Details of the Target

General Information of Target

Target ID LDTP13519
Target Name Proteasome activator complex subunit 2 (PSME2)
Gene Name PSME2
Gene ID 5721
Synonyms
Proteasome activator complex subunit 2; 11S regulator complex subunit beta; REG-beta; Activator of multicatalytic protease subunit 2; Proteasome activator 28 subunit beta; PA28b; PA28beta
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSVPGPSSPDGALTRPPYCLEAGEPTPGLSDTSPDEGLIEDLTIEDKAVEQLAEGLLSHY
LPDLQRSKQALQELTQNQVVLLDTLEQEISKFKECHSMLDINALFAEAKHYHAKLVNIRK
EMLMLHEKTSKLKKRALKLQQKRQKEELEREQQREKEFEREKQLTARPAKRM
Target Bioclass
Other
Family
PA28 family
Function
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Uniprot ID
Q9UL46
Ensemble ID
ENST00000216802.10
HGNC ID
HGNC:9569
ChEMBL ID
CHEMBL4295982

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y33(20.00)  LDD0257  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		K15(10.00)  LDD0274  [5]
STPyne
 Probe Info  		K15(3.31); K154(6.87); K177(9.13); K180(8.61)  LDD0277  [5]
OPA-S-S-alkyne
 Probe Info  		K15(6.45)  LDD3494  [6]
Probe 1
 Probe Info  		Y187(22.04); Y199(31.59); Y217(5.94)  LDD3495  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
THZ1-DTB
 Probe Info  		C91(1.09)  LDD0460  [8]
BTD
 Probe Info  		C91(1.20)  LDD2090  [9]
Sulforaphane-probe2
 Probe Info  		1.80  LDD0160  [10]
DA-P3
 Probe Info  		4.25  LDD0179  [11]
AHL-Pu-1
 Probe Info  		C91(2.45)  LDD0169  [12]
HHS-475
 Probe Info  		Y33(0.42)  LDD0264  [13]
HHS-465
 Probe Info  		Y239(5.91)  LDD2237  [14]
DBIA
 Probe Info  		C91(0.93)  LDD0078  [15]
N1
 Probe Info  		N.A.  LDD0245  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C91(0.00); C118(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C118(0.00); C91(0.00)  LDD0036  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C91(0.00); C118(0.00)  LDD0037  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C5(0.00); C91(0.00)  LDD0027  [19]
WYneC
 Probe Info  		N.A.  LDD0014  [20]
WYneN
 Probe Info  		C91(0.00); C5(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
ENE
 Probe Info  		N.A.  LDD0006  [20]
IPM
 Probe Info  		C5(0.00); C91(0.00)  LDD0005  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Acrolein
 Probe Info  		H183(0.00); H192(0.00); C91(0.00)  LDD0217  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C91(0.00); C118(0.00); C5(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y187(1.21); Y239(1.15); Y33(1.11)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		29.86  LDD1816  [26]
C135
 Probe Info  		10.34  LDD1817  [26]
C178
 Probe Info  		16.00  LDD1857  [26]
C206
 Probe Info  		21.71  LDD1881  [26]
C269
 Probe Info  		6.06  LDD1939  [26]
C278
 Probe Info  		76.64  LDD1948  [26]
C284
 Probe Info  		40.50  LDD1954  [26]
C305
 Probe Info  		11.31  LDD1974  [26]
C313
 Probe Info  		13.74  LDD1980  [26]
C354
 Probe Info  		7.52  LDD2015  [26]
C363
 Probe Info  		16.11  LDD2024  [26]
C364
 Probe Info  		15.35  LDD2025  [26]
C388
 Probe Info  		36.76  LDD2047  [26]
C391
 Probe Info  		13.45  LDD2050  [26]
C403
 Probe Info  		15.78  LDD2061  [26]
C413
 Probe Info  		12.30  LDD2069  [26]
FFF probe11
 Probe Info  		12.16  LDD0471  [27]
FFF probe13
 Probe Info  		14.93  LDD0475  [27]
FFF probe14
 Probe Info  		12.13  LDD0477  [27]
FFF probe2
 Probe Info  		10.39  LDD0463  [27]
FFF probe3
 Probe Info  		8.99  LDD0464  [27]
FFF probe6
 Probe Info  		7.00  LDD0467  [27]
Alk-rapa
 Probe Info  		2.76  LDD0213  [28]
DA-2
 Probe Info  		N.A.  LDD0070  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C91(1.05)  LDD2142  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C91(1.02)  LDD2117  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C91(2.45)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C91(0.97)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C91(1.03)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C91(0.93)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C91(0.83)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C91(0.86)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C91(0.86)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C91(0.78)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C91(0.89)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C91(0.94)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C91(1.25)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C91(1.10)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C91(0.99)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C91(0.99)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C91(1.02)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C91(1.02)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C91(1.19)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C91(0.94)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C91(0.94)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C91(0.99)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C91(1.06)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C91(0.86)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C91(0.89)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C91(1.01)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C91(1.02)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C91(0.89)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C91(0.86)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C91(0.97)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C91(0.89)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C91(0.94)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C91(0.94)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C91(0.96)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C91(0.93)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C91(1.14)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C91(1.30)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C91(1.29)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C91(1.11)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C91(1.33)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C91(1.28)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C91(1.20)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C91(1.33)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C91(1.40)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C91(1.34)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C91(1.47)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C91(1.24)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C91(0.91)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C91(1.44)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C91(1.38)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C91(1.29)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C91(0.85)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C91(0.86)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C91(0.69)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C91(0.95)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C91(0.62)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C91(0.93)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C91(0.77)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C91(0.96)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C91(1.18)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C91(1.40)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C91(1.53)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C91(0.92)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C91(1.00)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C91(1.24)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C91(0.97)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C91(1.19)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C91(0.95)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C91(0.99)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C91(1.01)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C91(0.95)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C91(1.04)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C91(1.10)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C91(1.03)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C91(1.00)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C91(1.05)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C91(0.84)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C91(0.93)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C91(1.08)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