Details of the Target

General Information of Target

Target ID LDTP00991
Target Name Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)
Gene Name SYNCRIP
Gene ID 10492
Synonyms
HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding, cytoplasmic RNA-interacting protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDER
AIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPD
EAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVP
LFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISV
ANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAA
QARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQ
FGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQR
QAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGG
YEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARG
GAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDH
SGNYGYKSENQEFYQDTFGQQWK
Target Bioclass
Other
Subcellular location
Cytoplasm; Nucleus, nucleoplasm
Function
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
Uniprot ID
O60506
Ensemble ID
ENST00000355238.11
HGNC ID
HGNC:16918
ChEMBL ID
CHEMBL4295997

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.N285TfsTer22 DBIA    Probe Info 
FTC133 SNV: p.G269D DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y488H DBIA    Probe Info 
JURKAT Insertion: p.N285KfsTer8 Compound 10    Probe Info 
LS180 SNV: p.R548H DBIA    Probe Info 
MOLT4 SNV: p.A374V IA-alkyne    Probe Info 
P31FUJ SNV: p.S230A DBIA    Probe Info 
PC9 SNV: p.G155S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 48 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [2]
P1
 Probe Info  		10.00  LDD0448  [3]
P2
 Probe Info  		10.00  LDD0449  [3]
P3
 Probe Info  		10.00  LDD0450  [3]
P8
 Probe Info  		1.82  LDD0451  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y205(20.00); Y293(20.00); Y373(11.50); Y276(10.96)  LDD0257  [5]
TH216
 Probe Info  		Y205(20.00); Y373(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K221(10.00); K297(10.00); K363(1.14)  LDD0274  [7]
STPyne
 Probe Info  		K168(6.25); K363(5.00)  LDD0277  [7]
AZ-9
 Probe Info  		D136(10.00)  LDD2209  [8]
Probe 1
 Probe Info  		Y47(7.30); Y276(12.11); Y373(21.72)  LDD3495  [9]
BTD
 Probe Info  		C96(0.95)  LDD2115  [10]
AHL-Pu-1
 Probe Info  		C96(2.85)  LDD0171  [11]
HHS-482
 Probe Info  		Y205(1.34)  LDD0285  [12]
HHS-475
 Probe Info  		Y570(0.80); Y205(1.16)  LDD0264  [13]
HHS-465
 Probe Info  		Y205(10.00)  LDD2237  [14]
DBIA
 Probe Info  		C237(1.09)  LDD0078  [15]
5E-2FA
 Probe Info  		H87(0.00); H296(0.00); H377(0.00); H233(0.00)  LDD2235  [16]
AMP probe
 Probe Info  		N.A.  LDD0200  [17]
ATP probe
 Probe Info  		K100(0.00); K297(0.00); K282(0.00); K283(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [18]
IA-alkyne
 Probe Info  		C289(0.00); C96(0.00); C237(0.00)  LDD0032  [19]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [20]
IPIAA_L
 Probe Info  		C289(0.00); C237(0.00)  LDD0031  [20]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [18]
ATP probe
 Probe Info  		N.A.  LDD0035  [21]
IPM
 Probe Info  		C237(0.00); C289(0.00); C96(0.00)  LDD0025  [22]
JW-RF-010
 Probe Info  		C96(0.00); C237(0.00)  LDD0026  [22]
TFBX
 Probe Info  		C289(0.00); C96(0.00); C237(0.00)  LDD0027  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [23]
Compound 10
 Probe Info  		C211(0.00); C289(0.00); C96(0.00)  LDD2216  [24]
Compound 11
 Probe Info  		N.A.  LDD2213  [24]
NHS
 Probe Info  		K168(0.00); K256(0.00); K282(0.00); K363(0.00)  LDD0010  [25]
SF
 Probe Info  		Y205(0.00); Y570(0.00); K117(0.00); K338(0.00)  LDD0028  [26]
Phosphinate-6
 Probe Info  		C237(0.00); C289(0.00); C96(0.00)  LDD0018  [27]
Ox-W18
 Probe Info  		W314(0.00); W322(0.00)  LDD2175  [28]
1c-yne
 Probe Info  		K143(0.00); K412(0.00); K168(0.00); K42(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		H277(0.00); C289(0.00); H226(0.00); H54(0.00)  LDD0217  [29]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [29]
Crotonaldehyde
 Probe Info  		C289(0.00); C96(0.00); H226(0.00); H87(0.00)  LDD0219  [29]
Methacrolein
 Probe Info  		C237(0.00); C289(0.00); C96(0.00); H87(0.00)  LDD0218  [29]
AOyne
 Probe Info  		5.70  LDD0443  [30]
NAIA_5
 Probe Info  		C289(0.00); C211(0.00); C237(0.00)  LDD2223  [31]
PAL-AfBPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.61  LDD0367  [32]
C004
 Probe Info  		6.73  LDD1714  [33]
C087
 Probe Info  		8.94  LDD1779  [33]
C129
 Probe Info  		5.82  LDD1811  [33]
C161
 Probe Info  		9.78  LDD1841  [33]
C165
 Probe Info  		20.25  LDD1845  [33]
C166
 Probe Info  		7.41  LDD1846  [33]
C191
 Probe Info  		11.88  LDD1868  [33]
C196
 Probe Info  		11.16  LDD1872  [33]
C218
 Probe Info  		12.55  LDD1892  [33]
C220
 Probe Info  		11.55  LDD1894  [33]
C232
 Probe Info  		44.02  LDD1905  [33]
C249
 Probe Info  		13.36  LDD1922  [33]
C293
 Probe Info  		15.89  LDD1963  [33]
C313
 Probe Info  		13.45  LDD1980  [33]
C314
 Probe Info  		11.16  LDD1981  [33]
C322
 Probe Info  		5.78  LDD1988  [33]
C338
 Probe Info  		21.41  LDD2001  [33]
C348
 Probe Info  		10.93  LDD2009  [33]
C353
 Probe Info  		7.57  LDD2014  [33]
C383
 Probe Info  		10.93  LDD2042  [33]
C391
 Probe Info  		13.74  LDD2050  [33]
C420
 Probe Info  		10.41  LDD2075  [33]
C431
 Probe Info  		13.55  LDD2086  [33]
FFF probe11
 Probe Info  		14.01  LDD0471  [34]
FFF probe12
 Probe Info  		7.60  LDD0473  [34]
FFF probe13
 Probe Info  		18.31  LDD0475  [34]
FFF probe14
 Probe Info  		12.19  LDD0477  [34]
FFF probe2
 Probe Info  		20.00  LDD0463  [34]
FFF probe3
 Probe Info  		15.06  LDD0464  [34]
FFF probe6
 Probe Info  		5.48  LDD0467  [34]
JN0003
 Probe Info  		13.28  LDD0469  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [35]
VE-P
 Probe Info  		N.A.  LDD0396  [36]
DA-2
 Probe Info  		N.A.  LDD0070  [37]
OEA-DA
 Probe Info  		5.59  LDD0046  [38]
STS-1
 Probe Info  		N.A.  LDD0068  [39]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C96(2.85)  LDD0171  [11]
