Details of the Target

General Information of Target

Target ID LDTP02925
Target Name ATP-dependent 6-phosphofructokinase, liver type (PFKL)
Gene Name PFKL
Gene ID 5211
Synonyms
ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; PFK-L; EC 2.7.1.11; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVDLEKLRASGAGKAIGVLTSGGDAQGMNAAVRAVTRMGIYVGAKVFLIYEGYEGLVE
GGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHGITNLCVIGGDG
SLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDS
ALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE
NFMCERLGETRSRGSRLNIIIIAEGAIDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQ
RGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLMECVQMTKEVQK
AMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPKEKSNFSLAILNVGAPAAGMNAAVRS
AVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESI
VENIRIYGIHALLVVGGFEAYEGVLQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLG
SDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFN
IHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGH
LQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFS
PVTELKKDTDFEHRMPREQWWLSLRLMLKMLAQYRISMAAYVSGELEHVTRRTLSMDKGF
Target Bioclass
Enzyme
Family
Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade 'E' sub-subfamily
Subcellular location
Cytoplasm
Function
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway. {|HAMAP-Rule:MF_03184}.
Uniprot ID
P17858
Ensemble ID
ENST00000349048.9
HGNC ID
HGNC:8876
ChEMBL ID
CHEMBL2191

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.H602Y DBIA    Probe Info 
AGS SNV: p.C522R DBIA    Probe Info 
HT SNV: p.Y514N DBIA    Probe Info 
J82 SNV: p.L58I DBIA    Probe Info 
MOLT4 SNV: p.D168N IA-alkyne    Probe Info 
NCIH1993 Deletion: p.I230SfsTer28
Insertion: p.F229VfsTer17		 .
RKO Deletion: p.P410RfsTer5 DBIA    Probe Info 
TOV21G SNV: p.R201K DBIA    Probe Info 
YSCCC SNV: p.S339L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.73  LDD0402  [1]
A-EBA
 Probe Info  		3.93  LDD0215  [2]
AZ-9
 Probe Info  		5.27  LDD0393  [3]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y674(20.00); Y634(7.94)  LDD0257  [5]
TH214
 Probe Info  		Y674(20.00)  LDD0258  [5]
TH216
 Probe Info  		Y633(20.00); Y674(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K614(7.69)  LDD0275  [7]
Probe 1
 Probe Info  		Y43(78.97); Y385(33.72); Y633(9.59); Y694(63.94)  LDD3495  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
BTD
 Probe Info  		C708(0.72)  LDD2109  [10]
DA-P3
 Probe Info  		4.86  LDD0183  [11]
AHL-Pu-1
 Probe Info  		C334(3.16)  LDD0172  [12]
HPAP
 Probe Info  		3.08  LDD0063  [13]
DBIA
 Probe Info  		C708(21.84); C351(4.84); C630(16.51)  LDD0209  [14]
HHS-482
 Probe Info  		Y674(0.84)  LDD0285  [15]
HHS-475
 Probe Info  		Y640(0.66); Y153(1.12)  LDD0264  [16]
HHS-465
 Probe Info  		Y633(5.09); Y640(10.00); Y674(10.00); Y694(10.00)  LDD2237  [17]
5E-2FA
 Probe Info  		H453(0.00); H660(0.00)  LDD2235  [18]
ATP probe
 Probe Info  		K392(0.00); K386(0.00); K715(0.00); K713(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		C114(0.00); C630(0.00); C351(0.00); C334(0.00)  LDD0038  [20]
IA-alkyne
 Probe Info  		C114(0.00); C170(0.00); C334(0.00)  LDD0032  [21]
Lodoacetamide azide
 Probe Info  		C114(0.00); C630(0.00); C351(0.00); C334(0.00)  LDD0037  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		C114(0.00); C170(0.00); C334(0.00); C630(0.00)  LDD2226  [23]
TFBX
 Probe Info  		N.A.  LDD0027  [22]
KY-26
 Probe Info  		N.A.  LDD0301  [24]
IPM
 Probe Info  		C708(0.00); C351(0.00)  LDD0005  [25]
NHS
 Probe Info  		K474(0.00); K8(0.00)  LDD0010  [25]
STPyne
 Probe Info  		N.A.  LDD0009  [25]
Acrolein
 Probe Info  		C708(0.00); C351(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		C708(0.00); C351(0.00)  LDD0218  [26]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		10.30  LDD0443  [28]
NAIA_5
 Probe Info  		C89(0.00); C708(0.00); C653(0.00); C351(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		26.54  LDD1733  [29]
FFF probe11
 Probe Info  		6.96  LDD0472  [30]
FFF probe13
 Probe Info  		5.80  LDD0476  [30]
FFF probe2
 Probe Info  		5.11  LDD0463  [30]
FFF probe3
 Probe Info  		13.16  LDD0465  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
DA-2
 Probe Info  		N.A.  LDD0070  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C708(0.92)  LDD2117  [10]
 LDCM0025  4SU-RNA HEK-293T C334(3.16)  LDD0172  [12]
 LDCM0214  AC1 HEK-293T C351(0.97); C630(1.01); C708(1.06); C170(0.99)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C351(0.96); C630(1.19); C708(1.00); C170(0.95)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C351(1.00); C630(0.97); C708(1.13); C170(0.87)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C351(0.93); C630(0.88); C708(1.23); C114(0.95)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C351(0.95); C630(0.94); C708(1.02); C114(0.91)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C351(0.90); C630(1.06); C708(1.05); C114(1.01)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C351(1.03); C630(1.13); C708(1.03); C170(1.13)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C351(1.03); C630(1.28); C708(1.18); C170(1.16)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C351(1.06); C630(1.07); C708(1.09); C170(0.71)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C351(0.97); C630(1.07); C708(1.07); C170(1.00)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C351(1.02); C630(0.82); C708(1.09); C114(0.91)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C351(0.97); C630(1.03); C708(1.09); C170(1.01)