Details of the Target

General Information of Target

Target ID LDTP02964
Target Name Regulator of chromosome condensation (RCC1)
Gene Name RCC1
Gene ID 1104
Synonyms
CHC1; Regulator of chromosome condensation; Cell cycle regulatory protein; Chromosome condensation protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP
ALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEK
VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASG
NDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHV
RFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFS
GGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV
TKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLLVKDKEQ
S
Target Bioclass
Other
Subcellular location
Nucleus
Function
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA.
Uniprot ID
P18754
Ensemble ID
ENST00000373831.7
HGNC ID
HGNC:1913

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.S145F DBIA    Probe Info 
ETK1 SNV: p.P388H DBIA    Probe Info 
NCIH1155 SNV: p.G151S DBIA    Probe Info 
RT112 SNV: p.K335N DBIA    Probe Info 
SNU1 Deletion: p.P13QfsTer11 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y89(20.00); Y375(11.33); Y194(10.98); Y316(6.54)  LDD0257  [2]
TH216
 Probe Info  		Y194(16.68)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K232(7.94); K24(10.00); K335(10.00)  LDD0277  [4]
DBIA
 Probe Info  		C383(1.23); C93(1.04); C229(0.98)  LDD3310  [5]
BTD
 Probe Info  		C93(1.15)  LDD2089  [6]
AHL-Pu-1
 Probe Info  		C308(2.13); C198(8.93)  LDD0170  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C81(0.00); C352(0.00); C93(0.00); C308(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C93(0.00); C81(0.00); C352(0.00); C308(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		C93(0.00); C81(0.00); C308(0.00); C198(0.00)  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C81(0.00); C352(0.00); C93(0.00); C308(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
NHS
 Probe Info  		K120(0.00); K161(0.00); K114(0.00); K335(0.00)  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
1c-yne
 Probe Info  		K114(0.00); K335(0.00); K161(0.00); C198(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		C308(0.00); C81(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C93(0.00); C308(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		C93(0.00); C198(0.00)  LDD0236  [17]
AOyne
 Probe Info  		8.80  LDD0443  [18]
NAIA_5
 Probe Info  		C81(0.00); C352(0.00); C93(0.00); C308(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		N.A.  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]
DA-2
 Probe Info  		N.A.  LDD0070  [23]
STS-1
 Probe Info  		N.A.  LDD0068  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C93(0.98)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C93(1.14); C352(1.05)  LDD2117  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C352(0.74)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C93(1.05)  LDD2131  [6]
 LDCM0025  4SU-RNA DM93 C308(2.13); C198(8.93)  LDD0170  [7]
 LDCM0214  AC1 HEK-293T C93(0.91); C198(0.94); C81(1.10)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C93(1.13); C198(1.11); C81(0.89)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C93(1.10); C198(0.99); C81(1.23)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C93(0.92); C198(0.98)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C93(1.00); C198(0.99); C81(1.21)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C93(1.03); C198(1.03)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C93(1.03); C198(0.95); C81(1.12)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C93(1.01); C198(1.02); C81(0.96)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C93(0.91); C198(0.91); C81(1.00)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C93(1.21); C198(1.09); C81(1.03)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C93(0.98); C198(0.94)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C93(1.04); C198(1.09); C81(1.18)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C93(1.14); C198(1.01); C81(1.22)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C93(1.14); C198(1.11)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C93(1.18); C198(1.05); C81(0.95)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C93(0.93); C198(0.98); C81(1.07)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C93(1.02); C198(1.05); C81(0.94)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C93(1.08); C198(0.94); C81(1.11)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C93(0.97); C198(0.96)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C93(1.11); C198(1.05); C81(1.22)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C93(1.06); C198(0.95); C81(1.14)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C93(1.11); C198(0.98); C81(1.39)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C93(1.05); C198(1.01)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C93(1.01); C198(1.02); C81(1.00)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C93(1.05); C198(0.98); C81(1.13)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C93(1.14); C198(1.14); C81(0.86)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C93(1.08); C198(0.94); C81(1.22)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C93(0.93); C198(1.07)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C93(1.22); C198(1.15); C81(1.29)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C93(1.16); C198(1.00); C81(1.31)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C93(1.13); C198(1.03)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C93(0.90); C198(1.13)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C93(1.04); C198(0.99); C81(1.03)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C93(1.01); C198(0.98); C81(1.04)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C93(0.99); C198(1.03); C81(0.88)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C93(1.10); C198(1.08); C81(1.21)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C93(1.11); C198(1.10)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C93(1.07); C198(1.09); C81(1.18)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C93(1.03); C198(1.00); C81(1.26)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C93(1.11); C198(1.11)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C93(1.08); C198(1.04); C81(0.91)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C93(1.04); C198(1.06); C81(1.07)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C93(1.11); C198(1.10); C81(1.29)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C93(1.12); C198(1.12); C81(0.83)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C93(1.34); C198(1.12); C81(1.14)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C93(1.03); C198(1.03)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C93(1.06); C198(1.15); C81(1.17)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C93(0.93); C198(1.07); C81(1.11)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C93(1.11); C198(1.06)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C93(0.99); C198(1.01); C81(1.01)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C93(0.93); C198(0.89); C81(1.12)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C93(1.09); C198(1.09); C81(0.94)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C93(1.15); C198(0.96); C81(1.28)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C93(0.98); C198(0.98); C81(1.21)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C93(1.00); C198(0.99)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C93(1.09); C198(1.08); C81(1.23)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C93(1.10); C198(1.07); C81(1.18)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C93(1.09); C198(0.99)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C93(1.11); C198(1.00); C81(1.08)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C93(1.03); C198(1.01)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C93(1.02); C198(0.99); C81(0.94)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C93(1.10); C198(1.17); C81(1.18)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C93(0.95); C198(0.93); C81(1.07)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C93(0.98); C198(1.02); C81(1.00)  