 LDCM0214  AC1 HCT 116 C211(1.00); C237(1.05)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C211(0.83); C237(0.94)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C211(0.75); C237(1.29)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C211(0.79); C237(1.33)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C211(0.75); C237(1.13)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C211(0.63); C237(1.20)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C211(0.73); C237(1.11)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C211(0.69); C237(1.11)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C211(0.66); C237(1.06)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C211(0.60); C237(0.99)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C211(0.79); C237(1.10)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C211(0.84); C237(1.01)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C211(0.87); C237(0.90)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C211(0.76); C237(1.03)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C211(0.82); C237(0.95)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C211(0.54); C237(0.99)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C211(1.17); C237(1.23)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C211(0.88); C237(1.08)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C211(0.80); C237(1.20)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C211(0.87); C237(1.15)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C211(0.90); C237(1.15)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C211(0.82); C237(1.06)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C211(0.84); C237(1.22)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C211(1.01); C237(0.83)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C211(1.13); C237(1.07)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C211(1.12); C237(1.01)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C211(0.80); C237(0.99)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C211(1.50); C237(1.34)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C211(0.99); C237(1.17)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C211(1.12); C237(1.15)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C211(0.92); C237(1.20)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C211(0.97); C237(1.08)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C211(1.42); C237(0.86)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C211(1.35); C237(1.41)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C211(1.10); C237(1.27)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C211(1.42); C237(1.19)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C211(0.96); C237(1.24)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C211(1.04); C237(1.23)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C211(0.89); C237(1.29)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C211(0.88); C237(1.26)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C211(0.94); C237(1.52)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C211(0.96); C237(1.14)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C211(0.92); C237(1.62)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C211(0.76); C237(1.57)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C211(1.41); C237(0.87)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C211(0.67); C237(1.80)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C211(0.76); C237(1.64)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C211(1.07); C237(1.87)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C211(0.83); C237(1.08)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C211(0.77); C237(1.19)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C211(0.79); C237(1.19)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C211(0.85); C237(1.05)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C211(0.73); C237(1.06)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C211(0.67); C237(1.11)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C211(0.69); C237(0.92)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C237(1.07); C211(1.30)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C211(0.87); C237(0.90)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C211(0.89); C237(0.99)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C237(0.83); C211(0.92)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C211(0.45); C237(1.03)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C211(0.77); C237(0.95)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C211(0.72); C237(1.00)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C211(0.94); C237(0.94)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C211(0.96); C237(1.11)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C211(1.10); C237(1.20)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C237(0.69); C211(0.85)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C237(0.73); C211(1.18)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C211(0.81); C237(1.10)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C237(0.95); C211(1.14)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C237(0.80); C211(1.14)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C237(0.92); C211(1.19)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C237(0.78); C211(1.07)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C237(0.87); C211(1.25)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C237(0.50); C211(0.79)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C237(0.59); C211(0.65)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C237(0.54); C211(0.68)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C237(0.58); C211(0.64)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C211(0.67); C237(0.84)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C211(0.91); C237(1.33)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C211(0.67); C237(0.77)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C211(0.65); C237(0.94)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C211(0.54); C237(0.79)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C237(0.59); C211(0.60)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C237(0.61); C211(0.64)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C237(0.83); C211(1.17)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C237(0.77); C211(1.13)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C237(0.68); C211(1.22)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C211(0.96); C237(1.11)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C211(0.84); C237(1.09)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C211(0.81); C237(1.94)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C211(0.90); C237(1.15)