Details of the Target

General Information of Target

Target ID	LDTP02297
Target Name	Vimentin (VIM)
Gene Name	VIM
Gene ID	7431
Synonyms	Vimentin
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE EIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSE AANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQD TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSS LNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
Target Bioclass	Other
Family	Intermediate filament family
Subcellular location	Cytoplasm
Function	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Uniprot ID	P08670
Ensemble ID	ENST00000224237.9
HGNC ID	HGNC:12692
ChEMBL ID	CHEMBL3712854

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 54 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
m-APA Probe Info	9.76	LDD0402	[2]
P1 Probe Info	3.12	LDD0452	[3]
P2 Probe Info	3.03	LDD0453	[3]
P3 Probe Info	6.28	LDD0454	[3]
P8 Probe Info	10.00	LDD0455	[3]
A-EBA Probe Info	3.44	LDD0215	[4]
CY-1 Probe Info	13.72	LDD0243	[5]
CY4 Probe Info	3.37	LDD0244	[5]
N1 Probe Info	5.96	LDD0242	[5]
FBP2 Probe Info	2.09	LDD0323	[6]
TH211 Probe Info	Y291(20.00); Y11(12.82); Y30(11.29); Y276(5.96)	LDD0257	[7]
TH216 Probe Info	Y400(20.00); Y276(17.03); Y30(9.07); Y117(8.08)	LDD0259	[7]
AZ-9 Probe Info	E329(1.09); E354(0.87); E408(0.78); E288(1.15)	LDD2208	[8]
ONAyne Probe Info	K313(0.00); K188(0.00); K439(0.00); K120(0.00)	LDD0273	[9]
OPA-S-S-alkyne Probe Info	K168(3.85); K294(4.08); K334(5.59); K104(6.79)	LDD3494	[10]
HHS-482 Probe Info	Y117(1.06); Y276(0.82); Y291(0.44); Y30(0.94)	LDD0285	[11]
HHS-475 Probe Info	Y30(0.73); Y358(0.76); Y11(0.78); Y53(0.79)	LDD0264	[12]
HHS-465 Probe Info	Y117(8.47); Y30(10.00); Y53(10.00); Y61(10.00)	LDD2237	[13]
DBIA Probe Info	C328(1.04)	LDD0078	[14]
5E-2FA Probe Info	N.A.	LDD2235	[15]
AMP probe Probe Info	K439(0.00); K294(0.00); K188(0.00)	LDD0200	[16]
ATP probe Probe Info	K439(0.00); K294(0.00); K188(0.00); K292(0.00)	LDD0199	[16]
1d-yne Probe Info	N.A.	LDD0358	[17]
4-Iodoacetamidophenylacetylene Probe Info	N.A.	LDD0038	[18]
IA-alkyne Probe Info	N.A.	LDD0032	[19]
IPIAA_H Probe Info	N.A.	LDD0030	[20]
IPIAA_L Probe Info	N.A.	LDD0031	[20]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[18]
ATP probe Probe Info	N.A.	LDD0035	[21]
BTD Probe Info	N.A.	LDD0004	[22]
JW-RF-010 Probe Info	N.A.	LDD0026	[23]
NAIA_4 Probe Info	N.A.	LDD2226	[24]
TFBX Probe Info	N.A.	LDD0027	[23]
WYneC Probe Info	N.A.	LDD0014	[22]
WYneN Probe Info	N.A.	LDD0021	[22]
WYneO Probe Info	N.A.	LDD0022	[22]
Compound 10 Probe Info	N.A.	LDD2216	[25]
Compound 11 Probe Info	N.A.	LDD2213	[25]
ENE Probe Info	N.A.	LDD0006	[22]
IPM Probe Info	N.A.	LDD0005	[22]
NHS Probe Info	K139(0.00); K235(0.00); K282(0.00); K439(0.00)	LDD0010	[22]
PPMS Probe Info	N.A.	LDD0008	[22]
SF Probe Info	Y150(0.00); K294(0.00); Y291(0.00); Y11(0.00)	LDD0028	[26]
STPyne Probe Info	K334(0.00); K235(0.00); K188(0.00); K139(0.00)	LDD0009	[22]
VSF Probe Info	N.A.	LDD0007	[22]
Phosphinate-6 Probe Info	N.A.	LDD0018	[27]
Ox-W18 Probe Info	N.A.	LDD2175	[28]
1c-yne Probe Info	K188(0.00); K104(0.00); K235(0.00); K129(0.00)	LDD0228	[17]
Acrolein Probe Info	C328(0.00); H437(0.00); H462(0.00); H461(0.00)	LDD0217	[29]
Cinnamaldehyde Probe Info	N.A.	LDD0220	[29]
Crotonaldehyde Probe Info	C328(0.00); H461(0.00); H437(0.00); H462(0.00)	LDD0219	[29]
Methacrolein Probe Info	C328(0.00); H462(0.00); H437(0.00)	LDD0218	[29]
MPP-AC Probe Info	N.A.	LDD0428	[30]
TPP-AC Probe Info	N.A.	LDD0427	[30]