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C351(0.98); C630(0.98); C708(1.04); C114(0.96)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C351(1.03); C630(0.98); C708(1.00); C114(1.04)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C351(1.02); C630(0.94); C708(0.92); C170(1.06)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C351(1.03); C630(1.13); C708(1.16); C170(1.06)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C351(0.99); C630(1.09); C708(1.17); C170(1.04)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C351(0.95); C630(1.11); C708(1.40); C170(1.02)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C351(0.97); C630(0.99); C708(1.16); C114(1.00)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C351(0.98); C630(1.11); C708(0.97); C170(0.96)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C351(1.02); C630(1.00); C708(1.07); C170(0.89)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C351(0.94); C630(1.07); C708(1.07); C114(1.03)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C351(1.02); C630(1.02); C708(1.03); C114(1.13)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C351(0.99); C630(0.96); C708(1.00); C170(0.99)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C351(1.01); C630(1.02); C708(1.10); C170(1.32)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C351(0.99); C630(1.08); C708(0.96); C170(0.97)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C351(1.05); C630(1.01); C708(1.12); C170(0.94)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C351(0.98); C630(1.00); C708(1.21); C114(1.09)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C351(1.00); C630(1.01); C708(0.96); C170(1.08)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C351(0.96); C630(0.99); C708(1.01); C114(0.90)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C351(0.99); C630(0.93); C708(1.07); C114(1.15)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C351(0.92); C630(0.89); C708(1.23); C114(0.97)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C351(0.97); C630(0.97); C708(0.99); C170(1.22)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C351(1.01); C630(1.02); C708(1.05); C170(1.23)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C351(0.99); C630(1.12); C708(0.94); C170(0.86)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C351(0.97); C630(1.05); C708(1.08); C170(0.83)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C351(0.96); C630(0.79); C708(1.09); C114(0.91)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C351(0.97); C630(1.06); C708(0.95); C170(1.07)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C351(0.90); C630(0.96); C708(0.91); C114(1.02)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C351(0.96); C630(1.05); C708(1.08); C114(0.88)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C351(1.03); C630(0.96); C708(0.93); C170(1.13)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C351(1.00); C630(1.15); C708(1.03); C170(1.14)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C351(0.99); C630(0.97); C708(1.01); C170(1.05)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C351(0.97); C630(1.11); C708(1.06); C170(0.90)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C351(1.02); C630(0.96); C708(0.93); C170(0.82)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C351(0.98); C630(0.91); C708(1.18); C114(0.97)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C351(0.97); C630(1.02); C708(1.01); C170(1.11)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C351(0.94); C630(1.02); C708(0.93); C114(1.11)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C351(1.00); C630(1.09); C708(1.06); C114(1.15)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C351(0.99); C630(0.93); C708(0.94); C170(1.02)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C351(1.04); C630(1.04); C708(1.01); C170(1.18)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C351(0.97); C630(0.97); C708(0.95); C170(0.83)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C351(0.97); C630(0.91); C708(0.95); C170(0.84)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C351(0.94); C630(1.09); C708(0.97); C114(1.04)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C351(0.98); C630(0.79); C708(1.04); C114(0.99)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C351(0.98); C630(1.07); C708(0.91); C170(1.02)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C351(0.92); C630(1.09); C708(0.98); C114(1.07)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C351(1.03); C630(0.94); C708(1.05); C114(0.96)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C351(0.96); C630(0.96); C708(0.95); C170(1.27)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C351(0.99); C630(0.98); C708(1.00); C114(0.90)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C351(0.94); C630(0.96); C708(0.96); C170(1.02)  LDD1569  [35]
 LDCM0248  AKOS034007472 HEK-293T C351(0.97); C630(1.00); C708(0.93); C170(1.05)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C351(1.03); C630(1.11); C708(1.14); C170(1.12)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C351(0.96); C630(1.00); C708(1.00); C170(1.23)  LDD1514  [35]
 LDCM0087  Capsaicin HEK-293T 4.93  LDD0185  [11]
 LDCM0108  Chloroacetamide HeLa C351(0.00); C708(0.00); H390(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C89(20.00); C630(20.00); C170(20.00); C708(2.07)  LDD2227  [23]