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C237(0.69); C211(1.05)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C237(0.67); C211(0.89)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C237(0.69); C211(0.87)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C237(0.77); C211(0.94)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C237(0.70); C211(0.88)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C211(0.92); C237(1.54)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C211(0.79); C237(1.36)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C211(0.90); C237(1.62)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C211(0.62); C237(1.36)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C211(0.81); C237(2.00)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C211(0.72); C237(1.25)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C211(1.12); C237(1.25)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C211(0.91); C237(1.40)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C211(0.76); C237(0.81)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C211(0.89); C237(1.48)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C211(0.54); C237(0.77)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C211(0.44); C237(0.97)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C211(0.82); C237(0.95)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C211(0.83); C237(1.15)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C211(0.72); C237(1.05)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C211(0.94); C237(1.03)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C211(0.78); C237(0.92)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C211(0.85); C237(1.24)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C211(0.74); C237(1.15)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C211(0.85); C237(0.92)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C211(0.72); C237(0.97)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C211(0.59); C237(1.25)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C211(0.76); C237(1.23)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C211(0.43); C237(1.26)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C237(0.51); C211(0.94)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C237(0.57); C211(0.99)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C211(1.00); C237(1.06)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C211(0.62); C237(0.64)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C237(0.52); C211(1.02)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C237(0.66); C211(0.79)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C211(0.49); C237(0.52)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C237(0.53); C211(0.83)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C211(0.56); C237(0.79)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C237(0.51); C211(0.76)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C237(0.56); C211(0.81)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C237(0.54); C211(1.05)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C237(0.72); C211(0.73)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C211(1.02); C237(1.20)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C237(0.51); C211(0.84)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C237(0.62); C211(0.91)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C211(0.59); C237(0.66)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C211(0.41); C237(0.97)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C211(0.47); C237(1.25)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C211(0.53); C237(1.31)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C211(0.58); C237(1.47)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C211(0.79); C237(1.24)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C211(0.57); C237(1.34)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C211(0.51); C237(1.20)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C211(0.83); C237(1.03)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C211(0.40); C237(0.96)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C211(0.37); C237(1.23)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C211(0.53); C237(1.11)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C211(0.63); C237(1.39)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C211(1.12); C237(1.55)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C211(0.51); C237(1.42)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C211(0.44); C237(1.51)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C211(0.33); C237(1.40)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C211(0.73); C237(1.29)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C211(0.97); C237(0.91)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C211(0.96); C237(0.97)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C211(0.76); C237(1.13)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 11.41  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C237(1.09)  LDD0078  [15]
 LDCM0630  CCW28-3 231MFP C289(2.37)  LDD2214  [40]
 LDCM0108  Chloroacetamide HeLa H277(0.00); C237(0.00); C289(0.00); H87(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C237(20.00); C96(1.14); C289(0.85)  LDD2227  [31]
 LDCM0367  CL1 HCT 116 C237(0.86); C211(1.02)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C211(0.73); C237(0.99)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C211(0.84); C237(1.15)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C237(0.95); C211(1.05)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C237(0.84); C211(1.22)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C237(0.76); C211(1.32)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C237(0.84); C211(1.25)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C211(0.96); C237(1.07)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C211(0.86); C237(0.94)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C211(0.81); C237(0.99)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C211(0.78); C237(1.06)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C237(0.79); C211(0.92)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C211(0.76); C237(0.90)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C211(0.75); C237(0.95)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