PAL-AfBPP Probe

Click To Hide/Show 100 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C003 Probe Info	19.43	LDD1713	[31]
C017 Probe Info	5.82	LDD1725	[31]
C022 Probe Info	7.06	LDD1728	[31]
C040 Probe Info	9.45	LDD1740	[31]
C041 Probe Info	7.06	LDD1741	[31]
C052 Probe Info	7.01	LDD1750	[31]
C053 Probe Info	6.87	LDD1751	[31]
C055 Probe Info	15.03	LDD1752	[31]
C056 Probe Info	23.59	LDD1753	[31]
C063 Probe Info	18.00	LDD1760	[31]
C070 Probe Info	11.47	LDD1766	[31]
C085 Probe Info	5.03	LDD1777	[31]
C087 Probe Info	27.28	LDD1779	[31]
C091 Probe Info	10.85	LDD1782	[31]
C092 Probe Info	20.97	LDD1783	[31]
C106 Probe Info	24.76	LDD1793	[31]
C108 Probe Info	9.99	LDD1795	[31]
C112 Probe Info	31.34	LDD1799	[31]
C130 Probe Info	6.32	LDD1812	[31]
C134 Probe Info	22.01	LDD1816	[31]
C139 Probe Info	11.16	LDD1821	[31]
C145 Probe Info	9.58	LDD1827	[31]
C153 Probe Info	19.03	LDD1834	[31]
C158 Probe Info	12.30	LDD1838	[31]
C161 Probe Info	10.34	LDD1841	[31]
C165 Probe Info	12.21	LDD1845	[31]
C169 Probe Info	20.11	LDD1849	[31]
C187 Probe Info	22.01	LDD1865	[31]
C191 Probe Info	12.30	LDD1868	[31]
C193 Probe Info	5.39	LDD1869	[31]
C201 Probe Info	33.82	LDD1877	[31]
C206 Probe Info	16.91	LDD1881	[31]
C210 Probe Info	99.73	LDD1884	[31]
C212 Probe Info	5.28	LDD1886	[31]
C213 Probe Info	19.03	LDD1887	[31]
C216 Probe Info	5.70	LDD1890	[31]
C218 Probe Info	13.93	LDD1892	[31]
C220 Probe Info	11.47	LDD1894	[31]
C228 Probe Info	19.84	LDD1901	[31]
C232 Probe Info	47.84	LDD1905	[31]
C238 Probe Info	15.78	LDD1911	[31]
C244 Probe Info	20.11	LDD1917	[31]
C246 Probe Info	12.64	LDD1919	[31]
C249 Probe Info	15.56	LDD1922	[31]
C252 Probe Info	8.40	LDD1925	[31]
C269 Probe Info	10.41	LDD1939	[31]
C277 Probe Info	7.36	LDD1947	[31]
C284 Probe Info	30.06	LDD1954	[31]
C289 Probe Info	32.00	LDD1959	[31]
C293 Probe Info	17.03	LDD1963	[31]
C296 Probe Info	21.26	LDD1966	[31]
C305 Probe Info	11.00	LDD1974	[31]
C313 Probe Info	28.25	LDD1980	[31]
C314 Probe Info	14.03	LDD1981	[31]
C317 Probe Info	7.11	LDD1983	[31]
C338 Probe Info	31.34	LDD2001	[31]
C339 Probe Info	4.96	LDD2002	[31]
C346 Probe Info	16.45	LDD2007	[31]
C347 Probe Info	6.68	LDD2008	[31]
C348 Probe Info	12.55	LDD2009	[31]
C350 Probe Info	27.10	LDD2011	[31]
C354 Probe Info	8.06	LDD2015	[31]
C355 Probe Info	40.50	LDD2016	[31]
C356 Probe Info	8.22	LDD2017	[31]
C361 Probe Info	23.75	LDD2022	[31]
C362 Probe Info	63.56	LDD2023	[31]
C363 Probe Info	25.11	LDD2024	[31]
C364 Probe Info	23.43	LDD2025	[31]
C382 Probe Info	12.04	LDD2041	[31]
C383 Probe Info	14.32	LDD2042	[31]
C388 Probe Info	49.18	LDD2047	[31]
C390 Probe Info	28.64	LDD2049	[31]
C391 Probe Info	44.94	LDD2050	[31]
C397 Probe Info	9.71	LDD2056	[31]
C403 Probe Info	17.27	LDD2061	[31]
C407 Probe Info	19.84	LDD2064	[31]
C413 Probe Info	18.51	LDD2069	[31]
C419 Probe Info	8.69	LDD2074	[31]
C420 Probe Info	18.00	LDD2075	[31]
C429 Probe Info	12.38	LDD2084	[31]
C431 Probe Info	14.52	LDD2086	[31]
C433 Probe Info	7.94	LDD2088	[31]
FFF probe11 Probe Info	20.00	LDD0471	[32]
FFF probe12 Probe Info	11.28	LDD0473	[32]
FFF probe13 Probe Info	20.00	LDD0475	[32]
FFF probe14 Probe Info	17.95	LDD0477	[32]
FFF probe15 Probe Info	6.55	LDD0478	[32]
FFF probe2 Probe Info	20.00	LDD0463	[32]
FFF probe3 Probe Info	20.00	LDD0464	[32]
FFF probe4 Probe Info	13.14	LDD0466	[32]
FFF probe6 Probe Info	15.04	LDD0467	[32]
FFF probe7 Probe Info	6.64	LDD0483	[32]
FFF probe9 Probe Info	9.38	LDD0470	[32]
JN0003 Probe Info	20.00	LDD0469	[32]
STS-2 Probe Info	N.A.	LDD0139	[33]
Diazir Probe Info	Y61(0.00); E329(0.00); E354(0.00); E134(0.00)	LDD0011	[22]
BD-F Probe Info	A352(0.00); S87(0.00); N93(0.00); I92(0.00)	LDD0024	[34]
LD-F Probe Info	E346(0.00); V353(0.00); A355(0.00); E348(0.00)	LDD0015	[34]
DA-2 Probe Info	N.A.	LDD0070	[35]
OEA-DA Probe Info	12.41	LDD0046	[36]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0548	1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one	MDA-MB-231	C328(0.68)	LDD2142	[37]
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C328(0.78)	LDD2112	[37]
LDCM0502	1-(Cyanoacetyl)piperidine	MDA-MB-231	C328(0.37)	LDD2095	[37]
LDCM0537	2-Cyano-N,N-dimethylacetamide	MDA-MB-231	C328(0.54)	LDD2130	[37]
LDCM0524	2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide	MDA-MB-231	C328(0.95)	LDD2117	[37]
