Details of the Target

General Information of Target

Target ID LDTP01922
Target Name Hemoglobin subunit epsilon (HBE1)
Gene Name HBE1
Gene ID 3046
Synonyms
HBE; Hemoglobin subunit epsilon; Epsilon-globin; Hemoglobin epsilon chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFDSFGNLSSPSAILGNPK
VKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPENFKLLGNVMVIILATHFG
KEFTPEVQAAWQKLVSAVAIALAHKYH
Target Bioclass
Other
Family
Globin family
Function The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.
Uniprot ID
P02100
Ensemble ID
ENST00000292896.3
HGNC ID
HGNC:4830

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.87  LDD0215  [1]
STPyne
 Probe Info  		K62(6.56)  LDD0277  [2]
HPAP
 Probe Info  		3.00  LDD0063  [3]
DBIA
 Probe Info  		C94(1.33)  LDD1507  [4]
2PCA
 Probe Info  		N.A.  LDD0034  [5]
VSF
 Probe Info  		N.A.  LDD0007  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
TER-AC
 Probe Info  		N.A.  LDD0426  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		7.51  LDD0465  [9]
DA-2
 Probe Info  		N.A.  LDD0070  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C94(1.33)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C94(1.14)  LDD1508  [4]
 LDCM0276  AC17 HEK-293T C94(1.32)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C94(1.16)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C94(1.26)  LDD1518  [4]
 LDCM0284  AC24 HEK-293T C94(1.07)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C94(1.26)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C94(1.27)  LDD1525  [4]
 LDCM0293  AC32 HEK-293T C94(0.95)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C94(1.55)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C94(1.22)  LDD1534  [4]
 LDCM0302  AC40 HEK-293T C94(1.02)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C94(1.33)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C94(1.18)  LDD1543  [4]
 LDCM0310  AC48 HEK-293T C94(0.98)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C94(0.98)  LDD1550  [4]
 LDCM0313  AC50 HEK-293T C94(0.95)  LDD1552  [4]
 LDCM0319  AC56 HEK-293T C94(0.99)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C94(0.29)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C94(0.41)  LDD1560  [4]
 LDCM0328  AC64 HEK-293T C94(0.84)  LDD1567  [4]
 LDCM0345  AC8 HEK-293T C94(0.87)  LDD1569  [4]
 LDCM0356  AKOS034007680 HEK-293T C94(1.46)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C94(0.95)  LDD1514  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0369  CL100 HEK-293T C94(1.09)  LDD1573  [4]
 LDCM0373  CL104 HEK-293T C94(1.01)  LDD1577  [4]
 LDCM0377  CL108 HEK-293T C94(1.00)  LDD1581  [4]
 LDCM0382  CL112 HEK-293T C94(1.17)  LDD1586  [4]
 LDCM0386  CL116 HEK-293T C94(1.06)  LDD1590  [4]
 LDCM0390  CL12 HEK-293T C94(1.11)  LDD1594  [4]
 LDCM0391  CL120 HEK-293T C94(1.02)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C94(1.00)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C94(0.74)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C94(0.92)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C94(0.85)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C94(0.99)  LDD1609  [4]
 LDCM0412  CL24 HEK-293T C94(1.26)  LDD1616  [4]
 LDCM0416  CL28 HEK-293T C94(1.10)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C94(0.94)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C94(0.83)  LDD1623  [4]
 LDCM0425  CL36 HEK-293T C94(1.21)  LDD1629  [4]
 LDCM0429  CL4 HEK-293T C94(1.04)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C94(1.01)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C94(0.77)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C94(0.85)  LDD1636  [4]
 LDCM0438  CL48 HEK-293T C94(1.38)  LDD1642  [4]
 LDCM0440  CL5 HEK-293T C94(0.76)  LDD1644  [4]
 LDCM0443  CL52 HEK-293T C94(1.12)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C94(1.16)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C94(1.24)  LDD1648  [4]
 LDCM0451  CL6 HEK-293T C94(0.81)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C94(1.31)  LDD1655  [4]
 LDCM0456  CL64 HEK-293T C94(1.33)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C94(1.42)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C94(1.39)  LDD1661  [4]
 LDCM0465  CL72 HEK-293T C94(1.33)  LDD1668  [4]
 LDCM0469  CL76 HEK-293T C94(0.94)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C94(1.32)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C94(1.07)  LDD1674  [4]
 LDCM0478  CL84 HEK-293T C94(1.22)  LDD1681  [4]
 LDCM0482  CL88 HEK-293T C94(0.90)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C94(0.96)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C94(1.04)  LDD1688  [4]
 LDCM0491  CL96 HEK-293T C94(1.11)  LDD1694  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0229  [7]
 LDCM0014  Panhematin K562 3.00  LDD0063  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit alpha (HBA1; HBA2) Globin family P69905
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hemoglobin subunit theta-1 (HBQ1) Globin family P09105
Hemoglobin subunit zeta (HBZ) Globin family P02008

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.