LDD1514  [25]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C352(0.41)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C198(0.00); C308(0.00); C81(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C93(1.06); C198(1.06)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C93(0.74); C198(0.88); C81(0.79)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C93(1.07); C198(0.99); C81(0.96); C352(1.12)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C93(0.95); C198(0.99)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C93(0.92); C198(1.04); C81(0.80)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C93(1.04); C198(0.96); C81(0.81); C352(1.07)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C93(1.26); C198(1.01); C81(0.98); C352(1.16)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C93(1.05); C198(0.89)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C93(1.09); C198(1.00); C81(0.89)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C93(1.11); C198(0.83); C81(0.84); C352(1.16)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C93(1.07); C198(1.01); C81(0.98); C352(1.13)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C93(1.01); C198(0.94)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C93(1.00); C198(1.01)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C93(0.85); C198(0.96); C81(0.89)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C93(1.00); C198(0.89); C81(0.74); C352(1.09)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C93(1.11); C198(0.93); C81(0.89); C352(1.08)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C93(1.09); C198(1.07)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C93(0.97); C198(0.92); C81(0.79)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C93(1.06); C198(0.96); C81(0.95); C352(1.16)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C93(1.28); C198(0.93); C81(0.97); C352(1.21)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C93(1.00); C198(1.00)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C93(0.98); C198(0.97); C81(0.89)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C93(1.20); C198(1.00); C81(1.03); C352(1.24)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C93(1.08); C198(1.05); C81(1.63)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C93(1.16); C198(1.09); C81(0.81); C352(1.22)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C93(0.99); C198(1.05)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C93(0.98); C198(0.98); C81(0.84)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C93(0.90); C198(0.85); C81(0.80); C352(1.04)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C93(1.12); C198(0.97); C81(0.81); C352(1.29)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C93(1.05); C198(1.07)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C93(1.02); C198(0.94); C81(0.79)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C93(1.03); C198(0.94); C81(0.99); C352(1.10)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C93(1.19); C198(0.98); C81(0.82); C352(1.23)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C93(0.96); C198(0.98)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C93(1.04); C198(1.05); C81(0.80)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C93(0.86); C198(0.78); C81(0.68); C352(0.94)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C93(1.27); C198(1.11); C81(0.87); C352(1.26)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C93(0.68); C198(0.91); C81(0.84)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C93(1.18); C198(1.07); C81(0.93)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C93(1.11); C198(0.96); C81(1.09)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C93(0.94); C198(1.11); C81(0.84)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C93(0.77); C198(1.01)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C93(1.03); C198(0.92); C81(0.89)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C93(1.01); C198(1.09); C81(1.00)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C93(0.98); C198(1.14)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C93(0.98); C198(1.05); C81(2.09)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C93(0.90); C198(0.95)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C93(1.02); C198(1.01); C81(0.81)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C93(1.03); C198(0.85); C81(0.85); C352(1.07)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C93(1.07); C198(1.06); C81(0.74); C352(1.14)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C93(0.95); C198(0.96); C81(1.11)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C93(0.91); C198(1.01); C81(0.90); C352(0.93)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C93(1.15); C198(1.14); C81(0.97)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C93(1.01); C198(1.05); C81(1.01)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C93(0.97); C198(0.93)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C93(0.84); C198(0.86); C81(0.82)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C93(1.14); C198(1.00); C81(1.01)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C93(1.04); C198(1.20)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C93(0.94); C198(0.97); C81(1.73)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C93(1.14); C198(1.03)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C93(1.03); C198(0.95); C81(0.87); C352(1.15)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C93(1.11); C198(1.03); C81(0.90); C352(1.36)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C93(1.16); C198(1.05); C81(0.94); C352(1.04)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C93(0.89); C198(0.93); C81(1.07)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C93(1.09); C198(1.26); C81(0.99)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C93(1.24); C198(1.07); C81(1.07)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C93(1.04); C198(0.99)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C93(0.85); C198(0.94); C81(0.91)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C93(1.07); C198(1.10); C81(1.04)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C93(1.01); C198(1.12)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C93(1.03); C198(0.98); C81(1.80)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C93(1.23); C198(1.12)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C93(0.76); C198(0.90); C81(0.91)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