LDCM0558	2-Cyano-N-phenylacetamide	MDA-MB-231	C328(1.30)	LDD2152	[37]
LDCM0510	3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C328(0.99)	LDD2103	[37]
LDCM0539	3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile	MDA-MB-231	C328(0.37)	LDD2132	[37]
LDCM0214	AC1	HEK-293T	C328(1.01)	LDD0812	[14]
LDCM0215	AC10	HEK-293T	C328(1.30)	LDD0813	[14]
LDCM0216	AC100	HEK-293T	C328(1.00)	LDD0814	[14]
LDCM0217	AC101	HEK-293T	C328(0.91)	LDD0815	[14]
LDCM0218	AC102	HEK-293T	C328(0.87)	LDD0816	[14]
LDCM0219	AC103	HEK-293T	C328(1.03)	LDD0817	[14]
LDCM0220	AC104	HEK-293T	C328(0.90)	LDD0818	[14]
LDCM0221	AC105	HEK-293T	C328(0.89)	LDD0819	[14]
LDCM0222	AC106	HEK-293T	C328(1.04)	LDD0820	[14]
LDCM0223	AC107	HEK-293T	C328(0.99)	LDD0821	[14]
LDCM0224	AC108	HEK-293T	C328(0.97)	LDD0822	[14]
LDCM0225	AC109	HEK-293T	C328(1.04)	LDD0823	[14]
LDCM0226	AC11	HEK-293T	C328(1.04)	LDD0824	[14]
LDCM0227	AC110	HEK-293T	C328(0.85)	LDD0825	[14]
LDCM0228	AC111	HEK-293T	C328(0.91)	LDD0826	[14]
LDCM0229	AC112	HEK-293T	C328(0.84)	LDD0827	[14]
LDCM0230	AC113	PaTu 8988t	C328(0.91)	LDD1109	[14]
LDCM0231	AC114	PaTu 8988t	C328(1.25)	LDD1110	[14]
LDCM0232	AC115	PaTu 8988t	C328(0.95)	LDD1111	[14]
LDCM0233	AC116	PaTu 8988t	C328(1.16)	LDD1112	[14]
LDCM0234	AC117	PaTu 8988t	C328(1.10)	LDD1113	[14]
LDCM0235	AC118	PaTu 8988t	C328(1.75)	LDD1114	[14]
LDCM0236	AC119	PaTu 8988t	C328(1.35)	LDD1115	[14]
LDCM0237	AC12	HEK-293T	C328(1.59)	LDD0835	[14]
LDCM0238	AC120	PaTu 8988t	C328(1.55)	LDD1117	[14]
LDCM0239	AC121	PaTu 8988t	C328(1.33)	LDD1118	[14]
LDCM0240	AC122	PaTu 8988t	C328(1.25)	LDD1119	[14]
LDCM0241	AC123	PaTu 8988t	C328(1.04)	LDD1120	[14]
LDCM0242	AC124	PaTu 8988t	C328(1.71)	LDD1121	[14]
LDCM0243	AC125	PaTu 8988t	C328(1.59)	LDD1122	[14]
LDCM0244	AC126	PaTu 8988t	C328(1.14)	LDD1123	[14]
LDCM0245	AC127	PaTu 8988t	C328(1.45)	LDD1124	[14]
LDCM0246	AC128	HEK-293T	C328(1.03)	LDD0844	[14]
LDCM0247	AC129	HEK-293T	C328(1.36)	LDD0845	[14]
LDCM0249	AC130	HEK-293T	C328(0.95)	LDD0847	[14]
LDCM0250	AC131	HEK-293T	C328(0.99)	LDD0848	[14]
LDCM0251	AC132	HEK-293T	C328(1.24)	LDD0849	[14]
LDCM0252	AC133	HEK-293T	C328(1.06)	LDD0850	[14]
LDCM0253	AC134	HEK-293T	C328(1.14)	LDD0851	[14]
LDCM0254	AC135	HEK-293T	C328(0.94)	LDD0852	[14]
LDCM0255	AC136	HEK-293T	C328(0.98)	LDD0853	[14]
LDCM0256	AC137	HEK-293T	C328(1.08)	LDD0854	[14]
LDCM0257	AC138	HEK-293T	C328(1.17)	LDD0855	[14]
LDCM0258	AC139	HEK-293T	C328(1.12)	LDD0856	[14]
LDCM0259	AC14	HEK-293T	C328(1.09)	LDD0857	[14]
LDCM0260	AC140	HEK-293T	C328(1.08)	LDD0858	[14]
LDCM0261	AC141	HEK-293T	C328(1.28)	LDD0859	[14]
LDCM0262	AC142	HEK-293T	C328(1.16)	LDD0860	[14]
LDCM0263	AC143	HEK-293T	C328(1.01)	LDD0861	[14]
LDCM0264	AC144	HEK-293T	C328(0.99)	LDD0862	[14]
LDCM0265	AC145	HEK-293T	C328(1.06)	LDD0863	[14]
LDCM0266	AC146	HEK-293T	C328(1.02)	LDD0864	[14]
LDCM0267	AC147	HEK-293T	C328(0.87)	LDD0865	[14]
LDCM0268	AC148	HEK-293T	C328(0.83)	LDD0866	[14]
LDCM0269	AC149	HEK-293T	C328(0.96)	LDD0867	[14]
LDCM0270	AC15	HEK-293T	C328(1.24)	LDD0868	[14]
LDCM0271	AC150	HEK-293T	C328(0.85)	LDD0869	[14]
LDCM0272	AC151	HEK-293T	C328(1.04)	LDD0870	[14]
LDCM0273	AC152	HEK-293T	C328(0.95)	LDD0871	[14]
LDCM0274	AC153	HEK-293T	C328(0.98)	LDD0872	[14]
LDCM0621	AC154	HEK-293T	C328(0.86)	LDD2162	[14]
LDCM0622	AC155	HEK-293T	C328(1.01)	LDD2163	[14]
LDCM0623	AC156	HEK-293T	C328(1.02)	LDD2164	[14]
LDCM0624	AC157	HEK-293T	C328(0.84)	LDD2165	[14]
LDCM0276	AC17	HEK-293T	C328(1.21)	LDD0874	[14]
LDCM0277	AC18	HEK-293T	C328(1.29)	LDD0875	[14]
LDCM0278	AC19	HEK-293T	C328(1.48)	LDD0876	[14]
LDCM0279	AC2	HEK-293T	C328(1.25)	LDD0877	[14]
LDCM0280	AC20	HEK-293T	C328(1.39)	LDD0878	[14]
LDCM0281	AC21	HEK-293T	C328(1.23)	LDD0879	[14]
LDCM0282	AC22	HEK-293T	C328(1.21)	LDD0880	[14]
LDCM0283	AC23	HEK-293T	C328(1.23)	LDD0881	[14]
LDCM0284	AC24	HEK-293T	C328(1.18)	LDD0882	[14]
LDCM0285	AC25	HEK-293T	C328(0.70)	LDD0883	[14]
LDCM0286	AC26	HEK-293T	C328(0.67)	LDD0884	[14]
LDCM0287	AC27	HEK-293T	C328(1.03)	LDD0885	[14]
LDCM0288	AC28	HEK-293T	C328(0.94)	LDD0886	[14]
LDCM0289	AC29	HEK-293T	C328(0.95)	LDD0887	[14]
LDCM0290	AC3	HEK-293T	C328(1.01)	LDD0888	[14]
LDCM0291	AC30	HEK-293T	C328(0.74)	LDD0889	[14]
LDCM0292	AC31	HEK-293T	C328(0.76)	LDD0890	[14]
LDCM0293	AC32	HEK-293T	C328(0.74)	LDD0891	[14]
