.08)  LDD1632  [26]
 LDCM0429  CL4 HEK-293T C100(1.04)  LDD1633  [26]
 LDCM0430  CL40 HEK-293T C100(1.00)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C100(1.13)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C100(1.06)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C100(1.01)  LDD1637  [26]
 LDCM0438  CL48 HEK-293T C100(1.26)  LDD1642  [26]
 LDCM0439  CL49 HEK-293T C100(1.08)  LDD1643  [26]
 LDCM0440  CL5 HEK-293T C100(0.98)  LDD1644  [26]
 LDCM0441  CL50 HEK-293T C100(0.93)  LDD1645  [26]
 LDCM0443  CL52 HEK-293T C100(1.04)  LDD1646  [26]
 LDCM0444  CL53 HEK-293T C100(1.08)  LDD1647  [26]
 LDCM0445  CL54 HEK-293T C100(1.11)  LDD1648  [26]
 LDCM0446  CL55 HEK-293T C100(1.05)  LDD1649  [26]
 LDCM0451  CL6 HEK-293T C100(1.13)  LDD1654  [26]
 LDCM0452  CL60 HEK-293T C100(1.02)  LDD1655  [26]
 LDCM0453  CL61 HEK-293T C100(0.99)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C100(0.99)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C100(1.02)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C100(1.25)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C100(1.06)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C100(1.11)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C100(1.02)  LDD1662  [26]
 LDCM0462  CL7 HEK-293T C100(1.21)  LDD1665  [26]
 LDCM0465  CL72 HEK-293T C100(1.16)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C100(1.01)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C100(1.12)  LDD1670  [26]
 LDCM0469  CL76 HEK-293T C100(1.06)  LDD1672  [26]
 LDCM0470  CL77 HEK-293T C100(1.09)  LDD1673  [26]
 LDCM0471  CL78 HEK-293T C100(1.00)  LDD1674  [26]
 LDCM0472  CL79 HEK-293T C100(0.95)  LDD1675  [26]
 LDCM0478  CL84 HEK-293T C100(1.40)  LDD1681  [26]
 LDCM0479  CL85 HEK-293T C100(0.96)  LDD1682  [26]
 LDCM0480  CL86 HEK-293T C100(0.98)  LDD1683  [26]
 LDCM0481  CL87 HEK-293T C100(1.03)  LDD1684  [26]
 LDCM0482  CL88 HEK-293T C100(1.12)  LDD1685  [26]
 LDCM0483  CL89 HEK-293T C100(1.05)  LDD1686  [26]
 LDCM0485  CL90 HEK-293T C100(1.33)  LDD1688  [26]
 LDCM0486  CL91 HEK-293T C100(1.06)  LDD1689  [26]
 LDCM0491  CL96 HEK-293T C100(1.25)  LDD1694  [26]
 LDCM0492  CL97 HEK-293T C100(0.90)  LDD1695  [26]
 LDCM0493  CL98 HEK-293T C100(1.11)  LDD1696  [26]
 LDCM0494  CL99 HEK-293T C100(0.91)  LDD1697  [26]
 LDCM0495  E2913 HEK-293T C100(1.09)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C72(5.28)  LDD1702  [6]
 LDCM0468  Fragment33 HEK-293T C100(0.92)  LDD1671  [26]
 LDCM0427  Fragment51 HEK-293T C100(1.01)  LDD1631  [26]
 LDCM0107  IAA HeLa H170(0.00); H268(0.00); H283(0.00); H27(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C100(0.91)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C100(1.19)  LDD1497  [26]
 LDCM0024  KB05 MEWO C100(4.08)  LDD3319  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C72(1.15)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C72(0.53)  LDD2121  [6]
 LDCM0109  NEM HeLa H268(0.00); H283(0.00); H170(0.00); H27(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C72(0.64)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C72(1.06)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C72(0.86)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C72(1.10)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C72(1.60)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C72(0.89)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C72(0.45)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C72(0.98)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C72(0.88)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C72(0.70)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C72(0.67)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C72(1.26)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C72(0.84)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C72(0.84)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C72(1.07)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C72(0.95)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C72(0.57)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C72(0.52)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C72(1.07)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C72(0.84)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C72(1.81)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C72(0.85)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C72(0.71)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C72(0.87)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C72(0.73)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C72(0.96)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C72(0.74)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C72(1.06)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C72(0.45)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C72(1.28)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C72(1.40)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C72(0.84)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C72(1.79)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C72(0.81)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C72(0.38)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C72(0.97)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C72(1.95)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C72(2.99)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C72(0.76)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C72(2.49)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C72(0.89)  LDD2148  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C72(0.89)  LDD2151  [6]
 LDCM0131  RA190 MM1.R 2.84  LDD0299  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein O-mannose kinase (POMK) Ser/Thr protein kinase family Q9H5K3

References

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3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402