Details of the Target

General Information of Target

Target ID LDTP08275
Target Name Serine/threonine-protein kinase pim-3 (PIM3)
Gene Name PIM3
Gene ID 415116
Synonyms
Serine/threonine-protein kinase pim-3; EC 2.7.11.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily
Subcellular location
Cytoplasm
Function
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
TTD ID
T16596
Uniprot ID
Q86V86
DrugMap ID
TTCGOIN
Ensemble ID
ENST00000360612.5
HGNC ID
HGNC:19310
ChEMBL ID
CHEMBL5407

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0073  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid21982499c14k Small molecular drug D06UKS
Pmid22136433c20 Small molecular drug D06HVH
Pmid24900749c1a Small molecular drug D04TPA
Patented
Click To Hide/Show 31 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bdbm50061601 Small molecular drug D04VSB
Bdbm50061608 Small molecular drug D06OKX
Bdbm50061612 Small molecular drug D08JUU
N-{4 Small molecular drug D0J6HN
Us8481586, 15 Small molecular drug D06TGF
Us8481586, 40 Small molecular drug D0M0TH
Us8481586, 5 Small molecular drug D0NE0N
Us8592455, 3 Small molecular drug D0OS2I
Us8592455, 90 Small molecular drug D0X0BB
Us8669361, 102 Small molecular drug D0D0WQ
Us8669361, 103 Small molecular drug D0WH9N
Us8669361, 105 Small molecular drug D0DT0E
Us8669361, 107 Small molecular drug D0I0CN
Us8759338, 1 Small molecular drug D0XJ2J
Us8759338, 12 Small molecular drug D0P4NQ
Us8759338, 2 Small molecular drug D0GV1S
Us8829193, 1 Small molecular drug D0P9UF
Us8829193, 2 Small molecular drug D0ZC0E
Us8829193, 3 Small molecular drug D04MCF
Us8889696, Staurosporine Small molecular drug D04JJM
Us8987457, 117 Small molecular drug D0LK3O
Us8987457, 15 Small molecular drug D0WU1C
Us8987457, 198 Small molecular drug D0NX6B
Us9434725, 113 Small molecular drug D0ZY3D
Us9434725, 285 Small molecular drug D0JL8G
Us9434725, 315 Small molecular drug D07SHE
Us9580418, Example 11 Small molecular drug D0QU7N
Us9580418, Example 8 Small molecular drug D05ZQI
Us9682991, 2 Small molecular drug D0V5JW
Us9682991, 23 Small molecular drug D00HBJ
Us9682991, 7 Small molecular drug D0EH6G

References

1 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.