LDCM0294	AC33	HEK-293T	C328(0.83)	LDD0892	[14]
LDCM0295	AC34	HEK-293T	C328(0.79)	LDD0893	[14]
LDCM0296	AC35	PaTu 8988t	C328(1.04)	LDD1175	[14]
LDCM0297	AC36	PaTu 8988t	C328(1.27)	LDD1176	[14]
LDCM0298	AC37	PaTu 8988t	C328(1.28)	LDD1177	[14]
LDCM0299	AC38	PaTu 8988t	C328(1.14)	LDD1178	[14]
LDCM0300	AC39	PaTu 8988t	C328(1.33)	LDD1179	[14]
LDCM0301	AC4	HEK-293T	C328(1.06)	LDD0899	[14]
LDCM0302	AC40	PaTu 8988t	C328(1.38)	LDD1181	[14]
LDCM0303	AC41	PaTu 8988t	C328(1.09)	LDD1182	[14]
LDCM0304	AC42	PaTu 8988t	C328(1.17)	LDD1183	[14]
LDCM0305	AC43	PaTu 8988t	C328(1.14)	LDD1184	[14]
LDCM0306	AC44	PaTu 8988t	C328(1.40)	LDD1185	[14]
LDCM0307	AC45	PaTu 8988t	C328(1.33)	LDD1186	[14]
LDCM0308	AC46	PaTu 8988t	C328(1.15)	LDD1187	[14]
LDCM0309	AC47	PaTu 8988t	C328(1.15)	LDD1188	[14]
LDCM0310	AC48	PaTu 8988t	C328(1.27)	LDD1189	[14]
LDCM0311	AC49	PaTu 8988t	C328(1.67)	LDD1190	[14]
LDCM0312	AC5	HEK-293T	C328(1.05)	LDD0910	[14]
LDCM0313	AC50	PaTu 8988t	C328(1.59)	LDD1192	[14]
LDCM0314	AC51	PaTu 8988t	C328(0.44)	LDD1193	[14]
LDCM0315	AC52	PaTu 8988t	C328(1.19)	LDD1194	[14]
LDCM0316	AC53	PaTu 8988t	C328(1.74)	LDD1195	[14]
LDCM0317	AC54	PaTu 8988t	C328(1.79)	LDD1196	[14]
LDCM0318	AC55	PaTu 8988t	C328(1.29)	LDD1197	[14]
LDCM0319	AC56	PaTu 8988t	C328(1.55)	LDD1198	[14]
LDCM0320	AC57	HEK-293T	C328(1.09)	LDD0918	[14]
LDCM0321	AC58	HEK-293T	C328(1.25)	LDD0919	[14]
LDCM0322	AC59	HEK-293T	C328(1.14)	LDD0920	[14]
LDCM0323	AC6	HEK-293T	C328(2.00)	LDD0921	[14]
LDCM0324	AC60	HEK-293T	C328(1.41)	LDD0922	[14]
LDCM0325	AC61	HEK-293T	C328(1.34)	LDD0923	[14]
LDCM0326	AC62	HEK-293T	C328(1.12)	LDD0924	[14]
LDCM0327	AC63	HEK-293T	C328(1.40)	LDD0925	[14]
LDCM0328	AC64	HEK-293T	C328(1.05)	LDD0926	[14]
LDCM0329	AC65	HEK-293T	C328(1.18)	LDD0927	[14]
LDCM0330	AC66	HEK-293T	C328(1.17)	LDD0928	[14]
LDCM0331	AC67	HEK-293T	C328(1.40)	LDD0929	[14]
LDCM0332	AC68	HEK-293T	C328(0.93)	LDD0930	[14]
LDCM0333	AC69	HEK-293T	C328(0.99)	LDD0931	[14]
LDCM0334	AC7	HEK-293T	C328(1.44)	LDD0932	[14]
LDCM0335	AC70	HEK-293T	C328(0.99)	LDD0933	[14]
LDCM0336	AC71	HEK-293T	C328(1.00)	LDD0934	[14]
LDCM0337	AC72	HEK-293T	C328(1.11)	LDD0935	[14]
LDCM0338	AC73	HEK-293T	C328(1.03)	LDD0936	[14]
LDCM0339	AC74	HEK-293T	C328(1.04)	LDD0937	[14]
LDCM0340	AC75	HEK-293T	C328(0.90)	LDD0938	[14]
LDCM0341	AC76	HEK-293T	C328(0.98)	LDD0939	[14]
LDCM0342	AC77	HEK-293T	C328(0.94)	LDD0940	[14]
LDCM0343	AC78	HEK-293T	C328(0.90)	LDD0941	[14]
LDCM0344	AC79	HEK-293T	C328(0.96)	LDD0942	[14]
LDCM0345	AC8	HEK-293T	C328(1.29)	LDD0943	[14]
LDCM0346	AC80	HEK-293T	C328(0.97)	LDD0944	[14]
LDCM0347	AC81	HEK-293T	C328(0.90)	LDD0945	[14]
LDCM0348	AC82	HEK-293T	C328(0.93)	LDD0946	[14]
LDCM0349	AC83	HEK-293T	C328(1.17)	LDD0947	[14]
LDCM0350	AC84	HEK-293T	C328(1.17)	LDD0948	[14]
LDCM0351	AC85	HEK-293T	C328(0.93)	LDD0949	[14]
LDCM0352	AC86	HEK-293T	C328(1.27)	LDD0950	[14]
LDCM0353	AC87	HEK-293T	C328(1.15)	LDD0951	[14]
LDCM0354	AC88	HEK-293T	C328(1.15)	LDD0952	[14]
LDCM0355	AC89	HEK-293T	C328(1.34)	LDD0953	[14]
LDCM0357	AC90	HEK-293T	C328(1.05)	LDD0955	[14]
LDCM0358	AC91	HEK-293T	C328(0.97)	LDD0956	[14]
LDCM0359	AC92	HEK-293T	C328(1.00)	LDD0957	[14]
LDCM0360	AC93	HEK-293T	C328(0.90)	LDD0958	[14]
LDCM0361	AC94	HEK-293T	C328(1.01)	LDD0959	[14]
LDCM0362	AC95	HEK-293T	C328(1.23)	LDD0960	[14]
LDCM0363	AC96	HEK-293T	C328(0.97)	LDD0961	[14]
LDCM0364	AC97	HEK-293T	C328(1.16)	LDD0962	[14]
LDCM0365	AC98	HEK-293T	C328(0.94)	LDD0963	[14]
LDCM0366	AC99	HEK-293T	C328(0.95)	LDD0964	[14]
LDCM0545	Acetamide	MDA-MB-231	C328(0.40)	LDD2138	[37]
LDCM0520	AKOS000195272	MDA-MB-231	C328(0.62)	LDD2113	[37]
LDCM0248	AKOS034007472	HEK-293T	C328(2.41)	LDD0846	[14]
LDCM0356	AKOS034007680	HEK-293T	C328(2.06)	LDD0954	[14]
LDCM0275	AKOS034007705	HEK-293T	C328(1.82)	LDD0873	[14]
LDCM0156	Aniline	NCI-H1299	N.A.	LDD0404	[2]
LDCM0020	ARS-1620	HCC44	C328(1.04)	LDD0078	[14]
LDCM0498	BS-3668	MDA-MB-231	C328(0.45)	LDD2091	[37]
LDCM0630	CCW28-3	231MFP	C328(1.38); C328(1.14)	LDD2214	[38]
LDCM0108	Chloroacetamide	HeLa	H238(0.00); C328(0.00); H462(0.00); H437(0.00)	LDD0222	[29]
LDCM0367	CL1	PaTu 8988t	C328(0.94)	LDD1246	[14]
LDCM0368	CL10	PaTu 8988t	C328(1.43)	LDD1247	[14]
LDCM0369	CL100	HEK-293T	C328(0.96)	LDD0967	[14]
LDCM0370	CL101	HEK-293T	C328(1.49)	LDD0968	[14]