C237(0.90); C211(0.94)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C237(0.57); C211(1.00)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C211(0.65); C237(0.87)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C211(0.76); C237(1.06)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C211(0.60); C237(0.87)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C211(0.60); C237(0.76)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C211(0.61); C237(1.18)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C237(0.69); C211(0.93)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C237(0.72); C211(0.82)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C211(0.66); C237(0.86)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C237(0.78); C211(0.85)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C211(0.68); C237(1.21)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C211(0.87); C237(1.45)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C211(0.67); C237(1.38)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C211(0.57); C237(1.19)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C211(0.91); C237(1.05)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C211(0.86); C237(1.21)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C211(0.97); C237(1.32)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C211(0.71); C237(1.28)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C237(0.81); C211(0.90)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C237(0.90); C211(0.99)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C237(0.79); C211(0.79)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C211(0.88)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C211(1.00)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C211(1.13)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C211(0.92)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C237(0.92); C211(1.10)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C211(0.76)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C211(0.61)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C211(0.55)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C211(0.96)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C211(0.61)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C211(0.59)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C211(0.72)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C211(0.70)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C211(0.72)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C211(0.65)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C211(1.06); C237(0.95)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C211(0.88)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C211(0.89); C237(0.97)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C211(1.09); C237(0.81)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C211(0.91); C237(0.75)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C211(0.65); C237(0.84)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C211(0.78); C237(1.01)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C211(0.94); C237(0.76)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C211(0.70); C237(0.71)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C211(0.67); C237(0.73)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C211(0.94); C237(0.94)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C211(0.65); C237(0.90)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C211(0.95); C237(0.68)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C211(0.60); C237(0.72)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C211(0.65); C237(0.66)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C211(0.78); C237(0.64)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C211(0.61); C237(0.92)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C211(1.09); C237(1.04)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C211(1.06); C237(1.18)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C211(1.28); C237(1.06)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C211(1.21); C237(1.03)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C211(0.96); C237(0.99)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C211(1.15); C237(0.85)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C211(0.96); C237(0.93)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C211(0.88); C237(1.05)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C211(1.47); C237(1.44)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C211(1.16); C237(1.15)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C211(1.20); C237(1.15)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C211(1.07); C237(1.24)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C211(1.16); C237(1.20)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C211(1.08); C237(1.00)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C211(1.02); C237(1.15)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C211(1.01); C237(0.95)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C211(1.13); C237(0.99)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C237(0.88)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C237(0.93)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C237(0.85)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C237(0.76)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C237(0.86)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C237(0.88)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C237(0.65)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C237(1.11)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C237(0.93)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C211(0.72); C237(0.79)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C237(0.95)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C237(0.88)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C237(0.89)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C237(0.88)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C237(0.78)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C211(1.18); C237(1.10)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C211(1.34); C237(1.11)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C211(0.94); C237(0.94)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C211(0.90); C237(