 LDCM0367  CL1 HEK-293T C351(0.96); C630(1.27); C708(1.10); C170(1.14)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C351(1.00); C630(0.98); C708(0.96); C114(1.17)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C351(0.96); C630(0.97); C708(1.01); C170(1.10)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C351(0.95); C630(1.03); C708(0.93); C170(0.91)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C351(0.96); C630(0.97); C708(0.95); C170(1.12)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C351(0.99); C630(1.17); C708(0.98); C170(0.83)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C351(0.95); C630(1.03); C708(1.04); C170(0.91)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C351(0.93); C630(1.09); C708(1.06); C170(1.05)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C351(0.95); C630(1.05); C708(1.02); C170(0.98)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C351(0.99); C630(1.09); C708(1.04); C170(0.88)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C351(1.01); C630(1.26); C708(1.18); C170(0.87)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C351(0.95); C630(1.06); C708(0.98); C170(0.94)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C351(1.01); C630(1.04); C708(1.33); C114(1.38)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C351(0.96); C630(1.06); C708(1.02); C170(0.98)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C351(1.01); C630(1.05); C708(0.97); C170(0.83)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C351(0.98); C630(0.97); C708(0.92); C170(0.90)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C351(0.97); C630(1.07); C708(1.00); C170(1.10)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C351(0.98); C630(1.03); C708(0.94); C170(1.16)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C351(1.01); C630(1.23); C708(1.09); C170(0.93)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C351(0.97); C630(1.06); C708(0.90); C170(1.05)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C351(0.94); C630(1.16); C708(0.97); C170(0.90)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C351(0.94); C630(1.04); C708(0.90); C170(0.96)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C351(0.99); C630(0.99); C708(0.95); C170(0.87)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C351(0.93); C630(0.97); C708(0.97); C170(1.38)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C351(1.01); C630(1.03); C708(0.92); C170(1.00)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C351(0.95); C630(1.07); C708(0.93); C170(0.83)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C351(1.00); C630(1.12); C708(0.93); C170(0.81)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C351(1.01); C630(1.33); C708(1.06); C170(0.82)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C351(0.96); C630(1.10); C708(0.89); C170(0.92)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C351(0.95); C630(0.96); C708(0.98); C170(0.92)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C351(0.98); C630(1.08); C708(0.94); C170(0.85)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C351(0.96); C630(1.19); C708(1.01); C170(0.87)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C351(0.98); C630(0.98); C708(1.00); C170(0.99)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C351(0.94); C630(1.13); C708(0.99); C170(1.15)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C351(1.01); C630(1.07); C708(0.98); C170(1.04)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C351(0.92); C630(1.31); C708(1.19); C170(0.84)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C351(0.97); C630(1.05); C708(0.92); C170(1.02)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C351(0.92); C630(1.17); C708(1.30); C170(1.11)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C351(1.00); C630(1.08); C708(1.12); C170(0.97)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C351(1.00); C630(1.00); C708(1.01); C170(0.80)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C351(1.03); C630(0.90); C708(1.00); C170(0.94)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C351(0.90); C630(0.93); C708(1.09); C114(0.92)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C351(0.99); C630(1.26); C708(1.02); C170(1.18)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C351(0.96); C630(1.03); C708(1.08); C114(1.13)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C351(0.97); C630(0.95); C708(1.22); C114(1.22)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C351(0.94); C630(0.96); C708(0.93); C170(1.39)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C351(0.93); C630(1.10); C708(1.01); C170(0.98)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C351(0.97); C630(1.04); C708(0.98); C170(0.99)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C351(1.00); C630(1.23); C708(1.15); C170(1.05)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C351(0.98); C630(1.06); C708(1.08); C170(0.92)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C351(1.03); C630(1.15); C708(1.22); C170(1.07)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C351(1.02); C630(1.14); C708(0.95); C170(0.98)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C351(1.00); C630(1.08); C708(1.13); C170(0.92)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C351(1.00); C630(0.99); C708(1.09); C170(0.83)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C351(0.92); C630(1.08); C708(1.41); C114(0.98)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C351(0.97); C630(1.29); C708(0.87); C170(1.05)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C351(0.95); C630(0.98); C708(1.12); C114(1.10)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C351(1.02); C630(1.03); C708(1.16); C114(1.16)