LDCM0371	CL102	HEK-293T	C328(1.20)	LDD0969	[14]
LDCM0372	CL103	HEK-293T	C328(1.51)	LDD0970	[14]
LDCM0373	CL104	HEK-293T	C328(1.11)	LDD0971	[14]
LDCM0374	CL105	HEK-293T	C328(1.05)	LDD0972	[14]
LDCM0375	CL106	HEK-293T	C328(1.34)	LDD0973	[14]
LDCM0376	CL107	HEK-293T	C328(1.57)	LDD0974	[14]
LDCM0377	CL108	HEK-293T	C328(1.14)	LDD0975	[14]
LDCM0378	CL109	HEK-293T	C328(1.30)	LDD0976	[14]
LDCM0379	CL11	PaTu 8988t	C328(1.07)	LDD1258	[14]
LDCM0380	CL110	HEK-293T	C328(1.52)	LDD0978	[14]
LDCM0381	CL111	HEK-293T	C328(1.26)	LDD0979	[14]
LDCM0382	CL112	HEK-293T	C328(0.74)	LDD0980	[14]
LDCM0383	CL113	HEK-293T	C328(0.89)	LDD0981	[14]
LDCM0384	CL114	HEK-293T	C328(0.78)	LDD0982	[14]
LDCM0385	CL115	HEK-293T	C328(0.76)	LDD0983	[14]
LDCM0386	CL116	HEK-293T	C328(0.83)	LDD0984	[14]
LDCM0387	CL117	PaTu 8988t	C328(1.08)	LDD1266	[14]
LDCM0388	CL118	PaTu 8988t	C328(1.11)	LDD1267	[14]
LDCM0389	CL119	PaTu 8988t	C328(1.27)	LDD1268	[14]
LDCM0390	CL12	PaTu 8988t	C328(1.10)	LDD1269	[14]
LDCM0391	CL120	PaTu 8988t	C328(1.14)	LDD1270	[14]
LDCM0392	CL121	PaTu 8988t	C328(1.26)	LDD1271	[14]
LDCM0393	CL122	PaTu 8988t	C328(1.29)	LDD1272	[14]
LDCM0394	CL123	PaTu 8988t	C328(1.43)	LDD1273	[14]
LDCM0395	CL124	PaTu 8988t	C328(1.55)	LDD1274	[14]
LDCM0396	CL125	HEK-293T	C328(1.01)	LDD0994	[14]
LDCM0397	CL126	HEK-293T	C328(1.01)	LDD0995	[14]
LDCM0398	CL127	HEK-293T	C328(1.12)	LDD0996	[14]
LDCM0399	CL128	HEK-293T	C328(1.14)	LDD0997	[14]
LDCM0400	CL13	PaTu 8988t	C328(1.80)	LDD1279	[14]
LDCM0401	CL14	PaTu 8988t	C328(1.62)	LDD1280	[14]
LDCM0402	CL15	PaTu 8988t	C328(1.11)	LDD1281	[14]
LDCM0403	CL16	HEK-293T	C328(1.02)	LDD1001	[14]
LDCM0404	CL17	HEK-293T	C328(1.03)	LDD1002	[14]
LDCM0405	CL18	HEK-293T	C328(1.02)	LDD1003	[14]
LDCM0406	CL19	HEK-293T	C328(1.08)	LDD1004	[14]
LDCM0407	CL2	PaTu 8988t	C328(1.02)	LDD1286	[14]
LDCM0408	CL20	HEK-293T	C328(1.14)	LDD1006	[14]
LDCM0409	CL21	HEK-293T	C328(1.01)	LDD1007	[14]
LDCM0410	CL22	HEK-293T	C328(1.16)	LDD1008	[14]
LDCM0411	CL23	HEK-293T	C328(0.96)	LDD1009	[14]
LDCM0412	CL24	HEK-293T	C328(0.97)	LDD1010	[14]
LDCM0413	CL25	HEK-293T	C328(0.91)	LDD1011	[14]
LDCM0414	CL26	HEK-293T	C328(1.08)	LDD1012	[14]
LDCM0415	CL27	HEK-293T	C328(0.95)	LDD1013	[14]
LDCM0416	CL28	HEK-293T	C328(1.00)	LDD1014	[14]
LDCM0417	CL29	HEK-293T	C328(1.15)	LDD1015	[14]
LDCM0418	CL3	PaTu 8988t	C328(1.35)	LDD1297	[14]
LDCM0419	CL30	HEK-293T	C328(1.02)	LDD1017	[14]
LDCM0420	CL31	HEK-293T	C328(0.78)	LDD1018	[14]
LDCM0421	CL32	HEK-293T	C328(0.67)	LDD1019	[14]
LDCM0422	CL33	HEK-293T	C328(0.69)	LDD1020	[14]
LDCM0423	CL34	HEK-293T	C328(0.89)	LDD1021	[14]
LDCM0424	CL35	HEK-293T	C328(0.75)	LDD1022	[14]
LDCM0425	CL36	HEK-293T	C328(0.70)	LDD1023	[14]
LDCM0426	CL37	HEK-293T	C328(0.70)	LDD1024	[14]
LDCM0428	CL39	HEK-293T	C328(0.91)	LDD1026	[14]
LDCM0429	CL4	PaTu 8988t	C328(1.13)	LDD1308	[14]
LDCM0430	CL40	HEK-293T	C328(0.74)	LDD1028	[14]
LDCM0431	CL41	HEK-293T	C328(0.67)	LDD1029	[14]
LDCM0432	CL42	HEK-293T	C328(0.73)	LDD1030	[14]
LDCM0433	CL43	HEK-293T	C328(0.75)	LDD1031	[14]
LDCM0434	CL44	HEK-293T	C328(0.67)	LDD1032	[14]
LDCM0435	CL45	HEK-293T	C328(0.66)	LDD1033	[14]
LDCM0436	CL46	PaTu 8988t	C328(1.09)	LDD1315	[14]
LDCM0437	CL47	PaTu 8988t	C328(1.36)	LDD1316	[14]
LDCM0438	CL48	PaTu 8988t	C328(1.05)	LDD1317	[14]
LDCM0439	CL49	PaTu 8988t	C328(1.07)	LDD1318	[14]
LDCM0440	CL5	PaTu 8988t	C328(1.52)	LDD1319	[14]
LDCM0441	CL50	PaTu 8988t	C328(1.29)	LDD1320	[14]
LDCM0442	CL51	PaTu 8988t	C328(1.28)	LDD1321	[14]
LDCM0443	CL52	PaTu 8988t	C328(1.35)	LDD1322	[14]
LDCM0444	CL53	PaTu 8988t	C328(1.66)	LDD1323	[14]
LDCM0445	CL54	PaTu 8988t	C328(1.26)	LDD1324	[14]
LDCM0446	CL55	PaTu 8988t	C328(1.20)	LDD1325	[14]
LDCM0447	CL56	PaTu 8988t	C328(1.09)	LDD1326	[14]
LDCM0448	CL57	PaTu 8988t	C328(1.54)	LDD1327	[14]
LDCM0449	CL58	PaTu 8988t	C328(1.24)	LDD1328	[14]
LDCM0450	CL59	PaTu 8988t	C328(1.29)	LDD1329	[14]
LDCM0451	CL6	PaTu 8988t	C328(1.18)	LDD1330	[14]
LDCM0452	CL60	PaTu 8988t	C328(1.12)	LDD1331	[14]
LDCM0453	CL61	HEK-293T	C328(0.92)	LDD1051	[14]
LDCM0454	CL62	HEK-293T	C328(0.88)	LDD1052	[14]
LDCM0455	CL63	HEK-293T	C328(0.74)	LDD1053	[14]
LDCM0456	CL64	HEK-293T	C328(0.86)	LDD1054	[14]
LDCM0457	CL65	HEK-293T	C328(1.11)	LDD1055	[14]
LDCM0458	CL66	HEK-293T	C328(0.86)	LDD1056	[14]
LDCM0459	CL67	HEK-293T	C328(0.98)	LDD1057	[14]