C91(1.01)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C91(1.14)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C91(1.08)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C91(1.12)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C91(1.03)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C91(1.11)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C91(1.07)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C91(1.06)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C91(1.06)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C91(1.11)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C91(1.00)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C91(0.95)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C91(0.96)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C91(1.01)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C91(0.95)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C91(1.05)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C91(1.00)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C91(0.99)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C91(0.88)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C91(0.91)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C91(1.09)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C91(1.10)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C91(1.10)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C91(1.08)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C91(1.08)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C91(1.06)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C91(1.06)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C91(1.03)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C91(0.98)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C91(1.05)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C91(1.05)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C91(1.01)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C91(1.13)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C91(1.24)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C91(1.07)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C91(1.04)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C91(1.05)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C91(1.30)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C91(0.98)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C91(1.14)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C91(1.04)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C91(1.17)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C91(1.32)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C91(0.96)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C91(0.85)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C91(0.84)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C91(1.02)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C91(0.92)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C91(0.97)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C91(0.97)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C91(0.91)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C91(0.95)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C91(0.97)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C91(0.91)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C91(0.92)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C91(0.77)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C91(0.96)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C91(1.04)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C91(0.94)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C91(0.89)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C91(0.91)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C91(1.22)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C91(1.13)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C91(1.18)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C91(1.13)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C91(1.15)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C91(1.17)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C91(1.11)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C91(1.22)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C91(1.13)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C91(1.16)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C91(1.13)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C91(1.10)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C91(1.07)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C91(1.13)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C91(1.12)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C91(0.93)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C91(1.02)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C91(0.94)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C91(1.00)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C91(1.02)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 12.64  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C91(0.93)  LDD0078  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C5(0.97); C91(0.82)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C91(0.93)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C91(1.02)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C91(1.06)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C91(0.86)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C91(0.84)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C91(0.84)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C91(0.90)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C91(1.01)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C91(1.13)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C91(1.25)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C91(1.12)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C91(0.96)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C91(1.15)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C91(1.10)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C91(0.95)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C91(0.98)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C91(0.90)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C91(0.90)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C91(1.03)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C91(1.03)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C91(0.96)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C91(1.06)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C91(1.06)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C91(1.04)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C91(1.10)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C91(0.99)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C91(0.93)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C91(0.97)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C91(1.02)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C91(1.11)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C91(1.09)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C91(1.32)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C91(1.21)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C91(1.02)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C91(1.00)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C91(1.06)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C91(1.00)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C91(0.97)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C91(0.99)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C91(0.97)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C91(1.01)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C91(1.16)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C91(1.13)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C91(1.18)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C91(0.99)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C91(1.13)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C91(1.09)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C91(1.20)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C91(1.10)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C91(1.03)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C91(1.11)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C91(1.13)