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C351(0.89); C630(0.99); C708(1.04); C170(1.22)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C351(0.92); C630(1.13); C708(1.00); C170(1.03)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C351(1.00); C630(1.36); C708(1.16); C170(0.99)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C351(0.96); C630(1.20); C708(1.19); C170(1.00)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C351(1.00); C630(0.96); C708(1.06); C170(1.19)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C351(0.96); C630(0.98); C708(0.98); C170(1.15)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C351(0.97); C630(1.13); C708(1.04); C170(0.82)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C351(0.98); C630(1.07); C708(1.40); C170(0.86)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C351(0.91); C630(0.85); C708(1.26); C114(0.91)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C351(0.99); C630(1.36); C708(0.94); C170(1.12)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C351(0.96); C630(0.89); C708(1.09); C114(1.04)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C351(1.01); C630(1.04); C708(1.19); C114(1.05)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C351(0.88); C630(0.98); C708(0.98); C170(1.19)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C351(0.95); C630(1.00); C708(0.98); C170(0.89)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C351(1.03); C630(1.16); C708(1.13); C170(1.15)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C351(0.98); C630(0.90); C708(0.99); C170(1.08)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C351(0.93); C630(1.03); C708(1.02); C170(0.94)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C351(0.94); C630(1.02); C708(1.21); C170(1.15)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C351(0.93); C630(1.33); C708(1.34); C170(1.11)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C351(1.01); C630(0.94); C708(1.24); C170(0.86)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C351(0.81); C630(1.23); C708(1.79); C114(1.20)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C351(0.92); C630(1.18); C708(0.98); C170(1.17)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C351(0.92); C630(1.08); C708(1.05); C114(1.09)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C351(0.91); C630(0.98); C708(1.22); C114(1.08)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C351(0.96); C630(1.15); C708(1.06); C170(0.97)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C351(0.91); C630(1.12); C708(1.06); C170(1.26)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C351(0.93); C630(0.98); C708(1.01); C170(0.87)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C351(0.99); C630(1.01); C708(1.07); C170(0.97)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C351(1.00); C630(1.11); C708(0.96); C170(0.92)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C351(0.92); C630(1.07); C708(0.95); C170(0.91)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C351(1.00); C630(1.07); C708(1.12); C170(1.20)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C351(0.94); C630(1.12); C708(1.04); C170(0.93)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C351(0.95); C630(1.03); C708(1.05); C170(0.90)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C351(0.91); C630(0.86); C708(1.18); C114(0.96)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C351(0.98); C630(1.23); C708(1.08); C170(1.04)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C351(0.92); C630(1.21); C708(1.26); C170(0.80)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C351(0.91); C630(1.02); C708(1.01); C114(0.91)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C351(0.99); C630(0.93); C708(1.05); C114(0.95)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C351(0.90); C630(0.90); C708(0.99); C170(1.19)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C351(0.88); C630(1.21); C708(1.10); C170(0.91)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C351(1.00); C630(1.05); C708(0.93); C170(0.97)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C351(1.00); C630(1.01); C708(1.06); C170(0.91)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C351(0.95); C630(1.11); C708(1.09); C170(1.02)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C351(0.95); C630(1.19); C708(1.07); C170(1.01)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C351(0.97); C630(0.97); C708(1.11); C170(0.75)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C351(0.82); C630(1.06); C708(1.70); C114(1.06)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C351(0.90); C630(0.82); C708(1.03); C114(0.84)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C351(0.99); C630(1.05); C708(1.04); C170(1.05)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C351(0.91); C630(0.95); C708(1.05); C114(1.13)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C351(0.95); C630(0.91); C708(1.13); C114(1.08)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C351(0.92); C630(1.06); C708(1.03); C170(1.15)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C351(0.92); C630(1.00); C708(0.95); C170(0.94)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C351(0.98); C630(0.98); C708(1.01); C170(0.85)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C351(1.01); C630(1.36); C708(1.11); C170(0.80)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C351(0.98); C630(1.02); C708(0.96); C170(0.88)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C351(1.02); C630(0.98); C708(1.14); C170(0.91)