LDCM0460	CL68	HEK-293T	C328(0.83)	LDD1058	[14]
LDCM0461	CL69	HEK-293T	C328(0.82)	LDD1059	[14]
LDCM0462	CL7	PaTu 8988t	C328(1.30)	LDD1341	[14]
LDCM0463	CL70	HEK-293T	C328(0.87)	LDD1061	[14]
LDCM0464	CL71	HEK-293T	C328(0.90)	LDD1062	[14]
LDCM0465	CL72	HEK-293T	C328(0.83)	LDD1063	[14]
LDCM0466	CL73	HEK-293T	C328(0.92)	LDD1064	[14]
LDCM0467	CL74	HEK-293T	C328(0.83)	LDD1065	[14]
LDCM0469	CL76	HEK-293T	C328(1.05)	LDD1067	[14]
LDCM0470	CL77	HEK-293T	C328(0.84)	LDD1068	[14]
LDCM0471	CL78	HEK-293T	C328(1.07)	LDD1069	[14]
LDCM0472	CL79	HEK-293T	C328(1.03)	LDD1070	[14]
LDCM0473	CL8	PaTu 8988t	C328(1.23)	LDD1352	[14]
LDCM0474	CL80	HEK-293T	C328(1.10)	LDD1072	[14]
LDCM0475	CL81	HEK-293T	C328(1.00)	LDD1073	[14]
LDCM0476	CL82	HEK-293T	C328(0.96)	LDD1074	[14]
LDCM0477	CL83	HEK-293T	C328(0.92)	LDD1075	[14]
LDCM0478	CL84	HEK-293T	C328(1.08)	LDD1076	[14]
LDCM0479	CL85	HEK-293T	C328(1.19)	LDD1077	[14]
LDCM0480	CL86	HEK-293T	C328(1.17)	LDD1078	[14]
LDCM0481	CL87	HEK-293T	C328(1.18)	LDD1079	[14]
LDCM0482	CL88	HEK-293T	C328(1.44)	LDD1080	[14]
LDCM0483	CL89	HEK-293T	C328(1.11)	LDD1081	[14]
LDCM0484	CL9	PaTu 8988t	C328(1.42)	LDD1363	[14]
LDCM0485	CL90	HEK-293T	C328(1.21)	LDD1083	[14]
LDCM0486	CL91	HEK-293T	C328(1.02)	LDD1084	[14]
LDCM0487	CL92	HEK-293T	C328(1.15)	LDD1085	[14]
LDCM0488	CL93	HEK-293T	C328(1.06)	LDD1086	[14]
LDCM0489	CL94	HEK-293T	C328(1.26)	LDD1087	[14]
LDCM0490	CL95	HEK-293T	C328(1.13)	LDD1088	[14]
LDCM0491	CL96	HEK-293T	C328(1.07)	LDD1089	[14]
LDCM0492	CL97	HEK-293T	C328(1.23)	LDD1090	[14]
LDCM0493	CL98	HEK-293T	C328(1.17)	LDD1091	[14]
LDCM0494	CL99	HEK-293T	C328(1.13)	LDD1092	[14]
LDCM0495	E2913	HEK-293T	C328(1.15)	LDD1698	[39]
LDCM0213	Electrophilic fragment 2	MDA-MB-231	C328(0.86)	LDD1702	[37]
LDCM0468	Fragment33	HEK-293T	C328(0.87)	LDD1066	[14]
LDCM0427	Fragment51	HEK-293T	C328(0.68)	LDD1025	[14]
LDCM0116	HHS-0101	DM93	Y30(0.73); Y358(0.76); Y11(0.78); Y53(0.79)	LDD0264	[12]
LDCM0117	HHS-0201	DM93	Y53(0.62); Y358(0.63); Y61(0.63); Y38(0.64)	LDD0265	[12]
LDCM0118	HHS-0301	DM93	Y358(0.61); Y276(0.66); Y11(0.67); Y291(0.68)	LDD0266	[12]
LDCM0119	HHS-0401	DM93	Y358(0.58); Y30(0.70); Y53(0.73); Y61(0.73)	LDD0267	[12]
LDCM0120	HHS-0701	DM93	Y11(0.57); Y358(0.66); Y30(0.67); Y53(0.71)	LDD0268	[12]
LDCM0107	IAA	HeLa	H462(0.00); H437(0.00); C328(0.00); H461(0.00)	LDD0221	[29]
LDCM0123	JWB131	DM93	Y117(1.06); Y276(0.82); Y291(0.44); Y30(0.94)	LDD0285	[11]
LDCM0124	JWB142	DM93	Y117(1.35); Y276(0.79); Y291(0.54); Y30(0.75)	LDD0286	[11]
LDCM0125	JWB146	DM93	Y117(0.97); Y276(0.87); Y291(0.59); Y30(1.02)	LDD0287	[11]
LDCM0126	JWB150	DM93	Y117(2.76); Y276(2.67); Y291(1.86); Y30(2.97)	LDD0288	[11]
LDCM0127	JWB152	DM93	Y117(2.24); Y276(1.94); Y291(1.01); Y30(1.94)	LDD0289	[11]
LDCM0128	JWB198	DM93	Y117(0.86); Y276(0.97); Y291(0.05); Y30(1.24)	LDD0290	[11]
LDCM0129	JWB202	DM93	Y117(1.05); Y276(0.61); Y291(0.40); Y30(0.52)	LDD0291	[11]
LDCM0130	JWB211	DM93	Y117(0.91); Y276(0.99); Y291(0.49); Y30(0.95)	LDD0292	[11]
LDCM0022	KB02	HCT 116	C328(1.23)	LDD0080	[14]
LDCM0023	KB03	HCT 116	C328(1.01)	LDD0081	[14]
LDCM0024	KB05	HCT 116	C328(1.17)	LDD0082	[14]
LDCM0509	N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide	MDA-MB-231	C328(1.02)	LDD2102	[37]
LDCM0528	N-(4-bromophenyl)-2-cyano-N-phenylacetamide	MDA-MB-231	C328(0.63)	LDD2121	[37]
LDCM0109	NEM	HeLa	H462(0.00); H437(0.00); H461(0.00); K104(0.00)	LDD0223	[29]
LDCM0496	Nucleophilic fragment 11a	MDA-MB-231	C328(0.58)	LDD2089	[37]
LDCM0497	Nucleophilic fragment 11b	MDA-MB-231	C328(1.28)	LDD2090	[37]
LDCM0499	Nucleophilic fragment 12b	MDA-MB-231	C328(0.93)	LDD2092	[37]
LDCM0500	Nucleophilic fragment 13a	MDA-MB-231	C328(1.54)	LDD2093	[37]
LDCM0501	Nucleophilic fragment 13b	MDA-MB-231	C328(1.39)	LDD2094	[37]
LDCM0503	Nucleophilic fragment 14b	MDA-MB-231	C328(0.67)	LDD2096	[37]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C328(0.94)	LDD2097	[37]
LDCM0505	Nucleophilic fragment 15b	MDA-MB-231	C328(0.84)	LDD2098	[37]
LDCM0506	Nucleophilic fragment 16a	MDA-MB-231	C328(0.99)	LDD2099	[37]
LDCM0507	Nucleophilic fragment 16b	MDA-MB-231	C328(0.62)	LDD2100	[37]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C328(0.55)	LDD2101	[37]
LDCM0511	Nucleophilic fragment 18b	MDA-MB-231	C328(0.71)	LDD2104	[37]