1.15)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C211(0.69); C237(0.93)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C211(1.38); C237(1.00)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C211(0.90); C237(0.97)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C211(0.77); C237(1.38)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C211(0.82); C237(1.09)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C211(0.65); C237(1.43)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C211(0.94); C237(1.26)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C211(1.03); C237(1.24)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C211(0.96); C237(1.10)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C211(1.12); C237(1.23)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C211(0.60); C237(0.93)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C211(0.89); C237(1.03)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C211(0.92); C237(0.82)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C211(0.80); C237(1.38)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C211(1.06); C237(1.24)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C211(1.21); C237(0.86)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C211(1.09); C237(0.90)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C211(0.81); C237(1.13)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C211(0.80); C237(1.22)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C211(0.85); C237(1.35)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C211(0.68); C237(1.31)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C211(0.71); C237(1.37)  LDD0811  [15]
 LDCM0634  CY-0357 Hep-G2 C96(0.75)  LDD2228  [31]
 LDCM0495  E2913 HEK-293T C237(1.00); C96(1.03); C211(0.92)  LDD1698  [41]
 LDCM0625  F8 Ramos C211(0.62)  LDD2187  [42]
 LDCM0572  Fragment10 Ramos C211(0.35)  LDD2189  [42]
 LDCM0573  Fragment11 Ramos C211(1.40); C289(2.42)  LDD2190  [42]
 LDCM0574  Fragment12 Ramos C211(0.48)  LDD2191  [42]
 LDCM0575  Fragment13 Ramos C211(0.79)  LDD2192  [42]
 LDCM0576  Fragment14 Ramos C211(0.67); C289(0.40)  LDD2193  [42]
 LDCM0579  Fragment20 Ramos C211(0.43)  LDD2194  [42]
 LDCM0580  Fragment21 Ramos C211(1.52)  LDD2195  [42]
 LDCM0578  Fragment27 Ramos C211(1.03)  LDD2197  [42]
 LDCM0586  Fragment28 Ramos C211(1.93); C289(1.71)  LDD2198  [42]
 LDCM0588  Fragment30 Ramos C211(0.65)  LDD2199  [42]
 LDCM0589  Fragment31 Ramos C211(1.33)  LDD2200  [42]
 LDCM0590  Fragment32 Ramos C211(0.41)  LDD2201  [42]
 LDCM0468  Fragment33 HCT 116 C237(0.98)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C211(1.14)  LDD2203  [42]
 LDCM0566  Fragment4 Ramos C211(0.76); C289(0.68)  LDD2184  [42]
 LDCM0427  Fragment51 HCT 116 C211(0.50); C237(0.68)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C211(0.84)  LDD2204  [42]
 LDCM0614  Fragment56 Ramos C211(0.87)  LDD2205  [42]
 LDCM0569  Fragment7 Ramos C211(0.53); C289(0.49)  LDD2186  [42]
 LDCM0571  Fragment9 Ramos C211(0.55)  LDD2188  [42]
 LDCM0116  HHS-0101 DM93 Y570(0.80); Y205(1.16)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y205(0.87); Y570(10.42)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y205(0.95); Y570(10.36)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y205(0.79); Y570(10.44)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y205(1.06); Y570(10.19)  LDD0268  [13]
 LDCM0107  IAA HeLa H277(0.00); H54(0.00); H87(0.00); H233(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y205(1.34)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y205(2.65)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y205(1.09)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y205(3.56)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y205(1.99)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y205(0.21)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y205(1.29)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y205(0.66)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C237(1.00); C211(1.03)  LDD1492  [41]
 LDCM0023  KB03 HEK-293T C237(1.01); C211(0.99)  LDD1497  [41]
 LDCM0024  KB05 COLO792 C295(1.88); C59(2.45); C99(5.25)  LDD3310  [43]
 LDCM0109  NEM HeLa H277(0.00); H377(0.00); C289(0.00); H233(0.00)  LDD0223  [29]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C96(0.95)  LDD2115  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C96(1.37); C237(0.99)  LDD2206  [44]
 LDCM0628  OTUB2-COV-1 HEK-293T C96(0.64)  LDD2207  [44]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 1 (PRMT1) Protein arginine N-methyltransferase family Q99873
Protein arginine N-methyltransferase 8 (PRMT8) Protein arginine N-methyltransferase family Q9NR22
Bifunctional glutamate/proline--tRNA ligase (EPRS1) Class-I aminoacyl-tRNA synthetase family P07814
Caspase-6 (CASP6) Peptidase C14A family P55212
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Ras-related protein Rab-5A (RAB5A) Rab family P20339
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transcription initiation factor IIB (GTF2B) TFIIB family Q00403
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) Classic translation factor GTPase family P41091
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
Heat shock-related 70 kDa protein 2 (HSPA2) Heat shock protein 70 family P54652
Vimentin (VIM) Intermediate filament family P08670
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Intracellular hyaluronan-binding protein 4 (HABP4) . Q5JVS0
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
21 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
31 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
32 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
33 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
34 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
35 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
36 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
37 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
38 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
39 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
40 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
41 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
42 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
43 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
44 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.