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C351(0.99); C630(1.13); C708(1.04); C170(1.04)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C351(0.97); C630(1.28); C708(1.40); C170(1.03)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C351(1.02); C630(1.02); C708(1.18); C170(0.61)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C351(0.91); C630(1.09); C708(1.45); C114(1.00)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C351(0.94); C630(1.29); C708(0.90); C170(1.07)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C351(0.88); C630(0.88); C708(0.93); C114(0.96)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C351(0.91); C630(0.97); C708(1.13); C114(0.86)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C351(0.94); C630(0.92); C708(0.94); C170(0.99)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C351(0.97); C630(0.99); C708(0.99); C170(0.89)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C351(1.02); C630(0.97); C708(1.06); C170(1.04)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C351(0.99); C630(1.14); C708(1.06); C170(0.83)  LDD1697  [35]
 LDCM0634  CY-0357 Hep-G2 C351(0.51); C708(0.36)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C351(0.91); C630(1.15); C708(1.12); C170(1.05)  LDD1698  [35]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C351(1.25)  LDD1702  [10]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.86  LDD0183  [11]
 LDCM0625  F8 Ramos C351(0.97); C708(0.91); C114(0.68)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C351(1.12); C708(0.82)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C351(0.17); C708(0.06); C114(0.54)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C351(1.17); C708(1.07)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C351(0.88); C708(0.75)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C89(0.35); C351(0.65); C708(1.13); C114(1.30)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C708(0.97)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C89(1.94); C351(1.07); C708(0.80)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C89(1.21); C351(0.88); C708(0.77)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C351(0.78); C708(0.67)  LDD2197  [36]
 LDCM0586  Fragment28 Ramos C351(0.54)  LDD2198  [36]
 LDCM0588  Fragment30 Ramos C351(1.00); C708(0.75)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C351(0.97); C708(0.81)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C351(0.91); C708(0.66)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C351(1.04); C630(1.46); C708(1.22); C170(0.92)  LDD1671  [35]
 LDCM0596  Fragment38 Ramos C89(2.21); C351(0.84); C708(0.87)  LDD2203  [36]
 LDCM0566  Fragment4 Ramos C351(1.42); C708(1.40); C114(0.73)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C351(1.13); C630(1.34); C708(1.26); C170(1.23)  LDD1631  [35]
 LDCM0610  Fragment52 Ramos C351(0.96); C708(1.76)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C89(1.57); C351(0.75); C708(0.87)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C351(1.00); C708(1.43); C114(0.35)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C351(1.44); C708(1.00)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y640(0.66); Y153(1.12)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y640(0.63); Y153(1.07)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y153(1.00)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y153(1.20); Y640(1.24)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y153(0.74); Y640(1.13)  LDD0268  [16]
 LDCM0015  HNE MDA-MB-231 C708(0.94)  LDD0346  [36]
 LDCM0107  IAA HeLa N.A.  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y674(0.84)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y674(0.83)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y674(1.32)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y674(2.77)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y674(2.00)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y674(0.92)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y674(0.60)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y674(0.88)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HEK-293T C351(1.02); C630(0.90); C708(0.89); C170(0.96)  LDD1492  [35]
 LDCM0023  KB03 Jurkat C708(21.84); C351(4.84); C630(16.51)  LDD0209  [14]
 LDCM0024  KB05 HMCB C398(2.51); C755(3.63)  LDD3312  [37]
 LDCM0109  NEM HeLa H199(0.00); H610(0.00); H660(0.00); H453(0.00)  LDD0223  [26]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C708(0.72)  LDD2109  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C708(0.82)  LDD2123  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C708(1.06)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C708(1.01)  LDD2137  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C89(0.80)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C351(2.60); C89(0.34)  LDD2207  [38]
 LDCM0014  Panhematin K562 3.08  LDD0063  [13]
 LDCM0131  RA190 MM1.R C630(1.36); C708(1.19)  LDD0304  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent 6-phosphofructokinase, liver type (PFKL) Phosphofructokinase type A (PFKA) family P17858
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) Phosphofructokinase type A (PFKA) family P08237
tRNA modification GTPase GTPBP3, mitochondrial (GTPBP3) TrmE GTPase family Q969Y2
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
14 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
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17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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