LDCM0512	Nucleophilic fragment 19a	MDA-MB-231	C328(1.23)	LDD2105	[37]
LDCM0513	Nucleophilic fragment 19b	MDA-MB-231	C328(0.58)	LDD2106	[37]
LDCM0514	Nucleophilic fragment 20a	MDA-MB-231	C328(0.95)	LDD2107	[37]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C328(0.65)	LDD2108	[37]
LDCM0516	Nucleophilic fragment 21a	MDA-MB-231	C328(0.85)	LDD2109	[37]
LDCM0517	Nucleophilic fragment 21b	MDA-MB-231	C328(1.05)	LDD2110	[37]
LDCM0518	Nucleophilic fragment 22a	MDA-MB-231	C328(1.10)	LDD2111	[37]
LDCM0521	Nucleophilic fragment 23b	MDA-MB-231	C328(0.63)	LDD2114	[37]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C328(0.43)	LDD2115	[37]
LDCM0523	Nucleophilic fragment 24b	MDA-MB-231	C328(0.80)	LDD2116	[37]
LDCM0525	Nucleophilic fragment 25b	MDA-MB-231	C328(0.81)	LDD2118	[37]
LDCM0526	Nucleophilic fragment 26a	MDA-MB-231	C328(3.14)	LDD2119	[37]
LDCM0527	Nucleophilic fragment 26b	MDA-MB-231	C328(0.83)	LDD2120	[37]
LDCM0530	Nucleophilic fragment 28a	MDA-MB-231	C328(0.96)	LDD2123	[37]
LDCM0531	Nucleophilic fragment 28b	MDA-MB-231	C328(0.77)	LDD2124	[37]
LDCM0532	Nucleophilic fragment 29a	MDA-MB-231	C328(0.94)	LDD2125	[37]
LDCM0534	Nucleophilic fragment 30a	MDA-MB-231	C328(0.98)	LDD2127	[37]
LDCM0535	Nucleophilic fragment 30b	MDA-MB-231	C328(0.84)	LDD2128	[37]
LDCM0536	Nucleophilic fragment 31	MDA-MB-231	C328(1.40)	LDD2129	[37]
LDCM0540	Nucleophilic fragment 35	MDA-MB-231	C328(0.45)	LDD2133	[37]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C328(0.42)	LDD2134	[37]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C328(1.07)	LDD2135	[37]
LDCM0543	Nucleophilic fragment 38	MDA-MB-231	C328(1.19)	LDD2136	[37]
LDCM0544	Nucleophilic fragment 39	MDA-MB-231	C328(0.94)	LDD2137	[37]
LDCM0211	Nucleophilic fragment 3b	MDA-MB-231	C328(1.71)	LDD1700	[37]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C328(0.86)	LDD2140	[37]
LDCM0547	Nucleophilic fragment 41	MDA-MB-231	C328(0.71)	LDD2141	[37]
LDCM0549	Nucleophilic fragment 43	MDA-MB-231	C328(1.01)	LDD2143	[37]
LDCM0550	Nucleophilic fragment 5a	MDA-MB-231	C328(3.33)	LDD2144	[37]
LDCM0551	Nucleophilic fragment 5b	MDA-MB-231	C328(8.57)	LDD2145	[37]
LDCM0553	Nucleophilic fragment 6b	MDA-MB-231	C328(2.71)	LDD2147	[37]
LDCM0554	Nucleophilic fragment 7a	MDA-MB-231	C328(0.44)	LDD2148	[37]
LDCM0555	Nucleophilic fragment 7b	MDA-MB-231	C328(0.89)	LDD2149	[37]
LDCM0556	Nucleophilic fragment 8a	MDA-MB-231	C328(0.42)	LDD2150	[37]
LDCM0557	Nucleophilic fragment 8b	MDA-MB-231	C328(1.00)	LDD2151	[37]
LDCM0559	Nucleophilic fragment 9b	MDA-MB-231	C328(1.81)	LDD2153	[37]
LDCM0627	NUDT7-COV-1	HEK-293T	C328(2.07); C328(1.07)	LDD2206	[40]
LDCM0628	OTUB2-COV-1	HEK-293T	C328(0.89); C328(0.18)	LDD2207	[40]
LDCM0131	RA190	MM1.R	C328(1.12)	LDD0304	[41]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 19 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Adenylate kinase 2, mitochondrial (AK2)	Adenylate kinase family	P54819
Inositol hexakisphosphate kinase 1 (IP6K1)	Inositol phosphokinase (IPK) family	Q92551
Dihydropyrimidinase-related protein 1 (CRMP1)	Hydantoinase/dihydropyrimidinase family	Q14194
Histone acetyltransferase KAT7 (KAT7)	MYST (SAS/MOZ) family	O95251
Angiotensin-converting enzyme 2 (ACE2)	Peptidase M2 family	Q9BYF1
Protein prune homolog 2 (PRUNE2)	PPase class C family	Q8WUY3
Serine/threonine-protein kinase N1 (PKN1)	AGC Ser/Thr protein kinase family	Q16512
RAC-alpha serine/threonine-protein kinase (AKT1)	AGC Ser/Thr protein kinase family	P31749
RAC-beta serine/threonine-protein kinase (AKT2)	AGC Ser/Thr protein kinase family	P31751
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)	CAMK Ser/Thr protein kinase family	Q9UQM7
Tyrosine-protein kinase Blk (BLK)	Tyr protein kinase family	P51451
GTP-binding protein GEM (GEM)	RGK family	P55040
SPRY domain-containing SOCS box protein 1 (SPSB1)	SPSB family	Q96BD6
SPRY domain-containing SOCS box protein 2 (SPSB2)	SPSB family	Q99619
Acyl-coenzyme A thioesterase THEM4 (THEM4)	THEM4/THEM5 thioesterase family	Q5T1C6
Kinesin-like protein KIF9 (KIF9)	Kinesin family	Q9HAQ2
Tripartite motif-containing protein 14 (TRIM14)	TRIM/RBCC family	Q14142
Tripartite motif-containing protein 16 (TRIM16)	TRIM/RBCC family	O95361
Tubulin alpha-1C chain (TUBA1C)	Tubulin family	Q9BQE3