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C91(1.07)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C91(1.13)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C91(1.10)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C91(0.99)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C91(1.06)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C91(1.08)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C91(1.06)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C91(1.17)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C91(1.14)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C91(0.89)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C91(1.08)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C91(1.05)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C91(1.28)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C91(1.13)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C91(1.04)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C91(1.13)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C91(0.94)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C91(0.93)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C91(1.09)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C91(0.91)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C91(0.99)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C91(1.01)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C91(1.03)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C91(0.99)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C91(0.98)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C91(0.96)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C91(1.03)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C91(0.93)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C91(1.04)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C91(0.99)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C91(1.01)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C91(0.98)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C91(0.93)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C91(1.17)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C91(1.23)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C91(1.18)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C91(1.09)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C91(1.14)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C91(1.19)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C91(1.06)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C91(1.16)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C91(0.96)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C91(1.04)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C91(1.11)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C91(1.13)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C91(1.01)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C91(1.03)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C91(1.10)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C91(0.87)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C91(0.87)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C91(0.98)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C91(0.98)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C91(1.03)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C91(0.80)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C91(0.90)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C91(0.97)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C91(1.13)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C91(1.01)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C91(0.99)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C91(1.01)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C91(0.87)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C91(0.87)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C91(1.08)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C91(1.03)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C91(0.93)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C91(1.04)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C91(0.88)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C91(0.87)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C91(0.88)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C91(0.86)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C91(0.90)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C91(0.87)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C91(1.05)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C91(0.94)  LDD0811  [15]
 LDCM0027  Dopamine HEK-293T 4.25  LDD0179  [11]
 LDCM0495  E2913 HEK-293T C91(0.99); C118(1.25)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C91(8.99)  LDD1702  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 9.30  LDD0183  [11]
 LDCM0625  F8 Ramos C91(1.24)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C91(5.39)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C91(0.02); C118(3.83)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C91(7.75)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C91(2.88)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C91(1.87); C118(1.54)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C91(8.99)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C91(2.34)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C91(2.12)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C91(1.85)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C91(0.79)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C91(3.95)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C91(1.51)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C91(6.70)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C91(1.06)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C91(2.56)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C91(2.31); C118(0.89)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C91(1.13)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C91(4.31)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C91(2.63)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C91(2.25); C118(1.00)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C91(8.42)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y33(0.42)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y33(0.45)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y33(0.53)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y33(0.61)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y33(0.65)  LDD0268  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C91(1.51)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C91(0.79)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C91(1.00)  LDD0082  [15]
 LDCM0030  Luteolin HEK-293T 8.17  LDD0182  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C91(1.84)  LDD2121  [9]
 LDCM0109  NEM HeLa H192(0.00); H183(0.00)  LDD0223  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C91(1.20)  LDD2090  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C91(1.24)  LDD2104  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C91(1.23)  LDD2106  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C91(1.25)  LDD2109  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C91(0.80)  LDD2120  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C91(0.92)  LDD2123  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C91(1.12)  LDD2127  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C91(0.87)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C91(0.72)  LDD2143  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C91(3.20)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C91(0.70)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C91(0.89); C5(0.64)  LDD2207  [32]
 LDCM0029  Quercetin HEK-293T 4.04  LDD0181  [11]
 LDCM0131  RA190 MM1.R C91(1.15)  LDD0304  [33]
 LDCM0090  Rapamycin JHH-7 2.76  LDD0213  [28]
 LDCM0003  Sulforaphane MDA-MB-231 1.80  LDD0160  [10]
 LDCM0021  THZ1 HeLa S3 C91(1.09)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein phosphatase 23 (DUSP23) Protein-tyrosine phosphatase family Q9BVJ7
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome activator complex subunit 1 (PSME1) PA28 family Q06323
Proteasome activator complex subunit 2 (PSME2) PA28 family Q9UL46
Ubiquitin-like protein 5 (UBL5) . Q9BZL1

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
29 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.