C93(0.97); C198(1.00); C81(0.77)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C93(1.11); C198(1.00); C81(0.88); C352(1.10)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C93(0.75); C198(0.97); C81(1.05)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C93(0.87); C198(1.00); C81(0.98)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C93(1.11); C198(1.05); C81(0.77)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C93(0.90); C198(1.00)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C93(0.78); C198(0.88); C81(1.02)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C93(0.97); C198(1.05); C81(1.18)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C93(1.08); C198(1.15)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C93(1.07); C198(0.96); C81(0.88)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C93(0.97); C198(1.08); C81(2.35)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C93(1.02); C198(1.05)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C93(1.05); C198(1.04); C81(0.92)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C93(1.13); C198(0.91); C81(0.82); C352(1.13)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C93(0.97); C198(0.86); C81(0.83); C352(0.96)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C93(1.00); C198(1.04); C81(1.09)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C93(1.07); C198(0.94); C81(0.92)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C93(1.01); C198(1.02); C81(1.15)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C93(1.03); C198(1.06)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C93(0.98); C198(1.01); C81(0.94)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C93(0.99); C198(0.85); C81(1.09)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C93(1.06); C198(1.08); C81(1.10)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C93(1.06); C198(1.21)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C93(0.99); C198(1.02); C81(1.60)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C93(1.07); C198(1.00)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C93(1.01); C198(1.10); C81(0.88)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C93(1.04); C198(0.98); C81(0.83); C352(1.01)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C93(0.84); C198(0.89); C81(0.93)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C93(1.17); C198(1.10); C81(0.87)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C93(1.08); C198(1.22); C81(1.12)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C93(0.70); C198(0.68)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C93(0.95); C198(1.05)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C93(1.16); C198(1.05); C81(0.98)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C93(1.08); C198(1.13); C81(1.18)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C93(1.04); C198(1.11)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C93(0.99); C198(0.99); C81(1.53)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C93(0.99); C198(0.98)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C93(1.03); C198(0.99); C81(0.88)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C93(1.08); C198(0.80); C81(0.95); C352(1.04)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C93(1.15); C198(0.95); C81(0.96); C352(1.39)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C93(0.98); C198(1.04); C81(1.03)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C93(0.93); C198(1.09); C81(0.96)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C93(0.83); C198(0.89); C81(0.73)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C93(1.19); C198(0.99); C81(1.12)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C93(0.99); C198(1.07)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C93(0.99); C198(1.00); C81(1.03)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C93(1.03); C198(1.13); C81(1.13)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C93(0.82); C198(0.74)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C93(0.89); C198(0.97); C81(1.78)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C93(1.01); C198(0.95)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C93(0.93); C198(0.92); C81(0.89)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C93(1.00); C198(1.01); C81(1.03); C352(0.99)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C93(1.03); C198(1.00); C81(0.82); C352(1.12)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C93(1.05)  LDD1702  [6]
 LDCM0625  F8 Ramos C352(0.45)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C352(0.58)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C352(0.57)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C352(0.65)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C352(0.73)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C352(0.87)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C352(0.76)  LDD2194  [26]
 LDCM0582  Fragment23 Ramos C352(0.69)  LDD2196  [26]
 LDCM0588  Fragment30 Ramos C352(0.40)  LDD2199  [26]
 LDCM0590  Fragment32 Ramos C352(0.57)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C93(1.08); C198(0.85); C81(0.91); C352(1.20)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos C352(0.28)  LDD2203  [26]
 LDCM0427  Fragment51 HEK-293T C93(1.02); C198(1.05); C81(0.92)  LDD1631  [25]
 LDCM0610  Fragment52 Ramos C352(0.43)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C352(0.61)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C352(0.53)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C352(0.60)  LDD2188  [26]
 LDCM0107  IAA HeLa C308(0.00); H130(0.00)  LDD0221  [16]
 LDCM0022  KB02 Ramos C352(0.42)  LDD2182  [26]
 LDCM0023  KB03 Ramos C352(0.57)  LDD2183  [26]
 LDCM0024  KB05 COLO792 C383(1.23); C93(1.04); C229(0.98)  LDD3310  [5]
 LDCM0109  NEM HeLa H130(0.00); H410(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C93(1.15)  LDD2089  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C352(0.97)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C93(0.99)  LDD2099  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C352(0.73)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C93(1.58)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C93(1.31); C352(0.59)  LDD2109  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C352(0.97)  LDD2114  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C352(0.76)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C93(0.94); C352(0.89)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C352(0.84)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C93(1.36)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C93(1.65)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C93(1.70); C352(0.97)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C93(0.93)  LDD2137  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C352(0.71)  LDD2141  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C93(1.01)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C93(0.99); C352(0.49)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C352(1.23)  LDD2153  [6]
 LDCM0131  RA190 MM1.R C198(1.53); C352(1.45)  LDD0304  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) NTM1 family Q9BV86
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ran-binding protein 3 (RANBP3) . Q9H6Z4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.