Transporter and channel

Click To Hide/Show 5 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
14-3-3 protein zeta/delta (YWHAZ)	14-3-3 family	P63104
Beclin-1 (BECN1)	Beclin family	Q14457
Huntingtin (HTT)	Huntingtin family	P42858
Transmembrane channel-like protein 6 (TMC6)	TMC family	Q7Z403
Sodium channel modifier 1 (SCNM1)	.	Q9BWG6

Transcription factor

Click To Hide/Show 6 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Heat shock transcription factor, Y-linked (HSFY1; HSFY2)	HSF family	Q96LI6
Zinc finger protein 20 (ZNF20)	Krueppel C2H2-type zinc-finger protein family	P17024
Zinc finger protein 572 (ZNF572)	Krueppel C2H2-type zinc-finger protein family	Q7Z3I7
NF-kappa-B inhibitor delta (NFKBID)	NF-kappa-B inhibitor family	Q8NI38
Krueppel-like factor 11 (KLF11)	Sp1 C2H2-type zinc-finger protein family	O14901
Achaete-scute homolog 4 (ASCL4)	.	Q6XD76

Immunoglobulin

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Natural cytotoxicity triggering receptor 1 (NCR1)				Natural cytotoxicity receptor (NCR) family	O76036

Other

Click To Hide/Show 45 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Ataxin-10 (ATXN10)	Ataxin-10 family	Q9UBB4
BCAS3 microtubule associated cell migration factor (BCAS3)	BCAS3 family	Q9H6U6
Bystin (BYSL)	Bystin family	Q13895
CWF19-like protein 2 (CWF19L2)	CWF19 family	Q2TBE0
Epithelial splicing regulatory protein 1 (ESRP1)	ESRP family	Q6NXG1
Protein FAM161A (FAM161A)	FAM161 family	Q3B820
Protein FAM163A (FAM163A)	FAM163 family	Q96GL9
Protein INCA1 (INCA1)	INCA family	Q0VD86
Desmin (DES)	Intermediate filament family	P17661
Glial fibrillary acidic protein (GFAP)	Intermediate filament family	P14136
Keratin, type I cytoskeletal 20 (KRT20)	Intermediate filament family	P35900
Keratin, type II cytoskeletal 75 (KRT75)	Intermediate filament family	O95678
Keratin, type II cytoskeletal 8 (KRT8)	Intermediate filament family	P05787
Nestin (NES)	Intermediate filament family	P48681
Neurofilament light polypeptide (NEFL)	Intermediate filament family	P07196
Neurofilament medium polypeptide (NEFM)	Intermediate filament family	P07197
Peripherin (PRPH)	Intermediate filament family	P41219
Syncoilin (SYNC)	Intermediate filament family	Q9H7C4
Vimentin (VIM)	Intermediate filament family	P08670
Ragulator complex protein LAMTOR1 (LAMTOR1)	LAMTOR1 family	Q6IAA8
Cytosolic iron-sulfur assembly component 2B (CIAO2B)	MIP18 family	Q9Y3D0
Periplakin (PPL)	Plakin or cytolinker family	O60437
Paraneoplastic antigen-like protein 5 (PNMA5)	PNMA family	Q96PV4
UV excision repair protein RAD23 homolog B (RAD23B)	RAD23 family	P54727
Ski-like protein (SKIL)	SKI family	P12757
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)	SNF5 family	Q12824
Beta-taxilin (TXLNB)	Taxilin family	Q8N3L3
Transcription elongation factor A protein 2 (TCEA2)	TFS-II family	Q15560
UPF0500 protein C1orf216 (C1orf216)	UPF0500 family	Q8TAB5
Protein VAC14 homolog (VAC14)	VAC14 family	Q08AM6
Vacuolar protein sorting-associated protein 11 homolog (VPS11)	VPS11 family	Q9H270
Armadillo repeat-containing protein 7 (ARMC7)	.	Q9H6L4
Cancer/testis antigen 55 (CT55)	.	Q8WUE5
Chromobox protein homolog 8 (CBX8)	.	Q9HC52
Coiled-coil domain-containing protein 120 (CCDC120)	.	Q96HB5
Fanconi anemia group G protein (FANCG)	.	O15287
mRNA decay activator protein ZFP36 (ZFP36)	.	P26651
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)	.	Q9HC29
Phostensin (PPP1R18)	.	Q6NYC8
Placental protein 13-like (LGALS14)	.	Q8TCE9
PRKC apoptosis WT1 regulator protein (PAWR)	.	Q96IZ0
Regulating synaptic membrane exocytosis protein 3 (RIMS3)	.	Q9UJD0
Telethonin (TCAP)	.	O15273
TP53-binding protein 1 (TP53BP1)	.	Q12888
Uncharacterized protein KIAA0408 (KIAA0408)	.	Q6ZU52

The Drug(s) Related To This Target

Approved

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Artenimol				.	DB11638

Investigative

Click To Hide/Show 1 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Phenethyl Isothiocyanate				Small molecular drug	DB12695

References

1	Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20. Mass spectrometry data entry: PXD025140
2	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3	Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4	2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print. Mass spectrometry data entry: PXD037665
5	Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
6	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
7	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8	2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9	A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10. Mass spectrometry data entry: PXD028270
10	A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w. Mass spectrometry data entry: PXD042888
11	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12	Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13	Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15	Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print. Mass spectrometry data entry: PXD042377
16	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
19	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20	SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25. Mass spectrometry data entry: PXD029500 , PXD031647
21	Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22. Mass spectrometry data entry: PXD006095 , PXD006096
22	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
24	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
25	Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20. Mass spectrometry data entry: PXD022279
26	Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022. Mass spectrometry data entry: PXD039931
27	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
28	Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6. Mass spectrometry data entry: PXD001377 , PXD005252
29	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30	Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
31	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
32	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33	Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
34	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
35	Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
36	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
37	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
38	Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
39	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
40	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
41	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

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Correspondence

Prof. Feng Zhu

Prof. Feng Ni